Review
Biochemistry & Molecular Biology
Xavier R. Chapa-Dubocq, Keishla M. Rodriguez-Graciani, Nelson Escobales, Sabzali Javadov
Summary: Mitochondria, known as the powerhouse of the cell, regulate various cellular processes including ion homeostasis, energy production, and cell death. The inner mitochondrial membrane (IMM) plays a critical role in controlling mitochondrial metabolism and function. The volume of the mitochondrial matrix, regulated by ion transport mechanisms, influences IMM remodeling and can affect mitochondrial respiration and cell survival. Despite extensive research, the mechanisms underlying changes in matrix volume and IMM remodeling in response to energy and oxidative stressors remain poorly understood. This review summarizes previous studies and discusses the interplay between matrix volume regulation and IMM remodeling.
Article
Cell Biology
Igor Khaliulin, Raimondo Ascione, Leonid N. Maslov, Haitham Amal, M. Saadeh Suleiman
Summary: The study demonstrates that 8-Br can alleviate cardiac injury before regional ischemia or at the beginning of reperfusion, protecting the heart from reperfusion damage. This effect may be associated with the inhibition of MPTP through HKII binding to mitochondria.
Article
Biochemistry & Molecular Biology
Maxime Schleef, Margaux Rozes, Bruno Pillot, Gabriel Bidaux, Fitsum Guebre-Egziabher, Laurent Juillard, Delphine Baetz, Sandrine Lemoine
Summary: This study aimed to investigate the effect of CsA preconditioning on kidney and mitochondrial functions. The results showed that CsA significantly improved renal function and mitochondrial functions, while the use of Hsp70 inhibitor abolished the protection afforded by CsA. In vitro experiments demonstrated that Hsp70 modulation could protect kidneys from ischemia reperfusion injury by regulating mitochondrial functions. This pathway may be targeted by drugs to provide new therapeutics for improving renal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Ping Huang, Si-Peng Wu, Ning Wang, Saiwang Seto, Dennis Chang
Summary: This study evaluated the protective effects of HSYA on cerebral I/R injury by inhibiting the opening of mPTP through the MEK/ERK/CypD pathway, reducing the release of CytC from mitochondria to protect cells and alleviate damage.
Article
Cardiac & Cardiovascular Systems
Hiran A. Prag, Dunja Aksentijevic, Andreas Dannhorn, Abigail Giles, John F. Mulvey, Olga Sauchanka, Luping Du, Georgina Bates, Johannes Reinhold, Duvaraka Kula-Alwar, Zhelong Xu, Luc Pellerin, Richard J. A. Goodwin, Michael P. Murphy, Thomas Krieg
Summary: Malonate selectively enters cardiomyocytes during reperfusion in a low pH environment caused by ischemia, protecting against cardiac ischemia/reperfusion injury.
CIRCULATION RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Stefano Comita, Saveria Femmino, Cecilia Thairi, Giuseppe Alloatti, Kerstin Boengler, Pasquale Pagliaro, Claudia Penna
Summary: Cardioprotective conditioning strategies such as pre- and post-conditioning maneuvers play a crucial role in stimulating pro-survival pathways like STAT3 for the preservation of cardiac health. The importance of STAT3 as a promoter of metabolic network and its interactions with processes aimed at maintaining mitochondrial functions have been highlighted in understanding cardioprotection phenomena.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Hector Chapoy Villanueva, Jae Hwi Sung, Jackie A. Stevens, Michael J. Zhang, Peyton M. Nelson, Lalitha S. Denduluri, Feng Feng, Timothy D. O'Connell, DeWayne Townsend, Julia C. Liu
Summary: Transport of Ca2+ into mitochondria through the mitochondrial Ca2+ uniporter complex is essential for ATP production, but excessive Ca2+ can be detrimental. Short-term deletion of the regulatory protein EMRE in the heart resulted in impaired Ca2+ uptake, attenuated ATP production, and improved cardiac function in an I/R model. However, long-term EMRE loss led to similar impairment in Ca2+ handling and function, but loss of protection against I/R injury. These findings suggest that long-term absence of EMRE restores susceptibility to I/R, despite impaired bioenergetic response.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Mahmood S. Mozaffari
Summary: The SGK family of proteins includes three paralogs, with SGK-1 being the most studied. SGK-1 plays a crucial role in regulating cell survival and proliferation, and also influences the pathogenesis of organ diseases. Therapeutic modulation of SGK-1 could potentially benefit conditions associated with ischemia-reperfusion injury.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Rene Ferrera, Marie Vedere, Megane Lo-Grasso, Lionel Augeul, Christophe Chouabe, Gabriel Bidaux, Delphine Baetz
Summary: This study aimed to evaluate the protective effects of postconditioning on DCD hearts. The results showed that CsA and POST could reduce necrosis and improve heart function. However, the efficacy of POST was lost if delayed beyond 3 minutes of reperfusion, while CsA treatment remained effective even if applied after a delay. Delayed CsA application correlated with better functional recovery and higher mitochondrial respiratory index, suggesting the crucial role of MPTP in delayed protection of DCD hearts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Noemi Daradics, Gergo Horvath, Laszlo Tretter, Agnes Paal, Andras Fulop, Andras Budai, Attila Szijarto
Summary: Depletion of CypD improves mitochondrial function following ALPPS and enhances liver growth.
