Oxidant Stress and Signal Transduction in the Nervous System with the PI 3-K, Akt, and mTOR Cascade
出版年份 2012 全文链接
标题
Oxidant Stress and Signal Transduction in the Nervous System with the PI 3-K, Akt, and mTOR Cascade
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 13, Issue 12, Pages 13830-13866
出版商
MDPI AG
发表日期
2012-10-26
DOI
10.3390/ijms131113830
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Prevention of β-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL
- (2016) Yan Chen Shang et al. Aging-US
- The severity of brain damage determines bone marrow stromal cell therapy efficacy in a traumatic brain injury model
- (2015) Celia Bonilla et al. JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
- Altered expression of base excision repair genes in response to high glucose-induced oxidative stress in HepG2 hepatocytes
- (2013) Jing Pang et al. MEDICAL SCIENCE MONITOR
- Impaired autophagic function in rat islets with aging
- (2012) Yu Liu et al. AGE
- Epidemiologic Merit of Obese-Years, the Combination of Degree and Duration of Obesity
- (2012) A. Abdullah et al. AMERICAN JOURNAL OF EPIDEMIOLOGY
- Mammalian target of rapamycin signaling in diabetic cardiovascular disease
- (2012) Zhao Chong et al. Cardiovascular Diabetology
- Deconvoluting mTOR biology
- (2012) Jason D. Weber et al. CELL CYCLE
- Nitric Oxide, Epileptic Seizures, and Action of Antiepileptic Drugs
- (2012) Monika Banach et al. CNS & Neurological Disorders-Drug Targets
- Nicotinamide Postpones Stroke in Stroke-Prone Spontaneously Hypertensive Rats
- (2012) Jin-Min Guo et al. CNS Neuroscience & Therapeutics
- Metformin preconditioning protects Daphnia pulex from lethal hypoxic insult involving AMPK, HIF and mTOR signaling
- (2012) Bo Sheng et al. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
- Altered Calmodulin Degradation and Signaling in Non-Neuronal Cells from Alzheimer’s Disease Patients
- (2012) Noemi Esteras et al. Current Alzheimer Research
- Effects of Supplemental Erythropoietin on Its Receptor Expression and Signal Transduction Pathways in Rat Model of Retinal Detachment
- (2012) Zhenggao Xie et al. CURRENT EYE RESEARCH
- WISP1 (CCN4) Autoregulates its Expression and Nuclear Trafficking of β-Catenin during Oxidant Stress with Limited Effects upon Neuronal Autophagy
- (2012) Shaohui Wang et al. CURRENT NEUROVASCULAR RESEARCH
- The Many Facets of Cell Injury: Angiogenesis to Autophagy
- (2012) Kenneth Maiese CURRENT NEUROVASCULAR RESEARCH
- EDITOR’S PERSPECTIVE [The Challenges for Drug Development: Cytokines, Genes, and Stem Cells]
- (2012) Kenneth Maiese CURRENT NEUROVASCULAR RESEARCH
- Wnt1 Inducible Signaling Pathway Protein 1 (WISP1) Blocks Neurodegeneration through Phosphoinositide 3 Kinase/Akt1 and Apoptotic Mitochondrial Signaling Involving Bad, Bax, Bim, and Bcl-xL
- (2012) Shaohui Wang et al. CURRENT NEUROVASCULAR RESEARCH
- Wnt1 Inducible Signaling Pathway Protein 1 (WISP1) Targets PRAS40 to Govern β-Amyloid Apoptotic Injury of Microglia
- (2012) Yan Chen Shang et al. CURRENT NEUROVASCULAR RESEARCH
- Erythropoietin attenuated vascular dysfunction and inflammation by inhibiting NADPH oxidase-derived superoxide production in nitric oxide synthase-inhibited hypertensive rat aorta
- (2012) Hiroe Toba et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Inhibition of Protein Tyrosine Phosphatase Improves Angiogenesis via Enhancing Ang-1/Tie-2 Signaling in Diabetes
- (2012) Jian-Xiong Chen et al. Experimental Diabetes Research
- Targeting disease through novel pathways of apoptosis and autophagy
- (2012) Kenneth Maiese et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- SIRT1: new avenues of discovery for disorders of oxidative stress
