Article
Biochemistry & Molecular Biology
Lay Teng Ang, Alana T. Nguyen, Kevin J. Liu, Angela Chen, Xiaochen Xiong, Matthew Curtis, Renata M. Martin, Brian C. Raftry, Chun Yi Ng, Uwe Vogel, Angelika Lander, Benjamin J. Lesch, Jonas L. Fowler, Alyssa R. Holman, Timothy Chai, Siva Vijayakumar, Fabian P. Suchy, Toshinobu Nishimura, Joydeep Bhadury, Matthew H. Porteus, Hiromitsu Nakauchi, Christine Cheung, Steven C. George, Kristy Red-Horse, Joseph B. Prescott, Kyle M. Loh
Summary: This study successfully generated >90% pure human artery or vein endothelial cells from pluripotent stem cells within 3-4 days and used them to investigate the infection and effects of Nipah and Hendra viruses on arteries. They found that these viruses preferentially infected arteries, which expressed higher levels of the viral-entry receptor. Virally infected artery cells quickly fused into syncytia containing multiple nuclei, but rapidly died. However, these viruses largely evaded innate immune detection and minimally elicited interferon signaling during artery infection.
Article
Cell Biology
Haojie Wu, Xiaohan Li, Chen Zhou, Qihong Yu, Shiyao Ge, Zihui Pan, Yangjing Zhao, Sheng Xia, Xiaoming Zhou, Xia Liu, Hui Wang, Qixiang Shao
Summary: In inflammatory conditions such as chemotherapy and microbial infections, mature dendritic cells (mDCs) can migrate into the thymus and inhibit the proliferation of thymic epithelial cells (TECs) by activating the Jagged1/Notch3 signaling pathway, leading to acute atrophy of the thymus. This process can be reversed by a gamma-secretase inhibitor, suggesting that thymus degeneration can be induced by mass migration or constant homing of mDCs.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Dennis Merk, Johannes Ptok, Philipp Jakobs, Florian von Ameln, Jan Greulich, Pia Kluge, Kathrin Semperowitsch, Olaf Eckermann, Heiner Schaal, Niloofar Ale-Agha, Joachim Altschmied, Judith Haendeler
Summary: The study showed that APEX1(1-20) can inhibit EC apoptosis, and identified SELENOT as a potential regulator gene to reduce LPS-induced EC activation and apoptosis. SELENOT, along with APEX1(1-20), can protect EC from activation and apoptosis effects, providing new therapeutic approaches for sepsis.
Article
Biochemistry & Molecular Biology
Sara Al-Ghadban, Samantha G. Walczak, Spencer U. Isern, Elizabeth C. Martin, Karen L. Herbst, Bruce A. Bunnell
Summary: This study aims to gain insights into the angiogenic processes in lipedema using human umbilical vein endothelial cells (HUVECs) as an in vitro model. The impacts of conditioned media (CM) from healthy and lipedema adipocytes on the expression levels of multiple endothelial and angiogenic markers in HUVECs were investigated. The results indicate that lipedema adipocyte-CM promotes angiogenesis through paracrine-driven mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kamrunnesa Tahmina, Narumi Hikawa, Atsushi Takahashi-Kanemitsu, Christopher Takaya Knight, Kengo Sato, Fumiko Itoh, Masanori Hatakeyama
Summary: Arteriosclerosis is closely related to cardiovascular diseases. Infection with Helicobacter pylori cagA-positive strains is involved in the development of arteriosclerosis. CagA is delivered into endothelial cells and activates inflammatory responses, accelerating the progression of arteriosclerosis/atherosclerosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Sheng Xia, Heather L. Menden, Sherry M. Mabry, Venkatesh Sampath
Summary: HDAC6 regulates VEGF-induced angiogenesis through acetylation and repression of NICD and SNW1 transcriptional regulators.
Article
Environmental Sciences
Yong Wang, Wen Li, Fangmei Huang, Xiaojian Wu, Wenbin Chen, Ming Dong, Jie Zhou
Summary: The study demonstrates that SCA inhibits the proliferation of myeloma cells by promoting pro-apoptotic proteins and targeting the expression of Notch3. This suggests that SCA may have potential for further development as a treatment for multiple myeloma.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Kai Chen, Rong Mou, Pengwei Zhu, Xiaodong Xu, Han Wang, Liujun Jiang, Yanhua Hu, Xiaosheng Hu, Liang Ma, Qingzhong Xiao, Qingbo Xu
Summary: Transplant arteriosclerosis is a major complication in long-term survivors of heart transplantation. Increased lymph flow from donor heart to host lymph nodes has been reported to play a role in transplant arteriosclerosis, but how lymphangiogenesis affects this process is unknown.
