Review
Oncology
Anna Markowska, Anita Chudecka-Glaz, Kazimierz Pitynski, Wlodzimierz Baranowski, Janina Markowska, Wlodzimierz Sawicki
Summary: Endometrial cancer is becoming more common in highly developed countries and is also affecting young women who want to preserve their fertility. Conservative treatment options, such as medication and local treatment, can be considered for these women.
Review
Biochemistry & Molecular Biology
Ana Teixeira-Marques, Catarina Lourenco, Miguel Carlos Oliveira, Rui Henrique, Carmen Jeronimo
Summary: Bladder cancer is the 10th most common cancer worldwide, and current diagnostic methods have limited sensitivity and lack effective prognostic biomarkers. Extracellular vesicles (EVs) have emerged as potential tools for liquid biopsy-based diagnosis and prognosis, as they carry biomarkers and play a crucial role in intercellular communication. However, there are advantages and downsides to using EVs in this context.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Yuan Fan, Xingchen Li, Jiaqi Wang, Yiqin Wang, Li Tian, Jianliu Wang
Summary: This study investigated pregnancy outcomes and associated factors in young patients receiving hormonal therapy for fertility-sparing treatment. Factors such as normal BMI, shorter time to complete remission, longer treatment duration, fewer hysteroscopy procedures, and thicker endometrium were found to be positive indicators for successful pregnancies. Additionally, successful pregnancy can protect the endometrium and assisted reproductive technology does not increase the risk of recurrence.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Oncology
Angela Cho, Shin-Wha Lee, Jeong-Yeol Park, Dae-Yeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim
Summary: Continued medical treatment is effective for early endometrial carcinoma patients who did not achieve complete response after at least 9 months of progestin therapy. Factors such as history of polycystic ovarian syndrome, histologic grade 2, and failure to achieve partial response within 12 months are associated with failure to achieve complete response.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Julia C. Golz, Kerstin Stingl
Summary: Campylobacter jejuni has a high genetic exchange potential, with natural transformation regulation factors largely unknown. Competence development is influenced by pH and oxygen conditions, but shows some adaptability and occurs in a neutral and microaerobic environment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Business
Francesca Serravalle, Virginia Vannucci, Eleonora Pantano
Summary: This study examines consumers' return behavior in China and Italy, two different cultural contexts. The findings reveal that cultural differences influence consumers' willingness to return at different stages of the purchase process. The study provides theoretical and managerial insights and suggests future research directions.
JOURNAL OF RETAILING AND CONSUMER SERVICES
(2022)
Review
Geriatrics & Gerontology
Faustino R. Perez-Lopez, Juan R. Ulloque-Badaracco, Maria T. Lopez-Baena, Junhua Yuan, Esteban A. Alarcon-Braga, Vicente A. Benites-Zapata
Summary: We conducted a systematic review and meta-analysis to examine the relationship between endometrial telomerase activity and endometrial cancer or hyperplasia. The results indicated a significant association between endometrial telomerase activity and both endometrial cancer and hyperplasia compared to control women. However, there was no significant difference in telomerase activity between endometrial cancer and hyperplasia patients.
Article
Oncology
Dan Kuai, Qingtao Tang, Wenyan Tian, Huiying Zhang
Summary: This study aimed to investigate endometrial hyperplasia (EH) and endometrial endometrioid cancer (EEC) and develop a mathematical model to predict the risk and improve clinical prognosis. Data were collected from young females with abnormal uterine bleeding or abnormal ultrasound endometrial echoes. The predictors included body mass index, polycystic ovary syndrome, anemia, infertility, menostaxis, abnormal uterine bleeding type, and endometrial thickness.
