Breakdown of endocytosis in the oncogenic activation of receptor tyrosine kinases

A combination of Trastuzumab and 17-AAG induces enhanced ubiquitinylation and lysosomal pathway-dependent ErbB2 degradation and cytotoxicity in ErbB2-overexpressing breast cancer cells

(2010) Srikumar M. Raja et al.   CANCER BIOLOGY & THERAPY

Activation of MET by Gene Amplification or by Splice Mutations Deleting the Juxtamembrane Domain in Primary Resected Lung Cancers

(2010) Ryoichi Onozato et al.   Journal of Thoracic Oncology

Regulation of endocytosis via the oxygen-sensing pathway

(2009) Yi Wang et al.   NATURE MEDICINE

Disruption of Vps4 and JNK Function in Drosophila Causes Tumour Growth

(2009) Lina M. Rodahl et al.   PLoS One

Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl

(2008) C. Slape et al.   BLOOD

Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia

(2008) M. H. Tomasson et al.   BLOOD

Roles for deregulated receptor tyrosine kinases and their downstream signaling molecules in hematologic malignancies

(2008) Itaru Matsumura et al.   CANCER SCIENCE

Regulation of the Met Receptor-tyrosine Kinase by the Protein-tyrosine Phosphatase 1B and T-cell Phosphatase

(2008) Veena Sangwan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor

(2008) Ingrid Roxrud et al.   JOURNAL OF CELL BIOLOGY

Reactive oxygen species: Current knowledge and applications in cancer research and therapeutic

(2008) Andy T.Y. Lau et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Prolonged EGFR Signaling by ERBB2-Mediated Sequestration at the Plasma Membrane

(2007) Martin Offterdinger et al.   TRAFFIC