p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome

Mutations in AEC syndrome skin reveal a role for p63 in basement membrane adhesion, skin barrier integrity and hair follicle biology

(2012) S.E. Clements et al.   BRITISH JOURNAL OF DERMATOLOGY

 Np63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation

(2012) R.-A. Romano et al.   DEVELOPMENT

Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome

(2012) Giustina Ferone et al.   EMBO Molecular Medicine

Desmosomal genodermatoses

(2011) G. Petrof et al.   BRITISH JOURNAL OF DERMATOLOGY

IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes

(2011) Gaetana Restivo et al.   EMBO JOURNAL

Lack of plakoglobin leads to lethal congenital epidermolysis bullosa: a novel clinico-genetic entity

(2011) Manuela Pigors et al.   HUMAN MOLECULAR GENETICS

Desmoglein as a Target in Skin Disease and Beyond

(2011) Masayuki Amagai et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis

(2011) Cory L. Simpson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas

(2011) E. Botti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hdac1 and Hdac2 Act Redundantly to Control p63 and p53 Functions in Epidermal Progenitor Cells

(2010) Matthew LeBoeuf et al.   DEVELOPMENTAL CELL

Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice

(2010) Helen A. Thomason et al.   JOURNAL OF CLINICAL INVESTIGATION

A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias

(2010) Francesca Moretti et al.   JOURNAL OF CLINICAL INVESTIGATION

p63 in Skin Development and Ectodermal Dysplasias

(2010) Maranke I. Koster   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Genome-Wide Profiling of p63 DNA–Binding Sites Identifies an Element that Regulates Gene Expression during Limb Development in the 7q21 SHFM1 Locus

(2010) Evelyn N. Kouwenhoven et al.   PLoS Genetics

Differential PERP regulation by TP63 mutants provides insight into AEC pathogenesis

(2009) Veronica G. Beaudry et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Dermatologic findings of ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome

(2009) Meena R. Julapalli et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

ΔNp63 knockdown mice: A mouse model for AEC syndrome

(2009) Maranke I. Koster et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Pathologic changes of skin and hair in ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome

(2009) Megan K. Dishop et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

p63 Suppresses Non-epidermal Lineage Markers in a Bone Morphogenetic Protein-dependent Manner via Repression of Smad7

(2009) Laura De Rosa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Desmoglein 1–dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesis

(2009) Spiro Getsios et al.   JOURNAL OF CELL BIOLOGY

Desmosomes at a glance

(2009) Bhushan V. Desai et al.   JOURNAL OF CELL SCIENCE

Classical Cadherins Regulate Desmosome Formation

(2009) Christian Michels et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

P-cadherin is a p63 target gene with a crucial role in the developing human limb bud and hair follicle

(2008) Y. Shimomura et al.   DEVELOPMENT

Perturbed desmosomal cadherin expression in grainy head-like 1-null mice

(2008) Tomasz Wilanowski et al.   EMBO JOURNAL

Direct targets of the TRP63 transcription factor revealed by a combination of gene expression profiling and reverse engineering

(2008) G. Della Gatta et al.   GENOME RESEARCH

A novel translation re-initiation mechanism for the p63 gene revealed by amino-terminal truncating mutations in Rapp-Hodgkin/Hay-Wells-like syndromes

(2008) T. Rinne et al.   HUMAN MOLECULAR GENETICS

Loss of desmocollin 3 in mice leads to epidermal blistering

(2008) J. Chen et al.   JOURNAL OF CELL SCIENCE

Tprg, a Gene Predominantly Expressed in Skin, Is a Direct Target of the Transcription Factor p63

(2008) Dario Antonini et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IKKα Is a p63 Transcriptional Target Involved in the Pathogenesis of Ectodermal Dysplasias

(2008) Barbara Marinari et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

EGFR and ADAMs Cooperate to Regulate Shedding and Endocytic Trafficking of the Desmosomal Cadherin Desmoglein 2

(2008) Jodi L. Klessner et al.   MOLECULAR BIOLOGY OF THE CELL

EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer

(2008) Vihren Kolev et al.   NATURE CELL BIOLOGY

Claudin-1 Is a p63 Target Gene with a Crucial Role in Epithelial Development

(2008) Teresa Lopardo et al.   PLoS One