标题
Novel therapeutic targets in primary biliary cirrhosis
作者
关键词
-
出版物
Nature Reviews Gastroenterology & Hepatology
Volume 12, Issue 3, Pages 147-158
出版商
Springer Nature
发表日期
2015-02-03
DOI
10.1038/nrgastro.2015.12
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Unmet clinical need in autoimmune liver diseases
- (2015) Jessica K. Dyson et al. JOURNAL OF HEPATOLOGY
- Amyloid-β pathology is attenuated by tauroursodeoxycholic acid treatment in APP/PS1 mice after disease onset
- (2015) Pedro A. Dionísio et al. NEUROBIOLOGY OF AGING
- Successful immunotherapy of autoimmune cholangitis by adoptive transfer of forkhead box protein 3+regulatory T cells
- (2014) H. Tanaka et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Innate immunity drives xenobiotic-induced murine autoimmune cholangitis
- (2014) C.-H. Chang et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Levels of Alkaline Phosphatase and Bilirubin Are Surrogate End Points of Outcomes of Patients With Primary Biliary Cirrhosis: An International Follow-up Study
- (2014) Willem J. Lammers et al. GASTROENTEROLOGY
- The Bile Acid Receptor TGR5 Activates the TRPA1 Channel to Induce Itch in Mice
- (2014) TinaMarie Lieu et al. GASTROENTEROLOGY
- P367 PHASE 2 STUDY EVALUATING THE EFFICACY AND SAFETY OF USTEKINUMAB IN PATIENTS WITH PRIMARY BILIARY CIRRHOSIS WHO HAD AN INADEQUATE RESPONSE TO URSODEOXYCHOLIC ACID
- (2014) G.M. Hirschfield et al. JOURNAL OF HEPATOLOGY
- O168 THE FIRST PRIMARY BILIARY CIRRHOSIS (PBC) PHASE 3 TRIAL IN TWO DECADES – AN INTERNATIONAL STUDY OF THE FXR AGONIST OBETICHOLIC ACID IN PBC PATIENTS
- (2014) F. Nevens et al. JOURNAL OF HEPATOLOGY
- Origin of myofibroblasts in the fibrotic liver in mice
- (2014) K. Iwaisako et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanisms of tissue injury in autoimmune liver diseases
- (2014) Evaggelia Liaskou et al. Seminars in Immunopathology
- Old and Novel Therapies for Primary Biliary Cirrhosis
- (2014) Albert Parés SEMINARS IN LIVER DISEASE
- The New Epidemiology of Primary Biliary Cirrhosis
- (2014) Laura Griffiths et al. SEMINARS IN LIVER DISEASE
- Animal Models of Primary Biliary Cirrhosis
- (2014) Jinjun Wang et al. SEMINARS IN LIVER DISEASE
- B-Cell Depletion With Rituximab in Patients With Primary Biliary Cirrhosis Refractory to Ursodeoxycholic Acid
- (2013) Robert P Myers et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Biliary Epithelial Senescence and Plasticity in Acute Cellular Rejection
- (2013) J. G. Brain et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Inhibition of αvβ6 Promotes Acute Renal Allograft Rejection in Nonhuman Primates
- (2013) D. J. Lo et al. AMERICAN JOURNAL OF TRANSPLANTATION
- The Immunobiology and Pathophysiology of Primary Biliary Cirrhosis
- (2013) Gideon M. Hirschfield et al. Annual Review of Pathology-Mechanisms of Disease
- Impact of primary biliary cirrhosis on perceived quality of life: The UK-PBC national study
- (2013) George F. Mells et al. HEPATOLOGY
- Peroxisome proliferator-activated receptor α activates human multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion
- (2013) Nisanne S. Ghonem et al. HEPATOLOGY
- IL-12/Th1 and IL-23/Th17 biliary microenvironment in primary biliary cirrhosis: Implications for therapy
- (2013) Chen-Yen Yang et al. HEPATOLOGY
- Pruritus in cholestasis: Facts and fiction
- (2013) Ulrich Beuers et al. HEPATOLOGY
- The TGR5 receptor mediates bile acid–induced itch and analgesia
- (2013) Farzad Alemi et al. JOURNAL OF CLINICAL INVESTIGATION
