Article
Multidisciplinary Sciences
Vikram Nimbalkar, Neeraj Vyawahare
Summary: The study demonstrates that L-carnitine has a protective effect against liver fibrosis induced by bile duct ligation, reducing oxidative stress and inhibiting the release of cytokines. L-carnitine can normalize body and liver weight in rats, and decrease iNOS levels.
Article
Biochemistry & Molecular Biology
Moritz Uhlig, Marc Hein, Moriz A. Habigt, Rene H. Tolba, Till Braunschweig, Marius J. Helmedag, Melissa Arici, Alexander Theissen, Axel Klinkenberg, Uwe Klinge, Mare Mechelinck
Summary: Cirrhotic patients often experience cirrhotic cardiomyopathy (CCM), which is studied in detail through animal models of bile duct ligation (BDL) and a second surgery. The study reveals delayed adaptability, impaired contractility at rest, reduced contractile reserve, increased creatine and transaminase levels, myocardial fibrosis, macrophage infiltration, systemic inflammation, altered expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1a), and increased expression of caspase-3. Structural changes in the myocardium are observed after 8 weeks. Transient myocardial insufficiency and secondary organ dysfunction occur after the second surgery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Bowen Yang, Tianning Sun, Yingle Chen, Hongbing Xiang, Jun Xiong, Shiting Bao
Summary: The study confirmed the crucial role of gut microbiota, particularly Bacteroides species, in cognitive dysfunction induced by bile duct ligation in mice.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mare Mechelinck, Marc Hein, Carolin Kupp, Till Braunschweig, Marius J. Helmedag, Axel Klinkenberg, Moriz A. Habigt, Uwe Klinge, Rene H. Tolba, Moritz Uhlig
Summary: This study investigates the influence of cholestatic liver cirrhosis on carotid arterial remodeling. The results show that cholestatic liver cirrhosis can significantly reduce the degree of carotid stenosis and the area of neointimal growth, which may lower the risk of restenosis after coronary intervention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Wouter Claeys, Lien Van Hoecke, Hannah Lernout, Clint De Nolf, Griet Van Imschoot, Elien Van Wonterghem, Daan Verhaege, Jonas Castelein, Anja Geerts, Christophe Van Steenkiste, Roosmarijn E. Vandenbroucke
Summary: Hepatic encephalopathy, a complication of liver cirrhosis, lacks brain-targeted therapies. Astrocytes and microglia have been implicated in its development. RNA-Seq analysis of sorted astrocytes and microglia in a mouse model of hepatic encephalopathy revealed transcriptional responses, particularly in microglia, enriched in inflammation and hypoxia pathways. Astrocytes showed increased corticoid receptor and oxidative stress signaling, while microglial transcriptome changes were linked to immune cell attraction. This study provides insights into the molecular mechanisms of hepatic encephalopathy and potential glial-directed therapeutic strategies.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Pharmacology & Pharmacy
Hamid Reza Moheimani, Taghi Amiriani, Ali Mohammad Alizadeh, Yahya Jand, Delaram Shakiba, Parham Sayyah Ensan, Fatemeh Jafarzadeh, Maryam Rajaei, Ayesheh Enayati, Mona Pourabouk, Shahriar Aliazadeh, Amir Hoshang Pourkhani, Zohreh Mazaheri, Mohammad Ali Zeyghami, Ahmadreza Dehpour, Vahid Khori
Summary: The study found that ischemic preconditioning can reduce myocardial infarct size, apoptotic indices, arrhythmia, and incidence of ventricular fibrillation in cirrhotic cardiomyopathy rats. Metformin and Cyclosporin-A can exert cardioprotective effects by balancing pAMPK and apoptosis in mitochondria.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Zihang Yuan, Jie Wang, Haoran Zhang, Yingying Miao, Qianhui Tang, Ziqiao Yuan, Cheng Nong, Zhicheng Duan, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu
Summary: In this study, researchers investigated the effects of triptolide (TP), a compound found in Tripterygium wilfordii Hook.f, on cholestasis-induced liver injury. They found that TP reduced liver enzyme levels and necrosis in a mouse model of common bile duct ligation (BDL) cholestasis. TP also inhibited cholangiocyte proliferation and alleviated BDL-induced hepatic fibrosis and inflammation by reducing the expression of RelB.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, Research & Experimental
Xin-lan Ge, Xuan Zhang, Chong-hui Li, Ke Pan, Lei He, Wei-zheng Ren
Summary: Compared to portal vein ligation (PVL), simultaneous bile duct and portal vein ligation (BPL) can significantly enhance hypertrophy of the intact liver. This study found that BPL can improve survival after extended hepatectomy independently of an increased remnant liver. BPL can induce faster restoration of canalicular integrity and limit bile acid retention, which is associated with activation of LKB1.
