Review
Obstetrics & Gynecology
B. Naser, C. Castelo-Branco, H. Meden, M. J. Minkin, D. Rachon, A. -m. Beer, S. Pickartz
Summary: The study found no scientific evidence to suggest that the use of Cimicifuga racemosa causes weight gain in menopausal women, with no confirmed or likely causal relationship among the 30 reported cases.
Article
Endocrinology & Metabolism
Jiming Chen, Huihui Wang, Zhiyong Dong, Junling Liu, Zhenyue Qin, Mingyue Bao, Hongxia Yu, Shoufeng Zhang, Wendi Zhang, Chunjian Qi, Jie Wu
Summary: This study successfully established a rat model of perimenopausal symptoms induced by GnRH-a injection. Black cohosh preparations were found to effectively relieve perimenopausal symptoms in rats, with no obvious impact on serum sex hormone levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Plant Sciences
Juergen Drewe, Georg Boonen, Carsten Culmsee
Summary: Cimicifuga extracts alleviate menopausal symptoms and age-related metabolic changes by modulating the AMP-activated protein kinase.
Article
Endocrinology & Metabolism
Camil Castelo-Branco, Concepcion Navarro, Estanislao Beltran, Fernando Losa, Marta Camacho
Summary: The Spanish Menopause Society has updated its position statement on black cohosh for the treatment of menopausal symptoms, stating that it is an effective and safe option for relieving vasomotor symptoms, especially in women with intense hot flushes.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Article
Chemistry, Medicinal
Sradhanjali Mohapatra, Ashif Iqubal, Mohammad Javed Ansari, Bisma Jan, Sultan Zahiruddin, Mohd Aamir Mirza, Sayeed Ahmad, Zeenat Iqbal
Summary: Women's health is a significant global concern that is often overlooked in developing countries. This review summarizes the importance of Cimicifuga racemosa (Black Cohosh) in women's health, particularly in the management of menopausal syndrome, mammary cancer, and osteoporosis.
Article
Chemistry, Analytical
Jeevitha Shanmughanandhan, Dhivya Shanmughanandhan, Subramanyam Ragupathy, Thomas A. Henry, Steven G. Newmaster
Summary: The study successfully developed a species-specific hydrolysis probe assay for raw materials and powders of A. racemosa, demonstrating 100% specificity, 99% efficiency, and 100% reliability in identifying the target species.
JOURNAL OF AOAC INTERNATIONAL
(2021)
Article
Obstetrics & Gynecology
Ryoichi Sadahiro, Lillian Nohara Matsuoka, Bing-Syuan Zeng, Keng-Hsu Chen, Bing-Yan Zeng, Hung-Yu Wang, Che-Sheng Chu, Brendon Stubbs, Kuan-Pin Su, Yu-Kang Tu, Yi-Cheng Wu, Pao-Yen Lin, Tien-Yu Chen, Yen-Wen Chen, Mein-Woei Suen, Malcolm Hopwood, Wei-Cheng Yang, Cheuk-Kwan Sun, Yu-Shian Cheng, Yow-Ling Shiue, Chao-Ming Hung, Yutaka J. Matsuoka, Ping-Tao Tseng
Summary: This updated meta-analysis aimed to compare the effectiveness of different black cohosh regimens in improving menopausal symptoms. The results showed that black cohosh extracts were associated with significant improvements in overall menopausal symptoms, hot flashes, and somatic symptoms, compared with placebo. However, black cohosh did not significantly improve anxiety or depressive symptoms.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2023)
Article
Geriatrics & Gerontology
Pluvio J. Coronado, Maria Fasero, Borja Otero, Sonia Sanchez, Esther de la Viuda, Isabel Ramirez-Polo, Placido Llaneza, Nicolas Mendoza, Laura Baquedano
Summary: During the Covid-19 confinement, peri- and postmenopausal women who engaged in physical and sexual activities showed higher health-related quality of life and resilience levels, while those using antidepressants had lower quality of life and resilience levels. Living with others was associated with higher quality of life in women.
Article
Geriatrics & Gerontology
Pluvio J. Coronado, Manuel Monroy, Maria Fasero, Rafael Sanchez-Borrego, Santiago Palacios, Javier Rejas, Miguel A. Ruiz
Summary: This study developed population-based norms for the Cervantes-SF scale, which measures the impact of menopause on the health-related quality of life (HRQOL) of women in Spain. The results showed a gradual increase in the impact of menopause on HRQOL as age increases, with significant differences in symptomatology and HRQOL impact among different age groups, as well as various factors such as generic HRQOL, comorbidities, history of osteoporotic fractures, educational level, and obesity.
Review
Oncology
Laura Garcia-Estevez, Javier Cortes, Silvia Perez, Isabel Calvo, Isabel Gallegos, Gema Moreno-Bueno
Summary: Breast cancer is the most common tumor in women globally, and the relationship between obesity and breast cancer risk is closely related to menopausal status. Obesity increases the risk of breast cancer in postmenopausal women but appears to be protective in premenopausal women.
