Article
Obstetrics & Gynecology
John K. Chan, Chunqiao Tian, Joshua P. Kesterson, Bradley J. Monk, Daniel S. Kapp, Brittany Davidson, Sharon Robertson, Larry J. Copeland, Joan L. Walker, Robert M. Wenham, Yovanni Casablanca, Nick M. Spirtos, Krishnansu S. Tewari, Jeffrey G. Bell
Summary: The study found that over 70% of patients with high-risk early-stage epithelial ovarian cancer present with one or more symptoms, with the most common being abdominal or pelvic pain. The proportion of women with symptoms and the number of symptoms increase with enlarging tumor size.
OBSTETRICS AND GYNECOLOGY
(2022)
Review
Obstetrics & Gynecology
Shayan Dioun, Jenny Wu, Ling Chen, Samantha Kaplan, Yongmei Huang, Alexander Melamed, Allison Gockley, Caryn M. St Clair, June Y. Hou, Ana Tergas, Fady Khoury-Collado, Hiroko Machida, Mikio Mikami, Koji Matsuo, Dawn L. Hershman, Jason D. Wright
Summary: Intraoperative ovarian capsule rupture is associated with decreased progression-free survival and overall survival in women with early-stage ovarian cancer undergoing initial surgical management, as indicated by a systematic review and meta-analysis of high-quality observational studies.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Oncology
Xuting Ran, Xinlin He, Zhengyu Li
Summary: This study evaluated the oncologic outcomes of laparoscopy and laparotomy in the management of early-stage ovarian cancer patients. The results showed that there is no difference in prognosis between laparoscopic and open surgery in women with stage I epithelial ovarian cancer. Laparoscopic treatment is safe and feasible for these patients.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Maria Teresa Climent, Anna Serra, Maria Llueca, Antoni Llueca
Summary: Ovarian cancer has a high mortality rate due to advanced diagnosis and high recurrence rate. Systemic chemotherapy is the standard treatment for recurrent ovarian cancer, but secondary cytoreductive surgery may also be effective. This study analyzed multiple randomized controlled trials and found significant improvements in overall survival and disease-free survival for patients who underwent complete secondary cytoreductive surgery.
Article
Oncology
Ting Deng, Kaijiang Liu, Liang Chen, Xiaojun Chen, Hua Wen Li, Hongyan Guo, Huijiao Zhang, Libing Xiang, Xin Feng, Xiaoyu Wang, Hextan Y. S. Ngan, Jianguo Zhao, Dongling Zou, Qing Liu, Jihong Liu
Summary: The LOVE study aims to compare the efficacy and safety of comprehensive staging surgery with or without lymphadenectomy in early-stage epithelial ovarian cancer and fallopian tube carcinomas. The hypothesis is that comprehensive staging surgery without lymphadenectomy is not inferior to traditional completion staging surgery in terms of oncological outcomes. Both groups of patients will receive standard adjuvant chemotherapy. The primary endpoint of the study is disease-free survival.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Medicine, General & Internal
Su Hyun Chae, Chulmin Lee, Sang-Hee Yoon, Seung-Hyuk Shim, Sun Joo Lee, Soo-Nyung Kim, Sochung Chung, Ji Young Lee
Summary: This study retrospectively analyzed data from 82 patients with early-stage ovarian cancer and found that sarcopenia can serve as a predictive prognostic factor for survival outcome in these patients. Further prospective studies with larger sample sizes are needed to confirm the extent to which sarcopenia can be used as a prognostic factor in ovarian cancer.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Oncology
Berta Diaz-Feijoo, Vicente Bebia, Alicia Hernandez, Juan Gilabert-Estalles, Silvia Franco-Camps, Javier de la Torre, Jaime Segrist, Anca Chipirliu, Silvia Cabrera, Assumpcio Perez-Benavente, Antonio Gil-Moreno
Summary: The study found no differences in surgical complications and oncological outcomes between the extraperitoneal and transperitoneal approaches, although more aortic nodes were retrieved with the extraperitoneal approach. The choice between the two laparoscopic routes ultimately depends on the surgeon's preference.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Nicolo Bizzarri, Luigi Pedone Anchora, Ali Kucukmetin, Nithya Ratnavelu, Porfyrios Korompelis, Camilla Fedele, Matteo Bruno, Giacomo Lorenzo Maria Di Fiore, Anna Fagotti, Francesco Fanfani, Giovanni Scambia, Gabriella Ferrandina
Summary: This study found that for early-stage cervical cancer patients, undergoing ovarian conservation surgery was associated with a lower risk of recurrence and fewer menopausal symptoms compared to oophorectomy. Therefore, considering the relatively low risk of ovarian metastasis and recurrence, ovarian conservation should be considered for pre-menopausal women.
