Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2)

cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity

(2011) Jianling Xie et al.   CELLULAR SIGNALLING

Akt signalling in health and disease

(2011) Ingeborg Hers et al.   CELLULAR SIGNALLING

Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size

(2011) Yanyun Gu et al.   DIABETES

Erythropoietin Protects Pancreatic β-cell Line NIT-1 Cells Against Cytokine-Induced Apoptosis via Phosphatidylinositol 3-Kinase/Akt Signaling

(2011) Hongxia Shuai et al.   ENDOCRINE RESEARCH

mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets

(2011) Samantha F. Moore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreased IRS Signaling Impairs  -Cell Cycle Progression and Survival in Transgenic Mice Overexpressing S6K in  -Cells

(2010) L. Elghazi et al.   DIABETES

PERK Activation at Low Glucose Concentration Is Mediated by SERCA Pump Inhibition and Confers Preemptive Cytoprotection to Pancreatic β-Cells

(2010) Claire E. Moore et al.   MOLECULAR ENDOCRINOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Different Effects of FK506, Rapamycin, and Mycophenolate Mofetil on Glucose-Stimulated Insulin Release and Apoptosis in Human Islets

(2009) James D. Johnson et al.   CELL TRANSPLANTATION

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin impairs metabolism-secretion coupling in rat pancreatic islets by suppressing carbohydrate metabolism

(2009) Makiko Shimodahira et al.   JOURNAL OF ENDOCRINOLOGY

Identification of cAMP-Dependent Kinase as a Third in Vivo Ribosomal Protein S6 Kinase in Pancreatic β-Cells

(2009) Claire E.J. Moore et al.   JOURNAL OF MOLECULAR BIOLOGY

Pathology of an Islet Transplant 2 Years After Transplantation: Evidence for a Nonimmunological Loss

(2009) R Neal Smith et al.   TRANSPLANTATION

Akt and PTEN: β-cell mass and pancreas plasticity

(2009) Lynda Elghazi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hyperglycemia Induces Apoptosis of Human Pancreatic Islet Endothelial Cells

(2008) Enrica Favaro et al.   AMERICAN JOURNAL OF PATHOLOGY

A decrease in cellular energy status stimulates PERK-dependent eIF2α phosphorylation and regulates protein synthesis in pancreatic β-cells

(2008) Edith Gomez et al.   BIOCHEMICAL JOURNAL

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

(2008) Tsuneo Ikenoue et al.   EMBO JOURNAL

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

(2008) Valeria Facchinetti et al.   EMBO JOURNAL

Biphasic Response of Pancreatic  -Cell Mass to Ablation of Tuberous Sclerosis Complex 2 in Mice

(2008) Y. Shigeyama et al.   MOLECULAR AND CELLULAR BIOLOGY

Disruption of Tsc2 in pancreatic   cells induces   cell mass expansion and improved glucose tolerance in a TORC1-dependent manner

(2008) L. Rachdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA