Article
Public, Environmental & Occupational Health
Runqi Zhang, Shuo Zhang, Jing Ming, Jing Xie, Baoguo Liu, Cuiqian Chen, Xiaojie Sun, Xuemei Zhen
Summary: This study evaluated the quality of life (QoL) and health status utility (HSU) of adult patients with beta-thalassemia major (beta-TM) in mainland China, and found poor QoL and HSU outcomes. The study highlighted the importance of social support and treatment compliance in improving patients' hemoglobin content, reducing comorbidities, and ensuring their QoL.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, Research & Experimental
Gunel Talibova, Zeynep Ozturk, Mesut Parlak, Alphan Kupesiz
Summary: This study measured SEPP concentrations in thalassemia patients for the first time, showing higher levels in TM patients compared to controls. Correlations between thyroid hormones and selenoproteins suggest that selenium may be necessary for thyroid function.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Medicine, General & Internal
Karuna M. Das, Usama M. A. Baskaki, Anisha Pulinchani, Huthaifa M. Ali, Taleb M. Almanssori, Klaus Van Gorkom, Amrita Das, Hany Dewedar, Sanjiv Sharma
Summary: In patients with thalassemia major, cardiac magnetic resonance feature-tracking (CMR-FT) can effectively diagnose subclinical left ventricular dysfunction and detect abnormal right ventricular dysfunction even in patients with normal right ventricular ejection fraction (RVEF). CMR-FT strain values serve as predictive indicators for myocardial iron overload.
Article
Biochemistry & Molecular Biology
Ayse Sahin, Elif Ozturk Er, Ersoy Oz, Zeynep Yildiz Yildirmak, Sezgin Bakirdere
Summary: The study found significant differences in the concentrations of Al, K, Sn, and Sb elements in the serum of patients with beta-thalassemia major compared to the control group. Higher levels of Al and Sb and lower levels of K and Sn elements were observed in patients, indicating an altered profile of serum trace element concentrations. Further research is needed to evaluate the potential of trace elements as biomarkers and for managing their levels to reduce related complications.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Medicine, General & Internal
Funda Eren, Ayca Koca Yozgat, Esra Firat Oguz, Salim Neselioglu, Ridvan Firat, Dilek Gurlek Gokcebay, Huesniye Nese Yarali, Namik Yasar Ozbek, Ozcan Erel
Summary: The aim of this study was to develop new strategies to prevent or reduce organ damage caused by iron-mediated oxidation in thalassemia major patients. Blood samples were taken from 70 patients before and after transfusion and various biomarkers related to oxidation and antioxidant defense were measured. The results showed that transfusion therapy increased both oxidation and antioxidant levels. Additionally, a new parameter called undepleted thiol level was introduced to assess the potential organ damage caused by oxidation in transfusion-dependent thalassemia patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Fadime Ersoy Dursun, Filiz Ozen
Summary: This study investigates the effects of SMPD1 gene variants on the clinical and laboratory findings in patients with beta-thalassemia major. The results suggest that patients with the SMPD1 gene variant have higher levels of plasma chitotriosidase, ferritin, and liver enzymes, and lower levels of leukocyte acid sphingomyelinase. These findings indicate a similarity between beta-thalassemia major and Niemann-Pick disease, and suggest a potential role of the SMPD1 gene variant in the clinical features of beta-thalassemia major.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Fatemeh Abbasi, Adel Tabesh, Amirmohammad Yavari, Rasoul Makaremi, Omid Bizhani, Mahboobeh Mahmood
Summary: This study evaluated the oral health status and oral health-related quality of life (OHRQoL) in Thalassemia Major patients. It was found that poor oral health conditions might adversely affect the OHRQoL in patients with Thalassemia Major.
Letter
Oncology
Manish Agrawal, Ezekiel Emanuel, Brian Richards, William Richards, Kim Roddy, Paul Thambi
Summary: This nonrandomized controlled trial used a 1-to-1 therapist-to-patient ratio to administer psilocybin to groups of patients with cancer who were diagnosed with major depression disorder to create a scalable, rapidly effective depression treatment.
