Autophagy inhibition in cancer therapy: metabolic considerations for antitumor immunity

Enhancing proteotoxic stress as an anticancer strategy

(2015) Steven Grant   Oncotarget

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

Adoptive T-Cell Therapy Using Autologous Tumor-Infiltrating Lymphocytes for Metastatic Melanoma

(2012) Richard Wu et al.   CANCER JOURNAL

Hypoxia-Induced Autophagy Promotes Tumor Cell Survival and Adaptation to Antiangiogenic Treatment in Glioblastoma

(2012) Y.-L. Hu et al.   CANCER RESEARCH

Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2)

(2012) A. D. Barlow et al.   DIABETOLOGIA

Autophagy Attenuates the Adaptive Immune Response by Destabilizing the Immunologic Synapse

(2012) Manon E. Wildenberg et al.   GASTROENTEROLOGY

Systemic immunoregulatory and proteogenomic effects of tacrolimus to sirolimus conversion in liver transplant recipients

(2012) Josh Levitsky et al.   HEPATOLOGY

Reply to: Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system

(2012) Laurence Zitvogel et al.   NATURE MEDICINE

Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system

(2012) Metamia Ciampricotti et al.   NATURE MEDICINE

Blocking Autophagy Prevents Bortezomib-Induced NF-κB Activation by Reducing I-κBα Degradation in Lymphoma Cells

(2012) Li Jia et al.   PLoS One

Metabolic pathways in T cell fate and function

(2012) Valerie A. Gerriets et al.   TRENDS IN IMMUNOLOGY

Paclitaxel resistance is associated with switch from apoptotic to autophagic cell death in MCF-7 breast cancer cells

(2012) G M A Ajabnoor et al.   Cell Death & Disease

Aberrant CD8+ T-Cell Responses and Memory Differentiation upon Viral Infection of an Ataxia-Telangiectasia Mouse Model Driven by Hyper-Activated Akt and mTORC1 Signaling

(2011) Anthony D. D'Souza et al.   AMERICAN JOURNAL OF PATHOLOGY

Differential Regulation of Simultaneous Antitumor and Alloreactive CD8+ T-Cell Responses in the Same Host by Rapamycin

(2011) S. Maleki Vareki et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Autophagy protects breast cancer cells from epirubicin-induced apoptosis and facilitates epirubicin-resistance development

(2011) Wei-Liang Sun et al.   Autophagy

The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

(2011) Dan Egan et al.   Autophagy

BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription

(2011) Z. Sheng et al.   BLOOD

Managing resistance in chronic myeloid leukemia

(2011) Sameek Roychowdhury et al.   BLOOD REVIEWS

Increased natural killer cells and decreased CD3+CD8+CD62L+ T cells in CML patients who sustained complete molecular remission after discontinuation of imatinib

(2011) Kazuma Ohyashiki et al.   BRITISH JOURNAL OF HAEMATOLOGY

Molecular determinants of immunogenic cell death elicited by anticancer chemotherapy

(2011) Oliver Kepp et al.   CANCER AND METASTASIS REVIEWS

Autophagy inhibition promotes paclitaxel-induced apoptosis in cancer cells

(2011) Guangmin Xi et al.   CANCER LETTERS

In Vivo Profiling of Hypoxic Gene Expression in Gliomas Using the Hypoxia Marker EF5 and Laser-capture Microdissection

(2011) D. Marotta et al.   CANCER RESEARCH

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery

(2011) J R Kovacs et al.   CELL DEATH AND DIFFERENTIATION

Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death

(2011) W Gao et al.   CELL DEATH AND DIFFERENTIATION

Alternative pathways for MHC class I presentation: a new function for autophagy

(2011) Magali Chemali et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular Pathways: BCR-ABL

(2011) D. Cilloni et al.   CLINICAL CANCER RESEARCH

Determinants of Successful CD8 + T-Cell Adoptive Immunotherapy for Large Established Tumors in Mice

(2011) Christopher A. Klebanoff et al.   CLINICAL CANCER RESEARCH

Principles and Current Strategies for Targeting Autophagy for Cancer Treatment

(2011) R. K. Amaravadi et al.   CLINICAL CANCER RESEARCH

Hydroxychloroquine: From Malaria to Autoimmunity

(2011) Ilan Ben-Zvi et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Emerging roles for mammalian target of rapamycin inhibitors in the treatment of solid tumors and hematological malignancies

(2011) Nushmia Z. Khokhar et al.   CURRENT OPINION IN ONCOLOGY

Dasatinib

(2011) Paul L. McCormack et al.   DRUGS

Mechanisms of drug resistance in kinases

(2011) Rina Barouch-Bentov et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Dynamic regulation of Th17 differentiation by oxygen concentrations

(2011) A. Ikejiri et al.   INTERNATIONAL IMMUNOLOGY

The mechanisms of cancer immunoescape and development of overcoming strategies

(2011) Tomonori Yaguchi et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Temporal Regulation of Intracellular Organelle Homeostasis in T Lymphocytes by Autophagy

