Article
Medicine, Research & Experimental
Jingyun Ren, Shiyu Zhu, Guojin Zhang, Xiaoyue Tan, Ling Qiu, Jianguo Lin, Lei Jiang
Summary: In this study, a PET probe named 68Ga-DOTA-R01-MG was developed for imaging alpha v beta 6-positive lung cancer, which demonstrated excellent stability and specific binding to the target. The probe showed rapid and good tumor uptake and clearance in animal models, indicating its potential as a promising PET tracer for imaging alpha v beta 6-positive lung cancer.
MOLECULAR PHARMACEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Ewa Brzozowska, Sameer Deshmukh
Summary: Integrins are crucial for cell adhesion, migration, and positioning. Studies have shown that the expression levels of Integrin αVβ6 are closely related to malignant diseases and patient prognosis. It plays a significant role in cancer progression and the activation of transforming growth factor β(TGF-β). While essential for normal function in healthy individuals, it can also be a target for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Marius Kemper, Alina Schiecke, Hanna Maar, Sergey Nikulin, Andrey Poloznikov, Vladimir Galatenko, Michael Tachezy, Florian Gebauer, Tobias Lange, Kristoffer Riecken, Alexander Tonevitsky, Achim Aigner, Jakob Izbicki, Udo Schumacher, Daniel Wicklein
Summary: The knockdown of ITGAV in PDA cells significantly reduces primary tumor growth, peritoneal carcinomatosis, and spontaneous pulmonary metastasis. ITGAV activates latent TGF-beta and drives epithelial-mesenchymal transition. Combined depletion of ITGAV on tumor cells and E- and P-selectins in the tumor-host almost abolishes intraperitoneal spread.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Immunology
Lian Ren, Fang Li, Ziyang Di, Yan Xiong, Shichen Zhang, Qing Ma, Xiaoen Bian, Zhiquan Lang, Qifa Ye, Yanfeng Wang
Summary: This study found that females have less extensive kidney damage in renal ischemia-reperfusion injury (IRI) compared to males. However, this protection diminishes after menopause, suggesting a role for estrogen in IRI. The study revealed that estradiol (E-2) supplementation ameliorates kidney injury and fibrosis in female rats, and the levels of TGF-beta RI are increased in ovariectomized rats. Further investigation showed that ER alpha could negatively regulate the expression of TGF-beta RI and that ER alpha knockdown blocked E-2-mediated protection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Regina Andrijes, Rahul K. Hejmadi, Matthew Pugh, Sundaresan Rajesh, Vera Novitskaya, Maha Ibrahim, Michael Overduin, Chris Tselepis, Gary W. Middleton, Balazs Gyorffy, Andrew D. Beggs, Fedor Berditchevski
Summary: Tspan6 has been identified as a regulator of CRC development and a potential predictive marker for EGFR-targeted therapies. Studies have shown that the deletion of Tspan6 leads to activation of EGF-dependent signaling pathways, and patients with high Tspan6 levels have better responses to Cetuximab therapy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Matteo Monieri, Paolo Rainone, Angelina Sacchi, Alessandro Gori, Anna Maria Gasparri, Angela Coliva, Antonio Citro, Benedetta Ferrara, Martina Policardi, Silvia Valtorta, Arianna Pocaterra, Massimo Alfano, Dean Sheppard, Lorenzo Piemonti, Rosa Maria Moresco, Angelo Corti, Flavio Curnis
Summary: The alpha v[36- and alpha v[38-integrins, cell-adhesion receptors upregulated in tumors, can bind to the tumor-homing peptide 5a containing an RGDL motif, suggesting its potential as a target for tumor imaging and therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jenq-Lin Yang, Weng-Ling Lin, Shun-Ban Tai, Yi-Siang Ciou, Chih-Ling Chung, Jih-Jung Chen, Pei-Feng Liu, Ming-Wei Lin, Chun-Lin Chen
Summary: Sinulariolide (SC-1), a natural extract from Sinularia flexibilis, has anti-inflammatory, anti-proliferative, and anti-migratory effects. The molecular pathway behind its anti-inflammatory effects remains unclear. In this study, we investigated the effects of SC-1 on TGF beta-induced IL-6 release. We found that SC-1 inhibited TGF beta-induced IL-6 secretion through the suppression of p38 MAPK signaling and subsequent inhibition of NF-kappa B nuclear translocation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Stefano Tomassi, Vincenzo Maria D'Amore, Francesco Saverio Di Leva, Andrea Vannini, Giacomo Quilici, Michael Weinmueller, Florian Reichart, Jussara Amato, Barbara Romano, Angelo Antonio Izzo, Salvatore Di Maro, Ettore Novellino, Giovanna Musco, Tatiana Gianni, Horst Kessler, Luciana Marinelli
Summary: Recent studies have shown that small RGD-containing cyclic pentapeptides could be a promising pharmaceutical approach for inhibiting herpes virus entry into cells, by selectively binding to alpha v beta 6/alpha v beta 8 integrins. The affinity of these compounds towards the integrins was rationalized through a combined NMR/molecular modeling approach, offering valuable insights for designing RGD integrin ligands with desired specificity.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Plant Sciences
Bo Liang, Xiao-Xiao Zhang, Rui Li, Yong-Chun Zhu, Xiao-Jie Tian, Ning Gu
Summary: Guanxin V shows anti-oxidative, anti-apoptotic, and anti-fibrotic effects in acute myocardial infarction by alleviating oxidative stress damage and apoptosis induced by the TGF-beta 1 signaling pathway.