Article
Reproductive Biology
Ozer Birge, Mehmet Sait Bakir, Selen Dogan, Hasan Aykut Tuncer, Tayup Simsek
Summary: The study evaluated the long-term outcomes of fertility-sparing surgery in patients with early stage ovarian cancer. The results suggest that fertility-sparing surgery has a positive impact on the prognosis of early stage ovarian cancer.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Oncology
Yuan Li, Jiashan Ding, Huimin Zheng, Lijiang Xu, Weiru Li, Minshan Zhu, Xiaolu Zhang, Cong Ma, Fangying Zhang, Peiwen Zhong, Dong Liang, Yubin Han, Siyou Zhang, Linsheng He, Jiaqi Li
Summary: For early-stage EOC and HGSOC, the study found that an appropriate number of examined lymph nodes is crucial for avoiding stage migration and improving survival outcomes.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Ting Deng, Qidan Huang, Ting Wan, Xiaoling Luo, Yanling Feng, He Huang, Jihong Liu
Summary: In patients with early-stage ovarian cancer, lymph node dissection did not show association with overall survival or progression-free survival, but was linked to a higher incidence of perioperative adverse events.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Valentina Ghirardi, Francesca De Felice, Andrea Rosati, Raffaella Ergasti, Salvatore Gueli Alletti, Floriana Mascilini, Giovanni Scambia, Anna Fagotti
Summary: This study aimed to identify the risk factors associated with tumor spillage during minimally invasive surgery (MIS) for early-stage ovarian cancer (OC) and develop a scoring system to estimate the risk of tumor rupture. The study found that larger tumor diameter and adhesions to the ovarian fossa peritoneum were independently associated with intraoperative cancer spillage. Additionally, there was a difference in disease-free survival between the rupture group and the non-rupture group.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2022)
Article
Oncology
Shambhavi Singh, Matthew D. Sutcliffe, Kathy Repich, Kristen A. Atkins, Jennifer A. Harvey, Kevin A. Janes
Summary: By combining stochastic profiling with 10-cell RNA sequencing, researchers identified a recurrent set of genes in luminal breast carcinoma cells, suggesting potential activation of pathways seen in other types of cancer.
Article
Oncology
Shen Yan, Yucun Liu, Guowei Chen, Yanpeng Yang
Summary: Despite advances in rectal cancer treatments, the rate of local recurrence remains relatively high, and there is currently no clear definition for early recurrence. This study aimed to establish a threshold to differentiate early and late recurrence, and analyze the risk and prognostic factors associated with them. The results showed that adjuvant radiotherapy was a protective factor for early recurrence, while factors such as lymphovascular invasion, positive surgical margin, and lack of re-neoadjuvant radiotherapy were associated with poorer survival in patients who required additional surgery.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Obstetrics & Gynecology
Elizabeth Suh-Burgmann, Natasha Brasic, Priyanka Jha, Yun-Yi Hung, Ruth B. Goldstein
Summary: This study aimed to evaluate the ultrasound findings associated with clinically detected early-stage high-grade serous ovarian cancer. Early-stage high-grade serous cancers rarely presented as masses of <5 cm or masses without solid components other than septations.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Oncology
Dimitrios Nasioudis, Stefan Gysler, Nawar Latif, Lory Cory, Robert L. Giuntoli II, Sarah H. Kim, Fiona Simpkins, Lainie Martin, Emily M. Ko
Summary: The prevalence of ERBB2 gene amplification was investigated among patients with gynecologic malignancies. The study found that ERBB2 amplification is frequently encountered in uterine serous carcinoma and mucinous ovarian carcinoma, but less common in endometrioid endometrial carcinoma.
GYNECOLOGIC ONCOLOGY
(2024)