- (2012) Zhao Zhong Chong et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy
- (2012) Rene L. Vidal et al. HUMAN MOLECULAR GENETICS
- ERK and Akt signaling pathways are involved in advanced glycation end product-induced autophagy in rat vascular smooth muscle cells
- (2012) PENGFEI HU et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Erythropoietin: New Directions for the Nervous System
- (2012) Kenneth Maiese et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Xanthigen Suppresses Preadipocyte Differentiation and Adipogenesis through Down-regulation of PPARγ and C/EBPs and Modulation of SIRT-1, AMPK, and FoxO Pathways
- (2012) Ching-Shu Lai et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Vinculin Functions as Regulator of Chondrogenesis
- (2012) Takao Koshimizu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- GLP1-derived nonapeptide GLP1(28–36)amide protects pancreatic β-cells from glucolipotoxicity
- (2012) Zhengu Liu et al. JOURNAL OF ENDOCRINOLOGY
- Neuroprotective effect of Buyang Huanwu Decoction against focal cerebral ischemia/reperfusion injury in rats – Time window and mechanism
- (2012) Lian-Dong Zhao et al. JOURNAL OF ETHNOPHARMACOLOGY
- Autophagy in hypoxia-ischemia induced brain injury
- (2012) Walter Balduini et al. Journal of Maternal-Fetal & Neonatal Medicine
- Neuroprotective properties of Loranthus parasiticus aqueous fraction against oxidative stress-induced damage in NG108-15 cells
- (2012) Daniel Zin Hua Wong et al. Journal of Natural Medicines
- Plasticity of Subventricular Zone Neuroprogenitors in MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) Mouse Model of Parkinson's Disease Involves Cross Talk between Inflammatory and Wnt/ -Catenin Signaling Pathways: Functional Consequences for Neuroprotection and Repair
- (2012) F. L'Episcopo et al. JOURNAL OF NEUROSCIENCE
- Understanding the basic mechanisms underlying seizures in mesial temporal lobe epilepsy and possible therapeutic targets: A review
- (2012) Casey M. O'Dell et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Erythropoietin alleviates post-ischemic injury of rat hearts by attenuating nitrosative stress
- (2012) Ming-Jen Lu et al. LIFE SCIENCES
- The Combined Deletion of S6K1 and Akt2 Deteriorates Glycemic Control in a High-Fat Diet
- (2012) C. Treins et al. MOLECULAR AND CELLULAR BIOLOGY
- Regulation of mTOR Complex 2 Signaling in Neurofibromatosis 2-Deficient Target Cell Types
- (2012) M. F. James et al. MOLECULAR CANCER RESEARCH
- Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
- (2012) Congcong He et al. NATURE
- A mouse model to identify cooperating signaling pathways in cancer
- (2012) Monica Musteanu et al. NATURE METHODS
- Recent Advances in the Treatment of Neurodegenerative Diseases Based on GSH Delivery Systems
- (2012) Ivana Cacciatore et al. Oxidative Medicine and Cellular Longevity
- Silymarin improves the behavioural, biochemical and histoarchitecture alterations in focal ischemic rats: A comparative evaluation with piracetam and protocatachuic acid
- (2012) Milind M. Muley et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Polydatin protects learning and memory impairments in a rat model of vascular dementia
- (2012) Run-Ping Li et al. PHYTOMEDICINE
- N-acetylcysteine Protects against Apoptosis through Modulation of Group I Metabotropic Glutamate Receptor Activity
- (2012) Lili Sun et al. PLoS One
- Systemic Bisperoxovanadium Activates Akt/mTOR, Reduces Autophagy, and Enhances Recovery following Cervical Spinal Cord Injury
- (2012) Chandler L. Walker et al. PLoS One
- Palmitate Activates Autophagy in INS-1E β-Cells and in Isolated Rat and Human Pancreatic Islets
- (2012) Luisa Martino et al. PLoS One
