Review
Endocrinology & Metabolism
Jie Zhang, Hongyan Jia, Feiyang Diao, Xiang Ma, Jiayin Liu, Yugui Cui
Summary: The efficacy of DHEA supplementation in patients with poor ovarian response (POR) or diminished ovarian reserve (DOR) undergoing IVF/ICSI was investigated. The results showed that DHEA treatment can increase the antral follicle count, reduce the level of bFSH, the need for gonadotropin doses, the days of stimulation, and the miscarriage rate. However, it did not significantly improve the live birth rate.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Wenshu Li, Wei Zhang, Huishan Zhao, Yongli Chu, Xuemei Liu
Summary: The depot GnRH agonist protocol showed significantly higher cumulative clinical pregnancy rates and cumulative live birth rates compared to mild ovarian stimulation protocol and GnRH antagonist protocol. Women who received the depot GnRH agonist had higher stimulation duration, total dose of gonadotropins, and endometrial thickness, as well as lower embryo transfer cancellation rate and abnormal endometrium rate.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Public, Environmental & Occupational Health
Oshrit Lebovitz, Jigal Haas, Nitzan Mor, Eran Zilberberg, Adva Aizer, Michal Kirshenbaum, Raoul Orvieto, Ravit Nahum
Summary: Poor ovarian responders face challenges in fertility treatments, and age and the number of retrieved oocytes are key factors affecting live birth. Patients younger than 40 years who meet the Bologna criteria have a higher probability of live birth.
Article
Obstetrics & Gynecology
Abbas Aflatoonain, Lida Saeed, Robabe Hosseinisadat
Summary: The study found that androgen administration in poor responders undergoing in vitro fertilization can reduce the total dose of gonadotropins, but it does not improve pregnancy outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Hakan Cakmak
Summary: Declining oocyte quality and quantity with age are the main factors affecting female reproductive success. Factors such as the female partner's age, ovarian reserve, previous fertility treatment outcomes, and pregnancy success data are used to predict live birth rates in IVF treatment. The chance of success after the age of 45 is extremely low, making IVF cycles with autologous oocytes discouraged. The number of mature eggs retrieved and available embryos for transfer are important predictors of pregnancy and live birth. Patients aged <= 45 should consider their age and expected ovarian response when deciding to attempt IVF. Patients with a poor prognosis should be fully informed about the prognosis, risks, costs, and alternatives before starting an IVF cycle.
FERTILITY AND STERILITY
(2022)
Article
Medicine, General & Internal
Shanshan Wu, Guimin Hao, Yunshan Zhang, Xiujuan Chen, Haiqin Ren, Yanli Fan, Yinfeng Zhang, Xingyu Bi, Chen Du, Lina Bai, Xueqing Wu, Jichun Tan
Summary: This large-scale study found that exposure to ambient air pollutants was associated with an increased risk of poor ovarian response, especially for women under 30 years old. The findings underscore the importance of reducing ambient air pollution exposure in women of reproductive age to protect human fertility.
Review
Medicine, General & Internal
Huisheng Yang, Chensi Zheng, Qiyan Zheng, Huanfang Xu, Xiaotong Li, Mingzhao Hao, Yigong Fang
Summary: Controlled ovarian hyperstimulation (COH) is a routine regimen used in IVF/ICSI treatment, and poor ovarian responders (PORs) often have higher follicle stimulating hormone levels and fewer retrieved oocytes. Researchers have proposed strategies and protocols to improve pregnancy outcomes for PORs, but clinical decisions regarding COH protocols for PORs remain controversial.
Article
Endocrinology & Metabolism
Yuan Liu, Rongjia Su, Yu Wu
Summary: The study found that both minimal ovarian stimulation (MOS) and GnRH antagonists result in low live birth rates for poor ovarian responders. However, the GnRH antagonist protocol is considered a suitable choice for PORs with comparable live birth rates, shorter times to live birth, and similar financial expenditure compared to repeated MOS.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Shuang Han, Yiwei Zhai, Qingqing Guo, Yiming Qin, Peihao Liu
Summary: Women with diminished ovarian reserve may have a higher incidence of hypertensive disorders of pregnancy compared to those with normal ovarian reserve, indicating the need for more strict antenatal care in DOR patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Iris T. Lee, Dara S. Berger, Nathanael Koelper, Suneeta Senapati, Monica Mainigi
Summary: According to this study, there are differences in ovarian responsiveness to gonadotropin stimulation among different races/ethnicities, with Black and Hispanic patients having higher ovarian responsiveness. However, this does not result in an increased live birth rate for these patients.
FERTILITY AND STERILITY
(2023)
Article
Endocrinology & Metabolism
Jinliang Zhu, Ying Wang, Lixue Chen, Ping Liu, Rong Li, Jie Qiao
Summary: The study revealed that growth hormone adjuvant therapy could increase the quantity and quality of oocytes, improving the live birth rate in expected poor responders.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
N. Massin, I Abdennebi, G. Porcu-Buisson, N. Chevalier, E. Descat, C. Pietin-Vialle, S. Goro, M. Brussieux, M. Pinto, M. Pasquier, H. Bry-Gauillard
Summary: This study compares the effectiveness of two treatment protocols in assisting conception for patients with poor ovarian response, and the results show that there is no significant difference in the number of oocytes retrieved between the dual ovarian stimulation in the same cycle and two consecutive antagonist cycles.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Yung-Ling Hou, Chia-Jung Li, Li-Te Lin, San-Nung Chen, Zhi-Hong Wen, Kuan-Hao Tsui
Summary: This study investigates the clinical benefits of DHEA supplementation for poor ovarian responders (POR) in in vitro fertilization (IVF) cycles and its potential mechanism on cumulus cells (CCs). The findings indicate that DHEA supplementation reduces mitochondrial fission in CCs and decreases the expression of PGAM5.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2022)
Article
Endocrinology & Metabolism
Fangyuan Li, Ruihui Lu, Cheng Zeng, Xin Li, Qing Xue
Summary: This study developed a predictive model to estimate the individual probability of clinical pregnancy failure for poor ovarian responders (PORs) undergoing IVF/ICSI. The model was constructed based on characteristics associated with pregnancy failure, and showed satisfactory performance in both the training and validation groups.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Xiaoyu Tu, Bingbing You, Miaomiao Jing, Chenxi Lin, Runju Zhang
Summary: The progestin-primed ovarian stimulation (PPOS) protocol is an effective alternative for advanced age women with diminished ovarian reserve (DOR), providing comparable reproductive outcomes and better control of premature LH surge. It also allows for a higher number of retrieved oocytes and top-quality embryos, which are positively associated with cumulative clinical pregnancy rate and cumulative live birth rate.
FRONTIERS IN ENDOCRINOLOGY
(2022)