Wai Lo

United States UConn

论文

评论了 Contamination of the marine environment by Antarctic research stations: Monitoring marine pollution at Casey station from 1997 to 2015
The first research stations in Antarctica were set up in the late 19th century, marking the beginning of a long history of scientific exploration on the continent. Over the years, numerous stations have been established, significantly advancing our knowledge of Antarctic ecosystems, climate, and geophysical processes, even in its most extreme environments. This particular study focuses on pollution and contamination patterns observed around Australia's Casey Station from 1997 to 2015. It reports elevated concentrations of metals, hydrocarbons, and polychlorinated biphenyls (PCBs), all exceeding recommended upper limits. The findings suggest that research stations in Antarctica could represent a moderate ecological threat to the marine ecosystems they are part of.

论文

评论了 Word differences in news media of lower and higher peace countries revealed by natural language processing and machine learning
This study, which analyzed over 700,000 English news articles and utilized five major independent indexes of peacefulness, demonstrates that natural language processing (NLP) and machine learning techniques can predict a country's level of peacefulness based on the prevalence of certain words in its news publications. The findings pave the way for further research into whether this approach is applicable to news articles in other languages and to explore the social factors that determine the vocabulary used in media across various nations.

论文

评论了 A growing plastic smog, now estimated to be over 170 trillion plastic particles afloat in the world’s oceans—Urgent solutions required
Data collected from over 11,000 stations monitoring the ocean indicate that the surface layer of our oceans is contaminated with approximately 82 to 358 trillion plastic particles. These particles collectively weigh between 1.1 and 4.9 million tonnes. The findings highlight the critical necessity of cutting down on worldwide plastic production and usage, alongside amplifying recycling efforts.

研讨会

评论了 AI tools in scientific publishing – an introduction
I think the authors need to disclose they have used AI in assisting their publications.

研讨会

评论了 Biomaterials-directed regenerative immunology
She is an icon in the field of biomaterilas. She was recently elected to the National Academy of Sciences. She was previously elected to the National Academy of Engineering and the National Academy of Medicine and is the first Johns Hopkins faculty member to be elected to all three National Academies.

期刊

评论了 Cell Reports Physical Science
They launched another Cell Reports journal named Cell Reports Sustainability but I don’t see it here.

期刊

评论了 Joule
Joule, a sister journal to Cell, is a home for outstanding and insightful research, analysis and ideas addressing a key global challenge: the need for more sustainable energy. Joule is a distinctive and forward-looking journal, bridging disciplines and scales of energy research. Joule connects all who are researching and analyzing the challenges — scientific, technical, economic, policy and social — of providing sustainable energy solutions. Joule spans scales of energy research, from fundamental laboratory research into energy conversion and storage up to impactful analysis at the global level. Joule will purposefully highlight and amplify the implications, challenges and opportunities of novel energy research for different groups working across the entire spectrum of the field.

期刊

评论了 One Earth
One Earth is Cell Press’ flagship sustainability journal. One Earth provides a home for high-quality research and perspectives that significantly advance our ability to better understand and address today’s sustainability challenges. We publish monthly thematic issues that aspire to break down barriers between the natural, social and applied sciences and the humanities, stimulate the cross-pollination of ideas, and encourage transformative research.

论文

评论了 Metabolic dysfunction-associated steatotic liver disease and risk of cardiovascular disease
The study explored the clinical implications of metabolic dysfunction-associated steatotic liver disease (MASLD) by assessing its prevalence and associated cardiovascular disease (CVD) risk in over 9.7 million Korean adults. Findings revealed a 27.5% prevalence of MASLD, with additional cases involving increased alcohol intake (MetALD) or other etiologies contributing to the overall prevalence of MASLD/related steatotic liver disease (SLD). Over a median follow-up of 12.3 years, those with MASLD/related SLD exhibited a significantly higher cumulative incidence and adjusted risk of CVD events compared to those without these conditions. This underscores the high CVD risk among individuals with MASLD/related SLD, affecting over a third of the studied population.

论文

评论了 Hierarchical TAF1-dependent co-translational assembly of the basal transcription factor TFIID
Good article!!! This study reveals that the biogenesis of the human TFIID complex, essential for initiating gene expression, occurs co-translationally, with all heterodimerization steps happening during protein synthesis. By employing RNA-immunoprecipitation, single-molecule imaging, proteomics, and structure-function analyses, the researchers identified TAF1 as a key scaffold for assembling TFIID submodules. This finding suggests a hierarchical model for TFIID assembly and hints that similar strategies may be used in the formation of other large protein complexes.

论文

评论了 Normalizing and denoising protein expression data from droplet-based single cell profiling
The study introduces "dsb," a method to normalize and denoise droplet-based protein expression data by addressing technical noise, which often obscures biological variations in multimodal single-cell profiling techniques. Through identifying protein-specific and cell-to-cell technical noise sources and validating across multiple datasets, dsb significantly enhances the detection of biologically meaningful cell populations compared to existing normalization methods.

论文

评论了 Building kinetic models for metabolic engineering
Building kinetic models in metabolic engineering involves mapping out key metabolic pathways, gathering enzyme kinetics data, and formulating these into mathematical models to predict how genetic modifications affect product synthesis. This process includes collecting enzyme parameters, integrating these into a network model, validating with experimental data, and conducting simulations to guide genetic engineering efforts for improved compound production. Iterative model refinement based on new data enhances predictive accuracy and production efficiency.

论文

评论了 Modular Metabolic Engineering for Biobased Chemical Production
Advancements in modular metabolic engineering help optimize microbial production of biobased chemicals by fine-tuning engineered pathways and employing microbial consortia, improving efficiency and supporting a sustainable biobased economy.

论文

评论了 Metabolic Engineering: Methodologies and Applications
Metabolic engineering enhances molecule production across multiple industries through genetic tweaks in microbial metabolism. This review covers its core process, key applications, case studies, and future outlook.