Review
Radiology, Nuclear Medicine & Medical Imaging
Anjan Bhattarai, Gary F. Egan, Paul Talman, Phyllis Chua, Zhaolin Chen
Summary: This review provides an overview of MRI techniques used to investigate iron dysregulation in ALS, highlighting their potential uses and limitations in disease diagnosis and prognosis. It recommends further longitudinal studies to validate the efficacy of these techniques and concludes that quantitative iron assessment using QSM in MRI holds great potential as a sensitive diagnostic and prognostic marker in ALS. Furthermore, combining multimodal neuroimaging markers with iron imaging may offer improved sensitivity in ALS diagnosis and prognosis, contributing significantly to clinical care and treatment trials.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
John Conklin, Maria Gabriela Figueiro Longo, Azadeh Tabari, Augusto Lio Goncalves Filho, Wei Liu, Daniel Nicolas Splitthoff, Wei-Ching Lo, Stephen F. Cauley, Kawin Setsompop, Pamela W. Schaefer, John E. Kirsch, Otto Rapalino, Susie Y. Huang
Summary: Wave-SWI showed superior performance compared to T2*w-GRE in terms of pathology visualization, signal dropout artifacts, visualization of normal anatomy, and overall image quality, and was non-inferior to standard SWI. Wave-SWI can be performed in a 1.5 T clinical setting with robust performance and preservation of diagnostic quality.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Felipe S. Furtado, Nathaniel D. Mercaldo, Thomas Vahle, Thomas Benkert, William R. Bradley, Lisa Ratanaprasatporn, Ravi Teja Seethamraju, Mukesh G. Harisinghani, Susanna Lee, Krista Suarez-Weiss, Lale Umutlu, Ciprian Catana, Kelsey L. Pomykala, Liran Domachevsky, Hanna Bernstine, David Groshar, Bruse R. Rosen, Onofrio Antonio Catalano
Summary: This study compared standard (STD-DWI) single-shot echo-planar imaging DWI and simultaneous multislice (SMS) DWI during whole-body positron emission tomography (PET)/MRI in terms of acquisition time, image quality, and lesion detection. The results showed that SMS-DWI shortened the acquisition time and maintained or improved the diagnostic yield in most anatomical regions. Therefore, SMS-DWI has important clinical application prospects in cancer staging and restaging.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Konrad A. Kruk, Tobias J. Dietrich, Simon Wildermuth, Sebastian Leschka, Andreas Toepfer, Stephan Waelti, Chan-Hi Olaf Kim, Sabine Guesewell, Tim Fischer
Summary: This study evaluated the feasibility of diffusion-weighted imaging (DWI) in diagnosing osteomyelitis and bone marrow edema in the forefoot. The measurement of apparent diffusion coefficient (ADC) values allowed for differentiation between healthy and abnormal bone and provided specific cutoff values for the confirmation or exclusion of osteomyelitis.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Pediatrics
Suraj D. Serai
Summary: Magnetic resonance imaging is widely used in pediatric body imaging, traditionally for qualitative analysis but now also for simple quantitative analysis. This paper reviews common quantitative MRI techniques and their clinical applications in body imaging.
PEDIATRIC RADIOLOGY
(2022)
Article
Medicine, General & Internal
Yuan-Hsi Tseng, Chien-Wei Chen, Min-Yi Wong, Teng-Yao Yang, Yu-Hui Lin, Bor-Shyh Lin, Yao-Kuang Huang
Summary: This study investigated the clinical manifestations of lower-limb varicose veins using magnetic resonance angiography. The results suggest that symptomatic varicose veins and increased symptom severity are associated with increased blood flow rate and volume in the great saphenous vein.
Article
Clinical Neurology
Sara Pietracupa, Matteo Bologna, Silvia Tommasin, Francesca Elifani, Federica Vasselli, Giulia Paparella, Nikolaos Petsas, Alfredo Berardelli, Patrizia Pantano
Summary: The study evaluated the role of iron deposition in subcortical nuclei of ET patients, finding no iron deposition in these areas, which is generally considered a marker of neurodegeneration. There were no significant differences in iron deposition between ET patients and HS.