(2011) W. Jia et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

Inhibition of autophagy: a new strategy to enhance sensitivity of chronic myeloid leukemia stem cells to tyrosine kinase inhibitors

(2011) Bruno Calabretta et al.   LEUKEMIA & LYMPHOMA

Unknown

(2011) Diahnn Futalan et al.   MOLECULAR MEDICINE

Combining mTor Inhibitors With Rapamycin-resistant T Cells: A Two-pronged Approach to Tumor Elimination

(2011) Leslie E Huye et al.   MOLECULAR THERAPY

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

(2011) Andrea Facciabene et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido

(2011) Vinod P Balachandran et al.   NATURE MEDICINE

NAC1 modulates sensitivity of ovarian cancer cells to cisplatin by altering the HMGB1-mediated autophagic response

(2011) Y Zhang et al.   ONCOGENE

Immunological Effects of Bevacizumab-Based Treatment in Metastatic Colorectal Cancer

(2011) M. Manzoni et al.   ONCOLOGY

Characterization of the Metabolic Phenotype of Rapamycin-Treated CD8+ T Cells with Augmented Ability to Generate Long-Lasting Memory Cells

(2011) Shan He et al.   PLoS One

CD4+Foxp3+ Regulatory T-cell Impairment by Paclitaxel is Independent of Toll-like Receptor 4

(2011) Y. Zhu et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Rapamycin-conditioned, alloantigen-pulsed myeloid dendritic cells present donor MHC class I/peptide via the semi-direct pathway and inhibit survival of antigen-specific CD8+ T cells in vitro and in vivo

(2011) Ryan T. Fischer et al.   TRANSPLANT IMMUNOLOGY

Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism

(2011) M Donadelli et al.   Cell Death & Disease

Clinical and immunomodulatory effects of bevacizumab and low-dose interleukin-2 in patients with metastatic renal cell carcinoma: results from a phase II trial

(2010) Jorge A. Garcia et al.   BJU INTERNATIONAL

Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells

(2010) Kazuhito Sasaki et al.   BMC CANCER

Chemoimmunotherapy

(2010) Leisha A. Emens   CANCER JOURNAL

Tumor Cell Death and ATP Release Prime Dendritic Cells and Efficient Anticancer Immunity

(2010) L. Aymeric et al.   CANCER RESEARCH

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Overview of macroautophagy regulation in mammalian cells

(2010) Maryam Mehrpour et al.   CELL RESEARCH

Decrease in CD4+ T-Cell Counts in Patients With Multiple Myeloma Treated With Bortezomib

(2010) Ulrike Heider et al.   Clinical Lymphoma Myeloma & Leukemia

In Vivo Requirement for Atg5 in Antigen Presentation by Dendritic Cells

(2010) Heung Kyu Lee et al.   IMMUNITY

The mTOR Kinase Determines Effector versus Memory CD8 + T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

(2010) Rajesh R. Rao et al.   IMMUNITY

Concomitant inhibition of AKT and autophagy is required for efficient cisplatin-induced apoptosis of metastatic skin carcinoma

(2010) Sofie Claerhout et al.   INTERNATIONAL JOURNAL OF CANCER

Chemotherapy Induces Macrophage Chemoattractant Protein-1 Production in Ovarian Cancer

(2010) Melissa A. Geller et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony

(2010) Kathryn G. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice

(2010) Rupal Ramakrishnan et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Rapamycin Augments Pathogen-Specific but Not Graft-Reactive CD8+ T Cell Responses

(2010) I. R. Ferrer et al.   JOURNAL OF IMMUNOLOGY

Macroautophagy Regulates Energy Metabolism during Effector T Cell Activation

(2010) V. M. Hubbard et al.   JOURNAL OF IMMUNOLOGY

Crosstalk between autophagy and apoptosis in the regulation of paclitaxel-induced cell death in v-Ha-ras-transformed fibroblasts

(2010) Ki-Hwan Eum et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Selective autophagy: ubiquitin-mediated recognition and beyond

(2010) Claudine Kraft et al.   NATURE CELL BIOLOGY

Tumor-Associated Macrophages and Survival in Classic Hodgkin's Lymphoma

(2010) Christian Steidl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Restoration of the immunogenicity of cisplatin-induced cancer cell death by endoplasmic reticulum stress

(2010) I Martins et al.   ONCOGENE

Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprograming

(2010) F Zhao et al.   ONCOGENE

PR1-Specific T Cells Are Associated with Unmaintained Cytogenetic Remission of Chronic Myelogenous Leukemia After Interferon Withdrawal

(2010) Shreya Kanodia et al.   PLoS One

Induction of Glucose Metabolism in Stimulated T Lymphocytes Is Regulated by Mitogen-Activated Protein Kinase Signaling

(2010) Aimee J. Marko et al.   PLoS One

Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells

(2010) Nathalie Carayol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment

(2010) G.-O. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The receptor tyrosine kinase MerTK regulates dendritic cell production of BAFF

(2009) P. R. Gohlke et al.   AUTOIMMUNITY

Identification ofAtg5-dependent transcriptional changes and increases in mitochondrial mass inAtg5-deficient T lymphocytes