- The impact of liver transplantation on the phenotype of primary biliary cirrhosis patients in the UK-PBC cohort
- (2013) Greta Pells et al. JOURNAL OF HEPATOLOGY
- Differential effects of norUDCA and UDCA in obstructive cholestasis in mice
- (2013) Peter Fickert et al. JOURNAL OF HEPATOLOGY
- P-Selectin-Mediated Monocyte-Cerebral Endothelium Adhesive Interactions Link Peripheral Organ Inflammation To Sickness Behaviors
- (2013) C. D'Mello et al. JOURNAL OF NEUROSCIENCE
- Bezafibrate normalizes alkaline phosphatase in primary biliary cirrhosis patients with incomplete response to ursodeoxycholic acid
- (2013) Sabela Lens et al. LIVER INTERNATIONAL
- Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology
- (2013) Ingmar Mederacke et al. Nature Communications
- ‘Out-patient’ albumin dialysis for cholestatic patients with intractable pruritus
- (2012) P. Leckie et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- CXCR3 axis in patients with primary biliary cirrhosis: a possible novel mechanism of the effect of ursodeoxycholic acid
- (2012) P. Manousou et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Molecular Targets for the Treatment of Fibrosing Cholangiopathies
- (2012) L J Maillette de Buy Wenniger et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Sex and Age Are Determinants of the Clinical Phenotype of Primary Biliary Cirrhosis and Response to Ursodeoxycholic Acid
- (2012) Marco Carbone et al. GASTROENTEROLOGY
- α5β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes
- (2012) Holger Gohlke et al. HEPATOLOGY
- Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions
- (2012) Andreas E. Kremer et al. HEPATOLOGY
- Therapeutic effect of cytotoxic T lymphocyte antigen 4/immunoglobulin on a murine model of primary biliary cirrhosis
- (2012) Amy Dhirapong et al. HEPATOLOGY
- 964 THE FARNESOID X RECEPTOR (FXR) AGONIST OBETICHOLIC ACID (OCA) INCREASES PLASMA FGF-19 CONCENTRATIONS AND DECREASES BILE ACID SYNTHESIS IN PRIMARY BILIARY CIRRHOSIS (PBC)
- (2012) H.-U. Marschall et al. JOURNAL OF HEPATOLOGY
- Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health
- (2012) Karin Dilger et al. JOURNAL OF HEPATOLOGY
- CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver
- (2012) Ye Htun Oo et al. JOURNAL OF HEPATOLOGY
- Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis
- (2012) Jimmy Z Liu et al. NATURE GENETICS
- Colitis associated with biological agents
- (2012) Hugh James Freeman WORLD JOURNAL OF GASTROENTEROLOGY
- Ursodeoxycholic acid and bile-acid mimetics as therapeutic agents for cholestatic liver diseases: An overview of their mechanisms of action
- (2012) Raoul Poupon Clinics and Research in Hepatology and Gastroenterology
- A biliary HCO3−umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes
- (2011) Simon Hohenester et al. HEPATOLOGY
- Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2 −/− (Abcb4 −/− ) mouse cholangiopathy model by promoting biliary HCO 3− output
- (2011) Anna Baghdasaryan et al. HEPATOLOGY
- Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid
- (2011) Masanobu Tsuda et al. HEPATOLOGY
- New insights on the pathogenesis of biliary cirrhosis provided by studies in FXR knockout mice
- (2011) Michel Fausther et al. JOURNAL OF HEPATOLOGY
- Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis
- (2011) George F Mells et al. NATURE GENETICS
- Pilot study: fenofibrate for patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid
- (2010) C. Levy et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Linking human beta retrovirus infection with primary biliary cirrhosis