Article
Fisheries
Zhen Zhang, Wenwen Ye, Guanghui Han, Chenghua Li, Zhimeng Lv
Summary: Inhibition of inflammatory response is crucial in controlling inflammation development and protecting organisms from excessive damage. Transforming growth factor beta (TGF-beta) plays a role in inhibiting inflammation in vertebrates. In this study, the role of TGF-beta in regulating inflammation in invertebrates was investigated using sea cucumbers. The results showed that AjTGF-beta negatively regulated inflammation and promoted damage repair through AjSMADs and collagen expression.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Review
Immunology
Xinru Gong, Zhoutong Han, Hongli Fan, Yuqi Wu, Yuanqiong He, Yijie Fu, Tianmin Zhu, Hui Li
Summary: This review examines the potential role of immune cells and cytokines in regulating inflammation and remodeling of chronic rhinosinusitis (CRS) mucosa. The study highlights the important connection between inflammation and remodeling in CRS and provides novel ideas for future research.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Marco Carlo Merlano, Matteo Paccagnella, Nerina Denaro, Andrea Abbona, Danilo Galizia, Dario Sangiolo, Loretta Gammaitoni, Erika Fiorino, Silvia Minei, Paolo Bossi, Lisa Licitra, Ornella Garrone
Summary: This study found that IL-6 and TGF-beta play a prognostic role in head and neck cancer patients with poor clinical characteristics. Nivolumab treatment positively modulates some Th1 cytokines, but it does not correlate with the outcome.
Article
Oncology
Wafaa S. Ramadan, Saleh Alkarim, Mohammed Moulay, Ghadeer Alrefeai, Fatma Alkudsy, Khalid Rehman Hakeem, Ashwaq Iskander
Summary: The challenges in treating hepatocellular carcinoma (HCC) are largely due to drug resistance or relapse, which is attributed to the presence of hepatic cancer stem cells (HCSCs). In this study, the therapeutic effect of ellagic acid (EA) on HCC and the reaction of the HCC microenvironment and HCSCs to EA therapy were evaluated.
Article
Cell Biology
Yanhong Zhang, Nina Yin, Anbang Sun, Qifang Wu, Wenzhu Hu, Xin Hou, Xixi Zeng, Min Zhu, Yanhong Liao
Summary: Kidney fibrosis plays a significant role in chronic kidney disease, and EMT is an important molecular mechanism contributing to fibrosis. The study suggests that TRPC6 knockout may ameliorate kidney fibrosis by inhibiting EMT and down-regulating the AKT-mTOR and ERK1/2 pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Abhilasha Srivastava, Harshita Sharma, Simran Khanna, Tejasvini Sadhu Balasundaram, Shibasish Chowdhury, Rajdeep Chowdhury, Sudeshna Mukherjee
Summary: HCC is associated with inflammation, and IL-6 and TGF-beta are enriched in HCC. IL-6 promotes proliferation by acting on NFkB, while TGF-beta induces mesenchymal transition and growth arrest. Combining IL-6 and TGF-beta weakens IL-6-induced proliferation but has little impact on mesenchymal transition. TGF-beta attenuates IL-6 effects by regulating receptor levels, downstream signaling, and the epigenome.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Christine Park, Tyler Schappe, Sarah Peskoe, Dinushika Mohottige, Norine W. Chan, Nrupen A. Bhavsar, Jane Pendergast, Allan D. Kirk, Lisa M. McElroy
Summary: The choice of deprivation index has an impact on conclusions about deprivation extent and identifying the most deprived communities. This study aimed to determine correlations among commonly used deprivation indices for transplant populations. Different deprivation indices were compared using a retrospective cohort of liver or kidney transplant patients. The choice of deprivation index affects the applicability of research findings on social risk and clinical outcomes. Careful selection of indices based on intended use and variable relevance is necessary for transplant populations.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Surgery
Mary E. Knatterud, Richard L. Simmons, William Payne, Peter Stock, Blanche Chavers, Nancy Ascher, Dixon Kaufman, Alan Kirk, Shafique Keshavjee, Abhinav Humar, Swaytha Ganesh, Christopher Hughes, Raja Kandaswamy, Arthur J. Matas
Summary: Dr. John S Najarian (1927-2020), the chairman of the University of Minnesota's Department of Surgery, was a trailblazer in surgery, clinical immunology, and transplantation. A delayed Festschrift was held on May 20, 2022, to honor his achievements. During the event, speakers discussed his numerous contributions to surgery, transplantation, and resident/fellow training, as well as ongoing research efforts to improve clinical outcomes. It is worth mentioning that Dr. Najarian was the founder of the journal Clinical Transplantation.
