The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation

A comparison of single-cell trajectory inference methods

(2019) Wouter Saelens et al.   NATURE BIOTECHNOLOGY

Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas

(2019) Qi Zhang et al.   GUT

The Role of Myeloid-Derived Cells in the Progression of Liver Disease

(2019) Chris John Weston et al.   Frontiers in Immunology

Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer

(2019) Lichun Ma et al.   CANCER CELL

Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

(2018) Elham Azizi et al.   CELL

A novel TGF-β and H19 signaling axis in tumor-initiating hepatocytes that regulates hepatic carcinogenesis

(2018) Jinqiang Zhang et al.   HEPATOLOGY

Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2

(2018) Tian Lan et al.   HEPATOLOGY

The immunology of hepatocellular carcinoma

(2018) Marc Ringelhan et al.   NATURE IMMUNOLOGY

Mouse models of hepatocellular carcinoma: an overview and highlights for immunotherapy research

(2018) Zachary J. Brown et al.   Nature Reviews Gastroenterology & Hepatology

Astrocyte elevated gene-1 (AEG-1) regulates macrophage activation in hepatocellular carcinogenesis

(2018) Chadia L Robertson et al.   CANCER RESEARCH

Lineage tracking reveals dynamic relationships of T cells in colorectal cancer

(2018) Lei Zhang et al.   NATURE

Targeting hepatic macrophages to treat liver diseases

(2017) Frank Tacke   JOURNAL OF HEPATOLOGY

New insights into the multidimensional concept of macrophage ontogeny, activation and function

(2016) Florent Ginhoux et al.   NATURE IMMUNOLOGY

AEG-1 promotes mesenchymal transition through the activation of Rho GTPases in human glioblastoma cells

(2016) Sang-Yoon Park et al.   ONCOLOGY REPORTS

STK4 regulates TLR pathways and protects against chronic inflammation–related hepatocellular carcinoma

(2015) Weiyun Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Quantitative analysis of the TNF-α-induced phosphoproteome reveals AEG-1/MTDH/LYRIC as an IKKβ substrate

(2015) Ramesh K. Krishnan et al.   Nature Communications

PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis

(2015) Wenjie Zhang et al.   Oncotarget

Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase

(2014) S. Peter et al.   EMBO Molecular Medicine

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

(2014) Susanne Walz et al.   NATURE

The expression of Survivin and NF-κB associated with prognostically worse clinicopathologic variables in hepatocellular carcinoma

(2014) Yi Jin et al.   TUMOR BIOLOGY

Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling

(2013) Guobin He et al.   CELL

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

(2013) S. Inoue et al.   GENES & DEVELOPMENT

A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma

(2013) Masato Fujii et al.   Medical Molecular Morphology

Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ

(2013) Hanh Chi Do-Umehara et al.   NATURE IMMUNOLOGY

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

(2012) Dianne H. Dapito et al.   CANCER CELL

Astrocyte elevated gene-1 promotes hepatocarcinogenesis: Novel insights from a mouse model

(2012) Jyoti Srivastava et al.   HEPATOLOGY

Miz1 Is a Critical Repressor of cdkn1a during Skin Tumorigenesis

(2012) Jan Hönnemann et al.   PLoS One

IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1

(2011) I. Saba et al.   BLOOD

Oncogene AEG-1 Promotes Glioma-Induced Neurodegeneration by Increasing Glutamate Excitotoxicity

(2011) S.-G. Lee et al.   CANCER RESEARCH

Metadherin Promotes Hepatocellular Carcinoma Metastasis through Induction of Epithelial-Mesenchymal Transition

(2011) K. Zhu et al.   CLINICAL CANCER RESEARCH

Obesity, inflammation, and liver cancer

(2011) Beicheng Sun et al.   JOURNAL OF HEPATOLOGY

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF- -induced JNK activation and inflammation

(2011) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatocyte IKKβ/NF-κB Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation

(2010) Guobin He et al.   CANCER CELL

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

The interaction between Myc and Miz1 is required to antagonize TGF -dependent autocrine signaling during lymphoma formation and maintenance

(2010) J. van Riggelen et al.   GENES & DEVELOPMENT

Bcl-6 and NF- B cistromes mediate opposing regulation of the innate immune response

(2010) G. D. Barish et al.   GENES & DEVELOPMENT

Transcription Factor Miz-1 Is Required to Regulate Interleukin-7 Receptor Signaling at Early Commitment Stages of B Cell Differentiation

(2010) Christian Kosan et al.   IMMUNITY

E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNF -induced JNK activation

(2010) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MTDH Activation by 8q22 Genomic Gain Promotes Chemoresistance and Metastasis of Poor-Prognosis Breast Cancer

(2009) Guohong Hu et al.   CANCER CELL

A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma

(2009) Johannes Haybaeck et al.   CANCER CELL

Angiotensin II Activates IκB Kinase Phosphorylation of RelA at Ser536 to Promote Myofibroblast Survival and Liver Fibrosis

(2009) Fiona Oakley et al.   GASTROENTEROLOGY

Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression

(2009) Byoung Kwon Yoo et al.   JOURNAL OF CLINICAL INVESTIGATION

Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1

(2009) S. Basu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma

(2009) M. Saito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF- -induced JNK1 activation

(2009) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NF- B as a Critical Link Between Inflammation and Cancer

(2009) M. Karin   Cold Spring Harbor Perspectives in Biology

Molecular Basis of Nuclear Factor- B Activation by Astrocyte Elevated Gene-1

(2008) D. Sarkar et al.   CANCER RESEARCH

Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1

(2008) Steffi Herold et al.   EMBO JOURNAL

EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features

(2008) Taro Yamashita et al.   GASTROENTEROLOGY