Article
Cardiac & Cardiovascular Systems
Olga M. Rusiecka, Filippo Molica, Morten S. Nielsen, Axel Tollance, Sandrine Morel, Maud Frieden, Marc Chanson, Kerstin Boengler, Brenda R. Kwak
Summary: This study found that deletion of the Pannexin1 (Panx1) gene in cardiac endothelial cells can alleviate cardiac ischaemia/reperfusion (I/R) injury and improve left ventricular function recovery. This cardioprotective effect seems to be mediated through its influence on cardiac mitochondria rather than reducing the inflammatory response. Therefore, Panx1 may represent a new target for controlling cardiac reperfusion damage.
CARDIOVASCULAR RESEARCH
(2023)
Article
Critical Care Medicine
Matthias Kohlhauer, Mathieu Panel, Marine Vermot des Roches, Estelle Faucher, Yara Abi Zeid Daou, Emilie Boissady, Fanny Lidouren, Bijan Ghaleh, Didier Morin, Renaud Tissier
Summary: The study found that cardiac and cerebral mitochondrial dysfunction showed similar patterns after cardiac arrest, with initial recovery within the first few hours but a significant increase in dysfunction after 24 hours. Despite greater neurological dysfunction after non-shockable cardiac arrest, mitochondrial dysfunction was still more pronounced after 24 hours.
Article
Biochemistry & Molecular Biology
Di Ren, Zhibin He, Julia Fedorova, Jingwen Zhang, Elizabeth Wood, Xiang Zhang, David E. Kang, Ji Li
Summary: Sesn2, a stress-inducible protein, declines with aging in the heart. Lack of Sesn2 results in cardiac aging-like dysfunction and intolerance to ischemia reperfusion stress. Sesn2 deficiency impairs mitochondrial function and affects oxidative phosphorylation complex activity, impacting the maintenance of cardiac mitochondrial integrity.
Article
Medicine, General & Internal
Kei Hayashida, Ryosuke Takegawa, Yusuke Endo, Tai Yin, Rishabh C. Choudhary, Tomoaki Aoki, Mitsuaki Nishikimi, Atsushi Murao, Eriko Nakamura, Muhammad Shoaib, Cyrus Kuschner, Santiago J. Miyara, Junhwan Kim, Koichiro Shinozaki, Ping Wang, Lance B. Becker
Summary: This study demonstrates that mitochondrial transplantation can improve survival and neurological recovery in post-cardiac arrest rats. Freshly isolated functional mitochondria significantly increased the 72-hour survival rate and improved various aspects of cardiac and neurological functions. These findings provide a foundation for further research and development of mitochondrial transplantation as a novel therapeutic strategy.
Article
Cardiac & Cardiovascular Systems
Ana C. M. Omoto, Jussara M. do Carmo, Benjamin Nelson, Nikaela Aitken, Xuemei Dai, Sydney Moak, Elizabeth Flynn, Zhen Wang, Alan J. Mouton, Xuan Li, John E. Hall, Alexandre A. da Silva
Summary: This study found that central nervous system actions of leptin can significantly improve cardiac function and mitochondrial metabolism after myocardial ischemia/reperfusion injury, regardless of sex. These effects are largely independent of cardiac sympathetic innervation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Nutrition & Dietetics
Apiwan Arinno, Nattayaporn Apaijai, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Left ventricular dysfunction is associated with various health conditions and pharmacological agents, with the overproduction of reactive oxygen species playing a crucial role. Maintaining the balance between oxidative stress and antioxidants is essential for proper cellular function. Resveratrol, as a potential therapeutic agent, has been shown to upregulate antioxidative capacity through increasing antioxidant genes, potentially improving cardiac mitochondrial function in cardiovascular diseases.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Zuzana Nichtova, Celia Fernandez-Sanz, Sergio de la Fuente, Yuexing Yuan, Stephen Hurst, Sebastian Lanvermann, Hui-Ying Tsai, David Weaver, Ariele Baggett, Christopher Thompson, Cedric Bouchet-Marquis, Peter Varnai, Erin L. Seifert, Gerald W. W. Dorn II, Shey-Shing Sheu, Gyorgy Csordas
Summary: Cardiac contractile function relies on the transfer of energy from mitochondria and Ca2+ from the sarcoplasmic reticulum (SR). Excessive stress can lead to mitochondrial Ca2+ overload and other abnormalities that can disrupt cardiac function. However, enhancing the connection between mitochondria and SR in a selective and chronic manner may improve cardiac performance and reduce vulnerability to stress-induced damage.
