Article
Urology & Nephrology
Franziska Buescheck, Christoph Fraune, Martina Kluth, Maximilian Lennartz, Ronald Simon, Claudia Hube-Magg, Christian Morlock, Silvano Barbieri, Carolin Wahl, Christian Eichelberg, Christina Moeller-Koop, Doris Hoeflmayer, Corinna Wittmer, Waldemar Wilczak, Guido Sauter, Margit Fisch, Till Eichenauer, Michael Rink
Summary: In summary, the study results identify a non-diploid DNA content as a predictor of unfavorable prognosis in clear cell and papillary carcinoma.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Pediatrics
Dalal Alatawi, Ismail Bakhsh, Soha Tashkandi, Abdullah Alqarni, Abjal Pasha Shaik, Manal Abudawood
Summary: B-cell Acute Lymphoblastic Leukemia is a common cancer in children in Saudi Arabia. This study evaluated the reliability of using fixed samples to accurately diagnose aneuploidy in B-ALL patients. The results showed a strong correlation between the DNA index obtained by flow cytometry and conventional cytogenetic analysis, highlighting the usefulness of the DNA index method in complementing the diagnosis of aneuploidy in B-ALL patients.
Article
Plant Sciences
Rithesh B. Natarajan, Pooja Pathania, Hardeep Singh, Anuradha Agrawal, Rajkumar Subramani
Summary: Genome size variation is an important attribute in evolutionary and species characterization. This study provides reliable information on the genome size and ploidy level of wild Musa species, which could be used in taxonomic and crop improvement programs.
Article
Pathology
Ruth Zhang, Peter S. Rabinovitch, Aras N. Mattis, Gregory Y. Lauwers, Won-Tak Choi
Summary: The majority of gastric intestinal metaplasia samples lack the aneuploidy that characterizes gastric dysplasia or cancer. Presence of gastric intestinal metaplasia alone may not be sufficient to indicate an increased risk for gastric cancer, and other high-risk features should be considered.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Fisheries
Hadiseh Dadras, Miroslav Blecha, Oleksandr Malinovskyi, Martin Flajshans, Ievgen Lebeda, Jiri Kristan, Tomas Policar
Summary: The research successfully induced 100% triploidy in pikeperch through cold temperature shock treatment, showing higher effectiveness and hatching rates.
Article
Agronomy
Cobes Gatarira, Lucia Sladekova, Alzbeta Nemeckova, Denisa Simonikova, Rajneesh Paliwal, Asrat Asfaw, Michael Abberton, Gueye Badara, Robert Asiedu, Jana Cizkova, Eva Hribova, Jaroslav Dolezel, David DeKoeyer, Victor Adetimirin, Ranjana Bhattacharjee
Summary: Yam is a herbaceous vine plant cultivated in the tropics and subtropics, with 11 cultivated species supporting over 300 million people. The study investigated the ploidy levels of 236 accessions, finding that most cultivars were diploid, triploid, or tetraploid, with wild species being diploid. Matching results were obtained from chromosome counting and genotyping-based methods, suggesting potential for successful breeding programs.
Article
Cell Biology
Hannah Lee, Peter S. Rabinovitch, Aras N. Mattis, Gregory Y. Lauwers, Won-Tak Choi
Summary: Analysis of non-conventional morphological patterns of epithelial dysplasia in IBD patients revealed a higher malignant potential and aneuploidy rate compared to conventional dysplasia, especially in CCD, hypermucinous, and GCD variants. These lesions often present as flat/invisible, suggesting a need for more intensive follow-up and treatment.
