Review
Surgery
Qing Wang, Shinji Mine, Motomi Nasu, Tetsu Fukunaga, Shuko Nojiri, Chun-Dong Zhang
Summary: This study found that esophageal cancer patients who undergo esophagectomy in high-volume hospitals have a higher overall survival rate compared to those in low-volume hospitals.
FRONTIERS IN SURGERY
(2023)
Review
Oncology
Jiafu Ji, Leiyu Shi, Xiangji Ying, Xinpu Lu, Fei Shan
Summary: The study found that gastric cancer patients who underwent surgery in high-volume centers had better overall survival, lower short-term mortality, more adequate lymphadenectomy, and shorter length of stay. However, hospital volume was not significantly associated with surgical complications, negative margin resection, or disease-free survival.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Hyunju Park, Hye In Kim, Jun-Ho Choe, Man Ki Chung, Young Ik Son, Soo Yeon Hahn, Na-young Hwang, Sook-young Woo, Sun Wook Kim, Jae Hoon Chung, Tae Hyuk Kim, Jee Soo Kim
Summary: The study found that surgeon volume is associated with long-term oncologic outcomes for MTC patients, with low/intermediate-volume surgeons being associated with higher disease recurrence.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
A. Broadbent, S. Rahman, B. Grace, R. Walker, F. Noble, J. Kelly, J. Byrne, T. Underwood
Summary: Complications have a significant impact on long-term survival after oesophagectomy for cancer, especially the cumulative effect of multiple complications. Interestingly, multiple minor complications have a worse effect on survival than major complications.
Review
Critical Care Medicine
Yip Han Chin, Clyve Yu Leon Yaow, Seth En Teoh, Mabel Zhi Qi Foo, Nan Luo, Nicholas Graves, Marcus Eng Hock Ong, Andrew Fu Wah Ho
Summary: This study aimed to evaluate the long-term survival outcomes and quality-of-life of out-of-hospital cardiac arrest (OHCA) patients. The study found lower survival rates in Asia compared to other regions, and higher survival rates in males and patients with initial shockable rhythm.
Review
Oncology
Andrea Grego, Alberto Friziero, Simone Serafini, Amanda Belluzzi, Lucia Moletta, Luca Maria Saadeh, Cosimo Sperti
Summary: Postoperative pancreatic fistula (POPF) after resection for pancreatic ductal adenocarcinoma (PDAC) is significantly associated with worse overall and disease-free survival.
Review
Anesthesiology
Chun-Yu Chang, Meng-Yu Wu, Yung-Jiun Chien, I-Min Su, Shih-Ching Wang, Ming-Chang Kao
Summary: The study suggests that patients undergoing cancer surgery with propofol-based total intravenous anesthesia (TIVA) have better overall survival compared to those receiving volatile anesthesia. However, there was no significant difference in recurrence-free survival between the two anesthesia techniques. Further randomized control trials are needed to confirm these findings.
ANESTHESIA AND ANALGESIA
(2021)
Review
Cardiac & Cardiovascular Systems
Simon A. Amacher, Chantal Bohren, Rene Blatter, Christoph Becker, Katharina Beck, Jonas Mueller, Nina Loretz, Sebastian Gross, Kai Tisljar, Raoul Sutter, Christian Appenzeller-Herzog, Stephan Marsch, Sabina Hunziker
Summary: This study investigated the long-term survival of OHCA patients who survived the initial hospital stay and found that the survival rate after 10 years was between 62% and 64%.
Review
Oncology
Kemin Li, Rutie Yin, Zhengyu Li
Summary: Frailty is associated with the poor long-term survival of patients with ovarian cancer, and high frailty may be an independent risk factor for poor survival.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Sivesh K. Kamarajah, Rohan R. Gujjuri, Muhammed Elhadi, Hamza Umar, James R. Bundred, Manjunath S. Subramanya, Richard P. T. Evans, Susan L. Powell, Ewen A. Griffiths
Summary: Elderly patients undergoing oesophagectomy for cancer are at increased risk of overall, pulmonary, and cardiac complications compared to younger patients. However, there is no increased risk of anastomotic leaks, but they do have lower 5-year overall and disease-free survival rates.
Review
Gastroenterology & Hepatology
Rohan R. Gujjuri, Sivesh K. Kamarajah, Sheraz R. Markar
Summary: Anastomotic leak (AL) after oesophageal cancer surgery has a negative impact on long-term survival, especially in low-volume centers. Efforts should be focused on early recognition and treatment of AL to minimize its impact on long-term survival in patients.
DISEASES OF THE ESOPHAGUS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Bernhard Pommer, Martina Danzinger, Loise Leite Aiquel, Joao Pitta, Robert Haas
Summary: This systematic literature review aimed to investigate the impact of implant placement and prosthetic loading timing on long-term treatment outcomes for single-tooth implants. The results showed no significant differences between different timing protocols, and it was inconclusive whether concepts like one abutment - one time and flap design had an impact on outcomes.
