Genetic inactivation ofNupr1acts as a dominant suppressor event in a two-hit model of pancreatic carcinogenesis

The humanNUPR1/P8gene is transcriptionally activated by transforming growth factor β via the SMAD signalling pathway

(2015) Roxane M. Pommier et al.   BIOCHEMICAL JOURNAL

EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma

(2012) Carolina Navas et al.   CANCER CELL

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

(2012) Christine M. Ardito et al.   CANCER CELL

Targeting heat shock factor 1 with a triazole nucleoside analog to elicit potent anticancer activity on drug-resistant pancreatic cancer

(2012) Yi Xia et al.   CANCER LETTERS

Homotypic cell cannibalism, a cell-death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer

(2012) Carla E. Cano et al.   EMBO Molecular Medicine

Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis

(2012) Tewfik Hamidi et al.   JOURNAL OF CLINICAL INVESTIGATION

EMT as the ultimate survival mechanism of cancer cells

(2012) Neha Tiwari et al.   SEMINARS IN CANCER BIOLOGY

A Central Role for RAF→MEK→ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma

(2012) Eric A. Collisson et al.   Cancer Discovery

p8 Expression controls pancreatic cancer cell migration, invasion, adhesion, and tumorigenesis

(2011) Maria Jose Sandi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Microarray-Based Class Discovery for Molecular Classification of Breast Cancer: Analysis of Interobserver Agreement

(2011) Alan Mackay et al.   JNCI-Journal of the National Cancer Institute

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

(2011) Eric A Collisson et al.   NATURE MEDICINE

A novel arylethynyltriazole acyclonucleoside inhibits proliferation of drug-resistant pancreatic cancer cells

(2010) Menghua Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Notch1 Functions as a Tumor Suppressor in a Model of K-ras–Induced Pancreatic Ductal Adenocarcinoma

(2010) Linda Hanlon et al.   CANCER RESEARCH

PTEN Loss Accelerates KrasG12D-Induced Pancreatic Cancer Development

(2010) R. Hill et al.   CANCER RESEARCH

miR-200a Regulates Epithelial-Mesenchymal to Stem-like Transition via ZEB2 and β-Catenin Signaling

(2010) Hongping Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nupr1: The Swiss-knife of cancer

(2010) Carla E. Cano et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Deficiency of the Transcriptional Regulator p8 Results in Increased Autophagy and Apoptosis, and Causes Impaired Heart Function

(2010) Derek K. Kong et al.   MOLECULAR BIOLOGY OF THE CELL

Advanced pancreatic carcinoma: current treatment and future challenges

(2010) Anastasios Stathis et al.   Nature Reviews Clinical Oncology

Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma

(2010) P. K. Mazur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Gene Expression Signature Associated with “K-Ras Addiction” Reveals Regulators of EMT and Tumor Cell Survival

(2009) Anurag Singh et al.   CANCER CELL

Aldehyde Dehydrogenase 1 Is a Marker for Normal and Malignant Human Colonic Stem Cells (SC) and Tracks SC Overpopulation during Colon Tumorigenesis

(2009) E. H. Huang et al.   CANCER RESEARCH

Genetic alterations in precancerous pancreatic lesions and their clinical implications

(2009) O. Turrini et al.   GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE

Loss of the Acinar-Restricted Transcription Factor Mist1 Accelerates Kras-Induced Pancreatic Intraepithelial Neoplasia

(2009) Guanglu Shi et al.   GASTROENTEROLOGY

Stress-inducible Protein p8 Is Involved in Several Physiological and Pathological Processes

(2009) Sandro Goruppi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The small chromatin-binding protein p8 coordinates the association of anti-proliferative and pro-myogenic proteins at the myogenin promoter

(2009) R. Sambasivan et al.   JOURNAL OF CELL SCIENCE

Novel Triazole Ribonucleoside Down-Regulates Heat Shock Protein 27 and Induces Potent Anticancer Activity on Drug-Resistant Pancreatic Cancer

(2009) Yi Xia et al.   JOURNAL OF MEDICINAL CHEMISTRY

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

(2009) Ulrich Wellner et al.   NATURE CELL BIOLOGY

Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells

(2009) Nawneet K. Kurrey et al.   STEM CELLS

Inactivation of TIF1γ Cooperates with KrasG12D to Induce Cystic Tumors of the Pancreas

(2009) David F. Vincent et al.   PLoS Genetics

ArgBP2-Dependent Signaling Regulates Pancreatic Cell Migration, Adhesion, and Tumorigenicity

(2008) D. Taieb et al.   CANCER RESEARCH