Article
Oncology
Federica Inturrisi, Birgit Lissenberg-Witte, Nienke J. Veldhuijzen, Johannes A. Bogaards, Guglielmo Ronco, Chris J. L. M. Meijer, Johannes Berkhof
Summary: The study found that HPV vaccination leads to a significant decline in lifetime CIN3+ risk, with the remaining absolute CIN3+ risk being very low. Even after nonavalent vaccination, primary HPV testing with adjunct cytology at five-year intervals seems feasible.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Medicine, General & Internal
Sarah J. Bowden, Triada Doulgeraki, Emmanouil Bouras, Georgios Markozannes, Antonios Athanasiou, Harriet Grout-Smith, Konstantinos S. Kechagias, Laura Burney Ellis, Verena Zuber, Marc Chadeau-Hyam, James M. Flanagan, Konstantinos K. Tsilidis, Ilkka Kalliala, Maria Kyrgiou
Summary: Persistent HPV infection is necessary but not sufficient for cervical cancer. Behavioral, environmental, or comorbid exposures may affect the development of cervical cancer. However, the validity of the observational studies describing these associations is still unclear.
Article
Oncology
Ryo Ikesu, Ayumi Taguchi, Konan Hara, Kei Kawana, Tetsushi Tsuruga, Jun Tomio, Yutaka Osuga
Summary: Previous studies have shown that individuals with HPV-related cervical lesions have different prognoses according to the HPV genotype, but failed to account for possible diagnostic misclassification. This retrospective study aimed to clarify the natural course of cervical lesions according to HPV genotype and estimate diagnostic misclassification. The study found that lesions in HPV 16-positive patients were more likely to progress to CIN3/cancer compared to lesions in patients with other HPV genotypes.
Article
Medicine, Research & Experimental
Yiran Liu, Shuzhen Wang, Jun Liu, Mingrui Su, Xiaoli Diao, Xiaolong Liang, Jianxin Zhang, Qiuxi Wang, Yuxin Zhan
Summary: Patients with CIN exhibit a distinct vaginal microbial profile characterized by a decrease in Lactobacillus and Pseudomonas, and an increase in Gardnerella, Prevotella, and Dialister. The proliferation and diminution of these two types of microbial communities are interrelated, suggesting a mutual restraint and balance among them. Disruption of this regulatory balance could potentially lead to the onset of cervical lesions and carcinogenesis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Microbiology
Hongyu Xie, Mingjing Wei, Lifang Yao, Yi Liu, Xing Xie, Xiao Li
Summary: This study investigates the relationship between single nucleotide polymorphisms (SNPs) in human papillomavirus (HPV) receptor associated genes and HPV susceptibility and clinical outcomes in Chinese women, and explores a new triaging strategy for non-16/18 high-risk HPV infection.
MICROBIOLOGY SPECTRUM
(2023)
Article
Oncology
Qiaoli Zheng, Xianzhen Chen, Rui Han, Jiang Zhu, Hui Wang, Lingjing Chen, Yinjing Song, Luxia Chen, Hao Cheng, Na Jin
Summary: The HPV58 E7 protein is highly expressed in both cervical cancer and CIN tissues. Combined with p16 and Ki-67 immunohistochemistry, the HPV58 E7 IHC may be sensitive and specific for evaluating HPV-driven cervical cancer and pre-cancerous lesions.
Article
Pathology
Anna D. Iacobone, Fabio Bottari, Maria E. Guerrieri, Ailyn M. Vidal Urbinati, Mariacristina Ghioni, Noemi Spolti, Ida Pino, Rita Passerini, Raffaela C. Di Pace, Dorella Franchi, Eleonora P. Preti
Summary: This study aimed to investigate the prevalence of high-risk HPV-negative CIN2+ cases, with results showing a notable proportion. It suggests that cotesting for HPV would help prevent missing such cases.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Oncology
Huei-Jean Huang, Hsiu-Jung Tung, Lan-Yan Yang, Angel Chao, Yun-Hsin Tang, Hung-Hsueh Chou, Wei-Yang Chang, Ren-Chin Wu, Chu-Chun Huang, Chiao-Yun Lin, Min-Jie Liao, Wei-Chun Chen, Cheng-Tao Lin, Min-Yu Chen, Kuan-Gen Huang, Chin-Jung Wang, Ting-Chang Chang, Chyong-Huey Lai
Summary: This observational study investigated the long-term outcomes and HPV genotype changes after conization for high-grade cervical intraepithelial neoplasia (HG-CIN). Results showed that active surveillance may reduce the severity of progression to cancer, and a majority of patients with recurrent CIN2+ had persistent type-specific HPV infections. Effective therapeutic vaccines for such cases are still needed.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Public, Environmental & Occupational Health
Ting Feng, Bei Cheng, Wenchao Sun, Yuhong Yang
Summary: The spontaneous clearance rate of HR-HPV infection in women with normal or low-grade lesions is 51.5% with a median time to clearance of 14.5 months. Age and initial viral load are independent risk factors affecting the spontaneous clearance of HR-HPV infection in the female genital tract. Intensive screening is recommended for non-young women or those with high viral loads.
