Wai Lo

United States UConn

论文

评论了 Obesity and Endothelial Function
Obesity, affecting over 1.9 billion adults globally, is a growing public health issue linked to increased cardiovascular morbidity and mortality, primarily due to its impact on endothelial function through various obesity-related complications. This review highlights the pathophysiological mechanisms behind obesity-induced endothelial dysfunction and explores potential therapeutic targets for mitigating cardiovascular risks.

论文

评论了 Bioactive Cell-Derived ECM Scaffold Forms a Unique Cellular Microenvironment for Lung Tissue Engineering
Chronic lung diseases are a major global health issue, and lung transplants, limited by donor availability, are the only definitive treatment for end-stage conditions. Lung tissue engineering (LTE) offers hope by aiming to regenerate damaged lung tissue, but it faces challenges due to the lung's complex structure. We've developed a promising solution: an extracellular matrix (ECM)-integrated scaffold, created through a process of cellularization, decellularization, and recellularization on our novel BETA scaffold. This scaffold, less than 5 µm thick and made of a co-polymeric material, allows human lung fibroblasts to grow and deposit ECM, mimicking the lung's microenvironment more accurately after a mild decellularization process. Our technique successfully preserves key ECM proteins, such as collagen I and IV, and supports the growth of primary fibroblasts and bronchial epithelial cells, indicating its potential for LTE applications. This biomimetic scaffold represents a significant step towards creating a functional replacement for damaged lung tissue.

研讨会

评论了 DL applications in MS proteomics and single-cell genomics
The application of DL in MS proteomics and single-cell genomics is rapidly evolving, offering exciting possibilities for uncovering the molecular underpinnings of MS and advancing personalized medicine.

基金

评论了 Humanities book support award
Interesting I am at Uconn, I am not aware of this support award.

研讨会

评论了 Planning and preparing your essential career documents—for researchers globally
This is a great topic. I want to congratulate the speaker and the Peeref for launching this important webinar.

期刊

评论了 Estudios de Historia Moderna y Contemporanea de Mexico
Can someone translates the content of this journal?

论文

评论了 Lipid Nanoparticles as Delivery Vehicles for Inhaled Therapeutics
Lipid nanoparticles (LNPs) are gaining attention as an efficient, non-viral method for delivering drugs, especially in the face of respiratory diseases highlighted by the COVID-19 pandemic. This review covers the advancements in LNP technology and pre-clinical studies on inhaled drugs, including small molecules, nucleic acids, and proteins/peptides, emphasizing the benefits of targeting the lungs to minimize systemic side effects and enhance drug effectiveness. It also addresses the challenges in formulation design and looks forward to the potential of LNPs in treating respiratory diseases through inhalation therapy.

论文

评论了 Vericiguat in Heart Failure: Characteristics, Scientific Evidence and Potential Clinical Applications
Despite advances in heart failure (HF) treatment, risks remain high, linked to dysfunction in the NO-sGC-cGMP pathway which vericiguat aims to correct by enhancing cGMP levels, thus reducing oxidative stress and improving heart function. Clinical trials, including SOCRATES-REDUCED and VICTORIA, have shown vericiguat to be effective in patients with reduced ejection fraction (HFrEF), while its benefits for those with preserved ejection fraction (HfpEF) are still under investigation.

论文

评论了 Stem Cell Therapy for Alzheimer’s Disease: A Scoping Review for 2017–2022
Alzheimer's disease (AD) significantly contributes to elderly mortality worldwide, with current treatments still under development. Stem cell therapy, offering advantages over drug therapies and other treatments, shows great promise. Four primary stem cell types are utilized in AD therapy: neural, mesenchymal, embryonic, and induced pluripotent stem cells, each with applications across cellular, animal model, and clinical levels. Research has predominantly focused on the cellular and animal model stages, with less progress at the clinical stage. Future research should broaden the types of stem cells studied, integrate cross-disciplinary approaches with other diseases, and aim for more timely and personalized stem cell therapies for AD.

论文

评论了 Novel Therapeutic Targets for Migraine
Migraine, a severe headache disorder linked to the trigeminal vascular system, greatly affects individuals' lives. Despite the introduction of various treatments, not all patients see significant improvement. The success of CGRP-targeted therapies emphasizes the need for research into the mechanisms of migraine to develop effective treatments. This review highlights potential therapeutic targets such as PACAP, adenosine, DOR, potassium channels, TRP, and ASIC channels, suggesting that understanding these mechanisms could lead to new treatments and better patient care.

论文

评论了 How the monarch got its spots: Long-distance migration selects for larger white spots on monarch butterfly wings
Monarch butterflies fly more than 2,000 miles from Canada to central Mexico each year, but only 30% survive the trip. Researchers have found that those with larger white spots on their wings are more successful and suggest that large white spots might have evolved to make wings more aerodynamic.

论文

评论了 Did people really drink bleach to prevent COVID-19? A guide for protecting survey data against problematic respondents
Reports of household cleaner ingestion in health behavior surveys during COVID-19 primarily come from problematic respondents, such as those who are inattentive, dishonest, or prone to systematically answering "yes" to all questions. These findings highlight the importance of employing methods in survey research to enhance measurement accuracy and prevent such respondents from compromising the validity of public health and medical studies.

论文

评论了 The efficacy of interventions in reducing belief in conspiracy theories: A systematic review
This systematic review of 13 papers shows that most interventions aimed at reducing conspiracy beliefs are inneffective. However, this analysis suggested that interventions that occurred before participants were exposed to conspiracy beliefs, or attempts to develop critical thinking skills in participants, could potentially help counter conspiracy beliefs.

论文

评论了 The Myth of Man the Hunter: Women’s contribution to the hunt across ethnographic contexts
Ethnographic reports of 63 different foraging societies around the globe reveal that women had a key role in hunting. These conclusions upend the paradigm that women in foraging societies gathered whereas men hunted, and support a re-analysis of the division of labor in these cultures.

论文

评论了 Better sleep, better life? testing the role of sleep on quality of life
This study showed that sleep quality is the most influential effector on five aspects of quality of life: wellbeing, life satisfaction, subjective health, work stress and happiness. While sleep duration and social jetlag are undoubtedly important, they are less impactful on our quality of life than obtaining a good night’s sleep.