CLINICAL TRANSPLANTATION
(2023)
Article
Surgery
Shu Li, Imran J. Anwar, Aidan J. Canning, Tuan Vo-Dinh, Allan D. Kirk, He Xu
Summary: Porcine vascular endothelial cells release extracellular vesicles expressing SLA-I, which can directly initiate T cell-mediated immune responses through xenorecognition and costimulation, suggesting a potential role in xenograft rejection.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Editorial Material
Surgery
Flavio Vincenti, Klemens Budde, Josep Grinyo, Lionel Rostaing, Allan D. Kirk, Christian P. Larsen
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Surgery
Andrew Adams, Linda C. Cendales, David K. C. Cooper, Emanuele Cozzi, John Gill, Eric Judd, Eliezer Katz, Allan D. Kirk, Jay A. Fishman, Peter P. Reese, Anji Wall, James F. Markmann
Summary: The US FDA held a meeting to discuss regulatory expectations for xenotransplantation products, and a summary was compiled by a committee, focusing on 7 key topics including preclinical evidence, porcine kidney function, ethical aspects, clinical trial design, infectious disease issues, industry perspectives, and regulatory oversight.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Critical Care Medicine
Rondi B. Gelbard, Hannah Hensman, Seth Schobel, Linda Stempora, Eric Gann, Dimitrios Moris, Christopher J. Dente, Timothy G. Buchman, Allan D. Kirk, Eric Elster
Summary: This study aimed to explore whether assessment of cell phenotypes using flow cytometry (FCM) could be used to identify pulmonary infection after thoracic trauma. The results showed that Acute Physiology and Chronic Health Evaluation score, highest pulse rate in first 24 hours, and frequency of CD4(+) central memory cells were the three key variables for identifying pulmonary infection after thoracic trauma. The study suggests that clinical and FCM data have diagnostic utility in the early identification of patients at risk of nosocomial pneumonia (PNA) following thoracic injury.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2023)
Article
Multidisciplinary Sciences
Miriam Manook, Danae Olaso, Imran J. Anwar, Janghoon Yoon, Isabel Delaura, Yeeun Bae, Dimitrios Moris, Brian Shaw, Mingqing Song, Alton B. Farris, Annette Jackson, Jean Kwun, Stuart Knechtle
Summary: This study examined the effectiveness of costimulation blockade and proteasome inhibition for desensitization in female NHPs sensitized by pregnancy alone. The results showed that the addition of belatacept and tacrolimus significantly prolonged graft survival and suppressed the production of donor-specific antibodies.
Article
Cell Biology
Imran J. Anwar, Dora M. Berman, Isabel Delaura, Qimeng Gao, Melissa A. Willman, Allison Miller, Alan Gill, Cindy Gill, Steve Perrin, Camillo Ricordi, Philip Ruiz, Mingqing Song, Joseph M. Ladowski, Allan D. Kirk, Norma S. Kenyon
Summary: This study investigated the anti-CD40 ligand (CD40L) immunosuppressant AT-1501 and found that it can enhance the survival and function of both islet and kidney allografts in nonhuman primate models, with better outcomes compared to conventional immunosuppression.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Meeting Abstract
Surgery
M. Song, K. Samy, B. M. Martin, Q. Gao, B. Collins, X. Luo, A. D. Kirk
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
A. D. Kirk, J. Shoji, D. Wojciechowski, J. Kim, W. Xu, T. M. Wilson, F. Vincenti
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
S. Li, I. J. Anwar, H. Xu, A. D. Kirk
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
S. Li, H. Xu, A. D. Kirk
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
I. J. Anwar, C. Z. Jordan, B. I. Shaw, Q. Gao, I. DeLaura, A. Dangi, I. Husain, M. Ribeiro, J. M. Ladowski, X. Luo, A. D. Kirk
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
I. J. Anwar, M. S. Mulvihill, R. Schmitz, B. I. Shaw, Z. W. Fitch, T. How, S. Li, H. Xu, A. D. Kirk
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
I. J. Anwar, Q. Gao, I. DeLaura, A. Miller, B. I. Shaw, K. Krynychka, A. D. Kirk
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
