Article
Biology
Dibesh Thapa, Joao de Sousa Valente, Brentton Barrett, Matthew John Smith, Fulye Argunhan, Sheng Y. Lee, Sofya Nikitochkina, Xenia Kodji, Susan D. Brain
Summary: Ageing is associated with increased vulnerability to environmental cold exposure, leading to impaired behavioural and vascular responses to skin local environmental cooling in aged mice. The decline in TRPM8 gene/protein expression in ageing mice suggests a reliance on remaining TRP receptor activity for cold-induced vascular response. Sympathetic-induced vasoconstriction is also reduced with aging, indicating a decline in the cold-induced vascular response necessary for maintaining body heat and health.
Article
Biophysics
Xiaojiang Xu, Timothy P. Rioux, Julio Gonzalez, Eric O. Hansen, John W. Castellani, William R. Santee, Anthony J. Karis, Adam W. Potter
Summary: The paper introduces a Cold Weather Ensemble Decision Aid (CoWEDA) that guides users on cold weather injury prevention, mission planning, and clothing selection by incorporating science from physiology, meteorology, clothing, and computer modeling. CoWEDA predicts the risk of frostbite and hypothermia, ensuring selected clothing ensembles are appropriate for expected weather conditions and activities. Additionally, it represents a significant enhancement of required clothing insulation and wind chill index-based guidance for cold weather safety and survival.
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
(2021)
Article
Neurosciences
Somayeh Ezzatpanah, Mina Baarnes Eriksen, Anne-Mari Gjestvang Moe, Fred Haugen
Summary: Chronic exposure to cold temperatures can alter thermosensory behaviors in mice, making them appear less sensitive to cold, potentially involving the TRPM8 molecular cold sensor in the process.
Article
Endocrinology & Metabolism
Alex L. Fedinec, Jianxiong Liu, Rong Zhang, Mimily Harsono, Massroor Pourcyrous, Helena Parfenova
Summary: Mild hypothermia produced by head cooling acutely and reversibly reduces specific endothelium-dependent cerebral vasodilator functions via TRPM8 activation, while preserving cerebral arteriolar smooth muscle functions.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Medicine, Research & Experimental
Sabrina Qader Kudsi, Bruna Candia Piccoli, Daniel Ardisson-Araujo, Gabriela Trevisan
Summary: This article aims to analyze the baseline distribution of TRPA1, TRPV1, TRPV4, and TRPM8 channels in human systems at the transcriptional level. Using the RNA-seq dataset, the transcriptional levels of these channels were investigated and compared in 95 human subjects representing 33 different tissues, providing essential suggestions for further studies on these proteins.
Article
Neurosciences
Chenyu Yang, Shanni Yamaki, Tyler Jung, Brian Kim, Ryan Huyhn, David D. McKemy
Summary: The detection of environmental temperatures is crucial for survival and inappropriate responses to thermal stimuli can negatively affect overall health. The physiological effect of cold is distinct and can be soothing and analgesic, but also agonizing in the context of tissue damage. Inflammatory mediators induce neurogenic inflammation that alters cold sensitivity through the activation of TRPV1 and TRPA1 ion channels.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Irina P. Voronova, Galina M. Khramova, Anna A. Evtushenko, Tamara Kozyreva
Summary: This study investigated the effects of activating peripheral TRPM8 in hypertensive rats on body temperature balance and mRNA expression of thermosensitive TRP ion channels in the hypothalamus. The findings showed that activating peripheral TRPM8 did not affect thermoregulatory parameters in hypertensive rats, but significantly increased the expression of Trpm8 in the hypothalamus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mariana A. Freitas, Amanda Vasconcelos, Elaine C. D. Goncalves, Eduarda G. Ferrarini, Gabriela B. Vieira, Donatella Cicia, Maira Cola, Raffaele Capasso, Rafael C. Dutra
Summary: Spirulina platensis is a super-food with anti-inflammatory, antioxidant, and analgesic properties, showing significant analgesic effects in rodent models of inflammatory pain by potentially modulating TRMP8 and TRPA1.