Article
Biochemistry & Molecular Biology
Imelda Ontoria-Oviedo, Gabor Foeldes, Sandra Tejedor, Joaquin Panadero, Tomoya Kitani, Alejandro Vazquez, Joseph C. Wu, Sian E. Harding, Pilar Sepulveda
Summary: The study established an iPSC-based cellular model to investigate the etiology of d-TGA, finding that iPSC-ECs from patients with d-TGA showed impaired ability to develop tubular structures in an in vitro capillary-like tube formation assay. Interactome studies revealed downregulation of biological processes related to Notch signaling, circulatory system development and angiogenesis in d-TGA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Haiyun Wang, Qiuling Huang, Jianhong Xia, Shan Cheng, Duanqing Pei, Xiaofei Zhang, Xiaodong Shu
Summary: MIB1 overexpression is detected in lung squamous carcinoma and adenocarcinoma and negatively correlates with patient survival. MIB1 induces EMT and cell migration through the Notch pathway, and degrades NRF2 in a Notch-independent manner, disrupting cellular antioxidant capacity.
MOLECULAR CANCER RESEARCH
(2022)
Review
Health Care Sciences & Services
Jolien Fledderus, Byambasuren Vanchin, Marianne G. Rots, Guido Krenning
Summary: Endothelial cell inflammatory activation and dysfunction play crucial roles in atherosclerosis pathophysiology and targeting endothelium could be an effective approach for antiatherogenic therapies. Specific epigenetic enzymes dysregulation, such as EZH2 and SIRT1, may worsen endothelial dysfunction in a pleiotropic manner. Commercially available drugs could be explored clinically to address this hypothesis.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cell Biology
Chien-Ting Wu, Peter Lidsky, Yinghong Xiao, Ivan T. Lee, Ran Cheng, Tsuguhisa Nakayama, Sizun Jiang, Janos Demeter, Romina J. Bevacqua, Charles A. Chang, Robert L. Whitener, Anna K. Stalder, Bokai Zhu, Han Chen, Yury Goltsev, Alexandar Tzankov, Jayakar Nayak, Garry P. Nolan, Matthias S. Matter, Raul Andino, Peter K. Jackson
Summary: There is evidence suggesting a complex relationship between COVID-19 and diabetes, with SARS-CoV-2 being able to directly induce beta cell killing and this effect being rescued by NRP1 inhibition.
Article
Pharmacology & Pharmacy
Ahmed Alafnan, Nasrin E. E. Khalifa, Talib Hussain, Mhdia Elhadi Osman
Summary: This study explores the anticancer effects of Cucurbitacin-B (Cur-B), a triterpenoid compound found in the Cucurbitaceae family, on androgen-dependent prostate cancer LNCaP cells. The results show that Cur-B inhibits cell viability, induces apoptosis and cell cycle arrest, and reduces the expression of the Notch signaling cascade in LNCaP cells. Cur-B has the potential to be a promising therapeutic agent for androgen-dependent prostate cancer.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Xichuan Zheng, Qihong Yu, Dan Shang, Chuanzheng Yin, Dawei Xie, Tong Huang, Xiaolong Du, Wenjie Wang, Xueke Yan, Chen Zhang, Wei Li, Zifang Song
Summary: TAK1 signaling pathway plays a crucial role in the proliferation and migration of vascular smooth muscle cells (VSMCs). This study reveals that activation of TAK1 controls autophagy activation and regulates cell cycle, proliferation, and migration responses in VSMCs. This provides a potential molecular mechanism and therapeutic target for preventing transplant vasculopathy.
Article
Cell Biology
Yash T. Katakia, Niyati P. Thakkar, Sumukh Thakar, Ashima Sakhuja, Raghav Goyal, Harshita Sharma, Rakshita Dave, Ayushi Mandloi, Sayan Basu, Ishan Nigam, Bhanu V. R. Kuncharam, Shibasish Chowdhury, Syamantak Majumder
Summary: The research suggests that dynamic chromatin modifications may trigger inflammatory and apoptotic responses in endothelial cells, and epigenetic reprogramming could potentially enhance outcomes in cardiovascular diseases associated with endothelial inflammation.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Immunology
Marion Drouin, Javier Saenz, Elise Chiffoleau
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Medicine, General & Internal
Brice Moukengue, Hannah K. Brown, Celine Charrier, Severine Battaglia, Marc Baud'huin, Thibaut Quillard, Therese M. Pham, Ioannis S. Pateras, Vassilis G. Gorgoulis, Thomas Helleday, Dominique Heymann, Ulrika Warpman Berglund, Benjamin Ory, Francois Lamoureux
Article
Rheumatology
Aurelie Najm, Francois-Marie Masson, Pauline Preuss, Steven Georges, Benjamin Ory, Thibaut Quillard, Shatakshi Sood, Carl S. Goodyear, Douglas J. Veale, Ursula Fearon, Benoit Le Goff, Frederic Blanchard
ARTHRITIS & RHEUMATOLOGY
(2020)
Article
Immunology
Melanie Chesneau, Hoa Le Mai, Richard Danger, Sabine Le Bot, Thi-Van-Ha Nguyen, Josselin Bernard, Cyrielle Poullaouec, Pierrick Guerrif, Sophie Conchon, Magali Giral, Beatrice Charreau, Nicolas Degauque, Sophie Brouard