NEUROLOGICAL SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Carsten W. K. P. Arnoldussen, Pascale Notten, Rutger Brans, Dammis Vroegindeweij, Lidwine W. Tick, Marlene H. W. van de Poel, Otmar R. M. Wikkeling, Louis-Jean Vleming, Ad Koster, Kon-Siong G. Jie, Esther M. G. Jacobs, Nils Planken, Cees H. A. Wittens, Hugo ten Cate, Joachim E. Wildberger, Arina J. ten Cate-Hoek
Summary: A dedicated MRV scoring system can assess the characteristics of iliofemoral deep vein thrombosis and predict procedural duration and success rate, helping to avoid unnecessary complications.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Davide Maraghelli, Michele Pietragalla, Cesare Cordopatri, Cosimo Nardi, Anna Julie Peired, Giandomenico Maggiore, Stefano Colagrande
Summary: Salivary gland tumours, rare and mainly located in the parotid gland, vary in malignancy based on location. Fine needle aspiration cytology and core needle biopsy are key for diagnosis, while MRI plays a growing role in providing additional information for assessment.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Neurosciences
YangYingQiu Liu, JunYi Dong, QingWei Song, Nan Zhang, WeiWei Wang, BingBing Gao, ShiYun Tian, ChunBo Dong, ZhanHua Liang, LiZhi Xie, YanWei Miao
Summary: This study quantitatively assessed the cerebral vein oxygen levels in AD patients using QSM, finding a significant negative correlation between cerebral venous MSV and cognitive scores. The results suggest that decreasing cerebral venous oxygen levels may impact cognitive status in AD patients and be associated with disease progression.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Computer Science, Interdisciplinary Applications
Sooyeon Ji, Jinhee Jeong, Se-Hong Oh, Yoonho Nam, Seung Hong Choi, Hyeong-Geol Shin, Dongmyung Shin, Woojin Jung, Jongho Lee
Summary: The quad-contrast imaging method introduces a new pulse sequence to acquire four contrast-weighted images in a short scan time, with further reduction achieved through deep learning-based parallel imaging reconstruction. The reconstructed high-quality images demonstrate lower errors and higher structural similarities compared to conventional methods.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Clinical Neurology
Koy Chong Ng Kee Kwong, Daisy Mollison, Rozanna Meijboom, Elizabeth N. York, Agniete Kampaite, Sarah-Jane Martin, David P. J. Hunt, Michael J. Thrippleton, Siddharthan Chandran, Adam D. Waldman
Summary: Rim lesions, characterized by a paramagnetic rim on susceptibility-based MRI, were detected in 27% of early relapsing-remitting MS patients in this multicenter study. The difference in longitudinal volume change between rim lesions and non-rim lesions is still unclear at this stage. Further validation and standardization in defining rim lesions as a biomarker of chronic inflammation are needed for potential translation into routine MS clinical practice.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hayato Tomita, Yuki Deguchi, Hirofumi Fukuchi, Atsuko Fujikawa, Yoshiko Kurihara, Kaoru Kitsukawa, Hidefumi Mimura, Yasuyuki Kobayashi
Summary: This study compared the acquisition time and image quality of CS and PI in oral T2-weighted imaging. The results showed that CSPI-T2WI had a shorter acquisition time and higher fat/muscle contrast ratio compared to PI-T2WI, with no significant differences in overall image quality, artifacts, and visualization of anatomical structures.
