Liver-Targeted Delivery of Small Interfering RNA of C–C Chemokine Receptor 2 with Tetrahedral Framework Nucleic Acid Attenuates Liver Cirrhosis

A dynamic DNA tetrahedron framework for active targeting

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Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis

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Mechanotransduction-induced glycolysis epigenetically regulates a CXCL1-dominant angiocrine signaling program in liver sinusoidal endothelial cells in vitro and in vivo

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Inflammasomes and Pyroptosis of Liver Cells in Liver Fibrosis

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Suppression of Lipopolysaccharide‐Induced Sepsis by Tetrahedral Framework Nucleic Acid Loaded with Quercetin

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A Tetrahedral Framework DNA‐Based Bioswitchable miRNA Inhibitor Delivery System: Application to Skin Anti‐Aging

(2022) Songhang Li et al.   ADVANCED MATERIALS

NF-κB: blending metabolism, immunity, and inflammation

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Myelosuppression Alleviation and Hematopoietic Regeneration by Tetrahedral‐Framework Nucleic‐Acid Nanostructures Functionalized with Osteogenic Growth Peptide

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Therapeutic siCCR2 Loaded by Tetrahedral Framework DNA Nanorobotics in Therapy for Intracranial Hemorrhage

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Functionalizing Framework Nucleic‐Acid‐Based Nanostructures for Biomedical Application

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Bioswitchable Delivery of microRNA by Framework Nucleic Acids: Application to Bone Regeneration

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Targeting the CCL2/CCR2 Axis in Cancer Immunotherapy: One Stone, Three Birds?

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Targeting CCR2/5 in the treatment of nonalcoholic steatohepatitis (NASH) and fibrosis: opportunities and challenges

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Cenicriviroc Treatment for Adults with Nonalcoholic Steatohepatitis and Fibrosis: Final Analysis of the Phase 2b CENTAUR Study

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Distinct Transcriptional Responses across Tissue-Resident Macrophages to Short-Term and Long-Term Metabolic Challenge

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Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis

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Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis

(2020) Prakash Ramachandran et al.   Nature Reviews Gastroenterology & Hepatology

Design, fabrication and applications of tetrahedral DNA nanostructure-based multifunctional complexes in drug delivery and biomedical treatment

(2020) Tao Zhang et al.   Nature Protocols

Tetrahedral framework nucleic acids act as antioxidants in acute kidney injury treatment

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CCR2 downregulation attenuates spinal cord injury by suppressing inflammatory monocytes

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Endothelial p300 Promotes Portal Hypertension and Hepatic Fibrosis Through C‐C Motif Chemokine Ligand 2–Mediated Angiocrine Signaling

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Framework nucleic acids as programmable carrier for transdermal drug delivery

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SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease

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Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension

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Intraperitoneal Route of Drug Administration: Should it Be Used in Experimental Animal Studies?

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Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis

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A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis

(2018) Scott L. Friedman et al.   HEPATOLOGY

Pharmacological inhibition of CCR2/5 signaling prevents and reverses alcohol-induced liver damage, steatosis and inflammation in mice

(2018) Aditya Ambade et al.   HEPATOLOGY

Burden of Liver Diseases in the World

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Attack on the Cell Membrane: The Pointy Ends of DNA Nanostructures Lead the Way

(2018) Pengfei Wang et al.   ACS Central Science

DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury

(2018) Dawei Jiang et al.   Nature Biomedical Engineering

Targeting hepatic macrophages to treat liver diseases

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Single-Particle Tracking and Modulation of Cell Entry Pathways of a Tetrahedral DNA Nanostructure in Live Cells

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Therapeutic siRNA silencing in inflammatory monocytes in mice

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