- The Interaction between Early Life Epilepsy and Autistic-Like Behavioral Consequences: A Role for the Mammalian Target of Rapamycin (mTOR) Pathway
- (2012) Delia M. Talos et al. PLoS One
- PRAS40 Is an Integral Regulatory Component of Erythropoietin mTOR Signaling and Cytoprotection
- (2012) Zhao Zhong Chong et al. PLoS One
- Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin
- (2012) Zhao Zhong Chong et al. PROGRESS IN NEUROBIOLOGY
- NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity
- (2012) Emmanouil Fokas et al. Radiation Oncology
- Cardiovascular Disease and mTOR Signaling
- (2012) Zhao Zhong Chong et al. TRENDS IN CARDIOVASCULAR MEDICINE
- Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation
- (2012) Vojo Deretic et al. TRENDS IN CELL BIOLOGY
- Metabotropic glutamate receptor 5 mediates phosphorylation of vascular endothelial cadherin and nuclear localization of β-catenin in response to homocysteine
- (2012) Richard S. Beard et al. VASCULAR PHARMACOLOGY
- Neuroprotective cytokines repress PUMA induction in the 1-methyl-4-phenylpyridinium (MPP+) model of Parkinson’s disease
- (2011) Yeon-Hee Kook et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The functions of mTOR in ischemic diseases
- (2011) Seo-Kyoung Hwang et al. BMB Reports
- FoxO1, the transcriptional chief of staff of energy metabolism
- (2011) Stavroula Kousteni BONE
- Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats
- (2011) N Deblon et al. BRITISH JOURNAL OF PHARMACOLOGY
- ARNO regulates VEGF-dependent tissue responses by stabilizing endothelial VEGFR-2 surface expression
- (2011) Hanna K. Mannell et al. CARDIOVASCULAR RESEARCH
- High glucose upregulation of early-onset Parkinson's disease protein DJ-1 integrates the PRAS40/TORC1 axis to mesangial cell hypertrophy
- (2011) Falguni Das et al. CELLULAR SIGNALLING
- Synthesis and Comparison of Antioxidant Properties of Indole-Based Melatonin Analogue Indole Amino Acid Derivatives
- (2011) Sibel Suzen et al. Chemical Biology & Drug Design
- Oxidative stress and diabetes mellitus
- (2011) Hui Yang et al. CLINICAL CHEMISTRY AND LABORATORY MEDICINE
- Mitochondria: The Common Upstream Driver of Amyloid-β and Tau Pathology in Alzheimers Disease
- (2011) D. F.F. Silva et al. Current Alzheimer Research
- Metabotropic Glutamate Receptors and Interacting Proteins: Evolving Drug Targets
- (2011) Ralf Enz CURRENT DRUG TARGETS
- Multi-Target-Directed Ligands in Alzheimer's Disease Treatment
- (2011) M. Bajda et al. CURRENT MEDICINAL CHEMISTRY
- NMNAT Expression and its Relation to NAD Metabolism
- (2011) H. N. Jayaram et al. CURRENT MEDICINAL CHEMISTRY
- Erythropoietin Employs Cell Longevity Pathways of SIRT1 to Foster Endothelial Vascular Integrity During Oxidant Stress
- (2011) Jinling Hou et al. CURRENT NEUROVASCULAR RESEARCH
- Erythropoietin and Wnt1 Govern Pathways of mTOR, Apaf-1, and XIAP in Inflammatory Microglia
- (2011) Yan Chen Shang et al. CURRENT NEUROVASCULAR RESEARCH
- EPO Relies upon Novel Signaling of Wnt1 that Requires Akt1, FoxO3a,GSK-3β, and β-Catenin to Foster Vascular Integrity during Experimental Diabetes
- (2011) Zhao Zhong Chong et al. CURRENT NEUROVASCULAR RESEARCH
- Role of Sirtuins and Calorie Restriction in Neuroprotection: Implications in Alzheimers and Parkinsons Diseases
- (2011) Sarika Srivastava et al. CURRENT PHARMACEUTICAL DESIGN
- Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway
- (2011) Eva Maria Galan-Moya et al. EMBO REPORTS
- Effect of Chronic Regular Exercise on Serum Ischemia-Modified Albumin Levels and Oxidative Stress in Type 2 Diabetes Mellitus
- (2011) Sevil Kurban et al. ENDOCRINE RESEARCH
- Hyperoside protects primary rat cortical neurons from neurotoxicity induced by amyloid β-protein via the PI3K/Akt/Bad/BclXL-regulated mitochondrial apoptotic pathway
