Journal
GYNECOLOGIE OBSTETRIQUE & FERTILITE
Volume 38, Issue 9, Pages 536-540Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.gyobfe.2010.07.008
Keywords
Vitrification; Vitrified state; Cryoprotectant
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The use of high levels of cryoprotectants (CPs) in solutions applied to vitrify oocytes or embryos is an argument to still prefer slow freezing procedure. Is it a justified argument? Out of three studies using mice zygotes we may assume that (i) the intracellular concentration of CPs is far lower than the one in the vitrification solutions, (ii) the intracellular concentration of CPs in the vitrified zygote is in contrary to the common beliefs even lower than the one observed after a slow freezing procedure, (iii) survival after slow freezing reflects the presence of an intracellular vitrified state in these cells. (C) 2010 Published by Elsevier Masson SAS.
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