CURRENT MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Armagan Begum Ozel, Ozlem Tugce Cilingir-Kaya, Goksel Sener, Dilek Ozbeyli, Ali Sen, Ozlem Sacan, Refiye Yanardag, Aysen Yarat
Summary: Bitter melon, chard, and parsley extracts have been found to have neuroprotective effects against oxidative damage in the brain of rats with BDL-induced biliary cirrhosis. These plant extracts possess antioxidant properties and can be used as alternative treatments for brain damage caused by cirrhosis. Their safety and effectiveness make them potential neuroprotective agents in the treatment of liver cirrhosis-induced brain damage.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Cell Biology
Trinh Van Le, Hong-Thuy Phan-Thi, My-Xuan Huynh-Thi, Thanh Minh Dang, Ai Xuan Le Holterman, Gabriele Grassi, Thao-Uyen Nguyen-Luu, Nhung Hai Truong
Summary: Chloroquine (CQ) treatment has been shown to prevent hepatic stellate cell (HSC) activation and autophagy, leading to a reduction in liver fibrogenesis. In both in vitro and in vivo experiments, CQ inhibited HSC activation, improved liver function, and reduced liver injury.
Article
Immunology
Bo Zhou, Kai Chen, Haiyan Gong, Liyuan Zhao, Xinfeng Xing, Hongde Su, Yu Zhang
Summary: The composition of gut microbiota in rats was studied under bile duct ligation or biliary drainage. The bile duct obstruction was induced by extrahepatic bile duct ligation, while bile deficiency was caused by draining the bile via a percutaneous biliary drainage catheter. The DNA extracted from fecal samples was sequenced and analyzed. The results showed that bile duct obstruction altered the composition of gut microbiota, which was restored after biliary drainage. The study also identified the potential functions of the different microorganisms. Overall, the study highlights the significant changes in gut microbiota and their potential functions under bile duct-related conditions.
MICROBIAL PATHOGENESIS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yongquan Yu, Shuangshuang Xie, Kaiqi Wang, Fuzhi Zhang, Chao Jiang, Caixin Qiu, Jinxia Zhu, Wen Shen
Summary: This study demonstrates that ASL allows quantitative assessment of AKI induced by cholestatic cirrhosis in rats and serves as a noninvasive marker for the early and accurate diagnosis of AKI. The results show that RBF is closely correlated with HE score, HIF-1 alpha score, and PTC density, and can be used to distinguish AKI from non-AKI and mild from severe kidney injury in cirrhosis.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Biochemistry & Molecular Biology
Danbi Jo, Hee Kyung Kim, Young-Kook Kim, Juhyun Song
Summary: Thyroid hormone plays an important role in liver metabolism, and its levels are disrupted in liver failure and hepatic encephalopathy. This study investigates the gene expression changes in the thyroid glands of a bile duct ligation mouse model and confirms the alteration in thyroid function-related genes. Increased levels of free T4 and TSH are also observed in the blood of the mouse model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Sepideh Ganjalikhan-Hakemi, Majid Asadi-Shekaari, Fahimeh Pourjafari, Gholamreza Asadikaram, Masoumeh Nozari
Summary: This study investigated the effects of oral administration of agmatine on motor and cognitive deficits induced by bile duct ligation in an animal model of hepatic encephalopathy. The results showed that agmatine effectively reduced liver damage, balance deficits, and neuronal damage caused by the encephalopathy.
BRAIN AND BEHAVIOR
(2023)
Article
Toxicology
Manar M. Esmail, Noha M. Saeed, Haidy E. Michel, Reem N. El-Naga
Summary: Niclosamide shows promising potential as an antifibrotic agent in CLF through inhibition of NOTCH and Wnt pathways, reducing liver enzymes levels, oxidative stress, inflammation, and fibrosis markers.