(2009) Linda M. Stephenson et al.   Autophagy

Cytoprotective effect of imatinib mesylate in non-BCR-ABL-expressing cells along with autophagosome formation

(2009) Tadashi Ohtomo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A novel role for c-Src and STAT3 in apoptotic cell-mediated MerTK-dependent immunoregulation of dendritic cells

(2009) Z. Yi et al.   BLOOD

Influence of bevacizumab, sunitinib and sorafenib as single agents or in combination on the inhibitory effects of VEGF on human dendritic cell differentiation from monocytes

(2009) C Alfaro et al.   BRITISH JOURNAL OF CANCER

Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis

(2009) John M.L. Ebos et al.   CANCER CELL

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

The Role of ATF4 Stabilization and Autophagy in Resistance of Breast Cancer Cells Treated with Bortezomib

(2009) M. Milani et al.   CANCER RESEARCH

The Novel Role of Tyrosine Kinase Inhibitor in the Reversal of Immune Suppression and Modulation of Tumor Microenvironment for Immune-Based Cancer Therapies

(2009) J. Ozao-Choy et al.   CANCER RESEARCH

Cancer/testis (CT) antigens: Potential targets for immunotherapy

(2009) Otavia L. Caballero et al.   CANCER SCIENCE

Chloroquine and its analogs: A new promise of an old drug for effective and safe cancer therapies

(2009) V. Raja Solomon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Treatment with bortezomib of human CD4+ T cells preserves natural regulatory T cells and allows the emergence of a distinct suppressor T-cell population

(2009) B. Blanco et al.   HAEMATOLOGICA

Functional interaction of mammalian target of rapamycin complexes in regulating mammalian cell size and cell cycle

(2009) M. Rosner et al.   HUMAN MOLECULAR GENETICS

Tyrosine kinases and their substrates in B lymphocytes

(2009) Tomohiro Kurosaki et al.   IMMUNOLOGICAL REVIEWS

Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumour cell migration by dendritic cell-derived osteopontin

(2009) Meixiang Yang et al.   IMMUNOLOGY

Combined therapy of CD4+CD25+ regulatory T cells with low-dose sirolimus, but not calcineurin inhibitors, preserves suppressive function of regulatory T cells and prolongs allograft survival in mice

(2009) Anlun Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression

(2009) Hiroshi Fujimoto et al.   INTERNATIONAL JOURNAL OF CANCER

Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation

(2009) Jennifer S. Carew et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Targeting autophagy potentiates tyrosine kinase inhibitor–induced cell death in Philadelphia chromosome–positive cells, including primary CML stem cells

(2009) Cristian Bellodi et al.   JOURNAL OF CLINICAL INVESTIGATION

Chemotherapeutic Agents in Noncytotoxic Concentrations Increase Antigen Presentation by Dendritic Cells via an IL-12-Dependent Mechanism

(2009) G. V. Shurin et al.   JOURNAL OF IMMUNOLOGY

The Proteasome Inhibitor Bortezomib Enhances the Susceptibility to Viral Infection

(2009) M. Basler et al.   JOURNAL OF IMMUNOLOGY

Autophagy Is Essential for Mitochondrial Clearance in Mature T Lymphocytes

(2009) H. H. Pua et al.   JOURNAL OF IMMUNOLOGY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy

(2009) W.-X. Ding et al.   MOLECULAR CANCER THERAPEUTICS

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

An overview of small-molecule inhibitors of VEGFR signaling

(2009) S. Percy Ivy et al.   Nature Reviews Clinical Oncology

Differential Responses of Human Regulatory T Cells (Treg) and Effector T Cells to Rapamycin

(2009) Laura Strauss et al.   PLoS One

Cyclophosphamide Chemotherapy Sensitizes Tumor Cells to TRAIL-Dependent CD8 T Cell-Mediated Immune Attack Resulting in Suppression of Tumor Growth

(2009) Robbert G. van der Most et al.   PLoS One

Halofuginone Inhibits TH17 Cell Differentiation by Activating the Amino Acid Starvation Response

(2009) M. S. Sundrud et al.   SCIENCE

Divergent effects of hypoxia on dendritic cell functions

(2008) A. Mancino et al.   BLOOD

Tumor-specific Th17-polarized cells eradicate large established melanoma

(2008) P. Muranski et al.   BLOOD

Topotecan enhances immune clearance of gliomas

(2008) Jun Wei et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Paclitaxel reduces regulatory T cell numbers and inhibitory function and enhances the anti-tumor effects of the TLR9 agonist PF-3512676 in the mouse

(2008) Alain P. Vicari et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The immunogenicity of tumor cell death

(2008) Oliver Kepp et al.   CURRENT OPINION IN ONCOLOGY

Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1α

(2008) Jeremy Ben-Shoshan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells

(2008) Candace M. Cham et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Proteasome inhibition suppresses essential immune functions of human CD4+T cells

(2008) Carsten Berges et al.   IMMUNOLOGY

De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR

(2008) Johnthomas Kang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

(2008) Linda V Sinclair et al.   NATURE IMMUNOLOGY