Article
Computer Science, Artificial Intelligence
Randall Clark, Lawson Fuller, Jason A. Platt, Henry D. I. Abarbanel
Summary: This article introduces how to use methods from nonlinear dynamics and interpolation techniques from applied mathematics to construct discrete time dynamical rules that forecast observed neuron properties accurately, which is crucial for the development of neural network models and biological networks.
NEURAL COMPUTATION
(2022)
Article
Biochemistry & Molecular Biology
Laura Marongiu, Francesca Mingozzi, Clara Cigni, Roberta Marzi, Marco Di Gioia, Massimiliano Garre, Dario Parazzoli, Laura Sironi, Maddalena Collini, Reiko Sakaguchi, Takashi Morii, Mariacristina Crosti, Monica Moro, Stephane Schurmans, Tiziano Catelani, Rany Rotem, Miriam Colombo, Stephen Shears, Davide Prosperi, Ivan Zanoni, Francesca Granucci
Summary: Recognition of LPS by DCs involves the receptor complex CD14 and TLR4, and subsequent Ca2+ mobilization and NFAT activation require IP3R3 and ITPKB. Targeting ITPKB may offer a promising approach for anti-inflammatory therapies aimed at inhibiting specific DC functions.
Review
Pathology
Sun-Ji Park, Chuang Li, Ying Maggie Chen
Summary: Maintaining Ca2+ homeostasis is crucial for cellular function and survival, with the endoplasmic reticulum acting as the major intracellular Ca2+ store. Dysregulation of ER Ca2+ homeostasis is associated with various diseases, particularly in kidney diseases, highlighting the importance of ER Ca2+ channels, pumps, and binding proteins. Despite advancements in understanding, treatment for ER Ca2+ imbalance in kidney diseases remains elusive.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Guizhen Fan, Mariah R. Baker, Lara E. Terry, Vikas Arige, Muyuan Chen, Alexander B. Seryshev, Matthew L. Baker, Steven J. Ludtke, David Yule, Irina I. Serysheva
Summary: In this study, the cryo-EM structures of IP(3)R1 were determined, providing atomic details of IP3, Ca2+ and ATP binding. The authors identified the molecular motions of key domains and sidechains that regulate ligand binding and gating behavior of IP3R channels.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Nagendra Babu Thillaiappan, Holly A. Smith, Peace Atakpa-Adaji, Colin W. Taylor
Summary: The study demonstrates that the KRas-induced KRAP protein tethers a subset of IP3 receptors to actin, enabling them to evoke calcium signals. Loss of KRAP results in the disappearance of Ca2+ puffs and a global response to increased cytosolic Ca2+ concentration from more intense stimulation.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Ana M. Rossi, Andrew M. Riley, Genevieve Dupont, Taufiq Rahman, Barry V. L. Potter, Colin W. Taylor
Summary: Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) are intracellular Ca2+ channels linking extracellular stimuli to Ca2+ signals. Research shows that quantal responses to low IP3 concentrations do not require heterogeneous Ca2+ stores, and IP(3)Rs exhibit incremental responses to IP3 stimulation. This suggests that Ca2+ signals evoked by IP3 pulses arise from rapid activation and inactivation of a small fraction of IP(3)Rs.
Review
Neurosciences
Pragnya Chakraborty, Gaiti Hasan
Summary: Key components of endoplasmic reticulum (ER) Ca2+ release and store-operated Ca2+ entry (SOCE) are expressed in all metazoan cells. This review presents evidence on how these two mechanisms impact neuronal physiology and their interaction with ion channels in neurons. The careful regulation of neural SOCE is essential due to the detrimental effects of Ca2+ imbalance on neurons. The study also discusses different mechanisms of SOCE regulation in Drosophila and mammalian neurons, and their significance in human neurodegenerative diseases.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Multidisciplinary Sciences
Roberto Ornelas-Guevara, Diana Gil, Valerie Voorsluijs, Genevieve Dupont
Summary: Inositol 1,4,5-trisphosphate (IP3) plays a key role in calcium signaling. Previous studies overestimated the diffusion coefficient of IP3 in vivo, but new computational analysis shows that the effective diffusion coefficient is close to 100 μm(2)s(-1), significantly lower than previous estimations. This moderate reduction can be explained by the buffering effect of non-fully bound inactive IP3 receptors.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Valerio Farfariello, Dmitri Gordienko, Lina Mesilmany, Yasmine Touil, Emmanuelle Germain, Ingrid Fliniaux, Emilie Desruelles, Dimitra Gkika, Morad Roudbaraki, George Shapovalov, Lucile Noyer, Mathilde Lebas, Laurent Allart, Nathalie Zienthal-Gelus, Oksana Iamshanova, Franck Bonardi, Martin Figeac, William Laine, Jerome Kluza, Philippe Marchetti, Bruno Quesnel, Daniel Metzger, David Bernard, Jan B. Parys, Loic Lemonnier, Natalia Prevarskaya
Summary: This study reveals the mechanism of how alterations in mitochondrial function and calcium signaling contribute to cellular senescence and tumor growth. The downregulation of TRPC3 protein in senescent fibroblasts leads to increased mitochondrial calcium load and oxidative phosphorylation, promoting cellular senescence. The downregulation of TRPC3 in stromal cells also affects secretome and tumor progression, highlighting its importance in cancer development.