FRONTIERS IN ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Carolina Furtado Macruz, Sonia Maria Rolim Rosa Lima
Summary: This study assessed the effects of Cimicifuga racemosa (L.) Nutt on climacteric symptoms and sexual function in women receiving tamoxifen after breast cancer treatment. The results showed that Cimicifuga racemosa (L.) Nutt could improve climacteric symptoms and sexual function in women surgically treated for breast cancer.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sradhanjali Mohapatra, Mohd. Aamir Mirza, Sayeed Ahmad, Uzma Farooq, Mohammad Javed Ansari, Kanchan Kohli, Zeenat Iqbal
Summary: Black cohosh is a popular herb used to alleviate menopausal symptoms. This study aimed to develop an ethosomal gel containing a triterpene enriched fraction from black cohosh and evaluate its efficacy through transdermal application. By using a quality by design approach, the optimized ethosomal gel showed better performance compared to the conventional gel. Additional animal studies are needed to further validate these results.
Review
Psychiatry
Tsai-Ling Chen, Shu-Chen Chang, Chin-Yi Huang, Hsiu-Hung Wang
Summary: The meta-analysis findings suggest that mindfulness-based interventions can significantly improve quality of life and menopausal symptoms in menopausal women, but may not necessarily improve psychological and sexual symptoms. Further research is needed to validate the effects of such interventions in reducing vasomotor-related menopausal symptoms.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2021)
Article
Geriatrics & Gerontology
Santiago Palacios, Rafael Sanchez-Borrego, Beatriz Suarez Alvarez, Felix Lugo Salcedo, A. Javier Gonzalez Calvo, Juan Jose Quijano Martin, Maria J. Cancelo, Maria Fasero
Summary: This study aimed to assess the correlation between different therapeutic options for vulvovaginal atrophy and the quality of life of postmenopausal women. The results showed that postmenopausal women treated with ospemifene had better quality of life compared to those treated with vaginal moisturizers or local estrogen therapy, particularly in aspects related to sex life and couple relations.
Article
Obstetrics & Gynecology
Laura Baquedano, Javier Rejas-Gutierrez, Pluvio J. Coronado
Summary: The Cervantes-GSM questionnaire is a new tool designed to assess the impact of genitourinary symptoms on the quality of life in menopausal women. The questionnaire consists of 15 items across five domains: vulvovaginal symptoms, urinary symptoms, psychological (emotions), interference with daily activities, and sexuality. The preliminary results showed that the questionnaire has acceptable psychometric properties, including feasibility, internal consistency, factor structure, and construct validity.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2023)
Article
Obstetrics & Gynecology
T. L. B. Bretas, M. C. A. Issa, S. C. A. V. Fialho, E. A. G. Villar, L. G. C. Velarde, F. R. Perez-Lopez
Summary: The study found that CO2 laser treatment could improve the Vaginal Health Index and Female Sexual Function Index scores in postmenopausal women, while reducing the International Consultation on Incontinence Questionnaire Short Form score. Histological analysis showed an increase in total and superficial epithelial cell layers and type III collagen fibers in the vaginal wall after treatment.
Review
Endocrinology & Metabolism
Kumar Vivek, E. Prabhakar Reddy, Balachandar Thangappazham, Hemanth Raj, Faustino R. Perez-Lopez, Seshadri Reddy Varikasuvu
Summary: The meta-analysis showed that maternal serum/plasma adropin levels were significantly higher in GDM patients compared to non-GDM controls. Sensitivity analysis revealed that no individual study significantly influenced the overall outcome.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Kumar Vivek, Balachandar Thangappazham, Alekya Vykunta, Paresh P. Kulkarni, Faustino R. Perez-Lopez, Seshadri Reddy Varikasuvu
Summary: This meta-analysis found significantly decreased maternal serum irisin level in preeclampsia patients compared to normotensive pregnant women. The study highlights the importance of future evaluations of the diagnostic utility and associations of irisin with fetal and neonatal outcomes in preeclampsia.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Seshadri Reddy Varikasuvu, Faustino R. Perez-Lopez, Balachandar Thangappazham, Hemanth Raj, Alekya Vykunta
Summary: This meta-analysis found a significant decrease in circulating irisin levels after metformin intervention in PCOS patients, which was validated through sensitivity analysis. The higher pretreatment levels of irisin in PCOS patients may return to normal upon metformin treatment, suggesting a potential restoration of altered metabolic states.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Editorial Material
Obstetrics & Gynecology
F. R. Perez-Lopez, S. R. Varikasuvu
Summary: Postmenopausal vulvovaginal pain and atrophy require appropriate outcomes that correlate with symptoms and expected changes. In some studies, hormone and laser treatments did not show benefits due to inadequate measuring tools. It is important to follow the Core Outcomes in Menopause global initiative.
Article
Obstetrics & Gynecology
P. Garcia-Alfaro, I Rodriguez, F. R. Perez-Lopez
Summary: Handgrip strength (HGS) and dynapenia were not associated with hyperhomocysteinemia. Plasma homocysteine levels were significantly correlated with age, GFR, and creatinine.
