Oxidative Stress Mechanisms Underlying Parkinson’s Disease-Associated Neurodegeneration in C. elegans

How to treat Parkinson's disease in 2013

(2013) P. F. Worth   CLINICAL MEDICINE

DJR-1.2 of Caenorhabditis elegans is induced by DAF-16 in the dauer state

(2013) Ju-young Lee et al.   GENE

Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation

(2013) Masahiro Iguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early-Life Exposure to Methylmercury in Wildtype and pdr-1/parkin Knockout C. elegans

(2013) Ebany J. Martinez-Finley et al.   NEUROCHEMICAL RESEARCH

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection

(2013) Jean-François Trempe et al.   Frontiers in Neurology

Quantification ofin vivooxidative damage inCaenorhabditis elegansduring aging by endogenous F3-isoprostane measurement

(2012) Christiaan F. Labuschagne et al.   AGING CELL

Mutant LRRK2 Elicits Calcium Imbalance and Depletion of Dendritic Mitochondria in Neurons

(2012) Salvatore J. Cherra et al.   AMERICAN JOURNAL OF PATHOLOGY

Redox Proteomics Analyses of the Influence of Co-Expression of Wild-Type or Mutated LRRK2 and Tau on C. elegans Protein Expression and Oxidative Modification: Relevance to Parkinson Disease

(2012) Fabio Di Domenico et al.   ANTIOXIDANTS & REDOX SIGNALING

Further characterisation of the LPS model of Parkinson’s disease: A comparison of intra-nigral and intra-striatal lipopolysaccharide administration on motor function, microgliosis and nigrostriatal neurodegeneration in the rat

(2012) Deirdre B. Hoban et al.   BRAIN BEHAVIOR AND IMMUNITY

MRI and CT appearances in metabolic encephalopathies due to systemic diseases in adults

(2012) G. Bathla et al.   CLINICAL RADIOLOGY

Animal models of Parkinson’s disease

(2012) Fabio Blandini et al.   FEBS Journal

Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders

(2012) Micha M.M. Wilhelmus et al.   FREE RADICAL BIOLOGY AND MEDICINE

Organotellurium and organoselenium compounds attenuate Mn-induced toxicity in Caenorhabditis elegans by preventing oxidative stress

(2012) Daiana Silva Avila et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons

(2012) Seungmin Lee et al.   HUMAN MOLECULAR GENETICS

Human DJ-1 and its homologs are novel glyoxalases

(2012) Ju-young Lee et al.   HUMAN MOLECULAR GENETICS

ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons

(2012) Alvin P. Joselin et al.   HUMAN MOLECULAR GENETICS

Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity

(2012) C. Yao et al.   HUMAN MOLECULAR GENETICS

Dopamine-derived Quinones Affect the Structure of the Redox Sensor DJ-1 through Modifications at Cys-106 and Cys-53

(2012) Stefania Girotto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Voltage-dependent Anion Channels (VDACs) Recruit Parkin to Defective Mitochondria to Promote Mitochondrial Autophagy

(2012) Yu Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Classic and New Animal Models of Parkinson's Disease

(2012) Javier Blesa et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

DJ-1 Expression Modulates Astrocyte-Mediated Protection Against Neuronal Oxidative Stress

(2012) Steven J. Mullett et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Parkinson’s disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction

(2012) Xinglong Wang et al.   JOURNAL OF NEUROCHEMISTRY

DJ-1 Protects Against Dopamine Toxicity: Implications for Parkinson's Disease and Aging

(2012) N. Lev et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Quantitative In Vivo Redox Sensors Uncover Oxidative Stress as an Early Event in Life

(2012) Daniela Knoefler et al.   MOLECULAR CELL

Recent Advances in the Treatment of Neurodegenerative Diseases Based on GSH Delivery Systems

(2012) Ivana Cacciatore et al.   Oxidative Medicine and Cellular Longevity

Oxidative Stress in Genetic Mouse Models of Parkinson’s Disease

(2012) Mustafa Varçin et al.   Oxidative Medicine and Cellular Longevity

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

(2012) Kei Okatsu et al.   Nature Communications

A Role for SKN-1/Nrf in Pathogen Resistance and Immunosenescence in Caenorhabditis elegans

(2012) Diána Papp et al.   PLoS Pathogens

Isoprostane Generation and Function

(2011) Ginger L. Milne et al.   CHEMICAL REVIEWS

Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations

(2011) Balaraman Kalyanaraman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Depletion of a nucleolar protein activates xenobiotic detoxification genes in Caenorhabditis elegans via Nrf /SKN-1 and p53/CEP-1

(2011) Chi K. Leung et al.   FREE RADICAL BIOLOGY AND MEDICINE

Exploring real-time in vivo redox biology of developing and aging Caenorhabditis elegans