Article
Oncology
Baozhu Yi, Qian Xu, Zhixuan Zhang, Jinyi Zhang, Yi Xu, Luoqi Huang, Yue Hu, Quanmei Tu, Jingyun Chen
Summary: This study analyzed the types and distribution of HPV infections in patients with different cervical lesions. The results showed that HPV16, HPV58, and HPV52 were the most common high-risk HPV subtypes in various lesions. For patients with isolated HPV58 infection and normal TCT results, the indications for colposcopy may be relaxed, while for patients with isolated HPV52 infection and normal TCT results, follow-up review and colposcopy may be considered. It may be necessary to develop a more suitable HPV vaccine for the Asian population, such as HPV16/18/52/58, to better protect women's health.
FRONTIERS IN ONCOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Philip E. Castle, Brian Befano, Mark Schiffman, Nicolas Wentzensen, Thomas Lorey, Nancy Poitras, Marianne Hyer, Li C. Cheung
Summary: This study compared the risks of cervical intraepithelial neoplasia grade 2 (CIN2) or more severe diagnoses (CIN2+) between women living with HIV (WLWH) and women not known to have HIV (HIV[-]) following cervical cancer screening. WLWH were more likely to test HPV positive and have abnormal cytology compared to HIV[-] women. The results suggest that both populations could be managed similarly once the screening results are known.
PREVENTIVE MEDICINE
(2022)
Article
Virology
Ian N. Hampson
Summary: Vaccination programs with HPV vaccines have been proven effective in preventing HPV infection and related diseases. Reductions in vaccine-covered HPV types have also been observed in unvaccinated women, but the effects of vaccine-associated HPV type-replacement are still unclear.
Review
Immunology
Violante Di Donato, Giuseppe Caruso, Marco Petrillo, Evangelos Kontopantelis, Innocenza Palaia, Giorgia Perniola, Francesco Plotti, Roberto Angioli, Ludovico Muzii, Pierluigi Benedetti Panici, Giorgio Bogani
Summary: This meta-analysis demonstrated that adjuvant HPV vaccination is associated with a reduced risk of recurrent CIN 1+ and CIN 2+ after surgical treatment, based on the analysis of 11 selected studies.
Article
Immunology
Qianyu Guo, Wei Chen, Junyi Sun, Chunfang Zhao, Xue Bai, Yanan Zhang, Ke Liu, Lei Zhang, Suxia Shao
Summary: The cell wall skeleton of Nocardia rubra (Nr-CWS) has shown effectiveness in treating cervical human papillomavirus infection, possibly by stimulating the host immune system. CD4(+) T cells increase in cervical tissues after Nr-CWS treatment. Nr-CWS induces dendritic cell (DC) maturation and IL-12 secretion, leading to a Th1-type immune response through the activation of FPR3, clarifying the antiviral effects of Nr-CWS on human papillomavirus.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Infectious Diseases
Hong-Fang Zhi, Liu-Feng Yang, Jing Ge, Xuan-Tao Yang
Summary: This study analyzed the status of human papillomavirus (HPV) infections in women in Yunnan, China and their correlation with the grade of cervical intraepithelial neoplasia (CIN). The study found that HPV infection in Yunnan was dominated by single infection and high-risk HPV types. Patients aged 30 to 45 years had a higher incidence of high-grade squamous intraepithelial lesions (HSIL), and the most common high-risk HPV subtypes were HPV16, HPV58, and HPV52.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Engineering, Multidisciplinary
Xiaoyan Wang, Shaopeng Li, Yuanfei Han, Guangfa Huang, Jianwei Mao, Weijie Lu
Summary: TiC crystals are important reinforcements in metal matrix composites, but they can accelerate fatigue crack propagation and lead to premature fracture. To improve performance, reducing TiC content and minimizing crystal size are recommended.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Oncology
Jiajian Wang, Jie Dong, Yinjian Zhou, Kaiyi Wang, Min Pan, Zaixing Deng, Pengfei Wang, Ying Du, Weiguo Lu
Summary: This study aimed to assess the clinical performance of an HPV E6/E7 mRNA assay (Aptima HPV, AHPV) and AHPV 16 18/45 genotype assay (AHPV-GT) combined with age stratification for triaging women with atypical squamous cells of undetermined significance (ASC-US) cytology. The results showed that AHPV testing with age stratification is effective for triaging women with ASC-US cytology, and AHPV-GT testing may be a proper risk stratification method for women with AHPV-positive ASC-US cytology.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Min Wang, Xin Chen, Henglu Zhang, Lanlan Li, Yang Xu, Weiping Lu, Yibing Lu
Summary: This study reveals that ENSMUST00000147869 can inhibit the proliferation and fibrosis of MMCs by regulating Hspa9 and inhibiting its interaction with HMGB1. This finding may provide a molecular marker for diagnosis and a therapeutic target for DN.