Article
Medicine, General & Internal
M. R. Mirza, D. M. Chase, B. M. Slomovitz, R. dePont Christensen, Z. Novak, D. Black, L. Gilbert, S. Sharma, G. Valabrega, L. M. Landrum, L. C. Hanker, A. Stuckey, I. Boere, M. A. Gold, A. Auranen, B. Pothuri, D. Cibula, C. McCourt, F. Raspagliesi, M. S. Shahin, S. E. Gill, B. J. Monk, J. Buscema, T. J. Herzog, L. J. Copeland, M. Tian, Z. He, S. Stevens, E. Zografos, R. L. Coleman, M. A. Powell
Summary: Dostarlimab plus carboplatin-paclitaxel significantly improved progression-free survival in patients with endometrial cancer, particularly in the mismatch repair-deficient microsatellite instability-high population.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Anna L. Beavis, Batel Blechter, Omar Najjar, Amanda N. Fader, Payam Katebi Kashi, Anne F. Rositch
Summary: This study estimated the prevalence of endometrial hyperplasia and/or cancer (EH/EC) in patients 545 years old with abnormal uterine bleeding (AUB) and identified associated risk factors. The results showed that BMI and polycystic ovarian syndrome (PCOS) were associated with increased risk of EH/EC, while non-Hispanic Black race was associated with decreased risk. The prevalence of EH/EC varied widely depending on combinations of risk factors.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Ayey Madut, Veronika Fuchsova, Hong Man, Shabeel Askar, Ritu Trivedi, Elisabeth Elder, Christine L. Clarke, Gerard Wain, Alison Brand, Anna DeFazio, Terence Amis, Kristina Kairaitis
Summary: This study found a high prevalence of obstructive sleep apnea (OSA) in postmenopausal women with breast cancer (BC) and endometrial cancer (EC), but no significant associations were detected between OSA metrics and specific tumor characteristics.
Article
Medicine, General & Internal
Ryoko Katagiri, Motoki Iwasaki, Sarah Krull Abe, Md. Rashedul Islam, Md. Shafiur Rahman, Eiko Saito, Melissa A. Merritt, Ji-Yeob Choi, Aesun Shin, Norie Sawada, Akiko Tamakoshi, Woon-Puay Koh, Ritsu Sakata, Ichiro Tsuji, Jeongseon Kim, Chisato Nagata, Sue K. Park, Sun-Seog Kweon, Xiao-Ou Shu, Yu-Tang Gao, Shoichiro Tsugane, Takashi Kimura, Jian-Min Yuan, Seiki Kanemura, Yukai Lu, Yumi Sugawara, Keiko Wada, Min-Ho Shin, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang
Summary: This study found that late menarche, early menopause, and a higher number of deliveries were significantly associated with a lower risk of endometrial cancer. These findings from a large pooled study of Asian women add to the growing body of evidence on the association between reproductive factors and endometrial cancer risk.
Article
Obstetrics & Gynecology
Koji Matsuo, Rachel S. Mandelbaum, Shinya Matsuzaki, Maximilian Klar, Lynda D. Roman, Jason D. Wright
Summary: Endometrial cancer remains the most common gynecologic malignancy in the United States, with a majority being low-grade and an increasing incidence among young women. Early-stage, low-grade endometrial cancer generally has a favorable prognosis, and surgical treatment alone can often be curative. Young women should consider ovarian conservation to avoid the risks of surgical menopause.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Oncology
Jia-Li Feng, Suzanne C. Dixon-Suen, Susan J. Jordan, Penelope M. Webb
Summary: The study found that pre-diagnosis statin use was not associated with survival in women with endometrial cancer, but post-diagnosis statin use may improve survival, especially for type 1 cancers, hydrophilic statins, and new statin users after diagnosis.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Giacomo Montagna, Robin Schaffar, Andrea Bordoni, Alessandra Spitale, Daniela A. Terribile, Lorenzo Rossi, Yvan Bergeron, Bernadette W. A. van der Linden, Isabelle Konzelmann, Sabine Rohrmann, Katharina Staehelin, Manuela Maspoli-Conconi, Jean-Luc Bulliard, Francesco Meani, Olivia Pagani, Elisabetta Rapiti
Summary: This study retrospectively evaluated the treatment and outcomes of young women with breast cancer in Switzerland. The majority of patients received treatment according to international guidelines, but there were differences in quality of care across the different linguistic/geographic regions. After adjusting for multiple factors, only tumor characteristics and treatment period were independently associated with survival.
Article
Oncology
Dimitrios Nasioudis, Stefan Gysler, Nawar Latif, Lory Cory, Robert L. Giuntoli II, Sarah H. Kim, Fiona Simpkins, Lainie Martin, Emily M. Ko
Summary: The prevalence of ERBB2 gene amplification was investigated among patients with gynecologic malignancies. The study found that ERBB2 amplification is frequently encountered in uterine serous carcinoma and mucinous ovarian carcinoma, but less common in endometrioid endometrial carcinoma.
GYNECOLOGIC ONCOLOGY
(2024)