- (2011) Ke-Wu Zeng et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Increased Oxidative DNA Damage in Lean Normoglycemic Offspring of Type 2 Diabetic Patients
- (2011) A. Zengi et al. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
- Dietary wolfberry ameliorates retinal structure abnormalities in db/db mice at the early stage of diabetes
- (2011) Ling Tang et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- GADD34 mediates cytoprotective autophagy in mutant huntingtin expressing cells via the mTOR pathway
- (2011) Alise Hyrskyluoto et al. EXPERIMENTAL CELL RESEARCH
- System xc− regulates microglia and macrophage glutamate excitotoxicity in vivo
- (2011) Kristina A. Kigerl et al. EXPERIMENTAL NEUROLOGY
- Exercise modulates microRNAs that affect the PTEN/mTOR pathway in rats after spinal cord injury
- (2011) Gang Liu et al. EXPERIMENTAL NEUROLOGY
- Diabetes as a chronic metabolic stressor: Causes, consequences and clinical complications
- (2011) Lawrence P. Reagan EXPERIMENTAL NEUROLOGY
- Mammalian target of rapamycin (mTOR) inhibition reduces cerebral vasospasm following a subarachnoid hemorrhage injury in canines
- (2011) Weiguang Zhang et al. EXPERIMENTAL NEUROLOGY
- Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver
- (2011) Yu Li et al. FASEB JOURNAL
- Redox signaling and histone acetylation in acute pancreatitis
- (2011) Javier Escobar et al. FREE RADICAL BIOLOGY AND MEDICINE
- PACAP interactions in the mouse brain: Implications for behavioral and other disorders
- (2011) George K. Acquaah-Mensah et al. GENE
- Tissue plasminogen activator induces microglial inflammation via a noncatalytic molecular mechanism involving activation of mitogen-activated protein kinases and Akt signaling pathways and AnnexinA2 and Galectin-1 receptors
- (2011) David Pineda et al. GLIA
- Emodin-induced microglial apoptosis is associated with TRB3 induction
- (2011) Xueping Zhou et al. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
- The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway
- (2011) TAO CHEN et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Multiple Site Acetylation of Rictor Stimulates Mammalian Target of Rapamycin Complex 2 (mTORC2)-dependent Phosphorylation of Akt Protein
- (2011) Emily J. Glidden et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- β Common receptor integrates the erythropoietin signaling in activation of endothelial nitric oxide synthase
- (2011) Kuo-Hui Su et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance
- (2011) Rui-Hong Wang et al. JOURNAL OF CLINICAL INVESTIGATION
- The diversity of sex steroid action: the role of micro-RNAs and FOXO transcription factors in cycling endometrium and cancer
- (2011) Eric W-F Lam et al. JOURNAL OF ENDOCRINOLOGY
- On the Role of Phosphatidylinositol 3-Kinase, Protein Kinase B/Akt, and Glycogen Synthase Kinase-3β in Photodynamic Injury of Crayfish Neurons and Glial Cells
- (2011) Maxim A. Komandirov et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model
- (2011) Ana Roscic et al. JOURNAL OF NEUROCHEMISTRY
- Erythropoietin improves memory function with reducing endothelial dysfunction and amyloid-beta burden in Alzheimer’s disease models
- (2011) Soon-Tae Lee et al. JOURNAL OF NEUROCHEMISTRY
- Oestrogen Receptors and Signalling Pathways: Implications for Neuroprotective Effects of Sex Steroids in Parkinson’s Disease
- (2011) S. Al Sweidi et al. JOURNAL OF NEUROENDOCRINOLOGY
- Severe Global Cerebral Ischemia-Induced Programmed Necrosis of Hippocampal CA1 Neurons in Rat Is Prevented by 3-Methyladenine: A Widely Used Inhibitor of Autophagy
- (2011) Jin-Ye Wang et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- The Neurophysiology and Pathology of Brain Zinc