Article
Biochemistry & Molecular Biology
Leevi Halonen, Antti Pemmari, Elina Nummenmaa, Mari Haemaelaeinen, Teemu Moilanen, Katriina Vuolteenaho, Eeva Moilanen
Summary: This study found that human osteoarthritic chondrocytes express 19 different TRP genes, with significant expression of TRPM8. In addition, menthol and dexamethasone can regulate the expression of TRP channels. These results support the concept of TRPA1 and TRPM8 as potential novel drug targets in arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Construction & Building Technology
Jiansong Wu, Xinyu Ji, Zhuqiang Hu, Boyang Sun, Letian Li
Summary: This study aimed to investigate the physiological responses and thermal sensation during the recovery period after exposure to different degrees of cold environment. The results showed that under -10 degrees C and -15 degrees C conditions, blood pressure, heart rate, and local skin temperature still could not return to baseline levels.
BUILDING AND ENVIRONMENT
(2021)
Article
Multidisciplinary Sciences
Xiancui Lu, Zhihao Yao, Yunfei Wang, Chuanlin Yin, Jiameng Li, Longhui Chai, Wenqi Dong, Licheng Yuan, Ren Lai, Shilong Yang
Summary: Molecular thermosensors in animals, specifically the TRPM8 gene, play a critical role in accurately sensing and responding to ambient temperature fluctuations. Through the process of evolution, the TRPM8 gene has evolved to form and regulate different domains, allowing for distinct cold-sensitive properties among vertebrate TRPM8 orthologs. The acquisition of cold sensitivity in TRPM8 facilitated terrestrial adaptation during the water-to-land transition.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Medicinal
Sho Sanechika, Chika Shimobori, Katsuya Ohbuchi
Summary: This study evaluated the effects of flavonoid aglycones and their glycosides on TRP channel subtypes, finding that certain compounds can activate TRPA1 and inhibit TRPM8. The metabolization of these compounds in the intestines could potentially lead to the generation of TRPA1 agonists and TRPM8 antagonists.
JOURNAL OF NATURAL MEDICINES
(2021)
Article
Chemistry, Medicinal
Emoke Olah, Zoltan Rumbus, Viktoria Kormos, Valeria Tekus, Eszter Pakai, Hannah V. Wilson, Kata Fekete, Margit Solymar, Leonardo Kelava, Patrik Keringer, Balazs Gaszner, Matthew Whiteman, Julie Keeble, Erika Pinter, Andras Garami
Summary: Research has shown that H2S can induce hypothermia and vasodilation in mice by activating TRPA1 channels in hypothalamic neurons.
Article
Health Care Sciences & Services
Denis E. Naumov, Olesya O. Kotova, Dina A. Gassan, Ivana Y. Sugaylo, Evgeniya Y. Afanas'eva, Elizaveta G. Sheludko, Juliy M. Perelman
Summary: The study found that TRPM8 and TRPA1 gene polymorphisms do not significantly influence susceptibility to COPD, but the TRPA1 rs7819749 and TRPM8 rs11562975 genotypes are significantly associated with airway obstruction and lung function in COPD patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Weifeng Tian, Dongmei He, Jingjing Liu, Feiyu Chen, Wenjie Zhang, Jinsheng Hu, Shu Wang
Summary: Borneol, a traditional Chinese medicine, has been used to treat itchy skin. This study shows that applying borneol topically on the skin can effectively suppress drug-induced itching. Borneol's antipruritic effect is mainly achieved through inhibiting TRPA1 channels and activating TRPM8 channels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Food Science & Technology
Leonardo Kelava, David Nemeth, Peter Hegyi, Patrik Keringer, Dora K. Kovacs, Marta Balasko, Margit Solymar, Eszter Pakai, Zoltan Rumbus, Andras Garami
Summary: This study found that dietary capsaicinoid supplementation significantly reduced serum total cholesterol and low-density lipoprotein levels in humans, with no significant effect on high-density lipoprotein and triglyceride levels. Additional randomized controlled trials in a diverse population are needed to validate the effectiveness of dietary capsaicin supplementation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Cardiac & Cardiovascular Systems
Alexandra Balint, Lilla Hanak, Peter Hegyi, Zsolt Szakacs, Szimonetta Eitmann, Andras Garami, Margit Solymar, Katalin Marta, Zoltan Rumbus, Andras Komocsi
Summary: This meta-analysis evaluated the significance of low platelet reactivity (LPR) on adverse cardiovascular events among patients receiving coronary stent implantation. The results showed that LPR was associated with an increased bleeding risk and a decreased risk of non-fatal myocardial infarction and serious vascular events.