EUROPEAN RADIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Gregory J. Rees, Dominic Spencer Jolly, Ziyang Ning, T. James Marrow, Galina E. Pavlovskaya, Peter G. Bruce
Summary: This study utilized Na-23 MRI to directly observe the microstructural growth of sodium in an all-solid-state cell, revealing a porous dendritic morphology which was confirmed through various methods. The significantly larger T-2 contrast for dendritic growth compared to bulk metal electrode is attributed to increased sodium ion mobility within the dendrite. Na-23 T-2 contrast MRI of metallic sodium provides a clear and routine method for observing and isolating microstructural growth, complementing current techniques for analyzing dendritic growth in all-solid-state cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Multidisciplinary Sciences
Jasmin Probst, Marco Rohner, Malin Zahn, Marco Piccirelli, Athina Pangalu, Andreas Luft, Andreas Deistung, Jan Klohs, Susanne Wegener
Summary: Quantitative susceptibility mapping (QSM) can assess venous susceptibility in stroke patients after recanalization treatment, but no correlation was found with patient prognosis or clinical outcomes.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Obstetrics & Gynecology
Piya Chaemsaithong, Roberto Romero, Waranyu Lertrut, Arunee Singsaneh, Pisut Pongchaikul
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Dahiana M. Gallo, Roberto Romero, Mariachiara Bosco, Tinnakorn Chaiworapongsa, Nardhy Gomez-Lopez, Marcia Arenas-Hernandez, Eunjung Jung, Manaphat Suksai, Francesca Gotsch, Offer Erez, Adi L. Tarca
Summary: The study found that pregnant women with severe PPH had higher median maternal plasma concentrations of IL-16, IL-6, IL-12/IL-23p40, MCP-1, and IL-1 beta than patients without PPH. These cytokines could serve as biomarkers or therapeutic targets.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Doron Kabiri, Dror Raif Nesher, Danielle Luxenbourg, Amihai Rottenstreich, Joshua Rosenbloom, Yosef Ezra, Simcha Yagel, Shay Porat, Roberto Romero
Summary: Vaginal progesterone treatment in women with threatened preterm labor and a short cervix after 24 weeks of pregnancy is associated with lower rates of preterm birth. The treatment also prolongs the time interval from diagnosis to delivery and reduces the frequency of neonatal intensive care unit admission.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Maria Teresa Gervasi, Roberto Romero, Elisa Cainelli, Paola Veronese, Maria Rosa Tran, Eunjung Jung, Manaphat Suksai, Mariachiara Bosco, Francesca Gotsch
Summary: This study suggests that asymptomatic intra-amniotic inflammation in the mid-trimester of pregnancy can increase the risk of neurodevelopmental disorders in children. Early recognition and treatment of maternal immune activation may be a strategy for preventing such disorders in offspring.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Nandor Gabor Than, Roberto Romero, Daniel Gyorffy, Mate Posta, Gaurav Bhatti, Bogdan Done, Piya Chaemsaithong, Eunjung Jung, Manaphat Suksai, Francesca Gotsch, Dahiana M. Gallo, Mariachiara Bosco, Bomi Kim, Yeon Mee Kim, Tinnakorn Chaiworapongsa, Simona W. Rossi, Andras Szilagyi, Offer Erez, Adi L. Tarca, Zoltan Papp
Summary: This study identified different molecular subclasses of preeclampsia through longitudinal proteomic profiling, laying the foundation for the development of new diagnostic and personalized tools for prevention.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Tinnakorn Chaiworapongsa, Roberto Romero, Francesca Gotsch, Manaphat Suksai, Dahiana M. Gallo, Eunjung Jung, Arthur Krieger, Piya Chaemsaithong, Offer Erez, Adi L. Tarca
Summary: This study aimed to determine the prevalence, characteristics, and clinical significance of angiogenic/antiangiogenic factor abnormalities in women with preeclampsia stratified according to gestational age at delivery. The results showed that patients with early preeclampsia had an abnormal angiogenic profile in virtually all cases, whereas only 50% of women with preeclampsia at term had such abnormalities. These findings have implications for future clinical care and research.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Roberto Romero
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Tomi Kanninen, Eunjung Jung, Dahiana M. Gallo, Ramiro Diaz-Primera, Roberto Romero, Francesca Gotsch, Manaphat Suksai, Mariachiara Bosco, Tinnakorn Chaiworapongsa
Summary: Preeclampsia and fetal growth disorders are pregnancy-specific conditions that share common pathophysiological mechanisms. This study suggests that the severity of the maternal inflammatory response is highest in patients with preeclampsia, while patients with an SGA fetus also show elevated inflammatory response.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Agustin Conde-Agudelo, Roberto Romero
Summary: This review examines the efficacy of vaginal progesterone (VP) in preventing preterm birth (PTB) in different subsets of high-risk women. The evidence suggests that VP is effective in reducing the risk of PTB and improving perinatal outcomes in certain groups, such as singleton gestations with a short cervix. However, further research is needed to determine its efficacy in other high-risk groups.