NATURE COMMUNICATIONS
(2022)
Article
Biophysics
Victor Nicolai Friedhoff, Benjamin Lindner, Martin Falcke
Summary: This article investigates the randomness and properties of Ca2+ signaling in cells. The researchers found that the generation of Ca2+ spikes follows certain patterns and can be described as a process from one state to another. They proposed a theoretical model to explain the differences in spike behavior between different cell types and stimulating agonists, as well as the variability observed in experiments.
BIOPHYSICAL JOURNAL
(2023)
Review
Cell Biology
Jens Loncke, Allen Kaasik, Ilya Bezprozvanny, Jan B. Parys, Martijn Kerkhofs, Geert Bultynck
Summary: Organelles cooperate through membrane contact sites to regulate cellular homeostasis and function. Particularly, the communication between the endoplasmic reticulum and mitochondria enables efficient transmission of Ca2+ signals, tightly controlling mitochondrial functions at a microdomain level.
TRENDS IN CELL BIOLOGY
(2021)
Article
Cell Biology
Arthur Bassot, Junsheng Chen, Kei Takahashi-Yamashiro, Megan C. Yap, Christine Silvia Gibhardt, Giang N. T. Le, Saaya Hario, Yusuke Nasu, Jack Moore, Tomas Gutierrez, Lucas Mina, Heather Mast, Audric Moses, Rakesh Bhat, Klaus Ballanyi, Helene Lemieux, Roberto Sitia, Ester Zito, Ivan Bogeski, Robert E. Campbell, Thomas Simmen
Summary: Endoplasmic reticulum (ER) homeostasis relies on molecular regulators, such as calnexin and NOX4, to maintain mitochondrial metabolism and ER-mitochondria contacts. During ER stress induction, the PERK-ERO1a complex interacts and promotes oxidation of MERC proteins, controlling mitochondrial dynamics and improving ER-mitochondria Ca2+ flux for bioenergetics maintenance. This complex plays a crucial role in quick metabolic adaptation to ER stress.
Article
Biochemistry & Molecular Biology
Lukas Kuester, Themistoklis Paraschiakos, Kader Ebru Karakurt, Udo Schumacher, Bjoern-Philipp Diercks, Sabine Windhorst
Summary: The up-regulation of ITPKA in lung cancer cells is associated with increased migration and invasion, and its actin bundling activity is the main factor controlling this effect.
BIOSCIENCE REPORTS
(2023)
Article
Multidisciplinary Sciences
Na Tang, Wen Tian, Guang-Yuan Ma, Xiong Xiao, Lei Zhou, Ze-Zhi Li, Xiao-Xiao Liu, Chong-Yao Li, Ke-Han Wu, Wenjuan Liu, Xue-Ying Wang, Yuan-Yuan Gao, Xin Yang, Jianzhao Qi, Ding Li, Yang Liu, Wen-Sheng Chen, Jinming Gao, Xiao-Qiang Li, Wei Cao
Summary: Deficiency of TRPC1 and TRPC6 channels ameliorates LPS-induced heart failure, prolongs survival, and suppresses cardiac inflammation and ER Ca2+ release.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Takahiro Takano, Amanda M. Wahl, Kai-Ting Huang, Takanori Narita, John Rugis, James Sneyd, David Yule
Summary: In this study, researchers found that the Ca2+ signals in salivary secretion process in live mice initiate in the apical endoplasmic reticulum, forming highly localized trains of transient that fail to fully propagate, leading to large apical-basal gradients following optimal stimuli for secretion. A new mathematical model incorporating these findings will help to understand how salivary secretion can be optimally stimulated by apical Ca2+ signals.