- (2011) S. L. Sensi et al. JOURNAL OF NEUROSCIENCE
- Vascular endothelial growth factor in cerebral ischemia
- (2011) Yihui Ma et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Endogenous erythropoietin from astrocyte protects the oligodendrocyte precursor cell against hypoxic and reoxygenation injury
- (2011) Shin Kato et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling
- (2011) Wenjing Guo et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Rapamycin Promotes Autophagy and Reduces Neural Tissue Damage and Locomotor Impairment after Spinal Cord Injury in Mice
- (2011) Akira Sekiguchi et al. JOURNAL OF NEUROTRAUMA
- The anti-inflammatory and antioxidative effects of nicotinamide, a vitamin B3 derivative, are elicited by FoxO3 in human gestational tissues: implications for preterm birth
- (2011) Martha Lappas et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Silymarin protects neurons from oxidative stress associated damages in focal cerebral ischemia: A behavioral, biochemical and immunohistological study in Wistar rats
- (2011) Syed Shadab Raza et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Nicotinamide Attenuates the Decrease of Astrocytic Phosphoprotein PEA-15 in Focal Cerebral Ischemic Injury
- (2011) Phil-Ok KOH JOURNAL OF VETERINARY MEDICAL SCIENCE
- Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): a randomised, placebo-controlled, phase 3 study
- (2011) Marianne E Pavel et al. LANCET
- Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1
- (2011) Sara Fröjdö et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- The PI3K/Akt/mTOR pathway mediates retinal progenitor cell survival under hypoxic and superoxide stress
- (2011) Karan P. Sanghera et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration
- (2011) Arunkumar Asaithambi et al. Molecular Neurodegeneration
- Sustained axon regeneration induced by co-deletion of PTEN and SOCS3
- (2011) Fang Sun et al. NATURE
- Rapamycin passes the torch: a new generation of mTOR inhibitors
- (2011) Don Benjamin et al. NATURE REVIEWS DRUG DISCOVERY
- Adult neural precursors isolated from post mortem brain yield mostly neurons: An erythropoietin-dependent process
- (2011) Giovanni Marfia et al. NEUROBIOLOGY OF DISEASE
- Phospho-Rb Mediating Cell Cycle Reentry Induces Early Apoptosis Following Oxygen–Glucose Deprivation in Rat Cortical Neurons
- (2011) Ying Yu et al. NEUROCHEMICAL RESEARCH
- Nicotinamide attenuates the ischemic brain injury-induced decrease of Akt activation and Bad phosphorylation
- (2011) Phil-Ok Koh NEUROSCIENCE LETTERS
- Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation
- (2011) F Wang et al. ONCOGENE
- Oxygen Sensing in Retinal Health and Disease
- (2011) Clemens A.K. Lange et al. OPHTHALMOLOGICA
- Mammalian Target of Rapamycin: Hitting the Bull's-Eye for Neurological Disorders
- (2011) Zhao Zhong Chong et al. Oxidative Medicine and Cellular Longevity
- Gypenoside attenuates white matter lesions induced by chronic cerebral hypoperfusion in rats
- (2011) Guanglin Zhang et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits
- (2011) Smita Majumder et al. PLoS One
- Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation
- (2011) Y. Rong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy
- (2011) N. R. Sundaresan et al. Science Signaling
- α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 Attenuates Early Brain Injury in a Perforation Model of Subarachnoid Hemorrhage in Rats
- (2011) Kamil Duris et al. STROKE
- Erythropoietin, Forkhead Proteins, and Oxidative Injury: Biomarkers and Biology
- (2011) Kenneth Maiese et al. TheScientificWorldJOURNAL
- Vitamin E renders protection to PC12 cells against oxidative damage and apoptosis induced by single-walled carbon nanotubes
