Review
Gastroenterology & Hepatology
Xuan-Ke Ji, Sailaja Vatsalya Madhurapantula, Gui He, Kun-Yan Wang, Chun-Hua Song, Jian-Ying Zhang, Kai-Juan Wang
Summary: Gastric cancer is a leading cause of cancer-related deaths globally, especially in Asia where the incidence is high and the survival rate for advanced cases is low. COX-2 plays a crucial role in inflammatory responses and its genetic variations may affect susceptibility to gastric cancer, calling for further research to explore new therapeutic approaches.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Sang Hyeok Lee, Yoo Bhin Kim, Da-Hye Kim, Dong-Won Lee, Hong-Gu Lee, Rajesh Jha, Kyung-Woo Lee
Summary: The study found that dietary supplementation of flaxseed oil can significantly increase the content of omega-3 polyunsaturated fatty acids in egg yolks without affecting laying performance and egg quality. The addition of flaxseed oil in diets can impact the pH and malondialdehyde contents of egg yolks.
Article
Biochemistry & Molecular Biology
Haiyan Yao, Quanping Guo, Mengran Wang, Rui Wang, Zhaoqing Xu
Summary: A novel class of molecules with a basic structure of pyrazole N-aryl sulfonate was designed and synthesized using a new pyrazole sulfonate synthetic method. Several compounds within this class showed excellent anti-inflammatory and analgesic activities, as well as selective COX-2 inhibitory properties. The LD50 of two compounds in mice were found to be greater than 2000 mg/kg in acute oral toxicity assays conducted in vivo.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
Er-Ying Hao, De-He Wang, Yi-Fan Chen, Rong-Yan Zhou, Hui Chen, Ren-Lu Huang
Summary: This study found that reproductive aging in avian species is related to the mTOR signaling pathway, with different manifestations in the peak and late phases of egg production. The mTOR activity is age-specific, and a compensatory enhancement of the mTOR signaling cascade can regulate ovarian follicular development in aged laying hens.
Article
Oncology
Maeve Kiely, Ginger L. Milne, Tsion Z. Minas, Tiffany H. Dorsey, Wei Tang, Cheryl J. Smith, Francine Baker, Christopher A. Loffredo, Clayton Yates, Michael B. Cook, Stefan Ambs
Summary: The study investigated the association of urinary PGE-M levels with lethal prostate cancer in African American and European American men, finding a significant relationship between high PGE-M and all-cause mortality in African American men with prostate cancer who did not regularly use aspirin. This association disappeared among cases who reported using aspirin, suggesting a potential benefit of aspirin in reducing mortality among African American men with prostate cancer.
Article
Microbiology
Hengyong Xu, Yuxiang Lu, Dan Li, Chaoyang Yan, Yuru Jiang, Zhi Hu, Zhipeng Zhang, Ranran Du, Xiaoling Zhao, Yao Zhang, Yaofu Tian, Qing Zhu, Yiping Liu, Yan Wang
Summary: This study investigated the effects of dietary probiotics supplementation on laying performance, egg quality, serum hormone levels, immunity, antioxidant, and gut microbiota of layers at different laying stages. The results showed that the addition of probiotics improved egg weight, egg quality, ovarian development, hormone levels, antioxidant indices, and decreased proinflammatory factors. Probiotics also influenced the distribution and abundance of different bacterial phyla in the gut microbiota of laying hens at different laying stages. Furthermore, probiotics supplementation enriched important gene clusters related to metabolism, genetic information processing, and decreased the proportion of potential pathogenic bacteria. Overall, adding probiotics enhanced the performance, egg quality, immune function, and gut microbiota of layers, leading to improved production efficiency.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Ioannis P. Brouklogiannis, Evangelos C. Anagnostopoulos, Eirini Griela, Vasileios V. Paraskeuas, Konstantinos C. Mountzouris
Summary: The study aimed to investigate the effects of a phytogenic premix (PP) on the production performance and gene expression in the ovaries of laying hens. The results showed that the inclusion of PP improved laying rate and egg mass, and also had positive effects on the gene expression in the ovaries.