Article
Medicine, General & Internal
Giovanni Caocci, Olga Mulas, Susanna Barella, Valeria Orecchia, Brunella Mola, Alessandro Costa, Fabio Efficace, Giorgio La Nasa
Summary: This study examined the long-term health-related quality of life (HRQoL) in adult patients with transfusion-dependent Beta-Thalassemia Major (b-TM) treated with splenectomy or medical therapy. The results showed that there was no significant difference in HRQoL between patients who underwent splenectomy and those who did not. Splenectomy reduced the frequency of blood transfusions but increased the risk of cardiovascular complications and diabetes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Maria Vlachou, Vasileios Kamperidis, Efthymia Vlachaki, Georgios Tziatzios, Despoina Pantelidou, Afroditi Boutou, Chrysa Apostolou, Despoina Papadopoulou, George Giannakoulas, Haralambos Karvounis
Summary: The study found that left atrial peak systolic strain was independently associated with atrial arrhythmia burden in patients with beta-thalassemia major, regardless of the duration of blood transfusions and CMR T2*.
Article
Nursing
Maryam Askaryzadeh Mahani, Masoomeh Ghasemi, Mansour Arab, Zahra Baniasadi, Ali Omidi, Parichehr Sabaghzadeh Irani
Summary: This study examined the correlation between caregiver burden, depression, and quality of life among informal caregivers of thalassemia and hemodialysis patients in southeastern Iran during the COVID-19 pandemic. The results showed significant correlations between caregiver burden and depression, as well as caregiver burden and quality of life.
Article
Medicine, General & Internal
Olga Mulas, Fabio Efficace, Maria Grazia Orofino, Antonio Piroddi, Eugenia Piras, Adriana Vacca, Susanna Barella, Alessandro Costa, Johannes M. Giesinger, Giorgio La Nasa, Giovanni Caocci
Summary: This study investigated the health-related quality of life (HRQoL) of pediatric patients with beta thalassemia major (beta-TM) after hematopoietic stem cell transplantation (HSCT), compared to those treated with blood transfusions. The results showed that HSCT was associated with a higher HRQoL in various domains, and there was no significant difference in HRQoL between sibling or unrelated HLA-matched HSCT. The study highlights the importance of considering HSCT as a treatment option for pediatric patients with beta-TM and provides valuable information for physicians to counsel patients and parents.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Antonella Meloni, Laura Pistoia, Silvia Maffei, Paolo Marcheschi, Tommaso Casini, Anna Spasiano, Pier Paolo Bitti, Liana Cuccia, Elisabetta Corigliano, Paola Maria Grazia Sanna, Francesco Massei, Vincenzo Positano, Filippo Cademartiri
Summary: The study found that male thalassemia major patients were more likely to perceive cardiovascular disease as the greatest danger to their future health, while females were more inclined to select tumors as the greatest health problem for people of the same age. Both male and female patients demonstrated good knowledge of cardiovascular risk factors and preventive measures, with no gender differences in subjective well-being or perceived cardiovascular risk.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Michael J. Bonios, Epameinontas Fountas, Polyxeni Delaporta, Stamatis Kyrzopoulos, Antonis Kattamis, Stamatis N. Adamopoulos, Dimitris Tsiapras
Summary: The study investigated advanced echocardiography parameters for early identification of myocardial dysfunction in TM patients, finding GLS to be potentially more efficient than LVEF in detecting hemochromatosis-related cardiac dysfunction earlier.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Urology & Nephrology
Osama Tanous, Yossi Azulay, Raphael Halevy, Tal Dujovny, Neta Swartz, Raul Colodner, Ariel Koren, Carina Levin
Summary: A high prevalence of renal tubular damage was observed in TDT patients, particularly those treated with DFX; uNAG was negatively associated with mean 10-year serum ferritin, suggesting ICT's involvement in tubular injury. A significant decline in eGFR compared to a decade earlier was observed only in patients currently treated with DFX. Strict follow-up of renal function in TDT patients is warranted.