- (2011) Jingyun Wang et al. TOXICOLOGY IN VITRO
- Forkhead Homeobox Type O Transcription Factors in the Responses to Oxidative Stress
- (2010) Peter Storz ANTIOXIDANTS & REDOX SIGNALING
- Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia
- (2010) Ai-Ping Qin et al. Autophagy
- PTEN deletion prevents ischemic brain injury by activating the mTOR signaling pathway
- (2010) G.D. Shi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson's disease
- (2010) Mohd.Moshahid Khan et al. BRAIN RESEARCH
- Wnt1, FoxO3a, and NF-κB oversee microglial integrity and activation during oxidant stress
- (2010) Yan Chen Shang et al. CELLULAR SIGNALLING
- Diabetes Mellitus: Channeling Care through Cellular Discovery
- (2010) Kenneth Maiese et al. CURRENT NEUROVASCULAR RESEARCH
- Early Apoptotic Vascular Signaling is Determined by Sirt1 Through Nuclear Shuttling, Forkhead Trafficking, Bad, and Mitochondrial Caspase Activation
- (2010) Jinling Hou et al. CURRENT NEUROVASCULAR RESEARCH
- Mammalian Target of Rapamycin Complex 1 Suppresses Lipolysis, Stimulates Lipogenesis, and Promotes Fat Storage
- (2010) P. Chakrabarti et al. DIABETES
- Downregulation of AMPK Accompanies Leucine- and Glucose-Induced Increases in Protein Synthesis and Insulin Resistance in Rat Skeletal Muscle
- (2010) A. K. Saha et al. DIABETES
- The inhibitor of phagocytosis, O-phospho-l-serine, suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina
- (2010) Travis J. Bailey et al. EXPERIMENTAL EYE RESEARCH
- Oxidative stress: Biomarkers and novel therapeutic pathways
- (2010) Kenneth Maiese et al. EXPERIMENTAL GERONTOLOGY
- Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs
- (2010) Dongshan Yang et al. HUMAN MOLECULAR GENETICS
- Growth factors in ischemic stroke
- (2010) S. Lanfranconi et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice
- (2010) Denghong Zhang et al. JOURNAL OF CLINICAL INVESTIGATION
- Novel Avenues of Drug Discovery and Biomarkers for Diabetes Mellitus
- (2010) Kenneth Maiese et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease
- (2010) C. Malagelada et al. JOURNAL OF NEUROSCIENCE
- The mechanism for the neuroprotective effect of melatonin against methamphetamine-induced autophagy
- (2010) Chutikorn Nopparat et al. JOURNAL OF PINEAL RESEARCH
- FOXO3a governs early and late apoptotic endothelial programs during elevated glucose through mitochondrial and caspase signaling
- (2010) Jinling Hou et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease
- (2010) Jonathan H Fox et al. Molecular Neurodegeneration
- Termination of autophagy and reformation of lysosomes regulated by mTOR
- (2010) Li Yu et al. NATURE
- PTEN deletion enhances the regenerative ability of adult corticospinal neurons
- (2010) Kai Liu et al. NATURE NEUROSCIENCE
- Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
- (2010) F. L'Episcopo et al. NEUROBIOLOGY OF DISEASE
- DHEA prevents Aβ25–35-impaired survival of newborn neurons in the dentate gyrus through a modulation of PI3K-Akt-mTOR signaling
- (2010) Liang Li et al. NEUROPHARMACOLOGY
- ATP-mediated protein kinase B Akt/mammalian target of rapamycin mTOR/p70 ribosomal S6 protein p70S6 kinase signaling pathway activation promotes improvement of locomotor function after spinal cord injury in rats
- (2010) L.Y. Hu et al. NEUROSCIENCE
- Therapeutic Promise and Principles: Metabotropic Glutamate Receptors
- (2010) Kenneth Maiese et al. Oxidative Medicine and Cellular Longevity
- New Strategies for Alzheimer Disease and Cognitive Impairment
- (2010) Kenneth Maiese et al. Oxidative Medicine and Cellular Longevity
- A Fork in the Path: Developing Therapeutic Inroads with FoxO Proteins
- (2010) Kenneth Maiese et al. Oxidative Medicine and Cellular Longevity
