Article
Oncology
David Schweer, Namrata Anand, Abigail Anderson, J. Robert McCorkle, Khaga Neupane, Alexandra N. Nail, Brock Harvey, Kristen S. Hill, Frederick Ueland, Christopher Richards, Jill Kolesar
Summary: Ovarian cancer is a deadly female malignancy characterized by high rates of recurrence and chemotherapy resistance. Tumor-associated macrophages (TAMs) play a significant role in the tumor microenvironment and consist of mostly M2 protumor macrophages that promote chemo-resistance and metastasis. Vesicles engineered from M1 macrophages (MEVs) represent a novel therapeutic approach for converting M2 macrophages to M1-like phenotype macrophages.
FRONTIERS IN ONCOLOGY
(2023)
Review
Cell Biology
Dorota E. Jazwinska, Diana G. Kulawiec, Ioannis K. Zervantonakis
Summary: The metastatic ovarian cancer microenvironment is characterized by complex interactions between cancer cells and host cells, such as mesothelial cells and tumor-associated macrophages. Understanding the crosstalk between these cell types can provide insights into biomarkers and therapeutic targets for metastatic progression and chemotherapy sensitivity restoration.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Oncology
Yuanyuan An, Qing Yang
Summary: Ovarian cancer is influenced significantly by the tumor microenvironment, where macrophages play a crucial role in regulating the progression of the disease. Targeted therapy focusing on macrophages shows promise in treating ovarian cancer, despite facing challenges. Interactions between macrophages and other immune cells within the microenvironment also impact the development of ovarian cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Oncology
Marcin Wroblewski, Karolina Szewczyk-Golec, Iga Holynska-Iwan, Joanna Wroblewska, Alina Wozniak
Summary: Ovarian cancer is a prevalent malignancy among women worldwide, with metastasis and accumulation of ascites in the peritoneal cavity influencing carcinogenesis. Adipokines, such as adiponectin, play a role in both tumor growth and metastasis.
Article
Materials Science, Biomaterials
Can Cheng, Heng Li, Jingwen Liu, Liang Wu, Zhengdong Fang, Geliang Xu
Summary: Researchers have developed a polymer fiber film loaded with monocyte chemotactic protein-1 (MCP-1), which can regulate macrophage polarization through sustained release of MCP-1, thereby reducing foreign body reaction and promoting angiogenesis.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Oncology
Siting Li, Yuexin Hu, Ouxuan Liu, Xiao Li, Bei Lin
Summary: The study found that MCP-4 is highly expressed in ovarian cancer tissues and is associated with patient prognosis. MCP-4 overexpression promotes cell migration and invasion in ovarian cancer, inhibits apoptosis, and activates the p38 MAPK signaling pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Haitao Hu, Ting Ma, Nanqi Liu, Hong Hong, Lujiao Yu, Dantong Lyu, Xin Meng, Biao Wang, Xuefeng Jiang
Summary: Vasculogenic mimicry (VM) is a vessel-like structure independent of endothelial cells, commonly found in solid tumors. It is closely associated with tumor proliferation, invasion, metastasis, and poor patient prognosis. Various factors, including immune cells, cytokines, and signaling molecules, have been reported to be involved in ovarian cancer progression and VM formation. This review discusses the mechanisms regulating VM formation in ovarian cancer, the impact of cells, cytokines, and signaling molecules in the tumor microenvironment on VM formation, and the current clinical application of drugs targeting VM formation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Laura Ardighieri, Francesco Missale, Mattia Bugatti, Luisa Benerini Gatta, Irene Pezzali, Matilde Monti, Stefano Gottardi, Laura Zanotti, Eliana Bignotti, Antonella Ravaggi, Germana Tognon, Franco Odicino, Stefano Calza, Yoann Missolo-Koussou, Carola Hermine Ries, Julie Helft, William Vermi
Summary: This study identifies a subgroup of ovarian carcinomas with high levels of immune infiltrated cells that are associated with better outcomes and response to treatment. High levels of M1-polarized tumor-associated macrophages in high-grade serous carcinomas are linked to good prognosis and response to platinum-based therapies. This suggests the potential use of the CXCL10(+)IRF1(+)STAT1(+) macrophage subset as a biomarker for predicting T-cell activation and response to immunotherapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Caijiao Peng, Licheng Li, Guangxia Luo, Shanmei Tan, Ruming Xia, Lanjuan Zeng
Summary: In this study, genes associated with M2 macrophage infiltration in ovarian cancer were identified, and a model was developed to effectively predict patient prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Reproductive Biology
Xiaohui Xie, Juan He, Qiong Wang, Yaqiong Liu, Weiwei Chen, Kun Shi
Summary: This study revealed that FPR2 promotes invasion and metastasis of ovarian cancer cells by enhancing RhoA expression, influencing the migratory ability of EOCs, and stimulating M2 macrophage polarization. Additionally, inhibition of RhoA can impair EOC migration and induce differentiation of macrophages towards the M1 phenotype.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Oncology
Sihui Yu, Rui Yang, Tianhan Xu, Xi Li, Sufang Wu, Jiawen Zhang
Summary: This study revealed the tumor-supporting role of FMO2 and its association with immune components in epithelial ovarian cancer. It provides a potential target for stroma-oriented therapies against epithelial ovarian cancer.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Plant Sciences
Dasom Choi, Jeong Hee Choi, Kee-Jai Park, Changhyun Kim, Jeong-Ho Lim, Dong-Hwan Kim
Summary: This study aimed to determine the effect of ethylene (ET) and 1-methylcyclopropene (1-MCP) application on kiwifruit during storage, and to elucidate the molecular details of ET-mediated ripening process. Transcriptomic analysis revealed that ET and 1-MCP treatment had opposite effects on the target genes involved in kiwifruit ripening. Additionally, ET treatment rapidly triggered secondary metabolisms and amino acid biosynthesis in kiwifruit. This study provides important insights into the molecular details of ripening process in kiwifruit.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Medicine, Research & Experimental
Yeong-In Yang, Yi-Yue Wang, Ji-Hye Ahn, Bo-Hyung Kim, Jung-Hye Choi
Summary: Tumor cells can develop resistance to paclitaxel by secreting large amounts of CCL2, which not only acts as an autocrine factor to induce chemoresistance, but also functions as a chemokine to attract macrophages, contributing to chemoresistance. Inhibiting the CCL2/CCR2 signaling axis may improve the therapeutic response of patients with ovarian cancer to paclitaxel.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biology
Huiying Gu, Yundan Xu, Nicole Du, Yongqi Yu, Wei Zheng, Yansheng Du
Summary: The study demonstrates that oral exposure to lead can induce an increase in MCP-1 expression and infiltration of monocytes and macrophages in the choroid plexus. The activation of the p38 and NF-kappa B p65 pathways is involved in lead-induced MCP-1 expression.
Article
Cell Biology
Seung-Kye Cho, Kijun Lee, Jeong-Hwa Woo, Jung-Hye Choi
Summary: Ovarian cancer is a metastatic disease with extensive peritoneal dissemination. Noncancerous cells in the tumor microenvironment, such as macrophages and mesothelial cells, may contribute to ovarian cancer metastasis. This study found that macrophage-stimulated mesothelial cells exhibited increased adhesion to ovarian cancer cells. The upregulation of adhesion-related genes and the involvement of JNK and Akt signaling pathways were also observed.