CLINICAL ORAL IMPLANTS RESEARCH
(2021)
Article
Oncology
Murat Emre Reis, Mehmet Ulusahin, Arif Burak Cekic, Mehmet Arif Usta, Ali Guner
Summary: This study aimed to assess the combined impact of surgeon specialization and surgeon volume on both short- and long-term outcomes in patients underwent curative gastrectomy for gastric cancer. The study found that surgeon volume had a significant impact on short-term mortality, while specialization had a greater contribution to long-term survival.
Review
Medicine, General & Internal
Susanne Kuckuck, Robin Lengton, Mariette R. Boon, Eric Boersma, Brenda W. J. H. Penninx, Maryam Kavousi, Elisabeth F. C. van Rossum
Summary: The elevated cortisol levels in Cushing's syndrome are associated with metabolic and cardiovascular diseases. Studies show that long-term biological stress, measured as HairF and HairE levels, is consistently associated with the presence of cardiovascular disease, independent of standard risk factors.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Nora Karasz, Orsolya Juhasz, Marcell Imrei, Miklos Garami
Summary: This study found that hypovitaminosis D is associated with an increased risk of relapse and death in pediatric cancer patients. Lower serum Vitamin D concentrations may lead to earlier cancer recurrence or fatal outcomes.
Article
Surgery
K. Van Den Heede, T. Claerhout, S. Jansen, S. Blontrock, N. Brusselaers, S. Van Slycke
Summary: This long-term follow-up study by a single surgeon in a single center confirms the safety and excellent cure rates of surgery for renal hyperparathyroidism (rHPT), while highlighting the importance of long-term follow-up.
ACTA CHIRURGICA BELGICA
(2023)
Article
Oncology
Wilhelm Leijonmarck, Johannes Asplund, Sheraz R. Markar, Fredrik Mattsson, Jesper Lagergren
Summary: This study investigated the influence of weekday of gastrectomy on long-term survival in patients with gastric adenocarcinoma in Sweden. The results showed that there was no significant impact of surgery on Thursday-Friday compared to Monday-Wednesday on 5-year all-cause mortality and 5-year disease-specific mortality.
Review
Nutrition & Dietetics
Lea Ribet, Robin Dessalles, Corinne Lesens, Nele Brusselaers, Mickael Durand-Dubief
Summary: Food fermentation using sourdough, consisting of lactic bacteria and yeasts, is considered natural and beneficial. This study reviewed clinical evidence on the effects of sourdough bread on health and found that there is currently no clear consensus on its benefits compared to other bread types. Factors such as microbial composition, fermentation parameters, and cereal and flour types may influence the nutritional properties of bread. However, specific strains and fermentation conditions showed improvements in glycemic response, satiety, and gastrointestinal comfort. Further standardization is needed to determine the clinical health benefits of sourdough.
ADVANCES IN NUTRITION
(2023)
Article
Biology
Linnea Hases, Lina Stepanauskaite, Madeleine Birgersson, Nele Brusselaers, Ina Schuppe-Koistinen, Amena Archer, Lars Engstrand, Cecilia Williams
Summary: A high-fat diet can cause gut microbiota dysbiosis, chronic intestinal inflammation, and metabolic syndrome. There are sex differences in the microbiota composition, and female mice are less affected. Estrogenic ligands can attenuate high-fat diet-induced dysbiosis and impact the microbial composition, especially in males.
COMMUNICATIONS BIOLOGY
(2023)
Article
Oncology
Cecilia Radkiewicz, Johannes Asplund, Jesper Lagergren
Summary: In a population-based cohort study in Sweden, the authors found differences in incidence and survival between early-onset and later-onset esophagogastric adenocarcinoma. Male predominance was higher in early-onset cases, except for noncardia gastric cancer. Early-onset patients had more advanced stages and signet ring cell morphology. Incidence trends were similar between early-onset and later-onset cases, with an increase in esophageal adenocarcinoma, stable cardia cancer, and a decrease in noncardia gastric cancer. Early-onset patients had better survival, especially in localized stages and women.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Review
Oncology
Zhiqiang Liu, Yingfan Zhang, Jesper Lagergren, Shanshan Li, Jingru Li, Zhixian Zhou, Zhijian Hu, Shao-Hua Xie
Summary: This systematic review found that circulating levels of sex hormone binding globulin (SHBG) and testosterone may be associated with the risk of gastrointestinal cancer. Higher levels of SHBG were associated with increased risk of gastric and liver cancer, while higher levels of testosterone were associated with increased risk of liver cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Qiao-Li Wang, Giola Santoni, Jesper Lagergren
Summary: The association between diabetes, metformin use, and survival of esophageal cancer patients is not clear. A population-based cohort study found that diabetes was associated with increased all-cause mortality, while metformin use was associated with decreased all-cause mortality. More research is needed to determine if metformin affects survival in esophageal cancer.
