The Combined Deletion of S6K1 and Akt2 Deteriorates Glycemic Control in a High-Fat Diet

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

(2012) Mingjian Lu et al.   NATURE MEDICINE

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

PPARγ contributes to PKM2 and HK2 expression in fatty liver

(2012) Ganna Panasyuk et al.   Nature Communications

Separation of the gluconeogenic and mitochondrial functions of PGC-1  through S6 kinase

(2011) Y. Lustig et al.   GENES & DEVELOPMENT

S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy

(2011) Catherine Espeillac et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity

(2011) Shi-Bing Yang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

S6K1 Plays a Critical Role in Early Adipocyte Differentiation

(2010) Larissa S. Carnevalli et al.   DEVELOPMENTAL CELL

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

(2010) V. P. Houde et al.   DIABETES

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

(2010) J. E. Ayala et al.   Disease Models & Mechanisms

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1

(2009) C. C. Dibble et al.   MOLECULAR AND CELLULAR BIOLOGY

mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling

(2009) L.-A. Julien et al.   MOLECULAR AND CELLULAR BIOLOGY

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Rictor is a novel target of p70 S6 kinase-1

(2009) C Treins et al.   ONCOGENE

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Mammalian Target of Rapamycin and Diabetes: What Does the Current Evidence Tell Us?

(2009) B. Vodenik et al.   TRANSPLANTATION PROCEEDINGS

mTOR Inhibition by Rapamycin Prevents  -Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes

(2008) M. Fraenkel et al.   DIABETES

Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation

(2008) Samira Alliouachene et al.   JOURNAL OF CLINICAL INVESTIGATION

Dual role of proapoptotic BAD in insulin secretion and beta cell survival

(2008) Nika N Danial et al.   NATURE MEDICINE