Rugulactone and its Analogues Exert Antibacterial Effects through Multiple Mechanisms Including Inhibition of Thiamine Biosynthesis

Thiamin (Vitamin B1) Biosynthesis and Regulation: A Rich Source of Antimicrobial Drug Targets?

(2012) Qinglin Du et al.   International Journal of Biological Sciences

Targeting MgrA-Mediated Virulence Regulation in Staphylococcus aureus

(2011) Fei Sun et al.   CHEMISTRY & BIOLOGY

Stereoselective Synthesis of Both Enantiomers of Rugulactone

(2011) Dietrich Böse et al.   JOURNAL OF ORGANIC CHEMISTRY

Identification of Inhibitors against Mycobacterium tuberculosis Thiamin Phosphate Synthase, an Important Target for the Development of Anti-TB Drugs

(2011) Garima Khare et al.   PLoS One

An NMR Spectroscopic Method to Identify and Classify Thiol-Trapping Agents: Revival of Michael Acceptors for Drug Discovery?

(2010) Cristina Avonto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protein Reactivity of Natural Product-Derived γ-Butyrolactones

(2010) Martin H. Kunzmann et al.   BIOCHEMISTRY

The Tunable Functionality of α,β-Unsaturated Carbonyl Compounds Enables Their Differential Application in Biological Systems

(2010) Sabine Amslinger   ChemMedChem

Stereoselective synthesis and biological evaluation of (R)-rugulactone, (6R)-((4R)-hydroxy-6-phenyl-hex-2-enyl)-5,6-dihydro-pyran-2-one and its 4S epimer

(2010) D. Kumar Reddy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Catalytic Asymmetric Synthesis of Chiral Allylic Esters

(2010) Jeffrey S. Cannon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism of the Cobalt Oxazoline Palladacycle (COP)-Catalyzed Asymmetric Synthesis of Allylic Esters

(2010) Jeffrey S. Cannon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Showdomycin as a Versatile Chemical Tool for the Detection of Pathogenesis-Associated Enzymes in Bacteria

(2010) Thomas Böttcher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Total Synthesis of Rugulactone, an α-Pyrone from Cryptocarya rugulosa

(2010) Florent Allais et al.   SYNTHESIS-STUTTGART

Identification of small molecule inhibitors of pyruvate kinase M2

(2009) Matthew G. Vander Heiden et al.   BIOCHEMICAL PHARMACOLOGY

Both Thiamine Uptake and Biosynthesis of Thiamine Precursors Are Required for Intracellular Replication of Listeria monocytogenes

(2009) K. Schauer et al.   JOURNAL OF BACTERIOLOGY

A General Procedure for the Preparation of β-Ketophosphonates

(2009) Kevin M. Maloney et al.   JOURNAL OF ORGANIC CHEMISTRY

The nature ofStaphylococcus aureusMurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors

(2009) Katy L. Blake et al.   MOLECULAR MICROBIOLOGY

First total syntheses and absolute configuration of rugulactone and 6(R)-(4′-oxopent-2′-enyl)-5,6-dihydro-2H-pyran-2-one

(2009) Debendra K. Mohapatra et al.   TETRAHEDRON LETTERS

Stereoselective first total synthesis of (R)-rugulactone

(2009) D. Kumar Reddy et al.   TETRAHEDRON-ASYMMETRY

Cu-Catalyzed Azide−Alkyne Cycloaddition

(2008) Morten Meldal et al.   CHEMICAL REVIEWS

Inhibitors of the NF-κB Activation Pathway fromCryptocarya rugulosa¶

(2008) Tamara L. Meragelman et al.   JOURNAL OF NATURAL PRODUCTS