Article
Oncology
Eric Rios-Doria, Han T. Cun, Olga T. Filippova, Jennifer J. Mueller, Kaled M. Alektiar, Lora H. Ellenson, Vicky Makker, Yulia Lakhman, Mario M. Leitao Jr, Anuja Jhingran, Pamela T. Soliman, Nadeem R. Abu-Rustum
Summary: The study compared the clinical and pathologic characteristics of women with surgica stage I endometrial carcinoma and found that isolated vaginal recurrences can be detected earlier than non-vaginal recurrences, and the surgical approach does not appear to impact recurrence. Adjuvant vaginal brachytherapy carries a 1%-2% risk of isolated vaginal apex recurrence after primary surgery.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Plant Sciences
Xuan Luo, Jin Yang, Zhendong Zhu, Liangjun Huang, Asif Ali, Hafiz Hassan Javed, Wei Zhang, Ying Zhou, Liqin Yin, Peizhou Xu, Xingyu Liang, Yun Li, Jisheng Wang, Qiong Zou, Wanzhuo Gong, Haoran Shi, Lanrong Tao, Zeming Kang, Rong Tang, Hailan Liu, Shaohong Fu
Summary: The study found that the induction of DH individuals in Brassica napus is related to the genetic characteristics and aneuploidy of the parents, as well as the key gene regulation. Flow cytometry and SNP genotyping analysis showed differences between homozygotes and heterozygotes in the F-1 generation. Aneuploidy from allo-octoploid segregation did not significantly increase the DH induction rate, but reduced male infiltration rate and heterozygous site rate of induced F-1 generation.
Article
Oncology
Luning Mao, Jianghua Wu, Zhongjie Zhang, Lijun Mao, Yuejin Dong, Zufeng He, Haiyue Wang, Kaiwen Chi, Yumeng Jiang, Dongmei Lin
Summary: In this study, we evaluated the prognostic value of chromatin structure in early-stage lung cancer patients. We found that non-diploid DNA status and the combination of ploidy and nucleotyping can predict long-term outcomes. Patients with non-diploidy and chromatin homogenous status may benefit from adjuvant therapy.
Article
Oncology
Yan Hu, Qing Yu, Cuiyan Guo, Guangfa Wang
Summary: DNA-ICM can be used as an adjunct method for the detection of lung cancer, and its combination with basic bronchoscopy techniques can significantly increase the sensitivity, especially for patients suspected of peripheral lung cancer.
Article
Agronomy
Natalia Miler, Alicja Tymoszuk, Monika Rewers, Dariusz Kulus
Summary: This study investigates the effect of various chemical and thermal treatments on regeneration efficiency and ploidy level in chrysanthemum. The results show that ovaries have a greater organogenic potential and manipulating factors such as temperature and thidiazuron concentration can enhance regeneration efficiency and induce altered ploidy levels.
Article
Pathology
Naoki Akanuma, Peter S. Rabinovitch, Aras N. Mattis, Gregory Y. Lauwers, Won-Tak Choi
Summary: Fundic gland polyps (FGPs) can develop as a result of genetic factors or after proton pump inhibitor therapy. FGPs with dysplasia are similar to familial adenomatous polyposis (FAP) and often have APC mutations. However, FGPs rarely progress to advanced gastric neoplasia, indicating a limited role in gastric tumorigenesis.
Article
Oncology
Michelle Ertel, S. Allison Staley, Tam Nguyen, Austin Johnson, Austin Hopkins, Nerlyne Desravines, Johnathon Recknagel, Xinyi Zhang, Xianming Tan, Leslie H. Clark
Summary: The study found that the incidence of medical inoperability in clinical stage I endometrial cancer was 4.6%, with factors such as high body mass index, diabetes, coronary artery disease, and hypertension increasing the risk of inoperability. Despite maximal surgical effort and minimally invasive surgery achieving hysterectomy in over 95% of patients, there was a complication rate of 11.6%.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Anne Sophie V. M. van den Heerik, Nanda Horeweg, Carien L. Creutzberg, Remi A. Nout