Article
Oncology
Jianying Xu, Xuan Rao, Weiguo Lu, Xing Xie, Xinyu Wang, Xiao Li
Summary: This study aimed to identify risk factors for malignant lesions in asymptomatic endometrial polyps (EPs) diagnosed by ultrasound and establish a noninvasive predictor. The study found that abnormal uterine bleeding, large polyps, and blood flow signal in EPs were independent predictive factors for malignancy. A noninvasive predictor combining these factors showed excellent sensitivity and negative predictive value in distinguishing benign and malignant EPs.
FRONTIERS IN ONCOLOGY
(2022)
Article
Microbiology
Yunfeng Fu, Xiao Li, Ying Li, Weiguo Lu, Xing Xie, Xinyu Wang
Summary: This study compares the clinical performance of DH3 HPV assay and HC2 test for cervical cancer screening and finds similar sensitivity and specificity for detecting high-grade lesions between the two tests. DH3 assay has the advantage of providing 92% sensitivity in primary screening strategy.
MICROBIOLOGY SPECTRUM
(2022)
Article
Oncology
Elizabeth Zhang-Velten, You Zhang, Sepeadeh Radpour, Xuejun Gu, D. Nathan Kim, Prasanna Alluri, Chika Nwachukwu, Tsuicheng Chiu, Weiguo Lu, David Parsons, Jun Tan, Jennifer Gillespie, Stella Stevenson, Hak Choy, Robert Timmerman, Asal Rahimi
Summary: The article describes the institutional experience of using GammaPod for breast cancer radiation therapy from 2019 to 2021, including workflow, procedure step times, and techniques for improved efficiency.
PRACTICAL RADIATION ONCOLOGY
(2022)
Article
Peripheral Vascular Disease
Gang Peng, Weiping Lu, Kai Chen, Xiaodan Yang, Jianguo Wei, Bo Wang, Bingcang Huang
Summary: Fourdimensional CT angiography-CT perfusion (4D CTA-CTP)-integrated technology was used to evaluate the cerebral collateral circulation in patients with acute ischemic stroke (AIS). It was found that the mCTA cerebral collateral circulation score can independently predict the neurological prognosis of AIS patients, while the baseline serum S100B protein concentration cannot independently predict the neurological prognosis of AIS patients.
MICROVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Wenying Yang, Dalong Zhu, Shenglian Gan, Xiaolin Dong, Junping Su, Wenhui Li, Hongwei Jiang, Wenjuan Zhao, Minxiu Yao, Weihong Song, Yibing Lu, Xiuzhen Zhang, Huifang Li, Guixia Wang, Wei Qiu, Guoyue Yuan, Jianhua Ma, Wei Li, Ziling Li, Xiaoyue Wang, Jiao'e Zeng, Zhou Yang, Jingdong Liu, Yongqian Liang, Song Lu, Huili Zhang, Hui Liu, Ping Liu, Kuanlu Fan, Xiaozhen Jiang, Yufeng Li, Qing Su, Tao Ning, Huiwen Tan, Zhenmei An, Zhaoshun Jiang, Lijun Liu, Zunhai Zhou, Qiu Zhang, Xuefeng Li, Zhongyan Shan, Yaoming Xue, Hong Mao, Lixin Shi, Shandong Ye, Xiaomei Zhang, Jiao Sun, Ping Li, Tao Yang, Feng Li, Jingna Lin, Zhinong Zhang, Ying Zhao, Ruonan Li, Xiaohui Guo, Qi Yao, Weiping Lu, Shen Qu, Hongmei Li, Liling Tan, Wenbo Wang, Yongli Yao, Daoxiong Chen, Yulan Li, Jialin Gao, Wen Hu, Xiaoqiang Fei, Tianfeng Wu, Song Dong, Wenlong Jin, Chenzhong Li, Dong Zhao, Bo Feng, Yu Zhao, Yi Zhang, Xiaoying Li, Li Chen
Summary: In patients with inadequate glycemic control using metformin alone, dorzagliatin as an add-on therapy resulted in effective glycemic control with good tolerability and safety.
