Molecular Targets for the Treatment of Fibrosing Cholangiopathies

The Canalicular Bile Salt Export Pump BSEP (ABCB11) as a Potential Therapeutic Target

(2011) Bruno Stieger et al.   CURRENT DRUG TARGETS

TGR5 Sequence Variation in Primary Sclerosing Cholangitis

(2011) Johannes R. Hov et al.   DIGESTIVE DISEASES

A biliary HCO3−umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes

(2011) Simon Hohenester et al.   HEPATOLOGY

Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2 −/− (Abcb4 −/− ) mouse cholangiopathy model by promoting biliary HCO 3− output

(2011) Anna Baghdasaryan et al.   HEPATOLOGY

Pathophysiology and current management of pruritus in liver disease

(2011) Andreas E. Kremer et al.   Clinics and Research in Hepatology and Gastroenterology

The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes

(2010) Verena Keitel et al.   BIOLOGICAL CHEMISTRY

Bile salts and cholestasis

(2010) Lucas Maillette de Buy Wenniger et al.   DIGESTIVE AND LIVER DISEASE

Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver

(2010) Gerald U. Denk et al.   HEPATOLOGY

The biliary HCO3− umbrella: A unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies

(2010) Ulrich Beuers et al.   HEPATOLOGY

Overlap syndromes: The International Autoimmune Hepatitis Group (IAIHG) position statement on a controversial issue

(2010) Kirsten Muri Boberg et al.   JOURNAL OF HEPATOLOGY

Nuclear Receptor Regulation of the Adaptive Response of Bile Acid Transporters in Cholestasis

(2010) Martin Wagner et al.   SEMINARS IN LIVER DISEASE

Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2−/− mice

(2009) Emina Halilbasic et al.   HEPATOLOGY

Diagnosis and management of primary sclerosing cholangitis

(2009) Roger Chapman et al.   HEPATOLOGY

EASL Clinical Practice Guidelines: Management of cholestatic liver diseases

(2009)   JOURNAL OF HEPATOLOGY

Discovery of 6α-Ethyl-23(S)-methylcholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity

(2009) Roberto Pellicciari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Intestinal alkaline phosphatase regulates protective surface microclimate pH in rat duodenum

(2009) Misa Mizumori et al.   JOURNAL OF PHYSIOLOGY-LONDON

Secondary sclerosing cholangitis

(2009) Petra Ruemmele et al.   Nature Reviews Gastroenterology & Hepatology

Primary biliary cirrhosis

(2009) Simon Hohenester et al.   Seminars in Immunopathology

Extracellular nucleotides stimulate Cl− currents in biliary epithelia through receptor-mediated IP3 and Ca2+ release

(2008) Amal K. Dutta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors

(2008) Anatoliy I. Masyuk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Medical Treatment of Cholestatic Liver Disease

(2008) Gustav Paumgartner et al.   Clinics in Liver Disease

Immunoglobulin G4–Associated Cholangitis: Clinical Profile and Response to Therapy

(2008) Amaar Ghazale et al.   GASTROENTEROLOGY

Bile acids: Trying to understand their chemistry and biology with the hope of helping patients

(2008) Alan F. Hofmann   HEPATOLOGY

Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis

(2008) Christophe Corpechot et al.   HEPATOLOGY

The efficacy of ursodeoxycholic acid and bezafibrate combination therapy for primary biliary cirrhosis: A prospective, multicenter study

(2008) Shinji Iwasaki et al.   HEPATOLOGY RESEARCH

Fluid flow induces mechanosensitive ATP release, calcium signalling and Cl−transport in biliary epithelial cells through a PKCζ-dependent pathway

(2008) Kangmee Woo et al.   JOURNAL OF PHYSIOLOGY-LONDON