Article
Medicine, Research & Experimental
Xianfei Ji, Jennifer L. Bradley, Guanghui Zheng, Weiwei Ge, Jing Xu, Juntao Hu, Fenglian He, Rabiya Shabnam, Mary Ann Peberdy, Joseph P. Ornato, Qun Chen, Edward J. Lesnefsky, Wanchun Tang
Summary: Brain mitochondria are more sensitive to injury during cardiac arrest and resuscitation compared to cardiac mitochondria, particularly in terms of the sensitivity of Complex I in brain mitochondria. Therapeutic preservation of cerebral mitochondrial activity and function during cardiac arrest may improve post-resuscitation neurologic function.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Cell Biology
Artyom Y. Baev, Andrey Y. Vinokurov, Irina N. Novikova, Viktor V. Dremin, Elena V. Potapova, Andrey Y. Abramov
Summary: Neurodegenerative disorders are devastating diseases characterized by the loss of neurons in specific brain regions. Recent research has identified genes, toxins, and risk factors associated with these diseases, and has found similarities in the involvement of mitochondria, oxidative stress, and abnormal calcium signaling in neurons and astrocytes.
Review
Biochemistry & Molecular Biology
Alessandro Parente, Mauricio Flores Carvalho, Andrea Schlegel
Summary: The endothelium, forming the inner layer of blood vessels, plays a crucial role in intercellular communication and vascular homeostasis. Recent studies have highlighted the importance of endothelial cells in metabolic function and their response to flow changes, which are linked to mitochondrial health. The impact of different perfusion conditions on liver sinusoidal endothelial cells (LSECs) and their mitochondrial function in the context of liver transplantation is discussed in this article. The available ex situ machine perfusion strategies and their effects on LSEC health are described, with a focus on specific perfusion conditions such as pressure, duration, and oxygenation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Ji-fei Liu, Gang Su, Li-xia Chen, Juan-ping Zhou, Juan Gao, Jia-jia Zhang, Qiong-hui Wu, Wei Chen, De-yi Chen, Zhen-chang Zhang
Summary: This study investigated the beneficial effects and mechanisms of action of irisin in response to cerebral ischemia-reperfusion injury (CIRI). Irisin improved cerebral function, reduced cerebral infarct volume, protected neuronal cells against apoptosis, and alleviated oxidative stress through the prevention of mitochondrial fission, increased mitochondrial fusion, and activation of the PI3K/AKT/mTOR axis. Irisin is identified as a much-needed therapeutic for CIRI.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Engineering, Biomedical
Xiaoping Zhang, Yage Sun, Rong Yang, Bo Liu, Yang Liu, Jianhai Yang, Wenguang Liu
Summary: In this study, a mitochondria-targeted nanomicelle was designed for the treatment of myocardial ischemia-reperfusion injury. The nanomicelle was encapsulated into a pH/ROS dual responsive injectable hydrogel for controllable drug delivery. The treatment effectively restored mitochondrial function and attenuated oxidative stress in a rat model.
