Discoidin Domain Receptors: Unique Receptor Tyrosine Kinases in Collagen-mediated Signaling

Ste20-like kinase SLK, at the crossroads

(2013) Khalid N. Al-Zahrani et al.   Cell Adhesion & Migration

A tale of two collagen receptors, integrin β1 and discoidin domain receptor 1, in epithelial cell differentiation

(2012) Yi-Chun Yeh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Discoidin domain receptor tyrosine kinases: new players in cancer progression

(2012) Rajeshwari R. Valiathan et al.   CANCER AND METASTASIS REVIEWS

The role of pseudokinases in cancer

(2012) Hua Zhang et al.   CELLULAR SIGNALLING

Numb/Numbl-Opo Antagonism Controls Retinal Epithelium Morphogenesis by Regulating Integrin Endocytosis

(2012) Ozren Bogdanović et al.   DEVELOPMENTAL CELL

The Crystal Structures of TrkA and TrkB Suggest Key Regions for Achieving Selective Inhibition

(2012) T. Bertrand et al.   JOURNAL OF MOLECULAR BIOLOGY

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Discoidin Domain Receptors Promote α1β1- and α2β1-Integrin Mediated Cell Adhesion to Collagen by Enhancing Integrin Activation

(2012) Huifang Xu et al.   PLoS One

Structure of the Discoidin Domain Receptor 1 Extracellular Region Bound to an Inhibitory Fab Fragment Reveals Features Important for Signaling

(2012) Federico Carafoli et al.   STRUCTURE

Transmembrane Collagen Receptors

(2011) Birgit Leitinger   Annual Review of Cell and Developmental Biology

Mechanisms of integrin activation and trafficking

(2011) Coert Margadant et al.   CURRENT OPINION IN CELL BIOLOGY

DDR1 Receptor Tyrosine Kinase Promotes Prosurvival Pathway through Notch1 Activation

(2011) Hyung-Gu Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Collagen I regulates the self-renewal of mouse embryonic stem cells through α2β1 integrin- and DDR1-dependent Bmi-1

(2011) Han Na Suh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Phosphotyrosine mediated protein interactions of the discoidin domain receptor 1

(2011) Simone Lemeer et al.   Journal of Proteomics

Phosphoproteomic studies of receptor tyrosine kinases: future perspectives

(2011) Paul H. Huang   Molecular BioSystems

Feedback regulation of EGFR signalling: decision making by early and delayed loops

(2011) Roi Avraham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrin-linked kinase: Not so ‘pseudo’ after all

(2011) G E Hannigan et al.   ONCOGENE

Survey of Tyrosine Kinase Signaling Reveals ROS Kinase Fusions in Human Cholangiocarcinoma

(2011) Ting-Lei Gu et al.   PLoS One

Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

(2011) Peter S. Hammerman et al.   Cancer Discovery

Molecular and Cellular Mechanisms of Ectodomain Shedding

(2010) Kazutaka Hayashida et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

The influence of discoidin domain receptor 2 on the persistence length of collagen type I fibers

(2010) Lalitha Sivakumar et al.   BIOMATERIALS

Collagen stimulates discoidin domain receptor 1-mediated migration of smooth muscle cells through Src

(2010) Katherine Kun Lu et al.   CARDIOVASCULAR PATHOLOGY

Mapping structural landmarks, ligand binding sites, and missense mutations to the collagen IV heterotrimers predicts major functional domains, novel interactions, and variation in phenotypes in inherited diseases affecting basement membranes

(2010) J. Des Parkin et al.   HUMAN MUTATION

Collagen binding specificity of the discoidin domain receptors: Binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1

(2010) Huifang Xu et al.   MATRIX BIOLOGY

Collective cell migration requires suppression of actomyosin at cell–cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6

(2010) Cristina Hidalgo-Carcedo et al.   NATURE CELL BIOLOGY

Protein kinases: evolution of dynamic regulatory proteins

(2010) Susan S. Taylor et al.   TRENDS IN BIOCHEMICAL SCIENCES

DDR1/E-cadherin complex regulates the activation of DDR1 and cell spreading

(2009) Chau-Zen Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Breakdown of endocytosis in the oncogenic activation of receptor tyrosine kinases

(2009) Jasmine V. Abella et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Navigating ECM Barriers at the Invasive Front: The Cancer Cell–Stroma Interface

(2009) R. Grant Rowe et al.   Annual Review of Cell and Developmental Biology

The relative roles of collagen adhesive receptor DDR2 activation and matrix stiffness on the downregulation of focal adhesion kinase in vascular smooth muscle cells

(2009) Kiran Bhadriraju et al.   BIOMATERIALS

Inhibition of Collagen Fibrillogenesis by Cells Expressing Soluble Extracellular Domains of DDR1 and DDR2

(2009) Lisa A. Flynn et al.   JOURNAL OF MOLECULAR BIOLOGY

Discoidin domain receptor 2 (DDR2) is required for maintenance of spermatogenesis in male mice

(2009) Kiyoshi Kano et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Linear combinations of docking affinities explain quantitative differences in RTK signaling

(2009) Andrew Gordus et al.   Molecular Systems Biology

Endosomes: A legitimate platform for the signaling train

(2009) J. E. Murphy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic, functional and motif-based analysis of C-terminal Src kinase-interacting proteins

(2009) Guang Yang et al.   PROTEOMICS

Crystallographic Insight into Collagen Recognition by Discoidin Domain Receptor 2

(2009) Federico Carafoli et al.   STRUCTURE

Differential Effects of EGFR Ligands on Endocytic Sorting of the Receptor

(2009) Kirstine Roepstorff et al.   TRAFFIC

Cell–collagen interactions: the use of peptide Toolkits to investigate collagen–receptor interactions

(2008) Richard W. Farndale et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Inhibition of collagen-induced discoidin domain receptor 1 and 2 activation by imatinib, nilotinib and dasatinib

(2008) Elizabeth Day et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Candidate Cell and Matrix Interaction Domains on the Collagen Fibril, the Predominant Protein of Vertebrates

(2008) Shawn M. Sweeney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping of SPARC/BM-40/Osteonectin-binding Sites on Fibrillar Collagens

(2008) Camilla Giudici et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Collagen I–mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1

(2008) Yasushi Shintani et al.   JOURNAL OF CELL BIOLOGY

Discoidin domain receptor 1 activation suppresses α2β1integrin-dependent cell spreading through inhibition of Cdc42 activity

(2008) Yi-Chun Yeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mapping of DDR1 Distribution and Oligomerization on the Cell Surface by FRET Microscopy

(2008) Cosmin Mihai et al.   JOURNAL OF MOLECULAR BIOLOGY

A Novel Dwarfism with Gonadal Dysfunction Due to Loss-of-Function Allele of the Collagen Receptor Gene,Ddr2, in the Mouse

(2008) Kiyoshi Kano et al.   MOLECULAR ENDOCRINOLOGY

Functional selectivity of EGF family peptide growth factors: Implications for cancer

(2008) Kristy J. Wilson et al.   PHARMACOLOGY & THERAPEUTICS

Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis

(2008) Pei Jin et al.   ARTHRITIS RESEARCH & THERAPY