Article
Optics
Hepeng Zhao, Xinchao Zhao, Xuehong Zhang, Zhuangzhuang Cui, Yu Ou-Yang, Maobin Xie, Min Zheng, Xueyu Guan, Lijun Wu, Xinglei Zhou, Lihui Li, Yushuang Zhang, Yang Li, Ying Jiang, Wei Lu, Xiaoli Zhu, Chao Peng, Xiao Wang, Shaowei Wang, Xiujuan Zhuang
Summary: This study demonstrates the realization of a silicon-based vertical cavity surface-emitting laser by controlled preparation of high-gain erbium silicate materials and novel design of high optical feedback microcavity. The laser exhibits a small footprint, high efficiency, and low lasing threshold, making it a potential sub-micrometer coherent light source for optical communication.
Article
Medicine, Research & Experimental
Yixuan Cen, Tingjia Zhu, Yanan Zhang, Lu Zhao, Jiawei Zhu, Lingfang Wang, Junfen Xu, Tian Ding, Xing Xie, Xinyu Wang, Weiguo Lu
Summary: This study identified a downregulated circular RNA (hsa_circ_0005358) derived from the host gene Gli1 in cervical cancer tissues, which suppressed the migration and invasion abilities of cervical cancer cells by interacting with polypyrimidine tract-binding protein 1 (PTBP1), ultimately reducing cancer metastasis.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Biotechnology & Applied Microbiology
Yanyi Lu, Lin Zeng, Min Li, Bowen Yan, Dandan Gao, Bangfu Zhou, Weiping Lu, Qinghua He
Summary: This study explored the possibility of identifying common wound infection bacteria in mixed culture using gas chromatograph-ion migration spectroscopy (GC-IMS). The headspace gas of single and mixed cultures of Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa was analyzed, and specific volatile organic compounds (mVOCs) were obtained. The findings suggest that GC-IMS can be used to identify compound bacteria based on specific mVOCs.
Review
Pharmacology & Pharmacy
Linwei Lu, Qianzhu Xu, Jun Wang, Sunyi Wu, Zimiao Luo, Weiyue Lu
Summary: Drug nanocrystals can enhance the solubility and bioavailability of poorly water-soluble drugs, and active tumor-targeted drug delivery systems can improve the efficacy and safety of chemotherapy.
Article
Engineering, Mechanical
Weiping Lu, Wen Cui, Xiaogang Zhang, Yali Zhang, Shu Yang, Jian Pu, Junyan Li, Zhongmin Jin
Summary: The friction and wear behaviors between cartilage replacement materials and articular cartilage are crucial for the function and performance of the replacements. This study investigated the difference between cross-shear motion and reciprocal linear motion on the frictional and wear behaviors of cartilage, as well as the effect of bearing surface roughness. The results showed that there was no significant difference between the two motion types. The water contact angle of the bearing surface affected the friction and wear behaviors for low roughness implants, while the surface roughness of the material affected the behaviors for high roughness implants. PEEK was found to be a suitable material for osteochondral implants.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART J-JOURNAL OF ENGINEERING TRIBOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qianqian Wu, Mingjing Wei, Lifang Yao, Xiaodong Cheng, Weiguo Lu, Xing Xie, Xiao Li
Summary: Hyperthermia can enhance the sensitivity of epithelial ovarian carcinoma cells with sufficient homologous recombination abilities to PARP inhibitors by impairing homologous recombination efficiency and increasing oxidative stress.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Engineering, Electrical & Electronic
Xin Li, Jian Chen, Jiale He, Jin Chen, Huijun Guo, Liao Yang, Chuan Shen, Feilong Yu, Zengyue Zhao, Guanhai Li, Xiaoshuang Chen, Wei Lu
Summary: This study proposes a collapse breakdown mechanism to explain the relatively low-voltage breakdown in traditional HgCdTe positive-intrinsic-negative structures. The competitive behavior in the breakdown phenomenon is revealed through temperature-change measurements. With optimized structure, high photoelectric gain and low dark current are achieved, and a semi-empirical formula is derived to predict the optimal doping concentrations. Results from literature further confirm the flexibility and universality of the mechanism.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2022)
