Review
Biochemistry & Molecular Biology
Machteld Sillen, Paul J. Declerck
Summary: TAFI, a proenzyme, is converted to a potent attenuator of the fibrinolytic system upon activation by thrombin, plasmin, or the thrombin/thrombomodulin complex. The development of molecules antagonizing TAFI function has gained much interest in the field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Arnaud-Pierre Schaffner, Patricia Sansilvestri-Morel, Nicole Despaux, Elisabeth Ruano, Thierry Persigand, Alain Rupin, Philippe Mennecier, Marie-Odile Vallez, Eric Raimbaud, Patrice Desos, Philippe Gloanec
Summary: Novel inhibitors targeting TAFIa designed in this paper show promising activity in thrombosis models, suggesting their potential for use in treating thrombotic diseases.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Clinical Neurology
Juan Marta-Enguita, Manuel Navarro-Oviedo, Roberto Munoz, Jorge Olier-Arenas, Guillermo Zalba, Ramon Lecumberri, Maite Mendioroz, Jose A. Paramo, Carmen Roncal, Josune Orbe
Summary: This study explores the presence of MMP-10 and TAFI in thrombi from ischemic stroke patients and their associations with clinical outcomes. The findings suggest that these hemostatic components in thrombus might influence response to thrombolytic treatment and patient outcomes. Further research is needed to explore the potential clinical impact of these findings on the development of new therapeutic strategies.
FRONTIERS IN NEUROLOGY
(2021)
Article
Hematology
Thomas Vanassche, Rachel P. Rosovsky, Fares Moustafa, Harry R. Buller, Annelise Segers, Indu Patel, Minggao Shi, Naoki Miyoshi, Venkatesh Mani, Zahi Fayad, Dominique Stephan, Jeannot Schmidt, Michael A. Grosso, Victor F. Tapson, Peter Verhamme, M. Huisman
Summary: This study evaluated the tolerability and efficacy of adding DS-1040 in patients with intermediate-risk PE. The results showed that adding DS-1040 did not increase bleeding risk, but also did not improve thrombus resolution or right ventricular dilation.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Medical Laboratory Technology
Hideo Wada, Katsuya Shiraki, Takeshi Matsumoto, Hideto Shimpo, Motomu Shimaoka
Summary: Clot waveform analysis (CWA) observes changes in transparency in a plasma sample based on clotting tests such as APTT, PT, and TT. It has been found that not only an abnormal waveform but also peak times and heights in derivative curves of CWA are useful for evaluating hemostatic abnormalities. Modified CWA, including PT with APTT reagent, dilute PT, and dilute TT, has potential in evaluating physiological or pathological hemostasis. Further research is needed to investigate the relevance and usefulness of CWA-APTT and modified CWA in various diseases.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Biochemical Research Methods
Jun X. Wheeler, Craig Thelwell, Peter Rigsby, Gail Whiting
Summary: In this study, a quantitative mass spectrometry method was established for measuring TAFI in human plasma. Traceability was achieved by using calibrators consisting of blank plasma spiked with a known amount of purified TAFI. This method enabled reliable and accurate measurement of TAFI concentration in plasma and demonstrated its applicability for assigning a common reference standard.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Kanako Yoshida, Tetsuji Takabayashi, Yoshimasa Imoto, Masafumi Sakashita, Yukinori Kato, Norihiko Narita, Shigeharu Fujieda
Summary: This study found that serum TAFI levels significantly increased after SLIT treatment, showing a significant negative correlation with C3a levels, and inhibited mast cell degranulation and chemokine expression in fibroblasts.
Article
Hematology
Patricia Sansilvestri-Morel, Alain Rupin, Arnaud-Pierre Schaffner, Florence Bertin, Philippe Mennecier, Isabelle Lapret, Paul J. Declerck, Philippe Baumy, Marie-Odile Vallez, Florence Petit-Dop, Isabelle Tupinon-Mathieu, Philippe Delerive
Summary: The new TAFIa inhibitor S62798 has been found to enhance fibrinolysis in both in vitro and in vivo studies, with minimal risk of bleeding. This inhibitor has the potential to be a therapeutic option for treating pulmonary embolism in combination with anticoagulants.
THROMBOSIS RESEARCH
(2021)
Article
Critical Care Medicine
Julia R. Coleman, Ernest E. Moore, Marguerite R. Kelher, Kenneth Jones, Mitchell J. Cohen, Anirban Banerjee, Christopher C. Silliman
Summary: This study revealed that thrombin-activatable fibrinolysis inhibitor (TAFI) plays a major role in fibrinolysis shutdown after trauma-induced coagulopathy.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2023)
Article
Endocrinology & Metabolism
Meili Cai, Xiaowen Shao, Feng Xing, Yuqin Zhang, Xinyu Gao, Qiongjing Zeng, Diliqingna Dilimulati, Shen Qu, Manna Zhang
Summary: The study demonstrates that canagliflozin is not inferior to metformin in improving insulin resistance in PCOS patients, with significant benefits in improving menstrual pattern, reducing body weight and total fat mass, and decreasing triglyceride levels.
DIABETES OBESITY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Erasmia Rouka, Sotirios G. Zarogiannis, Chrissi Hatzoglou, Konstantinos I. Gourgoulianis, Foteini Malli
Summary: This study focuses on the prediction and functional enrichment analysis of the TAFI interaction network and the microRNAs targeting the members of this network. It identifies the complement and coagulation cascades as well as neutrophil extracellular trap formation as pathways related to TAFI-related thrombosis and identifies important diseases such as cancer, stroke, and intracranial aneurysm associated with the identified microRNAs.
Article
Clinical Neurology
Joachim C. Mertens, Vanessa Blanc-Guillemaud, Karen Claesen, Pere Cardona, Dirk Hendriks, Benoit Tyl, Carlos A. Molina
Summary: The study evaluated the kinetics of CPU during ischemic stroke treatment, revealing rapid activation and deactivation of the CPU system following thrombolysis and thrombectomy, indicating that a CPU inhibitor would need to be administered during rtPA infusion and in the hours that follow.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Hematology
Ping Fang, Decheng Cai, Lijun Du, Fei Shen, Chengfang Zhang, Meijuan Li
Summary: The study suggests a protective role of the TAFI +1040C allele against recurrent spontaneous abortion, with a lower frequency of the C allele in RSA patients. The +1040CT genotype was significantly higher and the +1040CC genotype was significantly lower in RSA patients compared to controls.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2021)
Review
Pharmacology & Pharmacy
Congshun Ma, Qianru Xiang, Ge Song, Xuefei Wang
Summary: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease with no specific drug treatment. Quercetin (QUR), a flavonoid, has potential therapeutic effects for PCOS patients. However, the mechanisms of QUR in PCOS patients remain unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Hajer Aounallah, Melissa Regina Fessel, Mauricio Barbugiani Goldfeder, Eneas Carvalho, Chaima Bensaoud, Ana Marisa Chudzinski-Tavassi, Ali Bouattour, Youmna M'ghirbi, Fernanda Faria
Summary: The recombinant serpin Dromaserpin from the tick saliva showed promising anticoagulant activity and inhibition of thrombin-induced platelet aggregation, suggesting its potential as a therapeutic candidate for disorders related to blood clotting and platelet aggregation. Further research is warranted to explore its application in the development of new treatments for cardiovascular diseases and other related illnesses.