CIRCULATION RESEARCH
(2023)
Article
Medicine, Research & Experimental
Nurellya Faqhiraah Aziz, Anand Ramalingam, Jalifah Latip, Satirah Zainalabidin
Summary: S-Allylcysteine (SAC) has been proven to confer cardioprotection in various studies and its application in experimental models showed improvements in cardiac function, increased glutathione levels, and preserved mitochondrial permeability.
Article
Biochemistry & Molecular Biology
Anja V. Gruszczyk, Alva M. Casey, Andrew M. James, Hiran A. Prag, Nils Burger, Georgina R. Bates, Andrew R. Hall, Fay M. Allen, Thomas Krieg, Kourosh Saeb-Parsy, Michael P. Murphy
Summary: Cell models of cardiac ischemia-reperfusion injury are crucial for studying cardiac pathology, however, current monolayer cell models are inadequate in replicating in vivo injury. This study identified two reasons for the limitations: the presence of oxygen in cellular hypoxia models sustains mitochondrial oxidative phosphorylation, and the loss of lactate from cells during ischemia sustains glycolysis. By incubating isolated adult mouse cardiomyocytes anoxically and inhibiting lactate efflux, key markers of in vivo ischemia were recapitulated, allowing for the assessment of important aspects of cardiac IR injury in vitro.
Review
Cell Biology
Felipe Salazar-Ramirez, Roberto Ramos-Mondragon, Gerardo Garcia-Rivas
Summary: Ca2+plays a crucial role in mitochondrial function, and the communication between mitochondria and SR is essential for cellular energy production and signaling. The balance between mitochondria and SR maintains normal cellular function, and any imbalance can lead to abnormal excitability of cardiac cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Gaia Pedriali, Daniela Ramaccini, Esmaa Bouhamida, Mariusz R. R. Wieckowski, Carlotta Giorgi, Elena Tremoli, Paolo Pinton
Summary: Cardiovascular disease, particularly ischemic heart disease, is the leading cause of death worldwide. Myocardial ischemia-reperfusion injury (IRI), a side effect of clinical treatment for heart diseases, is still a major concern. Mitochondria play a crucial role in the pathogenesis of IRI, and disruptions in mitochondrial quality control processes exacerbate the injury. Targeting mitochondria may provide a new approach to control heart tissue damage following ischemia and reperfusion.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Rongjun Zou, Wanting Shi, Junxiong Qiu, Na Zhou, Na Du, Hao Zhou, Xinxin Chen, Li Ma
Summary: Empagliflozin can protect microvasculature during myocardial ischemia reperfusion injury (I/R) by inhibiting the DNA-PKcs/Fis1/mitochondrial fission pathway.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jan Lj Miljkovic, Nils Burger, Justyna M. Gawel, John F. Mulvey, Abigail A. I. Norman, Takanori Nishimura, Yoshiyuki Tsujihata, Angela Logan, Olga Sauchanka, Stuart T. Caldwell, Jordan L. Morris, Tracy A. Prime, Stefan Warrington, Julien Prudent, Georgina R. Bates, Dunja Aksentijevic, Hiran A. Prag, Andrew M. James, Thomas Krieg, Richard C. Hartley, Michael P. Murphy
Summary: This study developed a mitochondria-targeted agent, MitoPerSulf, that rapidly releases H2S within mitochondria. It is acutely protective against cardiac IR injury by inhibiting respiration at cytochrome c oxidase and preventing mitochondrial superoxide production.