TOXICOLOGY LETTERS
(2021)
Article
Gastroenterology & Hepatology
Jens Mittler, Kenneth D. Chavin, Stefan Heinrich, Roman Kloeckner, Tim Zimmermann, Hauke Lang
Summary: This study demonstrated the feasibility and success of duct-to-duct biliary reconstruction in selected patients requiring surgical repair for isolated AS after DDLT. Patients who underwent this procedure had fully normalized liver function tests post-operatively and did not require any biliary interventions. Although there were cases of post-operative complications such as intraoperative cholangiosepsis and subhepatic abscess, there were no perioperative deaths.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Surgery
Stefan Heinrich, Daniel Seehofer, Florian Corvinus, Verena Tripke, Tobias Huber, Florentine Huettl, Lea Penzkofer, Jens Mittler, Mohammad Abu Hilal, Hauke Lang
Summary: Laparoscopic liver surgery (LLS) offers significant advantages over open liver surgery in terms of cosmetic outcomes, postoperative quality of life, and length of hospital stay. Additionally, parenchyma-preserving resections in LLS appear to be cost-neutral in comparison to conventional liver resections.
Article
Surgery
Stefan Heinrich, Hauke Lang
Summary: The current literature supports the use of minimally invasive surgery for the resection of colorectal liver metastases and hepatocellular carcinoma, showing equivalent results to open surgery.
Article
Oncology
Philipp Mayer, Anne Kraft, Hagen R. Witzel, Nicole Marnet, Nina Horner, Wilfried Roth, Stefan Heinrich, Thilo Hackert, Frank Bergmann, Hans-Ulrich Kauczor, Miriam Klauss, Matthias M. Gaida
Summary: Pancreatic cancer is characterized by hypoxia, which can be predicted by DW-MRI. Lower random motion of water molecules in cancer lesions may indicate higher levels of hypoxia. DW-MRI is a potential tool for identifying high-risk pancreatic cancer lesions with a high hypoxic fraction.
Article
Surgery
Lea Penzkofer, Tobias Huber, Jens Mittler, Hauke Lang, Stefan Heinrich
Summary: This study suggests that liver resections in cirrhotic livers are feasible with proper patient selection and limitation of the extent of surgery. Comorbidities increase the postoperative mortality in addition to impaired liver function and should always be considered in the preoperative assessment of patients undergoing liver surgery.
ZENTRALBLATT FUR CHIRURGIE
(2023)
Article
Gastroenterology & Hepatology
Steffie Revia, Agnieszka Seretny, Lena Wendler, Ana Banito, Christoph Eckert, Kersten Breuer, Anand Mayakonda, Pavlo Lutsik, Matthias Evert, Silvia Ribback, Suchira Gallage, Ismaiel Chikh Bakri, Kai Breuhahn, Peter Schirmacher, Stefan Heinrich, Matthias M. Gaida, Mathias Heikenwaelder, Diego F. Calvisi, Christoph Plass, Scott W. Lowe, Darjus F. Tschaharganeh
Summary: Epigenetic modifiers, such as KDM6A, are frequently mutated in human cancer. This study found that Kdm6a deficiency accelerates tumor development in liver and pancreatic cancer models by hyperactivating mTORC1 signaling. KDM6A acts as a tumor suppressor and can be a potential target for mTORC1 inhibition in gastrointestinal cancers with KDM6A-deficient tumors.
Article
Oncology
Dirk Andreas Ridder, Lana Louisa Urbansky, Hagen Roland Witzel, Mario Schindeldecker, Arndt Weinmann, Kristina Berndt, Tiemo Sven Gerber, Bruno Christian Koehler, Federico Nichetti, Annekathrin Ludt, Nadine Gehrke, Joern Markus Schattenberg, Stefan Heinrich, Wilfried Roth, Beate Katharina Straub
Summary: The role of Tak1 in hepatocellular carcinoma (HCC) development has been investigated and it has been found that high nuclear Tak1 expression is associated with poor prognosis and vascular invasion in HCC patients.