Review
Cell Biology
Sandeep Malampati, Ju-Xian Song, Benjamin Chun-Kit Tong, Anusha Nalluri, Chuan-Bin Yang, Ziying Wang, Sravan Gopalkrishnashetty Sreenivasmurthy, Zhou Zhu, Jia Liu, Chengfu Su, Senthilkumar Krishnamoorthi, Ashok Iyaswamy, King-Ho Cheung, Jia-Hong Lu, Min Li
Article
Cell Biology
Cui-Zan Cai, Chuanbin Yang, Xu-Xu Zhuang, Ning-Ning Yuan, Ming-Yue Wu, Jie-Qiong Tan, Ju-Xian Song, King-Ho Cheung, Huanxing Su, Yi-Tao Wang, Bei-Sha Tang, Christian Behrends, Siva Sundara Kumar Durairajan, Zhenyu Yue, Min Li, Jia-Hong Lu
Summary: NRBF2, a component of the class III phosphatidylinositol 3-kinase (PtdIns3K) complex, plays a crucial role in modulating autophagosome maturation and APP-CTF degradation by interacting with RAB7 and maintaining its activity. This study reveals a novel mechanism by which NRBF2 regulates autophagy and protein degradation associated with Alzheimer's disease.
Review
Physiology
Akiyuki Taruno, Kengo Nomura, Tsukasa Kusakizako, Zhongming Ma, Osamu Nureki, J. Kevin Foskett
Summary: Recent research has made significant progress in understanding the molecular mechanisms behind taste transduction, including the identification of specific taste sensors and components for each taste sensation. The discovery of unconventional chemical synapses and insights into the structures of ion channels have provided new perspectives in the field of taste sensation and neurotransmission.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Review
Clinical Neurology
Alexis S. Huang, Benjamin C. K. Tong, Aston J. Wu, Xiaotong Chen, Sravan G. Sreenivasmurthy, Zhou Zhu, Jia Liu, Chengfu Su, Min Li, King-Ho Cheune
CURRENT ALZHEIMER RESEARCH
(2020)
Article
Chemistry, Multidisciplinary
Chuan-bin Yang, Jia Liu, Benjamin Chun-Kit Tong, Zi-ying Wang, Zhou Zhu, Cheng-fu Su, Sravan Gopalkrishnashetty Sreenivasmurthy, Jia-xi Wu, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Shi-ying Huang, King-ho Cheung, Ju-xian Song, Jie-qiong Tan, Jia-hong Lu, Min Li
Summary: The study reveals that TFEB, a key regulator of autophagy and lysosomal biogenesis, can promote cell apoptosis in response to 15d-PGJ2 through ROS-mediated translocation into the nucleus and subsequent upregulation of ATF4. This novel role of TFEB in apoptosis induction provides new insights into the complex mechanisms underlying cellular responses to 15d-PGJ2.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Cell Biology
Benjamin Chun-Kit Tong, Aston Jiaxi Wu, Alexis Shiying Huang, Rui Dong, Sandeep Malampati, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Sravan Gopalkrishnashetty Sreenivasmurthy, Zhou Zhu, Chengfu Su, Jia Liu, Juxian Song, Jia-Hong Lu, Jieqiong Tan, Weidong Pan, Min Li, King-Ho Cheung
Summary: This study identified a mechanism of impairment in the macroautophagy/autophagy-lysosomal pathway (ALP) in Alzheimer's disease, mediated by the lysosomal TPCN2/TPC2 channel. Targeting TPCN2 was shown to restore lysosomal function and reduce amyloid plaque accumulation, suggesting a potential therapeutic strategy for AD treatment in the future.
Article
Oncology
Cristina Aguirre-Portoles, Riley Payne, Aspen Trautz, J. Kevin Foskett, Christopher A. Natale, John T. Seykora, Todd W. Ridky
Summary: Testosterone signaling through ZIP9 mediates some of the sex differences in melanoma, and drugs that target AR can be repurposed to block ZIP9 and inhibit melanoma in males.
Article
Plant Sciences
Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Sanjib Senapati, Sandeep Malampati, Zhou Zhu, Cheng-Fu Su, Jia Liu, Xin-Jie Guan, Benjamin Chun-Kit Tong, King-Ho Cheung, Jie-Qiong Tan, Jia-Hong Lu, Siva Sundara Kumar Durairajan, Ju-Xian Song, Min Li
Summary: The study found that protopine (PRO) reduces abnormal tau protein in the brains of Alzheimer's disease (AD) patients, improving memory and cognition. The research confirmed the pharmacokinetics of PRO and its mechanism of action through experiments.