Article
Chemistry, Multidisciplinary
Zelin Chen, Xu Tan, Taotao Jin, Yu Wang, Linyong Dai, Gufang Shen, Can Zhang, Langfan Qu, Lei Long, Chongxing Shen, Xiaohui Cao, Jianwu Wang, Huijuan Li, Xiaofeng Yue, Chunmeng Shi
Summary: This study presents the potential of near infrared dye IR-780 for monitoring and protecting ischemic myocardium from injury. IR-780 selectively enters cardiomyocytes in at-risk heart tissues and can preconditon or administer timely to protect against cell death, myocardial remodeling, and heart failure induced by ischemia and oxidative stress. The dye binds to F0F1-ATP synthase in cardiomyocytes, decreases mitochondrial membrane potential, and slows down mitochondrial energy metabolism, leading to a quiescent mitochondria state and inhibition of mitochondrial permeability transition pore. Moderating mitochondrial function depression could be a targeted approach for developing cardioprotective reagents.
Article
Genetics & Heredity
Firdos Ahmad, Hezlin Marzook, Anamika Gupta, Aseel Aref, Kiran Patil, Amir Ali Khan, Mohamed A. Saleh, Walter J. Koch, James R. Woodgett, Rizwan Qaisar
Summary: Reperfusion after acute myocardial infarction exacerbates cardiac injury and adverse remodeling. Loss of the GSK-3α isoform may attenuate cardiac injury and provide beneficial effects by limiting myocardial inflammation, mitochondrial dysfunction, and metabolic derangement. Selective inhibition of GSK-3α may be beneficial in ischemia/reperfusion-induced cardiac injury.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Cardiac & Cardiovascular Systems
Benjamin Strauss, Malik Bisserier, Emerson Obus, Michael G. Katz, Anthony Fargnoli, Marine Cacheux, Joseph G. Akar, James P. Hummel, Lahouaria Hadri, Yassine Sassi, Fadi G. Akar
Summary: The study investigates the electrophysiological substrate and arrhythmic vulnerability in a new pure model of pulmonary arterial hypertension (PAH). It reveals right ventricular remodeling that promotes multiwavelet reentry underlying ventricular tachycardia/fibrillation (VT/VF).
Article
Cardiac & Cardiovascular Systems
Jaydev Dave, Nour Raad, Nishka Mittal, Lu Zhang, Anthony Fargnoli, Jae Gyun Oh, Maria Elisabetta Savoia, Jens Hansen, Marika Fava, Xiaoke Yin, Konstantinos Theofilatos, Delaine Ceholski, Erik Kohlbrenner, Dongtak Jeong, Lauren Wills, Mathieu Nonnenmacher, Kobra Haghighi, Kevin D. Costa, Irene C. Turnbull, Manuel Mayr, Chen-Leng Cai, Evangelia G. Kranias, Fadi G. Akar, Roger J. Hajjar, Francesca Stillitano
Summary: This study assessed the efficiency of in vivo genome editing using CRISPR/Cas9 and AAV9 in improving cardiac function in young adult mice with the human PLN-R14del mutation. The results showed that in vivo gene editing significantly reduced susceptibility to ventricular tachycardia and improved cardiac function in these mice, providing preclinical evidence for potential therapeutic interventions in patients with PLN-R14del mutation.
CARDIOVASCULAR RESEARCH
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Marine Cacheux, Fadi G. Akar
EUROPEAN HEART JOURNAL
(2022)
Article
Medicine, Research & Experimental
Kevin N. Su, Yina Ma, Marine Cacheux, Zeki Ilkan, Nour Raad, Grace K. Muller, Xiaohong Wu, Nicole Guerrera, Stephanie L. Thorn, Albert J. Sinusas, Marc Foretz, Benoit Viollet, Joseph G. Akar, Fadi G. Akar, Lawrence H. Young
Summary: AMPK plays an essential role in maintaining homeostasis in the atria by regulating key transcription factors that control the expression of atrial ion channels and gap junction proteins.