- Wnt1 Neuroprotection Translates into Improved Neurological Function during Oxidant Stress and Cerebral Ischemia ThroughAKT1and Mitochondrial Apoptotic Pathways
- (2010) Zhao Zhong Chong et al. Oxidative Medicine and Cellular Longevity
- Sustained Delivery of Nicotinamide Limits Cortical Injury and Improves Functional Recovery Following Traumatic Brain Injury
- (2010) Andrea M. Goffus et al. Oxidative Medicine and Cellular Longevity
- Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy
- (2010) Leslie Crews et al. PLoS One
- Physical Association of PDK1 with AKT1 Is Sufficient for Pathway Activation Independent of Membrane Localization and Phosphatidylinositol 3 Kinase
- (2010) Zhiyong Ding et al. PLoS One
- Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
- (2010) Patricia Spilman et al. PLoS One
- Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease
- (2010) Tao Ma et al. PLoS One
- Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells
- (2010) Nathalie Carayol et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Atg101, a novel mammalian autophagy protein interacting with Atg13
- (2009) Nao Hosokawa et al. Autophagy
- Multifaceted deaths orchestrated by mitochondria in neurones
- (2009) Phillip Nagley et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Neuroprotective effect of herpes simplex virus-mediated gene transfer of erythropoietin in hyperglycemic dorsal root ganglion neurons
- (2009) M. Chattopadhyay et al. BRAIN
- Small-Molecule Inhibitors of Phosphatidylinositol 3-Kinase/Akt Signaling Inhibit Wnt/ -Catenin Pathway Cross-Talk and Suppress Medulloblastoma Growth
- (2009) N. Baryawno et al. CANCER RESEARCH
- Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL
- (2009) S Luo et al. CELL DEATH AND DIFFERENTIATION
- The Forkhead Transcription Factor FOXO3a Controls Microglial Inflammatory Activation and Eventual Apoptotic Injury through Caspase 3
- (2009) Yan Shang et al. CURRENT NEUROVASCULAR RESEARCH
- FoxO3a Governs Early Microglial Proliferation and Employs Mitochondrial Depolarization with Caspase 3, 8, and 9 Cleavage During Oxidant Induced Apoptosis
- (2009) Yan Shang et al. CURRENT NEUROVASCULAR RESEARCH
- Upregulation of the Mammalian Target of Rapamycin Complex 1 Pathway by Ras Homolog Enriched in Brain in Pancreatic -Cells Leads to Increased -Cell Mass and Prevention of Hyperglycemia
- (2009) S. Hamada et al. DIABETES
- mTOR/S6 Kinase Pathway Contributes to Astrocyte Survival during Ischemia
- (2009) María Dolores Pastor et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Specific Activation of mTORC1 by Rheb G-proteinin VitroInvolves Enhanced Recruitment of Its Substrate Protein
- (2009) Tatsuhiro Sato et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The N-terminal tripeptide of insulin-like growth factor-I protects against β-amyloid-induced somatostatin depletion by calcium and glycogen synthase kinase 3β modulation
- (2009) Emma Burgos-Ramos et al. JOURNAL OF NEUROCHEMISTRY
- A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death
- (2009) Kyou-Chan Choi et al. JOURNAL OF NEUROCHEMISTRY
- Inhibition of the Mammalian Target of Rapamycin Signaling Pathway Suppresses Dentate Granule Cell Axon Sprouting in a Rodent Model of Temporal Lobe Epilepsy
- (2009) P. S. Buckmaster et al. JOURNAL OF NEUROSCIENCE
- The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy
- (2009) L.-H. Zeng et al. JOURNAL OF NEUROSCIENCE
- Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in -Synuclein Models of Parkinson's and Lewy Body Diseases
- (2009) B. Spencer et al. JOURNAL OF NEUROSCIENCE
- Autophagy-mediated stress response in motor neuron after transient ischemia in rabbits
- (2009) Hironori Baba et al. JOURNAL OF VASCULAR SURGERY
- ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