CARDIOLOGY JOURNAL
(2023)
Article
Endocrinology & Metabolism
Patrik Keringer, Nora Furedi, Balazs Gaszner, Alexandra Miko, Eszter Pakai, Kata Fekete, Emoke Olah, Leonardo Kelava, Andrej A. Romanovsky, Zoltan Rumbus, Andras Garami
Summary: The study found that centrally administered CCK can increase body temperature, and this hyperthermic effect requires activation of COX-2. CCK induces fever by altering the activity of classical thermoeffector pathways, and this effect is completely blocked by COX inhibitors.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Review
Medicine, Research & Experimental
Dora K. Kovacs, Noemi Gede, Laszlo Szabo, Peter Hegyi, Zsolt Szakacs, Bela Faludi, Agnes Sebok, Andras Garami, Margit Solymar, Daniel Kosa, Lilla Hanak, Zoltan Rumbus, Marta Balasko
Summary: This meta-analysis shows that combining weight loss with continuous positive airway pressure (CPAP) significantly improves blood pressure and blood lipid values in individuals with obstructive sleep apnea (OSA). However, adding CPAP to weight loss does not provide additional benefits for these cardiovascular parameters.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Polymer Science
Leonardo Kelava, Ivan Ivic, Eszter Pakai, Kata Fekete, Peter Maroti, Roland Told, Zoltan Ujfalusi, Andras Garami
Summary: We have developed a transparent resin material for additive manufacturing of a heat-exchange device in a wire myograph system. The material exhibits good mechanical and thermal stability, making it suitable for use in biomedical research. Animal experiments show that temperature has an impact on vasoconstriction mechanisms, highlighting the importance of studying temperature-dependent physiological processes.
Article
Biochemistry & Molecular Biology
Meena Patel, Hillary M. Peltier, Mark A. Matulenko, John R. Koenig, Marc J. C. Scanio, Rebecca J. Gum, Odile F. El-Kouhen, Meagan M. Fricano, Greta L. Lundgaard, Torben Neelands, Xu-Feng Zhang, Cenchen Zhan, Madhavi Pai, Nayereh Ghoreishi-Haack, Thomas Hudzik, Gary Gintant, Ruth Martin, Steve McGaraughty, Jun Xu, Daniel Bow, John C. Kalvass, Philip R. Kym, David A. DeGoey, Michael E. Kort
Summary: The voltage-gated sodium channel Na(v)1.7 is a promising target for pain treatment, and the discovery of 2-substituted quinolines and quinolones as potent small molecule Na(v)1.7 blockers has shown good efficacy and analgesic effects.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Review
Biology
Aba Lorincz, Alex Varadi, Peter Hegyi, Zoltan Rumbus, Mate Tuba, Anna Gabriella Lamberti, Margit Varju-Solymar, Andrea Parniczky, Balint Eross, Andras Garami, Gergo Jozsa
Summary: This study conducted a meta-analysis to evaluate the effectiveness of different dressings for paediatric second-degree burn injuries. The results showed that biosynthetic, silver foam, and amnion membrane dressings were associated with faster healing times and reduced complication rates. The number of dressing changes also had an impact on pain, narcosis, and treatment duration. However, due to heterogeneity among studies, no significant difference was found in the main outcomes. Further research is needed to determine the most effective treatment for these burns.
