Article
Nutrition & Dietetics
Gabriele Serreli, Micaela Rita Naitza, Sonia Zodio, Vera Piera Leoni, Martina Spada, Maria Paola Melis, Anna Boronat, Monica Deiana
Summary: Ferulic acid and its metabolites show efficacy in combating inflammation by limiting the expression and activity of proinflammatory enzymes, reducing NF-κB translocation, and promoting Nrf2 expression.
Article
Multidisciplinary Sciences
Uddalak Majumdar, Sathiyanarayanan Manivannan, Madhumita Basu, Yukie Ueyama, Mark C. Blaser, Emily Cameron, Michael R. McDermott, Joy Lincoln, Susan E. Cole, Stephen Wood, Elena Aikawa, Brenda Lilly, Vidu Garg
Summary: Nitric oxide regulates NOTCH pathway through S-nitrosylation to prevent calcific aortic valve disease.
Article
Food Science & Technology
Eun Hae Kim, Youn Young Shim, Hye In Lee, Sanghyun Lee, Martin J. T. Reaney, Mi Ja Chung
Summary: The current study found that astragalin and isoquercitrin from chamchwi had anti-neuroinflammatory effects by inhibiting the MAPK signaling pathway. Astragalin and isoquercitrin reduced the inflammatory response in LPS-induced microglial cells and hippocampus in mice.
Article
Biochemistry & Molecular Biology
Amelia Cataldi, Rosa Amoroso, Viviana di Giacomo, Susi Zara, Cristina Maccallini, Marialucia Gallorini
Summary: Nitric oxide plays a key role in physiological and pathological processes in mammals, and excessive production is associated with inflammation. Dental pulp inflammation caused by pathogenic bacteria may affect the functions of dental pulp stem cells. Inhibiting nitric oxide production could be a new strategy for treating inflammation and promoting the regeneration of the dentin-pulp complex. This study evaluated two acetamidines related to a selective inhibitor of nitric oxide, and the results showed that they have potential as anti-inflammatory compounds while retaining the mineralization and angiogenic potential of cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marialucia Gallorini, Monica Rapino, Helmut Schweikl, Amelia Cataldi, Rosa Amoroso, Cristina Maccallini
Summary: The study demonstrates that new iNOS inhibitors selectively reduce cytotoxicity, IL-6 secretion, and LPS-stimulated monocyte migration, indicating promising therapeutic potential.
Article
Biochemistry & Molecular Biology
Meng Liy Pan, Nur Nabilah Ahmad Puzi, Yin Yin Ooi, Rajesh Ramasamy, Sharmili Vidyadaran
Summary: The latest research shows that microglia phenotype is not limited to the binary states of "resting" and "activated", but exhibits wide diversity. Testing different stimulation protocols for BV2 microglia, we found differences in the response of the cells in terms of intracellular ROS, nitric oxide, CD40 expression, and migratory capacity.
Article
Biochemistry & Molecular Biology
Jesus Garcia Diaz, Rosalia Gonzalez Fernandez, Julio Cesar Escalona Arranz, Gabriel Llaurado Maury, Daniel Mendez Rodriguez, Linda De Vooght, Enrique Molina, Emmy Tuenter, Luc Pieters, Paul Cos
Summary: Oxidative stress is involved in many diseases, and natural antioxidants have shown potential in protecting against it. This study found that compounds in Croton linearis leaves can inhibit nitric oxide production and scavenge free radicals, making them a potential source of antioxidants for treating oxidative damage-related diseases.
Article
Plant Sciences
Weronika Skowronska, Sebastian Granica, Monika E. Czerwinska, Ewa Osinska, Agnieszka Bazylko
Summary: The study confirms the anti-inflammatory and antioxidant activity of elderberry leaves, particularly against reactive oxygen species. This suggests that elderberry leaves may be a potential medicinal plant with anti-inflammatory and antioxidant properties.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Raissa Volpatto Marques, Stefania Enza Sestito, Frederic Bourgaud, Sissi Miguel, Frederic Cailotto, Pascal Reboul, Jean-Yves Jouzeau, Sophie Rahuel-Clermont, Sandrine Boschi-Muller, Henrik Toft Simonsen, David Moulin
Summary: The study found that the biologically active extracts of Dicranum majus and Thuidium delicatulum exhibited significant anti-inflammatory effects, potentially serving as a perspective for developing innovative therapeutic agents.
Article
Multidisciplinary Sciences
Omar A. Alfituri, Enock M. Mararo, Pieter C. Steketee, Liam J. Morrison, Neil A. Mabbott
Summary: The study found that although increasing the local abundance of macrophages in the skin through colony stimulating factor 1 (CSF1) injection did not affect susceptibility to T. brucei infection, bacterial LPS-stimulation in the skin significantly reduced disease susceptibility to intradermal trypanosome infection. This implies that enhancing the ability of dermal macrophages to eliminate injected T. brucei parasites may help reduce the transmission of African trypanosomes in the future.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Hiromu Ito
Summary: The generation of nitric oxide enhances the expression of the porphyrin transporter HCP1, leading to increased accumulation of porphyrin in cells, providing new insights into tumor treatment strategies using PDT.
APPLIED SCIENCES-BASEL
(2021)
Article
Food Science & Technology
Gabriel Silva Xavier, Amanda Mara Teles, Carla Junqueira Moragas-Tellis, Maria do Socorro dos Santos Chagas, Maria Dutra Behrens, Wendel Fragoso de Freitas Moreira, Ana Lucia Abreu-Silva, Katia da Silva Calabrese, Maria do Desterro Soares Brandao Nascimento, Fernando Almeida-Souza
Summary: This study evaluated the effects of catechin-rich acai extract on inflammation control, showing inhibitory effects on macrophages and paw edema. The findings provide evidence for further research on E. oleracea seeds for inflammation treatment.
Article
Medicine, Research & Experimental
Mei-Hua Jin, Dong-Qin Chen, Ying-Hua Jin, Ying-Hao Han, Hu-Nan Sun, Taeho Kwon
Summary: Neuroinflammation is linked to various neurodegenerative diseases, with abnormal activation of microglial cells and overproduction of NO playing a crucial role. Hispidin, a polyphenol from Phellinus linteus, has been shown to significantly inhibit NO production in macrophages. This study demonstrated that Hispidin can effectively reduce NO production and iNOS expression in microglial cells, suggesting its potential as a therapeutic agent for NO-induced neuroinflammation and as a novel iNOS inhibitor.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cell Biology
Hyo-Jin An, Ji-Young Lee, Wansu Park
Summary: This study found that baicalin can inhibit the inflammatory response of macrophages activated by LPS, reduce the production of various inflammatory mediators, suppress oxidative stress, decrease the levels of phosphorylated p38 MAPK and Fas protein, and inhibit the expression of inflammatory genes.
Article
Cell Biology
Tao Huang, Congyun Zhao, Yi Zhao, Yuan Zhou, Lei Wang, Donghua Hang
Summary: RO4929097 can effectively inhibit RANKL-induced osteoclastogenesis, reduce NFATc1 protein expression, and decrease bone resorption. In vivo experiments demonstrate that RO4929097 has an inhibitory effect on LPS-induced bone resorption.