Article
Peripheral Vascular Disease
Shuhan Jiang, Wei Zhang, Qing Cao, Maryam Rahbar, William Cooke, Masayuki Ono, Kenichi Fujimaki, Atsushi Saito, Makoto Itonaga, Kenta Oda, Christopher Redman, Manu Vatish
Summary: The ExoCounter assay developed in this study can detect small placental extracellular vesicles in the plasma of pregnant women at high risk of developing preeclampsia, providing an opportunity for early intervention.
Article
Peripheral Vascular Disease
Francesca Gaccioli, Ulla Sovio, Sungsam Gong, Emma Cook, D. Stephen Charnock-Jones, Gordon C. S. Smith
Summary: This study aimed to investigate the relationship between protein levels of sFLT1 and PlGF in maternal serum and placental tissue lysates. The findings showed that the sFLT1:PlGF ratio is increased in both preeclampsia and FGR, but in preeclampsia, it is primarily driven by increased placental sFLT1 levels, while in FGR, it is primarily driven by decreased placental PlGF levels.
Article
Peripheral Vascular Disease
Amrita A. Khaire, Shivani R. Thakar, Girija N. Wagh, Sadhana R. Joshi
Summary: Women with preeclampsia show abnormal placental lipid metabolism, with higher lipid : lipoprotein ratios, particularly in those delivering preterm. Moreover, lower expression of genes involved in placental fatty acid oxidation and transport was observed in preeclampsia.
JOURNAL OF HYPERTENSION
(2021)
Article
Developmental Biology
Magdi M. Salih, Lobna E. Ali, Emad M. Eed, Ahmed Abu Siniyeh
Summary: The study found significant structural differences in the chorion and chorionic villi vessels of patients with preeclampsia compared to normotensive women, without significant differences in lumen area. Future research should focus on morphological events throughout pregnancy, including associations between arterial elastic properties and structural proteins in hypertensive patients.
Review
Medicine, General & Internal
Teresa M. MacDonald, Susan P. Walker, Natalie J. Hannan, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: Preeclampsia is a pregnancy-specific disease that has a significant impact on maternal and perinatal morbidity and mortality worldwide. Currently, there are limited options for predicting and diagnosing preeclampsia, and further research is needed to identify effective tests and biomarkers.
Review
Biochemistry & Molecular Biology
Mingyu Hu, Ji Li, Philip N. Baker, Chao Tong
Summary: Preeclampsia is a major threat to the health of mothers and newborns worldwide, primarily due to placental metabolic abnormalities leading to placental dysfunction.
Review
Environmental Sciences
Miaoliang Wu, Fuhui Yan, Qian Liu, Ganzhong Liao, Yilin Shen, Zhi Bai, Xiaoshan Liu
Summary: Preeclampsia (PE) is a disease that occurs after 20 weeks of pregnancy and is characterized by new onset hypertension and albuminuria or other end-organ damage. It is a major complication of pregnancy that can increase morbidity and mortality in pregnant women and fetuses, causing significant social burden. Recent research suggests that exposure to environmental xenobiotic compounds, particularly endocrine disruptors, may contribute to the development of PE. However, the specific mechanisms underlying this relationship remain unclear. This paper reviews the role and potential mechanism of PE induced by exogenous chemicals and provides an outlook on the environmental etiology of PE.
Review
Cell Biology
Megan A. Opichka, Matthew W. Rappelt, David D. Gutterman, Justin L. Grobe, Jennifer J. McIntosh
Summary: Preeclampsia is a life-threatening cardiovascular disorder associated with pregnancy, potentially caused by dysfunction in maternal and placental blood vessels and other factors. Current gaps in knowledge include detailed understanding of its underlying causes and effective treatment options.
Article
Surgery
Wangxiang Chen, Yan Guo, Xia Yao, Di Zhao
Summary: This study aimed to investigate the changes of blood lipid and serum inflammatory factors in pregnant women with hypetensive disorder complicating pregnancy (HDP) and their relationship with disease development. The results showed that the levels of blood lipid and serum inflammatory factors were closely related to the severity of HDP and had predictive value for HDP occurrence and development.
FRONTIERS IN SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Yu Yang, Lan Wu, Yan Lv, Zhijing Miao, Yuchuan Wang, Jun Yan, Jingyun Li, Chanjuan Li, Hongjuan Ding
Summary: This study aimed to use lipidomics to provide evidence for the etiology and potential therapeutic approaches for late-onset preeclampsia (LOPE). The findings revealed that the abundance of unsaturated triglycerides increased in LOPE patients, and other lipids such as phosphatidylcholine, sphingomyelin, and phosphatidylserine also increased. Lipidomics may help identify the pathogenesis underlying placental dysfunction in LOPE patients and provide potential therapeutic targets in the future.
Article
Cell Biology
Xiaotong Yang, Paula A. Benny, Elorri Cervera-Marzal, Biyu Wu, Cameron B. Lassiter, Joshua Astern, Lana X. Garmire
Summary: Variations in telomere length have been linked to aging, stress, and diseases. This study investigated the association between placental telomere length and preeclampsia. The results suggest that placental telomere length is not significantly different between severe preeclampsia cases and healthy controls, but it is negatively correlated with gestational age and influenced by race.
Article
Cell Biology
Leonardo Ermini, Abby Farrell, Sruthi Alahari, Jonathan Ausman, Chanho Park, Julien Sallais, Megan Melland-Smith, Tyler Porter, Michael Edson, Ori Nevo, Michael Litvack, Martin Post, Isabella Caniggia
Summary: Aberrant ceramide build-up in preeclampsia leads to exuberant autophagy-mediated trophoblast cell death. Lysosome formation is markedly increased in trophoblast cells of early-onset preeclamptic placentae, accompanied by augmented levels of transcription factor EB. Ceramide-induced lysosomal biogenesis and exocytosis contribute to maternal endothelial dysfunction in preeclampsia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Peng Xu, Yeling Ma, Hongyu Wu, Yan-Ling Wang
Summary: Disorders in placental cells are closely associated with adverse pregnancy outcomes, and microRNAs in the placenta play important roles in regulating placental cell behaviors. Placental exosome miRNAs can potentially target maternal cells for intercellular communication between the mother and fetus, serving as novel biomarkers for predicting diseases such as preeclampsia. The transfer of placental miRNAs through exosomes may offer targeted strategies for diagnosing, prognosing, or treating preeclampsia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jing Long, Yan Huang, Zhengshan Tang, Yali Shan, Dou Feng, Wenqin Wang, Juan Liu, Ying Huang, Hang Gu, Dewei Guo, Ruojin Yao, Xin Ni
Summary: This study demonstrates that dysfunction of placental 11 beta-hydroxysteroid dehydrogenase type 2 (11β-HSD2) contributes to the development of preeclampsia (PE) by causing mitochondrial dysfunction and mtDNA instability. These abnormalities impair trophoblast function and lead to the development of PE. The study also identifies excess ROS as a potential therapeutic target for treating PE.
Article
Multidisciplinary Sciences
Xinrui Wu, Qi Li, Jiawang Cai, Houxiang Huang, Shujuan Ma, Hongzhuan Tan
Summary: This study investigated the longitudinal changes of gut microbiota in hypertensive disorders in pregnancy (HDP) patients, identified differential microbiota, and detected causal associations. The findings provide insights into the pathogenesis of HDP and may contribute to the prevention and treatment of HDP from the perspective of gut microbiota.
SCIENTIFIC REPORTS
(2023)