Summary: Vaginal brachytherapy has become the treatment of choice for high-intermediate risk patients with early-stage endometrial cancer, providing maximal local tumor control and minimal side effects. An integrated risk stratification combining clinicopathologic and molecular factors is now being investigated to guide adjuvant therapy.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Obstetrics & Gynecology
Taejong Song, Min Kyu Kim, Yong Wook Jung, Bo Seong Yun, Seok Ju Seong, Chel Hun Choi, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim, Duk-Soo Bae
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2018)
Article
Oncology
Jung-Yun Lee, Jeong-Yeol Park, Sang Yoon Park, Jeong-Won Lee, Jae Weon Kim, Yong Beom Kim, Dae Hoon Jeong, Kwang-Beom Lee, Tae-Hun Kim, In Ho Lee, Min Chul Choi, Ki Hyung Kim, Yong-Man Kim, Yong Jae Lee, Sokbom Kang, Eric Pujade-Lauraine, So-Jin Shin, Dae Gy Hong, Seung-Hyuk Shim, Yun Hwan Kim, Taejong Song, Jaeman Bae, Jong-Min Lee, San Hui Lee, Eun-Ju Lee, Sang-Il Park, Sung-Jong Lee, Chulmin Lee, Taek Sang Lee, Suk-Joon Chang, Min Kyu Kim
GYNECOLOGIC ONCOLOGY
(2019)
Article
Oncology
Koji Matsuo, James C. Cripe, Katherine C. Kurnit, Michiko Kaneda, Audrey S. Garneau, Gretchen E. Glaser, Aaron Nizam, Rachel M. Schillinger, Michelle L. Kuznicki, Akira Yabuno, Shiori Yanai, Denise M. Garofalo, Jiro Suzuki, Jessica D. St Laurent, Ting-Tai Yen, Annie Y. Liu, Masako Shida, Mamoru Kakuda, Tetsuro Oishi, Shin Nishio, Jenna Z. Marcus, Sosuke Adachi, Tetsuji Kurokawa, Malcolm S. Ross, Max P. Horowitz, Marian S. Johnson, Min K. Kim, Alexander Melamed, Karime K. Machado, Kosuke Yoshihara, Yoshio Yoshida, Takayuki Enomoto, Kimio Ushijima, Shinya Satoh, Yutaka Ueda, Mikio Mikami, Bobbie J. Rimel, Rebecca L. Stone, Whitfield B. Growdon, Aikou Okamoto, Saketh R. Guntupalli, Kosei Hasegawa, Mian M. K. Shahzad, Dwight D. Im, Marina Frimer, Bobbie S. Gostout, Frederick R. Ueland, Shoji Nagao, Pamela T. Soliman, Premal H. Thaker, Jason D. Wright, Lynda D. Roman
GYNECOLOGIC ONCOLOGY
(2019)
Article
Oncology
Min C. Choi, Young S. Chung, Jeong-Won Lee, Byung S. Kwon, Byung K. Park, Se I. Kim, Seung-Hyuk Shim, Kwang-Beom Lee, Seok J. Seong, Sung J. Lee, San H. Lee, Heon-Jong Yoo, Taejong Song, Min K. Kim, Min-Hyun Baek, Sokbom Kang, Yong-Man Kim
EUROPEAN JOURNAL OF CANCER
(2020)
Article
Medical Laboratory Technology
Kuenyoul Park, Min Kyu Kim, Taegeun Lee, Jinyoung Hong, Hyun-Ki Kim, Sunyoung Ahn, Young-Jae Lee, Jisun Kim, Shin-Wha Lee, Jong Won Lee, Woochang Lee, Sail Chun, Byung Ho Son, Kyung Hae Jung, Yong-Man Kim, Won-Ki Min, Sei-Hyun Ahn
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2020)
Article
Oncology
Joseph J. Noh, Min Kyu Kim, Min Chul Choi, Jeong-Won Lee, Hyun Park, Sang Geun Jung, Won Duk Joo, Seung Hun Song, Chan Lee
Summary: This study investigated the frequency of mismatch repair deficiency/high microsatellite instability (MMRd/MSI-H) in gynecologic malignancies and the efficacy of immune checkpoint inhibitors (ICIs) in patients with recurrent gynecologic cancers. The results showed that MMRd/MSI-H is moderately to highly frequent in gynecologic cancers in the Korean population, and MMRd/MSI-H could be effective predictive biomarkers in gynecologic cancers of any type.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Byung Wook Kim, Min Chul Choi, Min Kyu Kim, Jeong-Won Lee, Min Tae Kim, Joseph J. Noh, Hyun Park, Sang Geun Jung, Won Duk Joo, Seung Hun Song, Chan Lee
Summary: To support genome-based precision medicine, machine learning models were developed to predict gynecologic cancer recurrence in patients using immune checkpoint inhibitors based on Lynch syndrome-related screening markers. Following data review and variable identification, the RF-based model showed the best performance in predicting cancer recurrence, with AUCs of 0.818 and 0.826 for different cross-validation methods. This study provides novel insights into predicting gynecologic cancer recurrence in patients using immune checkpoint inhibitors through machine learning methods.