(2011) Patricia Back et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases

(2011) Ebany J. Martinez-Finley et al.   Metallomics

The antioxidant Trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cells

(2011) Jung Hee Shim et al.   MITOCHONDRION

Ce-Duox1/BLI-3 Generated Reactive Oxygen Species Trigger Protective SKN-1 Activity via p38 MAPK Signaling during Infection in C. elegans

(2011) Ransome van der Hoeven et al.   PLoS Pathogens

High-throughput Screening and Biosensing with Fluorescent C. elegans Strains

(2011) Chi K. Leung et al.   Jove-Journal of Visualized Experiments

PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy

(2010) Sumihiro Kawajiri et al.   FEBS LETTERS

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

(2010) Kelly Jean Thomas et al.   HUMAN MOLECULAR GENETICS

Targeted gene deletions in C. elegans using transposon excision

(2010) Christian Frøkjær-Jensen et al.   NATURE METHODS

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2

(2010) H. Mortiboys et al.   NEUROLOGY

Genetic Animal Models of Parkinson's Disease

(2010) Ted M. Dawson et al.   NEURON

DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function

(2010) L.-Y. Hao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular Dopamine Potentiates Mn-Induced Oxidative Stress, Lifespan Reduction, and Dopaminergic Neurodegeneration in a BLI-3–Dependent Manner in Caenorhabditis elegans

(2010) Alexandre Benedetto et al.   PLoS Genetics

RNAi Screening Implicates a SKN-1–Dependent Transcriptional Response in Stress Resistance and Longevity Deriving from Translation Inhibition

(2010) Jinling Wang et al.   PLoS Genetics

Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1

(2009) Sang-Kyu Park et al.   AGING CELL

Condition-adapted stress and longevity gene regulation byCaenorhabditis elegansSKN-1/Nrf

(2009) Riva P. Oliveira et al.   AGING CELL

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Feeding a ROS-generator to Caenorhabditis elegans leads to increased expression of small heat shock protein HSP-16.2 and hormesis

(2009) Kai Hartwig et al.   Genes and Nutrition

Leucine-rich repeat kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

(2009) K. Venderova et al.   HUMAN MOLECULAR GENETICS

Caenorhabditits elegansLRK-1 and PINK-1 Act Antagonistically in Stress Response and Neurite Outgrowth

(2009) Julia Sämann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

(2009) Hui Xiong et al.   JOURNAL OF CLINICAL INVESTIGATION

Impaired dopamine release and synaptic plasticity in the striatum ofParkin−/− mice

(2009) Tohru Kitada et al.   JOURNAL OF NEUROCHEMISTRY

Parkin Protects against LRRK2 G2019S Mutant-Induced Dopaminergic Neurodegeneration in Drosophila

(2009) C.-H. Ng et al.   JOURNAL OF NEUROSCIENCE

Bacterial Artificial Chromosome Transgenic Mice Expressing a Truncated Mutant Parkin Exhibit Age-Dependent Hypokinetic Motor Deficits, Dopaminergic Neuron Degeneration, and Accumulation of Proteinase K-Resistant  -Synuclein

(2009) X.-H. Lu et al.   JOURNAL OF NEUROSCIENCE

LRRK2 Modulates Vulnerability to Mitochondrial Dysfunction in Caenorhabditis elegans

(2009) S. Saha et al.   JOURNAL OF NEUROSCIENCE

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET

Defective responses to oxidative stress in protein l-isoaspartyl repair-deficient Caenorhabditis elegans

(2009) Shilpi Khare et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The effect of different ubiquinones on lifespan in Caenorhabditis elegans

(2009) Yu-Ying Yang et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone

(2009) Aaron J. Przybysz et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondrial respiratory chain dysfunction variably increases oxidant stress in Caenorhabditis elegans

(2009) Stephen Dingley et al.   MITOCHONDRION

The WD40 Repeat Protein WDR-23 Functions with the CUL4/DDB1 Ubiquitin Ligase To Regulate Nuclear Abundance and Activity of SKN-1 in Caenorhabditis elegans

(2009) K. P. Choe et al.   MOLECULAR AND CELLULAR BIOLOGY

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetics of reaction of nitrogen dioxide with dihydrorhodamine and the reaction of the dihydrorhodamine radical with oxygen: Implications for quantifying peroxynitrite formation in cells

(2008) Lisa K. Folkes et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

(2008) Yongsung Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

DJ-1 protects against dopamine toxicity

(2008) Nirit Lev et al.   JOURNAL OF NEURAL TRANSMISSION

Pruning and loss of excitatory synapses by the parkin ubiquitin ligase

(2008) T. D. Helton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP

(2008) M. E. Haque et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

(2008) H. Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

(2008) J. Salazar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA