Article
Medicine, General & Internal
Pawel Kozlowski, Marcin Smiarowski, Wiktoria Przyborska, Karolina Zemlik, Milena Malecka-Gieldowska, Aleksandra Leszczynska, Marzena Garley, Olga Ciepiela
Summary: This study found that COVID-19 convalescents without other comorbidities related to endothelial impairment only showed slight evidence of endothelial dysfunction at least 6 months after infection.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Hematology
Madhvi Rajpurkar, Angela Forsyth, Marilyn Manco-Johnson
Summary: Current treatments are changing the phenotype of many severe haemophilia patients to mild haemophilia, but there are still unmet needs for those with mild-to-moderate haemophilia A and B. These patients may have similar complications to severe haemophilia patients, but they have unique challenges in diagnosis, bleeding symptoms, and treatment needs. Women with mild-to-moderate haemophilia are under-recognized and face their own unique challenges, highlighting the need for additional research and resources in this patient population.
Article
Hematology
Christopher Walsh, Lisa Boggio, Lanette Brown-Jones, Rachel Miller, Sarah Hawk, Brittany Savage, Kerry Hansen, Don Molter, Kim Baumann, Spencer Dunn, Mark W. Skinner, Kimberly Haugstad, Stormy Johnson, Tammy Davenport, Margaret Bradbury, Michelle Witkop, Hossam Saad, David L. Cooper
Summary: Patients with mild-to-moderate hemophilia face unique challenges and unmet needs, such as lack of proper education on disease management and prompt treatment of bleeds. Initiatives proposed include community engagement programs, revised transition guidelines, and diagnostic classification for this group of patients, as well as addressing challenges specific to women with hemophilia.
Article
Genetics & Heredity
Idaira Rodriguez-Santana, Pronabesh DasMahapatra, Tom Burke, Zalmai Hakimi, Jose Bartelt-Hofer, Jameel Nazir, Jamie O'Hara
Summary: The severity of hemophilia is associated with increasing economic and humanistic burden. The burden of moderate disease does not appear to be substantially different from that of severe hemophilia.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Hematology
Michelle Witkop, Michael Wang, Grace Hernandez, Michael Recht, Kim Baumann, David L. Cooper
Summary: Epidemiological studies have shown that joint bleeding can occur in patients with mild-to-moderate haemophilia, including women and girls. Two recent studies focused on identifying unmet needs in men and women with mild-to-moderate haemophilia, assessing the impact of pain on functional impairment and quality of life, and evaluating psychosocial needs in patients with haemophilia B, including females. Results from these studies highlighted the challenges faced by patients in gaining access to factor products and treatment centers, as well as the physical and psychosocial impacts experienced by individuals with mild-to-moderate haemophilia.
Article
Hematology
Valerie-Anne Chantrain, Catherine Lambert, Patrick De Smet, Sebastien Lobet, Anthe Foubert, Mira Meeus, Cedric Hermans, Nathalie Anne Roussel
Summary: This study aimed to assess the prevalence of pain, pain interference, and their relationship with health-related quality of life in male adults with haemophilia. The results showed that pain was a major issue for people with haemophilia, including those with mild haemophilia. The pain interfered with activities, emotions, sleep, and overall quality of life.
Article
Medicine, General & Internal
Kangmei Zhou, Jierong He, Lin Quan, Rong Guo
Summary: This study aims to evaluate the efficacy of acupuncture combined with Western medicine in improving cognitive function and activities of daily living in patients with Alzheimer's disease (AD). Using a randomized, single-blind, sham-acupuncture controlled trial, participants will be divided into treatment and control groups. After 24 weeks of continuous treatment, they will be followed up for another 24 weeks. Outcome measures include various assessments and blood tests. The results of this study will help determine whether the efficacy of acupuncture in the treatment of AD is due to the placebo effect.
Article
Clinical Neurology
Akanksha Chaurasiya, Jay Kumar Ranjan, Nityanand Pandey, Hari Shanker Asthana
Summary: This study aimed to investigate the association of affective symptoms and clinical factors with neurocognitive functioning in complicated mild and moderate TBI patients. The results showed that injury-related factors, anxiety, depressive symptoms, and head injury symptoms were all correlated with different domains of neurocognitive function in these patients. The study highlights the importance of considering affective symptoms in addition to clinical factors in the planning of rehabilitation programs for such patients in rural areas.