Article
Oncology
Yoo-Na Kim, Min Kyu Kim, Young Joo Lee, Youngeun Lee, Ji Yeon Sohn, Jung-Yun Lee, Min Chul Choi, Migang Kim, Sang Geun Jung, Won Duk Joo, Chan Lee
Summary: This study investigated the prevalence and relative contributions of Lynch Syndrome (LS) and non-LS mutations in Korean patients with endometrial cancer. By analyzing the medical records of 204 patients, it was found that 13% of patients had LS, and patients with LS were more likely to be younger at diagnosis and meet the Amsterdam II criteria. The study also identified a higher prevalence of non-endometrioid histology in patients with MSH6 or PMS2 mutations.
Article
Oncology
Sung Uk Lee, Joo-Young Kim, Min Kyu Kim, Young Seok Kim, Yeon Joo Kim, Keun-Yong Eom, Chan Woo Wee
Summary: This study investigated the current status of postoperative management of uterine endometrial cancer in Korea. The survey results showed that gynecologic cancer surgeons and radiation oncologists had different opinions on adjuvant treatment for advanced stage or unfavorable histology of EC.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Ha Kyun Chang, Seung-Hyuk Shim, Maria Lee, Won Moo Lee, Kyung Jin Eoh, Heon Jong Yoo, Mi Kyung Kim, Min Kyu Kim, Kwang-Beom Lee, Kyeong A. So, Young Tae Kim, Dae Woo Lee, Doo-Yoon Hyun, Jong-Min Lee
Summary: The sociomedical environment is changing, leading to a shift in the traditional authoritative physician-patient relationship. To meet legal requirements, improve patient understanding, and protect medical staff, the Korean Society of Gynecologic Oncology decided to standardize surgical consent forms.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)
Article
Obstetrics & Gynecology
Ha Kyun Chang, Seung-Hyuk Shim, Maria Lee, Won Moo Lee, Kyung Jin Eoh, Heon Jong Yoo, Mi Kyung Kim, Min Kyu Kim, Kwang-Beom Lee, Kyeong A. So, Young Tae Kim, Dae Woo Lee, Doo-Yoon Hyun, Jong-Min Lee
Summary: The sociomedical environment is changing, leading to a shift in the physician-patient relationship towards patient autonomy. To meet legal requirements and improve patient understanding, the Korean Society of Gynecologic Oncology has standardized surgical consent forms, including 16 basic items and figures, aiming to promote trust between patients and physicians.
OBSTETRICS & GYNECOLOGY SCIENCE
(2022)
Article
Oncology
Se Ik Kim, Jeong-Won Lee, Kidong Kim, Maria Lee, Jigeun Yoo, Min Chul Choi, Suhyun Hwangbo, Young Hwa Kwak, Jong-Min Lee, So-Jin Shin, Seung-Hyuk Shim, Min Kyu Kim
Summary: This study compared survival outcomes between bevacizumab (BEV) and olaparib (OLA) maintenance therapy in patients with BRCA-mutated, platinum-sensitive relapsed (PSR) high-grade serous ovarian carcinoma (HGSOC). The results showed that intention-to-treat OLA and actual use of OLA maintenance therapy were significantly associated with decreased disease recurrence risk compared to BEV.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Min Kyu Kim, Min Chul Choi, Myong Cheol Lim, Jae-Weon Kim
Summary: The study revealed a lack of awareness among Korean gynecologic oncologists regarding genetic risk assessment and patient counseling for Lynch syndrome-related endometrial cancer. There is a need for educating physicians and developing guidelines in this area.
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
(2021)
Article
Oncology
Min Chul Choi, Yong-Man Kim, Jeong-Won Lee, Yong Jae Lee, Dong Hoon Suh, Sung Jong Lee, Taek Sang Lee, Maria Lee, Dong Choon Park, Min Kyu Kim, Jong-Min Lee, Seung-Hyuk Shim, Seob Jeon, Kyung Jin Min, Mi Kyung Kim, Bo Wook Kim, Jeong Yeol Park, Byoung-Gie Kim, Dae Yeon Kim, Moon-Hong Kim, Hyun-Soo Kim, Jung-Yun Lee
Meeting Abstract
Oncology
Min Kyu Kim