Article
Veterinary Sciences
Ali Hatefi, Ahmad Zare Shahneh, Zarbakht Ansari Pirsaraie, Ali Mohammad Alizadeh, Mohammad Pouya Atashnak, Reza Masoudi, Frederic Pio
Summary: In this study, it was found that in aged laying hens, Salmeterol and Propranolol reduced ovarian inflammation and enhanced laying efficiency by decreasing the expression of pro- and anti-inflammatory mediators, increasing ovulation rate and follicular growth.
BMC VETERINARY RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Weihan Wang, Ruifen Kang, Meiling Liu, Zhong Wang, Lihong Zhao, Jianyun Zhang, Shimeng Huang, Qiugang Ma
Summary: Heat stress is a major threat to the global livestock industry, causing economic losses. Nutritional regulation, especially the supplementation of selenium, can enhance antioxidant capacity and immune response, and alleviate heat stress damage.
Article
Agriculture, Dairy & Animal Science
Vincenzo Tufarelli, Payam Baghban-Kanani, Saba Azimi-Youvalari, Babak Hosseintabar-Ghasemabad, Marina Slozhenkina, Ivan Gorlov, Frolova Maria Viktoronova, Alireza Seidavi, Vito Laudadio
Summary: The study showed that the 15% DTP and 5% DGP dietary treatments had a significant impact on improving egg yolk color, while most of the hens' performance indicators and egg quality parameters were not significantly affected by FSM and DTP supplementation.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Food Science & Technology
Tao Yuan, Junyi Li, Yanan Wang, Meiling Li, Ao Yang, Chenxi Ren, Desheng Qi, Niya Zhang
Summary: This study aimed to investigate the effects of Zearalenone (ZEA) on production performance, egg quality, ovarian function, and gut microbiota of laying hens. The results showed that ZEA had detrimental effects on the production performance, egg quality, and ovarian function of laying hens, and it also altered the composition of gut microbiota.
Article
Agriculture, Dairy & Animal Science
Weizhao He, Hao Wang, Chaohua Tang, Qingyu Zhao, Junmin Zhang
Summary: This study investigated the effects of astaxanthin supplementation on the egg quality, antioxidant capacity, and ovarian aging of aged laying hens. The results showed that astaxanthin improved egg yolk color and Haugh unit, increased the number of follicles in the ovary and reduced atresia. Astaxanthin also enhanced the antioxidant capacity, reduced cellular apoptosis, and improved serum reproductive hormone levels.
Article
Agriculture, Dairy & Animal Science
Kang Bai, Erying Hao, Chen-xuan Huang, Qiao-xian Yue, De-He Wang, Lei Shi, Yi-fan Chen, Hui Chen, Ren-lu Huang
Summary: Oxidative stress can lead to follicular atresia and decrease the quantity of follicles in each developmental stage, thus alleviating reproductive activity. Melatonin has been shown to mitigate oxidative stress in this model, but the underlying mechanism remains unclear.
Review
Biochemistry & Molecular Biology
Neha Nanda, Devinder K. Dhawan
Summary: COX-2 is an inducible enzyme associated with the development and progression of colorectal cancer. Inhibitors of COX-2 can prevent carcinogenesis of CRC, but prolonged use may increase the risk of cardiovascular complications. Further research is needed to identify COX-2 inhibitors with lower risks of such complications.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
Review
Oncology
Zexiong Gong, Weiguo Huang, Baiyun Wang, Na Liang, Songkai Long, Wanjun Li, Qier Zhou
Summary: Tumor-associated inflammation and aberrantly expressed biomarkers play crucial roles in the cancer microenvironment. COX-2, as a prominent inflammatory factor, is highly expressed in tumor cells and contributes to tumor growth, recurrence, and metastasis. Understanding the regulatory role of miRNAs in COX-2 post-transcriptional processes could provide new insights for developing novel COX-2 selective inhibitors based on miRNAs.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Oncology
Dimitrios Nasioudis, Stefan Gysler, Nawar Latif, Lory Cory, Robert L. Giuntoli II, Sarah H. Kim, Fiona Simpkins, Lainie Martin, Emily M. Ko
Summary: The prevalence of ERBB2 gene amplification was investigated among patients with gynecologic malignancies. The study found that ERBB2 amplification is frequently encountered in uterine serous carcinoma and mucinous ovarian carcinoma, but less common in endometrioid endometrial carcinoma.
GYNECOLOGIC ONCOLOGY
(2024)