Animal models of Parkinson’s disease

Drosophila melanogaster in the Study of Human Neurodegeneration

(2012) Frank Hirth   CNS & Neurological Disorders-Drug Targets

Cellular models to investigate biochemical pathways in Parkinson’s disease

(2012) Tiziana Alberio et al.   FEBS Journal

Temporal Expression of Mutant LRRK2 in Adult Rats Impairs Dopamine Reuptake

(2012) Hongxia Zhou et al.   International Journal of Biological Sciences

Modeling Neurodegeneration in Zebrafish

(2011) Yanwei Xi et al.   Current Neurology and Neuroscience Reports

Role of LRRK2 kinase dysfunction in Parkinson disease

(2011) Azad Kumar et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson's disease

(2011) Cameron H. Good et al.   FASEB JOURNAL

Phenylbutyrate Up-regulates the DJ-1 Protein and Protects Neurons in Cell Culture and in Animal Models of Parkinson Disease

(2011) Wenbo Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Rat Model of Progressive Nigral Neurodegeneration Induced by the Parkinson's Disease-Associated G2019S Mutation in LRRK2

(2011) J. Dusonchet et al.   JOURNAL OF NEUROSCIENCE

Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synuclein

(2011) Hoa A. Lam et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Impaired dopaminergic neuron development and locomotor function in zebrafish with loss ofpink1function

(2010) Yanwei Xi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S

(2010) X. Li et al.   JOURNAL OF NEUROSCIENCE

Parkin Is Protective against Proteotoxic Stress in a Transgenic Zebrafish Model

(2010) Mareike E. Fett et al.   PLoS One

Deletion of the WD40 Domain of LRRK2 in Zebrafish Causes Parkinsonism-Like Loss of Neurons and Locomotive Defect

(2010) Donglai Sheng et al.   PLoS Genetics

Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

(2009) Hong Qing et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models

(2009) Damla Pinar Karpinar et al.   EMBO JOURNAL

Bacterial Artificial Chromosome Transgenic Mice Expressing a Truncated Mutant Parkin Exhibit Age-Dependent Hypokinetic Motor Deficits, Dopaminergic Neuron Degeneration, and Accumulation of Proteinase K-Resistant  -Synuclein

(2009) X.-H. Lu et al.   JOURNAL OF NEUROSCIENCE

Intrastriatal lipopolysaccharide injection induces parkinsonism in C57/B6 mice

(2009) Randy L. Hunter et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein

(2009) Xian Lin et al.   NEURON

Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration

(2009) Suzana Gispert et al.   PLoS One

Modelling Parkinson-like neurodegeneration via osmotic minipump delivery of MPTP and probenecid

(2008) Daniel Alvarez-Fischer et al.   JOURNAL OF NEUROCHEMISTRY

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

(2008) C. A. Gautier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo alpha-synuclein overexpression in rodents: A useful model of Parkinson's disease?

(2007) Marie-Francoise Chesselet   EXPERIMENTAL NEUROLOGY