- (2009) Chang Hwa Jung et al. MOLECULAR BIOLOGY OF THE CELL
- The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events
- (2009) Kiran Bhaskar et al. Molecular Neurodegeneration
- The Vitamin Nicotinamide: Translating Nutrition into Clinical Care
- (2009) Kenneth Maiese et al. MOLECULES
- Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss
- (2009) Luke S Tain et al. NATURE NEUROSCIENCE
- Erythropoietin protects PC12 cells from β-amyloid25–35-induced apoptosis via PI3K/Akt signaling pathway
- (2009) Rong Ma et al. NEUROPHARMACOLOGY
- BDNF Activates mTOR to Regulate GluR1 Expression Required for Memory Formation
- (2009) Leandro Slipczuk et al. PLoS One
- Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy
- (2009) Maria Xilouri et al. PLoS One
- Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA-Induced Dyskinesia
- (2009) E. Santini et al. Science Signaling
- Caspase-3 Is Enriched in Postsynaptic Densities and Increased in Alzheimer's Disease
- (2008) Natalia Louneva et al. AMERICAN JOURNAL OF PATHOLOGY
- Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
- (2008) Ling-Hui Zeng et al. ANNALS OF NEUROLOGY
- Bile Acid Exposure Up-regulates Tuberous Sclerosis Complex 1/Mammalian Target of Rapamycin Pathway in Barrett's-Associated Esophageal Adenocarcinoma
- (2008) C.-J. Yen et al. CANCER RESEARCH
- Enhanced Tolerance against Early and Late Apoptotic Oxidative Stress in Mammalian Neurons through Nicotinamidase and Sirtuin Mediated Pathways
- (2008) Zhao Chong et al. CURRENT NEUROVASCULAR RESEARCH
- Erythropoietin and Oxidative Stress
- (2008) Kenneth Maiese et al. CURRENT NEUROVASCULAR RESEARCH
- mTOR Inhibition by Rapamycin Prevents -Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes
- (2008) M. Fraenkel et al. DIABETES
- Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
- (2008) Yuzuru Imai et al. EMBO JOURNAL
- Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling
- (2008) M. P. DeYoung et al. GENES & DEVELOPMENT
- Life Span Extension and Neuronal Cell Protection byDrosophilaNicotinamidase
- (2008) Vitaly Balan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of Proline-rich Akt Substrate of 40 kDa (PRAS40) Function by Mammalian Target of Rapamycin Complex 1 (mTORC1)-mediated Phosphorylation
- (2008) Lifu Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Role of Hypothalamic Mammalian Target of Rapamycin Complex 1 Signaling in Diet-Induced Obesity
- (2008) D. Cota et al. JOURNAL OF NEUROSCIENCE
- Protective effects of erythropoietin on tau phosphorylation induced by β-amyloid
- (2008) Zhi-kun Sun et al. JOURNAL OF NEUROSCIENCE RESEARCH
- A “FOXO” in sight: Targeting Foxo proteins from conception to cancer
- (2008) Kenneth Maiese et al. MEDICINAL RESEARCH REVIEWS
- The Mammalian Target of Rapamycin Complex 1 Regulates Leptin Biosynthesis in Adipocytes at the Level of Translation: The Role of the 5′-Untranslated Region in the Expression of Leptin Messenger Ribonucleic Acid
- (2008) Partha Chakrabarti et al. MOLECULAR ENDOCRINOLOGY
- Melatonin prevents ischemic brain injury through activation of the mTOR/p70S6 kinase signaling pathway
- (2008) Phil-Ok Koh NEUROSCIENCE LETTERS
- Erythropoietin: Elucidating new cellular targets that broaden therapeutic strategies
- (2008) Kenneth Maiese et al. PROGRESS IN NEUROBIOLOGY
- Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway
- (2008) K. K. Park et al. SCIENCE
- Effect of mTOR inhibitor on body weight: from an experimental rat model to human transplant patients
- (2008) Jordi Rovira et al. TRANSPLANT INTERNATIONAL
- OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins
- (2008) Kenneth Maiese et al. TRENDS IN MOLECULAR MEDICINE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started