Article
Oncology
Thilo Zander, Xue Jia, Gabriel Markson, Felix Dahm, Christoph Renner
Summary: Satraplatin demonstrates higher cytotoxic activity against hematological malignancies compared to solid organ cancer, particularly in lymphoma cell lines. Key characteristics for high sensitivity to Satraplatin include single BCL2 gene mutation and 9p21 copy-number deletions, with MTAP deficiency being identified as a biomarker of enhanced Satraplatin efficacy. This study provides the rationale for targeting specific lymphatic entities, such as cell lymphoma, to improve clinical outcome.
ANTICANCER RESEARCH
(2022)
Article
Surgery
Irina Staib-Lasarzik, Sophie Lehr, Ann Kristin Rosner, Ralph Timaru-Kast, Katharina Hoeter, Kai Bruns, Daniel Wollschlaeger, Stefan Heinrich, Serge C. Thal, Kristin Engelhard
Summary: This study found that intraoperative fluid replacement has no effect on postoperative serum levels of ampicillin and is not associated with surgical site infections (SSI). The control of serum levels during surgery does not seem necessary.
Article
Medicine, Research & Experimental
Tobias Huber, Laura Isabel Hanke, Christian Boedecker, Lukas Vradelis, Janine Baumgart, Stefan Heinrich, Fabian Bartsch, Jens Mittler, Alicia Schulze, Christian Hansen, Florentine Huettl, Hauke Lang
Summary: This study compares three different modes of demonstrating 3D reconstructions of liver CT scans and evaluates their applications in liver resection planning. The results of the study will help improve the accuracy and feasibility of liver surgery and provide guidance for teaching.
Article
Surgery
Verena Tripke, Tobias Huber, Janine Baumgart, Stefan Heinrich, Hauke Lang
Summary: This case report presents a rare case of hepatic echinococcosis. Through three-dimensional reconstruction based on preoperative CT scan, complete resection and vascular reconstruction were successfully performed. Liver resection for hepatic echinococcosis may require complex vascular resections and reconstructions.
ZENTRALBLATT FUR CHIRURGIE
(2022)
Article
Surgery
Tobias Huber, Florentine Huettl, Laura Isabel Hanke, Lukas Vradelis, Stefan Heinrich, Christian Hansen, Christian Boedecker, Hauke Lang
Summary: The resectability borders in liver surgery have significantly changed in recent decades due to the optimization of conservative treatment, improvement of imaging methods, and continuous development of surgical techniques. Technical developments such as three-dimensional segmentation, preoperative planning, and intraoperative navigation options have made complex procedures easier and safer. New technologies like 3D printing, virtual and augmented reality provide additional display options for individual patient anatomy. This review article provides an overview of the current state of available technologies and offers insights into the operating theatre of the future.
ZENTRALBLATT FUR CHIRURGIE
(2022)
Article
Oncology
Guillaume Fonteneau, Alexandra Redding, Hannah Hoag-Lee, Edward S. Sim, Stefan Heinrich, Matthias M. Gaida, Elda Grabocka
Summary: This study reveals that stress adaptation through phase-separation organelles SGs mediates PDAC development. Moreover, preexisting stress conditions such as obesity are a driving force behind tumor SG dependence, and enhanced SG levels are key determinants and a chemopreventive target for obesity-associated PDAC.
Article
Medicine, General & Internal
Lea Penzkofer, Jens Mittler, Stefan Heinrich, Nicolas Wachter, Beate K. Straub, Roman Kloeckner, Fabian Stoehr, Simon Johannes Gairing, Fabian Bartsch, Hauke Lang
Summary: Liver cirrhosis is a common risk factor for hepatocellular carcinoma (HCC), but a small percentage of HCC cases occur in non-cirrhotic livers. This study found that liver resection for non-cirrhotic HCC is an acceptable treatment approach with relatively good outcomes, even for extensive tumors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Stefan Heinrich, Juliane Theurer, Hauke Lang
Summary: Compared to colorectal and neuroendocrine liver metastases, liver surgery has not yet gained the same status for non-colorectal non-endocrine (NCNE) liver metastases. This is mainly due to different tumor biology and the lack of effective systemic treatment options in the past. However, even chemotherapy-naive patients with NCNE liver metastases can benefit from liver resection. With the significant advancements in systemic treatment in recent years, modern liver surgery will become an integral part of multimodality treatment concepts for several diseases.