Correction
Biochemistry & Molecular Biology
B. Nancolas, R. B. Sessions, A. P. Halestrap
BIOCHEMICAL JOURNAL
(2015)
Article
Biochemistry & Molecular Biology
Bethany Nancolas, Richard B. Sessions, Andrew P. Halestrap
BIOCHEMICAL JOURNAL
(2015)
Article
Physiology
Philippe Diolez, Isabelle Bourdel-Marchasson, Guillaume Calmettes, Philippe Pasdois, Dominique Detaille, Richard Rouland, Gilles Gouspillou
FRONTIERS IN PHYSIOLOGY
(2015)
Review
Cardiac & Cardiovascular Systems
Rafael Jaimes, Richard D. Walton, Philippe Pasdois, Olivier Bernus, Igor R. Efimov, Matthew W. Kay
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Bethany Nancolas, Lili Guo, Rong Zhou, Kavindra Nath, David S. Nelson, Dennis B. Leeper, Ian A. Blair, Jerry D. Glickson, Andrew P. Halestrap
BIOCHEMICAL JOURNAL
(2016)
Article
Biochemistry & Molecular Biology
Andrew P. Richardson, Andrew P. Halestrap
BIOCHEMICAL JOURNAL
(2016)
Review
Biochemistry & Molecular Biology
Kavindra Nath, Lili Guo, Bethany Nancolas, David S. Nelson, Alexander A. Shestov, Seung-Cheol Lee, Jeffrey Roman, Rong Zhou, Dennis B. Leeper, Andrew P. Halestrap, Ian A. Blair, Jerry D. Glickson
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2016)
Review
Cardiac & Cardiovascular Systems
Tatyana N. Andrienko, Philippe Pasdois, Goncalo C. Pereira, Matthew J. Ovens, Andrew P. Halestrap
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2017)
Review
Pharmacology & Pharmacy
Andrew P. Halestrap, Goncalo C. Pereira, Philippe Pasdois
BRITISH JOURNAL OF PHARMACOLOGY
(2015)
Article
Cardiac & Cardiovascular Systems
Richard D. Walton, Ali Pashaei, Marine E. Martinez, Marion Constantin, Josselin Duchateau, Laura Bear, Caroline Cros, Caroline Pascarel-Auclerc, Yunbo Guo, David Benoist, Virginie Dubes, Ndeye Rokhaya Faye, Sebastien Chaigne, Sebastien Dupuis, Dominique Detaille, Line Pourtau, Philippe Pasdois, Fabien Brette, Julien Rogier, Louis Labrousse, Meleze Hocini, Edward J. Vigmond, Michel Haissaguerre, Olivier Bernus
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2018)
Article
Multidisciplinary Sciences
Tatyana Andrienko, Philippe Pasdois, Andreas Rossbach, Andrew P. Halestrap
Article
Chemistry, Applied
Jerome Cleach, Philippe Pasdois, Philippe Marchetti, Denis Watier, Guillaume Duflos, Emmanuelle Goffier, Anne-Sophie Lacoste, Christian Slomianny, Thierry Grard, Philippe Lencel
Article
Multidisciplinary Sciences
Dominique Detaille, Philippe Pasdois, Audrey Semont, Pierre Dos Santos, Philippe Diolez
Article
Multidisciplinary Sciences
Mario Rienzo, Julien Imbault, Younes El Boustani, Antoine Beurton, Carolina Carlos Sampedrano, Philippe Pasdois, Mathieu Pernot, Olivier Bernus, Michel Haissaguerre, Thierry Couffinhal, Alexandre Ouattara
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Nestor Pallares-Lupon, Jason D. Bayer, Bastien Guillot, Guido Caluori, Girish S. Ramlugun, Kanchan Kulkarni, Virginie Loyer, Stephane Bloquet, Dounia El Hamrani, Jerome Naulin, Marion Constantin, Pierre Dos Santos, Olivier Bernus, Pierre Jais, Philippe Pasdois, Richard D. Walton
Summary: Structural remodeling is a common result of chronic pathological stresses on the heart. Understanding the properties of diseased tissue is critical for determining their interactions with arrhythmic behavior. Microscale tissue remodeling is emerging as an important source of lethal arrhythmia, especially in young adults.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)