Mesenchymal stromal cells in inflammatory bowel disease: conspirators within the ‘colitogenic niche’?

Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells

(2012) Yasuhiro Nemoto et al.   GUT

IL-7 Abrogates Suppressive Activity of Human CD4+CD25+FOXP3+ Regulatory T Cells and Allows Expansion of Alloreactive and Autoreactive T Cells

(2012) A.-K. Heninger et al.   JOURNAL OF IMMUNOLOGY

IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells

(2012) C. Penaranda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Luminal CD4+ T Cells Penetrate Gut Epithelial Monolayers and Egress From Lamina Propria to Blood Circulation

(2011) Yasuhiro Nemoto et al.   GASTROENTEROLOGY

Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease

(2011) R. Ciccocioppo et al.   GUT

Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study

(2010) Marjolijn Duijvestein et al.   GUT

Mesenchymal Stem Cells Inhibit Human Th17 Cell Differentiation and Function and Induce a T Regulatory Cell Phenotype

(2010) S. Ghannam et al.   JOURNAL OF IMMUNOLOGY

Mesenchymal Stromal Cells

(2009) Maria Ester Bernardo et al.   Annals of the New York Academy of Sciences