Editorial Material
Cardiac & Cardiovascular Systems
Valeria Novelli, Fadi G. Akar
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Physiology
Evan V. V. Jenkins, Dhani Dharmaprani, Madeline Schopp, Jing Xian Quah, Kathryn Tiver, Lewis Mitchell, Feng Xiong, Martin Aguilar, Kenneth Pope, Fadi G. Akar, Caroline H. H. Roney, Steven A. A. Niederer, Stanley Nattel, Martyn P. P. Nash, Richard H. H. Clayton, Anand N. N. Ganesan
Summary: This study characterizes the effect of an inspection paradox on the perception of phase singularities (PS) lifetimes in cardiac fibrillation. The results show that the inspection paradox leads to oversampling of PS with longer lifetimes. Considering the overall distribution of PS lifetimes helps minimize the inspection paradox.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Tyler L. Stevens, Heather R. Manring, Michael J. Wallace, Aaron Argall, Trevor Dew, Peter Papaioannou, Steve Antwi-Boasiako, Xianyao Xu, Stuart G. Campbell, Fadi G. Akar, Maegen A. Borzok, Thomas J. Hund, Peter J. Mohler, Sara N. Koenig, Mona El Refaey
Summary: In this study, a mouse model of ACM was developed to investigate the dual role of genetics and external stressors in ACM progression. The findings suggest that cardiovascular stress is a key trigger for unmasking both electrical and structural phenotypes in ACM.
Article
Multidisciplinary Sciences
Emmi Karkkainen, Sami Heikkinen, Maria Tengstrom, Veli-Matti Kosma, Arto Mannermaa, Jaana M. Hartikainen
Summary: This study demonstrates the clinical relevance of small non-coding RNAs (sncRNAs) in invasive breast cancer. SncRNAs can be used as prognostic and predictive biomarkers, providing new insights into breast cancer treatment.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Margaret McKay, Fadi G. Akar
CARDIOVASCULAR RESEARCH
(2023)
Review
Nutrition & Dietetics
Yongyan Song, Henry Wade, Bingrui Zhang, Wenhao Xu, Rongxue Wu, Shujin Li, Qiaozhu Su
Summary: Childhood metabolic syndrome (MetS) is a global problem and is linked to increased risk of cardiovascular disease in adulthood. Genetic variants in the fat mass and obesity-associated gene (FTO) have been found to contribute to early-onset MetS in children and adolescents. Specific FTO polymorphisms, such as rs9939609 and rs9930506, have been shown to be significantly associated with the development of MetS in this population. Mechanistically, these FTO polymorphisms lead to abnormal expression of FTO and related genes, promoting adipogenesis and appetite while reducing fat breakdown, satiety, and energy expenditure in carriers. This review highlights the importance of FTO polymorphisms in child and adolescent MetS, and explores the molecular mechanisms underlying the development of increased waist circumference, hypertension, and hyperlipidemia.
Article
Genetics & Heredity
Karim Ullah, Yan Li, Qiaoshan Lin, Kaichao Pan, Tu Nguyen, Solanki Aniruddhsingh, Qiaozhu Su, Willard Sharp, Rongxue Wu
Summary: This study performed a comparative analysis of two widely used mouse models of septic cardiomyopathy, and identified key genes and pathways involved in its development. The two models were able to induce septic heart dysfunction within 24 hours, but they had different transcriptome expression profiles and potentially diverse pathways contributing to sepsis-induced heart failure.
Review
Biology
Karim Ullah, Lizhuo Ai, Zainab Humayun, Rongxue Wu
Summary: In this review paper, the potential new therapies for ischemic heart disease (IHD) are discussed, focusing on the dysfunction of endothelial cells and the activation of hypoxia-inducible factors (HIFs), particularly HIF2 alpha and its partner ARNT. The review provides an overview of their signaling in endothelial cells, their roles in inflammation and maintaining blood vessel integrity, and their involvement in IHD. Targeting HIF2 alpha and ARNT in endothelial cells could offer promising new approaches for treating IHD.
Article
Cell Biology
Henry Wade, Kaichao Pan, Qihua Duan, Szczepan Kaluzny, Ekta Pandey, Linda Fatumoju, Viswanathan Saraswathi, Rongxue Wu, Edward N. Harris, Qiaozhu Su
Summary: This study uncovers a novel mechanism that links A. muciniphila and its membrane protein with host CREBH, IGF signaling, and miRNAs in mitigating intestinal inflammatory stress, gut barrier permeability, and promoting intestinal wound healing.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Marine Cacheux, Yina Ma, Xiaohong Wu, Joseph Akar, Lawrence H. Young, Fadi G. Akar
CIRCULATION RESEARCH
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Kaichao Pan, Qin Zhang, Karim Ullah, Ani Solanki, Allbert Sitikov, James K. Liao, Rongxue Wu
CIRCULATION RESEARCH
(2022)