Review
Endocrinology & Metabolism
Mauricio Tajada, Pena Dieste-Perez, Ana Sanz-Arenal, Gonzalo Perez-Roncero, Maria T. Lopez-Baena, Faustino R. Perez-Lopez
Summary: The study found no significant difference in leukocyte telomere length between PCOS patients and the control group, but PCOS patients were younger, had higher body mass index, and showed elevated levels of testosterone and luteinizing hormone compared to controls. Further research with larger sample sizes and additional outcomes is needed to confirm these findings.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Sebastian Yalle-Vasquez, Karem Osco-Rosales, Wendy Nieto-Gutierrez, Vicente Benites-Zapata, Faustino R. Perez-Lopez, Christoper A. Alarcon-Ruiz
Summary: Vitamin E supplementation improves glucose, lipid, and androgenic-related biomarkers in women with PCOS, but its effects on female hormones, BMI, and hirsutism are inconclusive.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Faustino R. Perez-Lopez, Maria T. Lopez-Baena, Gonzalo Perez-Roncero, Pena Dieste-Perez, Ricardo Saviron-Cornudella, Mauricio Tajada
Summary: Based on the findings of this study, female sexual function showed a decline during the SARS-CoV-2 pandemic compared to before the pandemic, indicating an increased risk of female sexual dysfunction. There were increased risks of sexual arousal, orgasm, satisfaction, and pain disorders. However, there were no significant differences in the desire and lubrication domains.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Review
Obstetrics & Gynecology
Faustino R. Perez-Lopez, Ricardo Saviron-Cornudella, Peter Chedraui, Maria T. Lopez-Baena, Gonzalo Perez-Roncero, Ana Sanz-Arenal, Marta Narvaez-Salazar, Pena Dieste-Perez, Mauricio Tajada
Summary: This meta-analysis compared obstetric and perinatal outcomes in pregnant women with laboratory-tested SARS-CoV-2 infection before delivery. The results showed that pregnant women with a positive PCR test had a higher risk of delivering at an earlier gestational age, preeclampsia, NICU admissions, stillbirths, and perinatal mortality.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Faustino R. R. Perez-Lopez, Junhua Yuan, Manuel Sanchez-Prieto, Maria T. Lopez-Baena, Gonzalo R. R. Perez-Roncero, Seshadri Reddy Varikasuvu
Summary: This systematic review and meta-analysis explored the levels of maternal and cord blood betatrophin in pregnant women with gestational diabetes mellitus (GDM) and normoglycemic controls. The results showed that women with GDM had higher levels of betatrophin in the second half of pregnancy compared to the normoglycemic controls. Additionally, women with GDM also had increased levels of insulin, glucose, glycosylated hemoglobin, HOMA-IR, LDL-cholesterol, HDL-cholesterol, triglycerides, and body mass index.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Endocrinology & Metabolism
Faustino R. Perez-Lopez, Maria T. Lopez-Baena, Gonzalo R. Perez-Roncero, Peter Chedraui, Seshadri Reddy Varikasuvu, Pascual Garcia-Alfaro
Summary: This systematic review and meta-analysis aimed to summarize the evidence on circulating asprosin and related hormones and metabolites in women with and without PCOS. Eight studies were evaluated, and the results showed that women with PCOS had significantly higher levels of circulating asprosin compared to those without PCOS.
GYNECOLOGICAL ENDOCRINOLOGY
(2023)
Review
Obstetrics & Gynecology
F. R. Perez-Lopez, A. M. Fernandez-Alonso, E. Mezones-Holguin, P. Vieira-Baptista
Summary: This review examines the clinical associations between specific low genitourinary tract clinical conditions in perimenopausal and postmenopausal women living with HIV. Despite appropriate antiretroviral therapy, these women may experience menstrual dysfunction, vaginal microbiome alterations, vaginal dryness, low sexual function, and increased risks of certain cancers and infections. Furthermore, menstrual dysfunction and early menopause could contribute to a higher risk of vascular atherosclerosis and osteoporosis. It is important to manage these risks and complications related to hormone dysfunction and early menopause in WLHIV.
Article
Endocrinology & Metabolism
Sandra C. Sanchez-Zarza, Anastasia K. Armeni, Peter Chedraui, Faustino R. Perez-Lopez, Antonio W. D. Gavilanes
Summary: This study aimed to determine the prevalence of menopausal symptoms and factors related to severity in mid-aged women. The results showed that menopausal symptoms were related to hormonal, sexual and other female aspects.
GYNECOLOGICAL ENDOCRINOLOGY
(2023)
Review
Obstetrics & Gynecology
Faustino R. Perez-Lopez, Maria T. Lopez-Baena, Juan R. Ulloque-Badaracco, Vicente A. Benites-Zapata
Summary: This study conducted a systematic review and meta-analysis to assess telomere length in women with gestational diabetes mellitus (GDM) and normoglycemic pregnant women (NPW) and their infants. The findings showed no significant differences in maternal and offspring telomere length between pregnancies with and without GDM.
REPRODUCTIVE SCIENCES
(2023)