Article
Plant Sciences
Ashok Iyaswamy, Senthil Kumar Krishnamoorthi, Huan Zhang, Sravan G. Sreenivasmurthy, Zhou Zhu, Jia Liu, Cheng-Fu Su, Xin-Jie Guan, Zi-Ying Wang, King-Ho Cheung, Ju-Xian Song, Siva Sundara Kumar Durairajan, Min Li
Summary: The study demonstrated that QYS extract improved cognitive function and attenuated AD pathology in 3XTg mice by promoting the expression of PPAR alpha and TFEB, and enhancing ALP both in vivo and in vitro.
Article
Chemistry, Multidisciplinary
Zhou Zhu, Liang-feng Liu, Cheng-fu Su, Jia Liu, Benjamin Chun-Kit Tong, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Sravan Gopalkrishnashetty Sreenivasmurthy, Xin-jie Guan, Yu-xuan Kan, Wen-jian Xie, Chen-liang Zhao, King-ho Cheung, Jia-hong Lu, Jie-qiong Tan, Hong-jie Zhang, Ju-xian Song, Min Li
Summary: This study synthesized various derivatives of the natural alkaloid Corynoxine B (Cory B) to find more potent autophagy inducers with improved brain bioavailability. The CB6 derivative was shown to enhance autophagy and protect against Parkinson's disease in vitro and in vivo by activating the PIK3C3 complex. CB6 administration improved motor dysfunction and prevented the loss of dopaminergic neurons in a mouse model of Parkinson's disease.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Biochemistry & Molecular Biology
Xinjie Guan, Ashok Iyaswamy, Sravan Gopalkrishnashetty Sreenivasmurthy, Chengfu Su, Zhou Zhu, Jia Liu, Yuxuan Kan, King-Ho Cheung, Jiahong Lu, Jieqiong Tan, Min Li
Summary: Selective autophagy plays an important role in the pathogenesis of Alzheimer's disease, and regulating selective autophagy can be an effective strategy for controlling this pathological process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ashok Iyaswamy, Xueli Wang, Senthilkumar Krishnamoorthi, Venkatapathy Kaliamoorthy, Sravan G. Sreenivasmurthy, Siva Sundara Kumar Durairajan, Ju-Xian Song, Benjamin Chun-kit Tong, Zhou Zhu, Cheng-Fu Su, Jia Liu, King-Ho Cheung, Jia-Hong Lu, Jie-Qiong Tan, Hung Wing Li, Man Shing Wong, Min Li
Summary: The accumulation of phosphorylated Tau aggregates and A beta oligomers are crucial factors in the development of Alzheimer's disease. A study found that the fluorescent probe F-SLOH effectively inhibited A beta aggregation and reduced various neuropathological changes in AD mouse models by promoting autophagy lysosomal degradation pathway.
Article
Cell Biology
Zhongming Ma, Usha Paudel, J. Kevin Foskett
Summary: The intensity of taste is strongly influenced by temperature, but there is a lack of comprehensive understanding about the physiological, hedonic, and commercial implications of this relationship. This study used patch-clamp electrophysiology to investigate the effects of temperature on taste-bud cell electrical excitability, revealing that temperature significantly affects the electrical activity of type II taste-bud cells. These findings provide a mechanism for understanding how temperature influences taste sensitivity and perception.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Anna Hau-Yee Kong, Aston Jiaxi Wu, Olivia Ka-Yi Ho, Maggie Ming-Ki Leung, Alexis Shiying Huang, Yuanyuan Yu, Ge Zhang, Aiping Lyu, Min Li, King-Ho Cheung
Summary: Neuroinflammation is a precursor to neurodegenerative diseases, and targeting it with aptamers offers potential diagnostic and therapeutic applications. This review summarizes the use of aptamers for diagnosing and treating inflammatory biomolecules and cells associated with neurodegenerative diseases. It also discusses the potential of short nucleotides for targeted brain delivery and the challenges of using aptamers as therapeutic agents. Overall, this review assesses the potential of aptamers as a pioneering approach for CNS target delivery and the treatment of neuroinflammation and neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Senthilkumar Krishnamoorthi, Ashok Iyaswamy, Sravan Gopalkrishnashetty Sreenivasmurthy, Abhimanyu Thakur, Karthick Vasudevan, Gaurav Kumar, Xin-Jie Guan, Kejia Lu, Isha Gaurav, Cheng-Fu Su, Zhou Zhu, Jia Liu, Yuxuan Kan, Selvaraj Jayaraman, Zhiqiang Deng, Ka Kit Chua, King-Ho Cheung, Zhijun Yang, Ju-Xian Song, Min Li
Summary: This study demonstrates that Caudatin can activate the PPARα-dependent ALP pathway, promoting the clearance of Aβ and phosphorylated-Tau in AD, thereby reducing the progression of the disease and improving cognitive dysfunction.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2023)