JOURNAL OF IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Chloe Coste, Nathalie Gerard, Chau Phi Dinh, Antoine Bruguiere, Caroline Rouger, Sow Tein Leong, Khalijah Awang, Pascal Richomme, Severine Derbre, Beatrice Charreau
Article
Urology & Nephrology
Alice Koenig, Sarah Mezaache, Jasper Callemeyn, Thomas Barba, Virginie Mathias, Antoine Sicard, Beatrice Charreau, Maud Rabeyrin, Frederique Dijoud, Cecile Picard, Vannary Meas-Yedid, Jean-Christophe Olivo-Marin, Emmanuel Morelon, Maarten Naesens, Valerie Dubois, Olivier Thaunat
Summary: The study found that the presence of missing self may exacerbate DSA-dependent NK cell activation, leading to worsening chronic antibody-mediated rejection. Detection of missing self in allograft endothelial cells can help identify patients at higher risk for kidney transplant failure.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Beatrice Charreau
Summary: Endothelial cells play a crucial role in maintaining vascular health by communicating with other cells over long distances, regulating processes such as blood clotting, inflammation, and immunity through the secretion of granules and extracellular vesicles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Melanie Lancien, Geraldine Bienvenu, Sonia Salle, Lucile Gueno, Magalie Feyeux, Emmanuel Merieau, Severine Remy, Amandine Even, Aurelie Moreau, Alice Molle, Cynthia Fourgeux, Flora Coulon, Gaelle Beriou, Laurence Bouchet-Delbos, Elise Chiffoleau, Peggy Kirstetter, Susan Chan, Steven M. Kerfoot, Saeed Abdu Rahiman, Veronica De Simone, Gianluca Matteoli, Gaelle Boncompain, Franck Perez, Regis Josien, Jeremie Poschmann, Maria Cristina Cuturi, Cedric Louvet
Summary: This study investigated the role of TMEM176A/B in DCs and found that they are crucial for antigen processing and presentation to CD4(+) T cells, suggesting a direct role in the MHC class II compartment for fine regulation of antigen presentation and CD4(+) T cell priming.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Amelie Rousseliere, Laurence Delbos, Celine Bressollette, Mailys Berthaume, Beatrice Charreau
Summary: This study quantitatively determined the frequency of various anti-HCMV immune cell subsets and qualitatively analyzed their phenotypes using spectral flow cytometry analysis. The results provide insights into the cellular immune responses to HCMV infection or vaccines, and can be used for monitoring and analysis of T-cell and NK cell responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Baptiste Lamarthee, Carole Burger, Charlotte Leclaire, Emilie Lebraud, Aniela Zablocki, Lise Morin, Xavier Lebreton, Beatrice Charreau, Renaud Snanoudj, Soeli Charbonnier, Tifanie Blein, Melanie Hardy, Julien Zuber, Simon Satchell, Morgan Gallazzini, Fabiola Terzi, Christophe Legendre, Jean Luc Taupin, Marion Rabant, Claire Tinel, Dany Anglicheau
Summary: The study demonstrates that using human glomerular endothelial cells with all HLA antigens deleted as targets and recapitulating a large array of potential non-HLA antibodies in a single test can confirm the detrimental impact of non-HLA antibodies on microvascular inflammation and graft outcome after kidney transplantation, independent of HLA antibodies.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Beatrice Charreau
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Marion Drouin, Javier Saenz, Vanessa Gauttier, Berangere Evrard, Geraldine Teppaz, Sabrina Pengam, Caroline Mary, Ariane Desselle, Virginie Thepenier, Emmanuelle Wilhelm, Emmanuel Merieau, Camille Ligeron, Isabelle Girault, Maria-Dolores Lopez, Cynthia Fourgeux, Debajyoti Sinha, Irene Baccelli, Aurelie Moreau, Cedric Louvet, Regis Josien, Jeremie Poschmann, Nicolas Poirier, Elise Chiffoleau
Summary: The study reveals that CLEC-1 acts as an immune checkpoint in myeloid cells, with its blockade enhancing antitumor immunity and showing potential as a novel target for cancer immunotherapy.
Meeting Abstract
Cardiac & Cardiovascular Systems
L. Bessueille, L. Kawtharany, T. Quillard, C. Goettsch, A. Briolay, S. Mebarek, K. Zibara, O. Peyruchaud, F. Duboeuf, C. Bouillot, E. Canet-Soulas, A. Pinkerton, J. L. Millan, D. Magne
Correction
Cardiac & Cardiovascular Systems
Claudia Goettsch, Agnieszka Strzelecka-Kiliszek, Laurence Bessueille, Thibaut Quillard, Laura Mechtouff, Slawomir Pikula, Emmanuelle Canet-Soulas, Jose Luis Millan, Caroline Fonta, David Magne
CARDIOVASCULAR RESEARCH
(2021)
Meeting Abstract
Surgery
Nicolas Jouand, Amelie Rousseliere, Audrey Rodallec, Magali Giral, Pierrick Guerif, Romain Oger, Mathilde Allard, Anne Cesbron, Celine Bessollette-Bodin, Nadine Gervois, Beatrice Charreau
TRANSPLANT INTERNATIONAL
(2019)