Article
Pediatrics
Abaa Lorincz, Anna Gabriella Lamberti, Zsolt Juhasz, Andras Garami, Gergo Jozsa
Summary: Zinc-hyaluronan-containing burn dressings have been found effective in promoting wound closure and reducing infection rates in pediatric facial thermal injuries. This study discovered that pediatric superficial partial-thickness burns on the face are common in infancy and often accompanied by injuries to the left upper limb. Application of the zinc-hyaluronan gel resulted in rapid wound closure and low complication rates, leading to a moderate length of hospitalization.
Article
Critical Care Medicine
Alexandra Csenkey, Emma Hargitai, Eszter Pakai, Bela Kajtar, Livia Vida, Aba Lorincz, Marin Gergics, Peter Vajda, Gergo Jozsa, Andras Garami
Summary: By comparing various treatment methods using a preclinical testing model, the combination of zinc-hyaluronan gel and silver foam dressing was found to be more effective in treating superficial partial-thickness burns.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Chemistry, Medicinal
Janos Garai, Balazs Radnai, Eszter Vamos, Dominika Kovacs, Viola Bagone Vantus, Zoltan Rumbus, Eszter Pakai, Andras Garami, Gergely Gulyas-Fekete, Attila Agocs, Marcell Kreko, Khadiza Zaman, Laszlo Prokai, Laszlo Orfi, Peter B. Jakus, Tamas Lorand
Summary: This study reports the synthesis, docking, and bioactivity of substituted benzylidene-1-indanone and -1-tetralone derivatives as MIF-tautomerase inhibitors. Many of these derivatives were effective inhibitors of MIF-tautomerase, with 1-indanone derivatives 16 and 20 being the most potent. Some compounds also acted as selective enolase or ketonase inhibitors. Additionally, several compounds exhibited anti-inflammatory effects and inhibited the production of NO, TNF alpha, and IL-6 in lipopolysaccharide-induced macrophages.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Janos Toldi, Leonardo Kelava, Sandor Marton, Diana Muhl, Peter Kustan, Zsolt Feher, Klaudia Maar, Janos Garai, Eszter Pakai, Andras Garami
Summary: This study found that the kinetics of MIF levels in serum can predict death in septic patients, especially in males. Additionally, lower levels of MIF in urine can also indicate death, without showing temporal changes.
SCIENTIFIC REPORTS
(2023)
Review
Chemistry, Medicinal
Eszter Bako, Peter Fehervari, Andras Garami, Fanni Dembrovszky, Emese Eszter Gunther, Peter Hegyi, Dezso Csupor, Andrea Boszormenyi
Summary: This study conducted a systematic review and meta-analysis to explore the effectiveness of topical essential oils in musculoskeletal disorders. The results showed that EO therapy had a positive impact on reducing pain and stiffness in these disorders.
Article
Biology
Angyalka Valik, Katalin Harangozo, Andras Garami, Zsolt Juhasz, Gergo Jozsa, Aba Lorincz
Summary: This study assessed the graft and donor areas of children who underwent autologous skin transplantation using two assessment scales. The results showed significant differences between parents and examiners in their perception of the children's scars. Medical professionals rated the donor site more positively than the transplanted area, highlighting the importance of evaluating the effectiveness and improvement techniques of autologous skin grafting.
Review
Cell Biology
Andras Garami, Peter Hegyi
Summary: Acute pancreatitis is a significant burden with no specific therapy. A paradigm shift towards personalized treatment approaches and clinical trials should be considered. The development of precision medicine in acute pancreatitis requires the establishment of an expert committee to coordinate activities and optimize patient care.