JOURNAL OF NEUROSCIENCES IN RURAL PRACTICE
(2021)
Review
Hematology
Anita H. Nadkarni, Ajit C. Gorakshakar, Pratibha M. Sawant, Khushnooma Y. Italia, Dipti S. Upadhye, Manju S. Gorivale, Pallavi R. Mehta, Priya Hariharan, Kanjaksha Ghosh, Roshan B. Colah
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2019)
Article
Hematology
Avani Shah, Parizad Patel, Keyur Patel, Binal Patel, Keyuri Jariwala, Preeti Sharma, Kanchan Mishra, Kanjaksha Ghosh
TRANSFUSION AND APHERESIS SCIENCE
(2020)
Article
Hematology
Kanjaksha Ghosh, Kinjalka Ghosh, Reepa Agarwal, Kiron Shah, Kanchan Mishra
TRANSFUSION AND APHERESIS SCIENCE
(2019)
Letter
Rheumatology
Kanjaksha Ghosh
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Medicine, Research & Experimental
Salam Alkindi, Said S. Almufargi, Anil Pathare
EXPERIMENTAL BIOLOGY AND MEDICINE
(2020)
Article
Multidisciplinary Sciences
Salam Alkindi, Ikhlas Al-Busaidi, Bushra Al-Salami, Samir Raniga, Anil Pathare, Samir K. Ballas
SCIENTIFIC REPORTS
(2020)
Article
Hematology
Avani Shah, Parizad Patel, Keyuri Jariwala, Farzin Qureshi, Kanchan Mishra, Sumit Bharadva, Kanjaksha Ghosh
Summary: There is a lack of data on the prevalence of rare blood group antigens among the blood donor population in South Gujarat due to the unavailability and high cost of antisera. This study used a PCR-based method to detect the presence of In-a and In-b antigens in regular voluntary blood donors. The frequency of In a antigen was found to be higher than Caucasians, lower than Iranians and Arabs, and comparable to Indians in Mumbai. This PCR-based method could be extremely helpful in creating a rare donor registry and screening blood donors on a large scale in the absence of antisera, particularly for low-frequency alleles like In-a.
TRANSFUSION AND APHERESIS SCIENCE
(2022)
Article
Medicine, General & Internal
Naglaa Fawaz, Ismail Beshlawi, Alauldeen Alqasim, Mathew Zachariah, Roberta Russo, Immacolata Andolfo, Antonella Gambale, Anil Pathare, Achille Iolascon
Summary: We report a case of transfusion-dependent chronic anemia in a child, with clinical and laboratory features suggestive of a chronic nonspherocytic hemolytic anemia and bone marrow features suggestive of congenital dyserythropoietic anemia. However, DNA studies revealed a novel mutation in the PKLR gene responsible for pyruvate kinase deficiency as the underlying condition. Molecular investigations using targeted next-generation sequencing identified the patient as homozygous for a novel missense mutation, while both parents were heterozygous for the same mutation.
CLINICAL CASE REPORTS
(2022)
Review
Hematology
Kanjaksha Ghosh, Kinjalka Ghosh
Summary: Monoclonal antibodies are increasingly used in hematology practice, either alone or in combination with other therapies, to improve outcomes in various hematological conditions. These antibodies have a wide range of applications in malignant and benign hematological diseases, as well as in different phases of stem cell transplantation. Advancements in protein engineering are rapidly improving the function of antibodies.
EXPERT REVIEW OF HEMATOLOGY
(2022)
Review
Medicine, Research & Experimental
Kanjaksha Ghosh, Durjoy K. Shome, Bipin Kulkarni, Malay K. Ghosh, Kinjalka Ghosh
Summary: Bone marrow fibrosis is a significant structural change in the marrow that is not well understood in terms of its causes. This review consolidates the current understanding of marrow fibrosis, highlighting the complex interactions between growth factors, cytokines, chemokines, and hormones. The involvement of various cells, molecules, and genetic/epigenetic changes in the fibrosis process is also discussed.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Suryyani Deb, Mohammad Azharuddin, Sofia Ramstrom, Kanjaksha Ghosh, Santiswarup Singha, Thobias Romu, Hirak Kumar Patra
Summary: Arterial thrombosis is caused by platelet-mediated thrombus formation in blood vessels, leading to severe cardiovascular diseases. To better predict and treat arterial thrombosis, we have developed a nanoparticle platform that can simultaneously monitor and restrict thrombus growth. The platform works by inhibiting receptors on platelets and visualizing the thrombus status through magnetic resonance imaging.
BIOENGINEERING-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Prashant P. Warang, Nikhil S. Shinde, Vinod D. Umare, Prajyot Deshmukh, Kanjaksha Ghosh, Manisha R. Madkaikar, Roshan B. Colah, Malay B. Mukherjee
Summary: This study evaluated the effects of fermented papaya preparation (FPP) on sickle cell patients, finding that it has the potential to reduce oxidative stress and protect red blood cell morphology. The analysis also revealed the presence of essential amino acids and vitamin D3 and derivatives in FPP.
Article
Biochemistry & Molecular Biology
Vinod Umare, Vandana Pradhan, Sneha Dadheech, Anjali Rajadhyaksha, Kanjaksha Ghosh, Anita Nadkarni
Article
Pathology
Sandhya Tamgadge, Treville Pereira, Sandeep Kale, Subraj Shetty, Avinash Tamgadge
INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY
(2020)
Article
Dermatology
Treville Pereira, J. Aswathy, Subraj Shetty, Avinash Tamgadge, Sandhya Tamgadge, Swati Gotmare
INDIAN DERMATOLOGY ONLINE JOURNAL
(2019)
