A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias

WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis

(2008) Y Li et al.   CELL DEATH AND DIFFERENTIATION

Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects

(2008) N. Lo Iacono et al.   DEVELOPMENT

Missense mutations that cause Van der Woude syndrome and popliteal pterygium syndrome affect the DNA-binding and transcriptional activation functions of IRF6

(2008) Hayley J. Little et al.   HUMAN MOLECULAR GENETICS

IKKα Is a p63 Transcriptional Target Involved in the Pathogenesis of Ectodermal Dysplasias

(2008) Barbara Marinari et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A skin microRNA promotes differentiation by repressing ‘stemness’

(2008) Rui Yi et al.   NATURE

Disruption of an AP-2α binding site in an IRF6 enhancer is associated with cleft lip

(2008) Fedik Rahimov et al.   NATURE GENETICS

Claudin-1 Is a p63 Target Gene with a Crucial Role in Epithelial Development

(2008) Teresa Lopardo et al.   PLoS One

The tumor suppressor activity of IKK  in stratified epithelia is exerted in part via the TGF-  antiproliferative pathway

(2008) B. Marinari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA