Article
Pediatrics
Nidhi Prakash, Renu Suthar, Bhupendra Kumar Sihag, Uma Debi, Rohit Manoj Kumar, Naveen Sankhyan
Summary: This study compared cardiac MRI (CMRI) with transthoracic echocardiography (TTE) for the diagnosis of cardiomyopathy in early ambulatory boys with Duchenne muscular dystrophy (DMD). The results showed that CMRI detected a higher percentage of early features of DMD-related cardiomyopathy compared to echocardiography.
FRONTIERS IN PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Daria De Giorgio, Deborah Novelli, Francesca Motta, Marianna Cerrato, Davide Olivari, Annasimon Salama, Francesca Fumagalli, Roberto Latini, Lidia Staszewsky, Luca Crippa, Christian Steinkuhler, Simonetta Andrea Licandro
Summary: Duchenne muscular dystrophy (DMD) is a common hereditary disease characterized by muscle degeneration. This study focused on D2-mdx mice as a model for DMD cardiomyopathy. The researchers found mild to moderate left ventricle remodeling, increased pulmonary vascular resistance, and prominent epicardial fibrosis in the right ventricle of these mice. The study highlights the need for further long-term investigation to determine if this model accurately represents DMD cardiomyopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Lorraine James, Jondavid Menteer, Lilith C. Moss, Ramon Durazo-Arvizu, John C. Wood, Leigh Ramos-Platt, Emmanuelle Tiongson, Jennifer A. Su
Summary: Dilated cardiomyopathy (DCM) is a common complication of Duchenne muscular dystrophy (DMD), and late gadolinium enhancement (LGE) on cardiac MRI indicates myocyte death and remodeling in DMD-related DCM. This retrospective study found that DMD patients with early LGE demonstrated a faster decline in left ventricular (LV) fractional shortening and received earlier medication therapy, suggesting aggressive clinical management based on abnormal MRI findings. Early onset of myocardial fibrosis, observed in approximately 34% of DMD patients before adolescence, may guide medical therapy and early counseling about cardiomyopathy progression.
PEDIATRIC CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Elisa Silvetti, Oreste Lanza, Fabiana Romeo, Annamaria Martino, Elisa Fedele, Chiara Lanzillo, Cinzia Crescenzi, Francesca Fanisio, Leonardo Calo
Summary: Cardiomyopathies are a group of diseases that affect the structure and function of the heart. Electrocardiogram (ECG) is a useful tool for diagnosing both symptomatic and asymptomatic individuals. Certain ECG findings, like inverted T waves in specific leads or low voltages, can be indicative of specific cardiomyopathies. Other non-specific findings, such as QRS fragmentation or changes in repolarization, can raise clinical suspicion and guide further imaging for a definitive diagnosis. These ECG alterations have prognostic value and can help in risk stratification. This review emphasizes the importance of ECG in the diagnostic workup of different cardiomyopathies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Sport Sciences
Laurent Chevalier, Hubert Cochet, Saagar Mahida, Sylvain Blanchard, Antoine Benard, Tanguy Cariou, Soumaya Sridi-Cheniti, Samy Benhenda, Stephane Doutreleau, Stephane Cade, Sylvain Guerard, Jean-Michel Guy, Pascale Trimoulet, Stephane Picard, Bernard Dusfour, Aurelie Pouzet, Stephanie Roseng, Marco Franchi, Pierre Jais, Isabelle Pellegrin
Summary: This prospective study aimed to characterize the cardiovascular sequelae of asymptomatic/mildly symptomatic COVID-19 among high/elite-level athletes. The findings showed that asymptomatic COVID-19 athletes had normal ECG and echocardiogram results, similar to the control group. There were no significant changes in troponin I and CRP values before and after the infection, but D-Dimer values increased after the infection. The study suggests that systematic cardiac assessment prior to resumption of training may not be necessary for asymptomatic COVID-19 athletes.
SPORTS MEDICINE-OPEN
(2022)
Review
Cardiac & Cardiovascular Systems
Alison L. Wand, Jonathan Chrispin, Elie Saad, Monica Mukherjee, Allison G. Hays, Nisha A. Gilotra
Summary: Cardiac sarcoidosis is a recognized cause of heart failure and arrhythmia. Diagnosing this condition has been historically challenging, but advancements in cardiac imaging have improved diagnostic capabilities. Echocardiography, cardiac magnetic resonance imaging, and F-18-fluorodeoxyglucose positron emission tomography are important tools for diagnosing and managing cardiac sarcoidosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Computer Science, Information Systems
Kasra Nezamabadi, Jacob Mayfield, Pengyuan Li, Gabriela Greenland, Sebastian Rodriguez, Bahadir Simsek, Parvin Mousavi, Hagit Shatkay, M. Roselle Abraham
Summary: This study developed a segmentation method that effectively identifies ECG waves in patients with hypertrophic cardiomyopathy, outperforming previous segmentation methods and demonstrating good performance in normal ECGs.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Marie Vincenti, Charlotte Farah, Pascal Amedro, Valerie Scheuermann, Alain Lacampagne, Olivier Cazorla
Summary: This study used 2D strain echocardiography to detect early cardiac dysfunction in mdx mouse model of Duchenne muscular dystrophy and investigated the preventive effects of a RyR2 stabilizer. The results showed significant decline in LV strains in mdx mice starting at 9 months of age, with segmental alterations in specific LV regions. Early administration of RyR2 stabilizer was effective in preventing these alterations.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Rui Zhang, Fan Zhao, Jing Wang, Yahong Qin, Tingting Wang, Ai-Ai Chu
Summary: Hypertrophic cardiomyopathy is a genetic heart disease, and left ventricular apical aneurysm is a rare subtype. Echocardiography-guided percutaneous intra-myocardial septal radiofrequency ablation can be an effective treatment for obstructive hypertrophic cardiomyopathy with left ventricular apical aneurysm.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Keke Wang, Pengfei Han, Lu Huang, Ying Xiao, Jianglong Hou, Pingliang Yang, Yuping Xie, Jindan Cai, Hongge Wang, Y. James Kang
Summary: This study critically evaluated a monkey model of myocardial ischemic infarction and developed a procedure for consistent results.
CARDIOVASCULAR TOXICOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Jayson R. Baman, James L. Cox, Patrick M. McCarthy, Daniel Kim, Ravi B. Patel, Rod S. Passman, Jane E. Wilcox
Summary: The article discusses the definition, classification, complex relationship with clinical atrial fibrillation (AF), imaging modalities, and clinical implications of atrial cardiomyopathies (ACM). It proposes a more unified approach to ACM recognition to drive further research in this complex field.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Haneen Ismail, Andrew J. J. Bradley, Jannet F. F. Lewis
Summary: This review examines the role of cardiac imaging, including echocardiography, cardiac MRI, and cardiac CT, in evaluating and managing pregnant women with valvular diseases, hypertrophic cardiomyopathy, and aortic pathology.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sarah A. M. Cuddy, Yesh Datar, Gavin Ovsak, Sunil Saith, Sean P. Murphy, Camden P. Bay, Mia Haddad, Brian Lilleness, Varsha Muralidhar, Alexandra Pipilas, Jacqueline Vuong, Eric Guardino, Mathew S. Maurer, Frederick L. Ruberg, Rodney H. Falk, Sharmila Dorbala
Summary: This study aimed to compare the diagnostic accuracy of different echocardiographic parameters in predicting transthyretin cardiac amyloidosis (ATTR-CM). The results showed that inferolateral wall thickness and average basal LS performed as well as or better than more complex echo ratios and multiparametric scores to predict ATTR-CM.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Clinical Neurology
Russell J. Butterfield, Sergey Kirkov, Kristin M. Conway, Nicholas Johnson, Dennis Matthews, Han Phan, Bo Cai, Pangaja Paramsothy, Shiny Thomas, Marcia L. Feldkamp
Summary: This study found no association between corticosteroid use after LOA and the onset of abnormal LV function, but a significant association with a delay in the onset of abnormal ppFVC.
Review
Clinical Neurology
Theodora Markati, Maryam Oskoui, Michelle A. Farrar, Tina Duong, Nathalie Goemans, Laurent Servais
Summary: Duchenne muscular dystrophy is a complex disease with various potential treatments, but glucocorticoids remain the only treatment that has been proven to slow disease progression. Other compounds are still awaiting further efficacy results. The rarity and variability of Duchenne muscular dystrophy pose challenges for clinical development.
Article
Oncology
Vanessa Sitte, Barbara Burkhardt, Roland Weber, Oliver Kretschmar, Martin Hersberger, Eva Bergstrasser, Martin Christmann
Summary: This study aimed to evaluate sensitive parameters for cardiac damage in childhood cancer survivors. The results showed that strain imaging and new cardiac biomarkers in HFpEF were more sensitive than standard echo and laboratory parameters.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Doris Skoric-Milosavljevic, Rafik Tadros, Fernanda M. Bosada, Federico Tessadori, Jan Hendrik van Weerd, Odilia Woudstra, Fleur V. Y. Tjong, Najim Lahrouchi, Fanny Bajolle, Heather J. Cordell, A. J. Agopian, Gillian M. Blue, Daniela Q. C. M. Barge-Schaapveld, Marc Gewillig, Christoph Preuss, Elisabeth M. Lodder, Phil Barnett, Aho Ilgun, Leander Beekman, Karel van Duijvenboden, Regina Bokenkamp, Martina Muller-Nurasyid, Hubert W. Vliegen, Thelma C. Konings, Joost P. van Melle, Arie P. J. van Dijk, Roland R. J. van Kimmenade, Jolien W. Roos-Hesselink, Gertjan Sieswerda, Folkert Meijboom, Hashim Abdul-Khaliq, Felix Berger, Sven Dittrich, Marc-Phillip Hitz, Julia Moosmann, Frank-Thomas Riede, Stephan Schubert, Pilar Galan, Mark Lathrop, Hans Markus Munter, Ammar Al-Chalabi, Christopher E. Shaw, Pamela J. Shaw, Karen E. Morrison, Jan H. Veldink, Leonard H. van den Berg, Sylvia Evans, Marcelo A. Nobrega, Ivy Aneas, Milena Radivojkov-Blagojevic, Thomas Meitinger, Erwin Oechslin, Tapas Mondal, M. Lynn Bergin, John F. Smythe, Luis Altamirano-Diaz, Jane Lougheed, Berto J. Bouma, Marie A. Chaix, Jennie Kline, Anne S. Bassett, Gregor Andelfinger, Roel L. F. van der Palen, Patrice Bouvagnet, Sally-Ann B. Clur, Jeroen Breckpot, Wilhelmina S. Kerstjens-Frederikse, David S. Winlaw, Ulrike M. M. Bauer, Seema Mital, Elizabeth Goldmuntz, Bernard Keavney, Damien Bonnet, Barbara J. Mulder, Michael W. T. Tanck, Jeroen Bakkers, Vincent M. Christoffels, Cornelis J. Boogerd, Alex Postma, Connie R. Bezzina
Summary: This study reveals the genetic mechanism of dextro-transposition of the great arteries (D-TGA), identifies a susceptibility locus near the WNT5A gene, and confirms the role of WNT5A in D-TGA. The findings provide important insights for the treatment of D-TGA.
CIRCULATION RESEARCH
(2022)
Article
Physiology
Kathrin Rottermann, Annika Weigelt, Tim Staebler, Benedikt Ehrlich, Sven Dittrich, Isabelle Schoeffl
Summary: This study compares the results of a mobile device-based outdoor running test with a treadmill test. The results show that the outdoor test is significantly shorter in duration and yields higher values for almost all cardiopulmonary variables. Testing very young children with a mobile device is a new alternative that allows for individualized and standardized exercise testing.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Pediatrics
Tim Stabler, Annika Weigelt, Kathrin Rottermann, Wolfgang Waellisch, Matthias Huebner, Sven Dittrich, Isabelle Schoeffl
Summary: The closure of sports facilities and schools during the lockdown has led to a significant decline in cardiopulmonary function in children with congenital heart disease. However, healthy children have seen improvements in their pulmonary function during confinement.
KLINISCHE PADIATRIE
(2023)
Article
Cardiac & Cardiovascular Systems
Frank Muench, Nicola Kwapil, Andreas Teske, Andre Rueffer, Sven Dittrich, Tilmann Volk, Ariawan Purbojo
Summary: Optimal myocardial protection is crucial for a successful outcome in heart surgery. However, strategies used in adult cardiac surgery cannot be directly applied to infant hearts. A concentration-dependent paediatric microplegia, which provides safe myocardial protection without haemodilution, has been introduced in clinical practice.
Article
Health Care Sciences & Services
Marko Klais, Ulrike Doll, Ariawan Purbojo, Sven Dittrich, Kathrin Rottermann
Summary: The study focuses on the implementation of the first tele-medical network for pediatric cardiology in Germany, analyzing the feasibility and technical characteristics. The data communication of the network showed that diagnostic data were mostly transmitted, while discharge letters were predominantly sent. The study also emphasized the successful utilization of the network in providing innovative patient care, especially in complex cases.
JOURNAL OF TELEMEDICINE AND TELECARE
(2023)
Article
Cardiac & Cardiovascular Systems
Jeffrey P. Jacobs, Thomas Krasemann, Claudia Herbst, Zdzislaw Tobota, Bohdan Maruszewski, Jose Fragata, Tjark Ebels, Vladimiro L. Vida, Ilkka Mattila, Andrzej Kansy, Boulos Asfour, Juergen Hoerer, Attilio A. Lotto, M. Sertac Cicek, Petru Liuba, Sven Dittrich, Massimo Chessa, Regina Bokenkamp, Gurleen Sharland, Katarina Hanseus, Nico A. Blom, George E. Sarris
Summary: The European Congenital Heart Surgeons Association (ECHSA) Congenital Database is the second largest clinical pediatric and congenital cardiac surgical database in the world. In order to bridge the gap between surgical and interventional cardiology data, the ECHSA has collaborated with The Association for European Paediatric and Congenital Cardiology to expand the database and capture data about interventional cardiology procedures. This new module aims to provide centers with access to their own outcome data as well as national and international aggregate data for benchmarking, and facilitate comparison between surgical and catheter interventional outcomes.
CARDIOLOGY IN THE YOUNG
(2023)
Article
Medicine, General & Internal
Christoph Treutlein, Martin Georg Zeilinger, Sven Dittrich, Jan-Peter Roth, Matthias Wetzl, Rafael Heiss, Wolfgang Wuest, Matthias Stefan May, Michael Uder, Oliver Rompel
Summary: The purpose of this study was to compare right ventricular functional parameters in children with surgically repaired congenital heart disease using real-time compressed sensing cardiac magnetic resonance imaging (cMRI). The results showed that using real-time compressed sensing cMRI provided high-quality images with reduced scan time.
Article
Cardiac & Cardiovascular Systems
Jeffrey P. Jacobs, Thomas Krasemann, Claudia Herbst, Zdzislaw Tobota, Bohdan Maruszewski, Jose Fragata, Tjark Ebels, Vladimiro L. Vida, Ilkka Mattila, Andrzej Kansy, Boulos Asfour, Juergen Hoerer, Attilio A. Lotto, M. Sertac Cicek, Petru Liuba, Sven Dittrich, Massimo Chessa, Regina Bokenkamp, Gurleen Sharland, Katarina Hanseus, Nico A. Blom, George E. Sarris
Summary: The ECHSA Congenital Database is the largest database for pediatric and congenital cardiac surgical data in Europe, filling a gap in the capability to analyze outcomes for surgical and interventional cardiology procedures at an international level. The new AEPC Interventional Cardiology Part of the ECHSA-CD aims to capture data about interventional cardiology procedures and provide robust outcome data for benchmarking and decision-making.
WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY
(2023)
Article
Pediatrics
Annika Weigelt, Steffen Bleck, Matthias Jens Huebner, Kathrin Rottermann, Wolfgang Waellisch, Patrick Morhart, Tariq Abu-Tair, Sven Dittrich, Isabelle Schoeffl
Summary: Pulmonary function is reduced in children after preterm birth, regardless of the presence of bronchopulmonary dysplasia and mechanical ventilation history. However, the impact on cardiopulmonary function in these children is unclear. This study found that moderate to late premature birth did not lead to limitations in cardiopulmonary function in comparison with term-born controls.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Cardiac & Cardiovascular Systems
Nicola Kwapil, Andreas Teske, Sven Dittrich, Robert Blumauer, Michela Cuomo, Ariawan Purbojo, Frank Muench
Summary: This study presents the implementation of a novel minimized hemodiafiltration (HDF) system in pediatric patients on ECMO, which allows safe patient volume management and effective elimination of urinary substances.
THORACIC AND CARDIOVASCULAR SURGEON
(2023)
Article
Cardiac & Cardiovascular Systems
Jonas Markus Kleinoeder, Ariawan Purbojo, Robert Blumauer, Michela Cuomo, Muhannad Alkassar, Sven Dittrich, Robert Cesnjevar
Summary: The long-term outcome and freedom from PVR after initial repair of TOF were evaluated in this study. The results showed that TOF repair has a beneficial long-term prognosis with low morbidity and mortality, but certain factors are associated with earlier reoperation.
THORACIC AND CARDIOVASCULAR SURGEON
(2022)
Article
Cardiac & Cardiovascular Systems
Julia Moosmann, Christian Schroeder, Oliver Rompel, Ariawan Purbojo, Sven Dittrich
Summary: This study illustrates the dynamics of thoracic and abdominal lymphatic abnormalities after Fontan through T2-weighted imaging. Fontan patients did not demonstrate significant changes in their lymphatic perfusion, despite clinical or hemodynamic changes.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Dietmar Boethig, Murat Avsar, Ulrike M. M. Bauer, Samir Sarikouch, Philipp Beerbaum, Felix Berger, Robert Cesnjevar, Ingo Daehnert, Sven Dittrich, Peter Ewert, Axel Haverich, Juergen Hoerer, Martin Kostelka, Joachim Photiadis, Eugen Sandica, Stephan Schubert, Aleksandra Urban, Dmitry Bobylev, Alexander Horke
Summary: This study evaluated the performance and durability of pulmonary valve replacement procedures in Germany, including both transcatheter and surgical valve replacements. The results showed that transcatheter valves had equivalent performance to surgical valves and extended durability. Different types of valves had different levels of durability, with homografts performing the best and Matrix P-valves performing the worst. The interval between procedures shortened significantly in most age groups below 40 years.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Johannes Weichsel, Benito Baldauf, Hendrik Bonnemeier, Ernest W. Lau, Sven Dittrich, Robert Cesnjevar
Summary: Ventricular assist devices (VADs) are commonly used to provide mechanical circulatory support for patients with end-stage heart failure. However, driveline infection remains a major challenge in VAD therapy. This study presents a novel treatment approach using a taurolidine-containing antimicrobial solution, which has shown successful eradication of VAD driveline infection and provides a potential alternative to device explantation.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