JNCI CANCER SPECTRUM
(2023)
Article
Oncology
Cecilia Radkiewicz, Therese M-L Andersson, Jesper Lagergren
Summary: This study calculated years of life lost (YLL) due to the top 10 solid tumors causing the most deaths, using data from the Swedish National Cancer and Cause of Death Registers. The results showed that lung and colorectal cancer remained the leading causes of YLL, while pancreatic and breast cancer moved up in rank. Prostate cancer, on the other hand, moved down in rank. Women consistently lost more life years due to lung and pancreatic cancer, and the decline in colorectal cancer mortality was only reflected as a YLL decline in women. YLL is a simple and intuitive measure that expands our understanding of the cancer burden on society.
JNCI CANCER SPECTRUM
(2023)
Article
Cell Biology
Sanjiv Risal, Congru Li, Qing Luo, Romina Fornes, Haojiang Lu, Gustaw Eriksson, Maria Manti, Claes Ohlsson, Eva Lindgren, Nicolas Crisosto, Manuel Maliqueo, Barbara Echiburu, Sergio Recabarren, Teresa Sir Petermann, Anna Benrick, Nele Brusselaers, Jie Qiao, Qiaolin Deng, Elisabet Stener-Victorin
Summary: The transgenerational effects of PCOS in female progeny are being investigated. This study examines whether sons born to mothers with PCOS transmit reproductive and metabolic phenotypes to their male progeny. The results show that PCOS-sons are more likely to be obese and have dyslipidemia, and a mouse model confirms that these dysfunctions are passed down to multiple generations. The study highlights the potential risk of transmission of reproductive and metabolic dysfunction through the male germline.
CELL REPORTS MEDICINE
(2023)
Article
Infectious Diseases
Frank Mulindwa, Barbara Castelnuovo, Nele Brusselaers, Robert Bollinger, George Yendewa, Willington Amutuhaire, Claudine Mukashaka, Jean-Marc Schwarz
Summary: Dolutegravir (DTG) is recommended as a first and second line antiretroviral therapy due to its favorable side effect profile, but there have been reports of accelerated hyperglycemia in some patients. However, at population level, DTG has been shown to have a lower risk of incident diabetes mellitus compared to other HIV drug classes. In Uganda, there have been similar reports of hyperglycemia during DTG use, leading to a recommendation to withhold DTG in patients with diabetes. However, it remains to be demonstrated whether this recommendation should apply to all patients with incident T2DM.
BMC INFECTIOUS DISEASES
(2023)
Article
Medicine, Research & Experimental
Wen Zhong, Hanna Danielsson, Nele Brusselaers, Dirk Wackernagel, Ulrika Sjobom, Karin Savman, Ingrid Hansen Pupp, David Ley, Anders K. Nilsson, Linn Fagerberg, Mathias Uhlen, Ann Hellstrom
Summary: This study investigated the changes in blood protein profiles during the first months of life in preterm infants and found that the variations in blood protein expression are mainly associated with the postnatal age of the infants. This provides an increased understanding of the development process after extremely preterm birth.
COMMUNICATIONS MEDICINE
(2023)
Letter
Public, Environmental & Occupational Health
Frank Mulindwa, Jean-Marc Schwarz, Nele Brusselaers, Simon Dujanga, George Yendewa, Barbara Castelnuovo
PAN AFRICAN MEDICAL JOURNAL
(2023)
Article
Surgery
Fien Van den Eynde, Klaas Van den Heede, Nele Brusselaers, Sam Van Slycke
Summary: The need for thyroid surgery is increasing in the elderly population due to aging, increased use of imaging studies, and higher prevalence of thyroid nodules and cancer. This study compared surgical outcomes in different age groups and found that patients aged 75 and older had a higher risk of complications, particularly bleeding, indicating that ambulatory surgery is not advisable for this age group.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Surgery
Klaas Van Den Heede, Nele Brusselaers, Esmee Breddels, Sebastien Gaujoux, Camille Buffet, Fabrice Menegaux, Nathalie Chereau
Summary: This study evaluated the prognostic impact of lymph node characteristics on patients with therapeutic neck dissection for clinically N1 classic PTC. The results showed that the number of harvested lymph node, presence of lymph node capsular rupture, and total lymph node ratio were associated with disease persistence or recurrence.
Article
Surgery
Sheraz R. Markar, Giola Santoni, Dag Holmberg, Joonas H. Kauppila, Jesper Lagergren
Summary: This study evaluated the association between annual hospital volume of bariatric surgery and long-term survival in patients with severe obesity. The results showed that higher annual hospital volume was associated with a lower risk of all-cause mortality.
BRITISH JOURNAL OF SURGERY
(2023)
