Journal
GYNECOLOGIC ONCOLOGY
Volume 151, Issue 3, Pages 519-524Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygyno.2018.09.016
Keywords
FAIMS; Ovarian neoplasm; Ovarian cancer; VOC; Owlstone Lonestar; Urine
Categories
Funding
- Finnish Cancer Foundation [MS738]
- Competitive Research Funding of Tampere University Hospital [9U036, 150618, 95045, 91044, 9V044, 151B03, 9U042]
- Tampere Tuberculosis Foundation
- Emil Aaltonen Foundation
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Aim. We hypothesized that field asymmetric waveform ion mobility spectrometry (FAIMS) as a novel artificial olfactory technology could differentiate urine of women with malignant ovarian tumors from controls and women with benign tumors, based on previous findings on the ability of canine olfactory system to smell cancer. Patients and methods. Preoperative urine samples from 51 women with ovarian tumors, both benign and malignant, and from 18 women with genital prolapse, as controls, were collected. The samples were analyzed by FAIMS device. Data analysis was processed by quadratic data analysis (QDA) and linear discriminant analysis (LDA), and cross-validated using 10-fold cross-validation. Results. Thirty-three women had malignant ovarian tumors, of which 18 were high-grade cancers. FAIMS distinguished controls from malignancies with the accuracy of 81.3% (sensitivity 91.2% and specificity 63.1%), and benign tumors from malignancies with the accuracy of 77.3% (sensitivity 91.5% and specificity 51.4%). Moreover, low grade tumors were also separated from high grade cancers and benign ovarian tumors with accuracies of 88.7% (sensitivity 87.8% and specificity 89.6%) and 83.9% (sensitivity 73.1% and specificity 92.9%), respectively. Conclusions. This proof of concept-study indicates that the FAIMS from urine has potential to discriminate malignant ovarian tumors from no tumor-bearing controls and benign tumors. (C) 2018 Elsevier Inc. All rights reserved.
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