JOURNAL OF PERINATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Dahiana M. Gallo, Roberto Romero, Mariachiara Bosco, Francesca Gotsch, Sunil Jaiman, Eunjung Jung, Manaphat Suksai, Carlos Lopez Ramon y Cajal, Bo Hyun Yoon, Tinnakorn Chaiworapongsa
Summary: Green-stained amniotic fluid, also known as meconium-stained amniotic fluid, is a common obstetric hazard. It can be caused by the passage of fetal colonic content or intraamniotic bleeding. Birth with green-stained amniotic fluid is associated with fetal acidemia and potential complications like respiratory distress and seizures. Infection/inflammation inside the amniotic fluid plays a role in the development of meconium-stained amniotic fluid and can lead to clinical chorioamnionitis and neonatal sepsis.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Obstetrics & Gynecology
Agustin Conde-Agudelo, Roberto Romero, Anoop Rehal, Maria L. Brizot, Vicente Serra, Eduardo Da Fonseca, Elcin Cetingoz, Argyro Syngelaki, Alfredo Perales, Sonia S. Hassan, Kypros H. Nicolaides
Summary: This study evaluated the efficacy of vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in twin pregnancies. The results showed that vaginal progesterone did not prevent preterm birth or improve perinatal outcomes in unselected twin pregnancies. However, it appeared to reduce the risk of preterm birth and neonatal morbidity and mortality in twin pregnancies with a sonographic short cervix.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Microbiology
Jonathan J. Panzer, Roberto Romero, Jonathan M. Greenberg, Andrew D. Winters, Jose Galaz, Nardhy Gomez-Lopez, Kevin R. Theis
Summary: The existence of a microbiota in the human placenta is still debated. Recent DNA sequencing investigations reported the presence of a microbiota in typical human term placentas, but it could be background DNA or contamination. Re-analysis of publicly available 16S rRNA gene datasets showed that Lactobacillus, a vaginal bacterium, was highly abundant in placentas but disappeared after applying DNA contaminant removal. Furthermore, bacterial profiles of placental samples clustered primarily by study origin and mode of delivery, suggesting that placentas delivered at term are unlikely to be the original source of observed bacterial DNA signals.
Letter
Obstetrics & Gynecology
Piya Chaemsaithong, Piroon Jenjaroenpun, Pisut Pongchaikul, Arunee Singsaneh, Iyarit Thaipisuttikul, Roberto Romero, Thidathip Wongsurawat
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Priya Prasad, Roberto Romero, Tinnakorn Chaiworapongsa, Nardhy Gomez-Lopez, Anderson Lo, Jose Galaz, Andreea B. B. Taran, Eunjung Jung, Francesca Gotsch, Nandor Gabor Than, Adi L. L. Tarca
Summary: Approximately 47% of women with preterm labor deliver at term, but their infants are at higher risk for being small for gestational age and having neurodevelopmental disorders. This study tested the involvement of components of the insulin-like growth factor system in preterm labor and found higher levels of certain components in women with a history of preterm labor.
FETAL DIAGNOSIS AND THERAPY
(2023)
Article
Medicine, Research & Experimental
Nardhy Gomez-Lopez, Roberto Romero, Maria Fernanda Escobar, Javier Andres Carvajal, Maria Paula Echavarria, Ludwig L. Albornoz, Daniela Nasner, Derek Miller, Dahiana M. Gallo, Jose Galaz, Marcia Arenas-Hernandez, Gaurav Bhatti, Bogdan Done, Maria Andrea Zambrano, Isabella Ramos, Paula Andrea Fernandez, Leandro Posada, Tinnakorn Chaiworapongsa, Eunjung Jung, Valeria Garcia-Flores, Manaphat Suksai, Francesca Gotsch, Mariachiara Bosco, Nandor Gabor Than, Adi L. Tarca
Summary: In this study, the plasma proteome of pregnant and non-pregnant COVID-19 patients and controls was characterized. The findings revealed shared and pregnancy-specific proteomic changes in COVID-19 patients compared to controls, and the plasma proteome accurately identifies COVID-19 patients, even when they are asymptomatic. This study provides insight into the pathogenesis of COVID-19 and explains the more severe outcomes observed in pregnant women.
COMMUNICATIONS MEDICINE
(2023)