- (2010) A.L. Mason et al. GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE
- Lysophosphatidic Acid Is a Potential Mediator of Cholestatic Pruritus
- (2010) Andreas E. Kremer et al. GASTROENTEROLOGY
- Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver
- (2010) Gerald U. Denk et al. HEPATOLOGY
- Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver
- (2010) Laura N. Cruz et al. HEPATOLOGY
- The biliary HCO3− umbrella: A unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies
- (2010) Ulrich Beuers et al. HEPATOLOGY
- B cell depletion therapy exacerbates murine primary biliary cirrhosis
- (2010) Amy Dhirapong et al. HEPATOLOGY
- Central nervous system dysfunction in primary biliary cirrhosis and its relationship to symptoms
- (2010) Claire McDonald et al. JOURNAL OF HEPATOLOGY
- 2 FARNESOID-X RECEPTOR AGONISTS: A NEW CLASS OF DRUGS FOR THE TREATMENT OF PBC? AN INTERNATIONAL STUDY EVALUATING THE ADDITION OF INT-747 TO URSODEOXYCHOLIC ACID
- (2010) A. Mason et al. JOURNAL OF HEPATOLOGY
- Modulation of the microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis
- (2010) Motoko Sasaki et al. JOURNAL OF HEPATOLOGY
- β-Adrenoceptor blockade in sclerosing cholangitis of Mdr2 knockout mice: antifibrotic effects in a model of nonsinusoidal fibrosis
- (2010) Ingo Strack et al. LABORATORY INVESTIGATION
- Impaired cerebral autoregulation in primary biliary cirrhosis: implications for the pathogenesis of cognitive decline
- (2010) Kieren G. Hollingsworth et al. LIVER INTERNATIONAL
- Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis
- (2010) Gideon M Hirschfield et al. NATURE GENETICS
- Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment
- (2010) Vivian Barry-Hamilton et al. NATURE MEDICINE
- Primary biliary cirrhosis
- (2009) Keith D. Lindor et al. HEPATOLOGY
- Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis
- (2009) Songwen Zhang et al. JOURNAL OF HEPATOLOGY
- EASL Clinical Practice Guidelines: Management of cholestatic liver diseases
- (2009) JOURNAL OF HEPATOLOGY
- Primary Biliary Cirrhosis Associated withHLA, IL12A,andIL12RB2Variants
- (2009) Gideon M. Hirschfield et al. NEW ENGLAND JOURNAL OF MEDICINE
- Characterization of time-related changes after experimental bile duct ligation
- (2008) P. Georgiev et al. BRITISH JOURNAL OF SURGERY
- Pilot Study of Peripheral Muscle Function in Primary Biliary Cirrhosis: Potential Implications for Fatigue Pathogenesis
- (2008) Kieren G. Hollingsworth et al. Clinical Gastroenterology and Hepatology
- Inhibition of Integrin αvβ6 on Cholangiocytes Blocks Transforming Growth Factor-β Activation and Retards Biliary Fibrosis Progression
- (2008) Eleonora Patsenker et al. GASTROENTEROLOGY
- Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC -/PKA-dependent mechanism in rat liver
- (2008) R Wimmer et al. GUT
- Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease
- (2008) Kanji Wakabayashi et al. HEPATOLOGY
- Cognitive impairment in primary biliary cirrhosis: Symptom impact and potential etiology
- (2008) Julia L. Newton et al. HEPATOLOGY
- Xenobiotic incorporation into pyruvate dehydrogenase complex can occur via the exogenous lipoylation pathway
- (2008) Hannah R. Walden et al. HEPATOLOGY
- Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis
- (2008) Christophe Corpechot et al. HEPATOLOGY
- Integrin αvβ6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies
- (2008) Yury Popov et al. JOURNAL OF HEPATOLOGY
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