Review
Biochemistry & Molecular Biology
Yury V. Zhernov, Sonya O. Vysochanskaya, Vitaly A. Sukhov, Olga K. Zaostrovtseva, Denis S. Gorshenin, Ekaterina A. Sidorova, Oleg V. Mitrokhin
Summary: Food hypersensitivity encompasses diseases driven by specific immune responses to certain foods, with conditions like eosinophilic esophagitis posing challenges in understanding their molecular mechanisms. Researchers aim to classify and identify primary diseases of non-IgE-mediated/mixed food hypersensitivity, exploring distinctive molecular features and discussing potential biomarkers and therapies for eosinophilic esophagitis. The pathogenesis of eosinophilic esophagitis involves complex interactions and signaling at molecular and cellular levels, with alterations in cytokine signaling pathways observed, although a definitive mechanism remains elusive. The position of esophagitis within allergic disorders and eosinophilic gastrointestinal disorders is currently ambiguous.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Luc Biedermann, Alex Straumann
Summary: This review provides an updated overview of the pathogenesis and clinical management of EoE, discussing treatment options and pointing out unresolved issues.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jesus Gonzalez-Cervera, Angel Arias, Pilar Navarro, Rocio Juarez-Tosina, Maria Cobo-Palacios, Jose M. Olalla, Teresa Angueira-Lapena, Alfredo J. Lucendo
Summary: The study evaluated the tolerance of sterilised milk in EoE patients and its impact on quality of life. The results showed that the majority of patients could tolerate sterilised milk in both the short-term and long-term, but it may cause EoE recurrence in some patients.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Immunology
Tao Zhang, Yuan Cheng, Yuliang Zhou, Zhenqiang Zhang, Shiqin Qi, Zhubin Pan
Summary: By evaluating the diagnostic value of C-reactive protein, interleukin-6, and specific markers for type I hypersensitivity in pediatric patients with severe acute appendicitis, it was found that CRP, IgE, IL-6, and IL-13 are independent risk factors for complicated acute appendicitis (CAA). The combination of these serological markers can be used to diagnose CAA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Tatsuro Nakamura
Summary: This review presents the roles of major lipid mediators released from mast cells, which will be helpful for a better understanding of the pathogenesis of allergic diseases and provide a new strategy for the diagnosis and treatment of allergic reactions.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Alessandra Vultaggio, Francesca Nencini, Susanna Bormioli, Elena Silvestri, Laura Dies, Emanuele Vivarelli, Enrico Maggi, Andrea Matucci
Summary: This study analyzed the modifications of drug-specific immune responses during drug desensitization (DD) in two patients with previous anti-drug antibody (ADA)-mediated hypersensitivity reactions (HR) to rituximab and tocilizumab. The findings revealed a progressive decrease in pre-procedure ADA titer with negativization during DD cycles, a decrease in BA-induced proliferation of effector cells, and an increase of circulating drug-specific Treg cells producing IL-35 during DD treatment. These changes suggest that DD treatment to two BA can inhibit humoral and cellular anti-drug responses in an antigen-restricted manner, potentially contributing to the safety of the procedure.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Zhu-Bin Pan, Tao Zhang, M. M. Yuan Cheng, M. M. Yu-Liang Zhou, M. M. Zhen-Qiang Zhang
Summary: The study found differences in type I hypersensitivity-induced inflammatory response in children of different age groups with acute appendicitis. The intensity of the hypersensitivity response was higher in younger children.
MOLECULAR IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Marco Vincenzo Lenti, Edoardo Savarino, Aurelio Mauro, Roberto Penagini, Francesca Racca, Matteo Ghisa, Giorgio Laserra, Stefania Merli, Elena Arsie, Valeria Longoni, Nicola de Bortoli, Andrea Sostilio, Elisa Marabotto, Sebastiano Ziola, Alessandro Vanoli, Fabiana Zingone, Brigida Barberio, Salvatore Tolone, Ludovico Docimo, Gaia Pellegatta, Giovanni Paoletti, Mentore Ribolsi, Alessandro Repici, Catherine Klersy, Antonio Di Sabatino
Summary: The study on 261 EoE patients revealed a significant diagnostic delay issue, influenced by both patient-related and physician-related factors. Factors like previous misdiagnosis, symptoms, and medical history could contribute to diagnostic delays.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Gastroenterology & Hepatology
Lillian Wang, Kristin C. Mara, Karthik Ravi, Tsung-Teh Wu, Thomas C. Smyrk, David A. Katzka, Jeffrey A. Alexander
Summary: This retrospective study aimed to determine the response rates and predictors of histologic response to elimination diets in adults with EoE. The results showed that a higher pre-SFED EREF score was associated with dietary non-response to SFED. Additionally, poor correlation between symptoms and histologic flares was observed, and ExSFED identified additional dietary responders. Therefore, histologic confirmation should be sought before committing patients to lifelong dietary changes.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Pediatrics
Mansoor Ahmed, Nyaish Mansoor, Tihami Mansoor
Summary: Eosinophilic oesophagitis is a chronic inflammatory disorder involving the esophagus, diagnosed by upper gastrointestinal endoscopy and esophageal biopsies. There is significant variation in treatment practices, including medications and dietary changes. Long-term treatment may be necessary to control symptoms and prevent complications.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Fisheries
Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Melanie Chollot, Vincent Saint-Martin, Sascha Trapp, Marisa Oliveira, Clare E. Bryant, Brian J. Ferguson
Summary: The innate immune response relies on the ability of host cells to detect and respond to microbial nucleic acids. Toll-like receptors (TLRs) play a crucial role in this process by distinguishing self from non-self. This study focused on TLR21, an avian TLR that recognizes bacterial DNA motifs. The findings suggest that avian TLR21 shares similar activation mechanisms to mammalian TLR9, highlighting the conservation of nucleic acid sensing mechanisms across species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Immunology
Melanie A. Ruffner, Zhe Zhang, Kelly Maurer, Amanda B. Muir, Antonella Cianferoni, Kathleen E. Sullivan, Jonathan M. Spergel
Summary: This study focused on milk-induced eosinophilic oesophagitis (EoE) patients undergoing epicutaneous immunotherapy (EPIT) and identified transcriptional changes in peripheral CD4(+) T cells, suggesting potential therapeutic effects of EPIT on EoE.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ashley L. Pyne, Mark W. Hazel, Amiko M. Uchida, Fares Qeadan, Kristine C. Jordan, Amy Holman, Brinnlie Harward, Gerald J. Gleich, Kathryn A. Peterson
Summary: This study found that there are immunoglobulins other than IgG4 and food-specific antibodies present in the oesophageal secretions of eosinophilic oesophagitis (EoE) patients. Patients with active EoE had elevated concentrations of IgG2, IgG4, and IgM in their oesophageal secretions, as well as increased levels of food-specific IgG1, IgG2, IgG4, and IgM. This suggests a potential role for multiple immunoglobulins and food-specific antibodies in the pathophysiology of EoE.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Medical Laboratory Technology
Didier G. Ebo, Kevin Heremans, Michiel Beyens, Marie-Line M. van der Poorten, Athina L. Van Gasse, Christel Mertens, Michel Van Houdt, Vito Sabato, Jessy Elst
Summary: The basophil activation test (BAT) is a reliable complementary diagnostic for IgE-dependent allergies, but it has limitations. In contrast, the mast cell activation test (MAT) using passively sensitized mast cells (MCs) has advantages such as using frozen serum samples and studying IgE-independent mechanisms.
CLINICA CHIMICA ACTA
(2022)
Article
Gastroenterology & Hepatology
Anupama Ravi, Eric Marietta, Jeffrey A. Alexander, Kathryn Peterson, Crystal Lavey, Debra M. Geno, Joseph A. Murray, David A. Katzka
Summary: The study found that food antigens show prolonged presence in the esophageal epithelium of EoE patients, potentially triggering the Th2 allergic pathway. Active EoE patients had higher antigen staining density compared to inactive patients, especially for whey.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Gastroenterology & Hepatology
Daniel J. Mulder, Mary E. Sherlock, David L. Lysecki
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2018)
Article
Pathology
Daniel J. Mulder, Aman Pooni, Nanette Mak, David J. Hurlbut, Sameh Basta, Christopher J. Justinich
AMERICAN JOURNAL OF PATHOLOGY
(2011)
Article
Gastroenterology & Hepatology
Christopher J. Justinich, Nanette Mak, Ivan Pacheco, Dan Mulder, Ron W. Wells, Michael G. Blennerhassett, R. John MacLeod
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2008)
Article
Gastroenterology & Hepatology
Sarah Gander, Daniel J. Mulder, Sarah Jones, John D. Ricketts, Don A. Soboleski, Christopher J. Justinich
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2010)
Article
Gastroenterology & Hepatology
Daniel J. Mulder, David Lobo, Nanette Mak, Christopher J. Justinich
DIGESTIVE DISEASES AND SCIENCES
(2012)
Article
Gastroenterology & Hepatology
D. J. Mulder, I. Pacheco, D. J. Hurlbut, N. Mak, G. T. Furuta, R. J. MacLeod, C. J. Justinich
Article
Cell Biology
Daniel J. Mulder, Nanette Mak, David J. Hurlbut, Christopher J. Justinich
Article
Pathology
D. J. Mulder, S. Gander, D. J. Hurlbut, D. A. Soboleski, R. G. Smith, C. J. Justinich
JOURNAL OF CLINICAL PATHOLOGY
(2009)
Editorial Material
Gastroenterology & Hepatology
Daniel J. Mulder, Lawrence C. Hookey, Christopher J. Justinich
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2010)
Article
Gastroenterology & Hepatology
Daniel J. Mulder, Lawrence C. Hookey, David J. Hurlbut, Christopher J. Justinich
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2011)
Article
Gastroenterology & Hepatology
Daniel J. Mulder, David J. Hurlbut, Angela J. Noble, Christopher J. Justinich
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2013)
Review
Immunology
D. J. Mulder, C. J. Justinich
MUCOSAL IMMUNOLOGY
(2011)
Editorial Material
Gastroenterology & Hepatology
Juan Putra, Daniel J. Mulder
DIGESTIVE AND LIVER DISEASE
(2019)
Article
Medicine, Research & Experimental
Gabriella Leung, Yuhuan Zhou, Philip Ostrowski, Sivakami Mylvaganam, Parastoo Boroumand, Daniel J. Mulder, Conghui Guo, Aleixo M. Muise, Spencer A. Freeman
Summary: The deficiency of ARPC1B can disrupt the nucleation of ARP2/3 complexes by WASP, affecting the cytoskeletal structures in B cells and macrophages, leading to increased tonic signaling in immune cells and impacting the threshold for activation in response to microbial-associated molecular patterns. This highlights the critical role of ARPC1B in controlling steady-state signaling of immune cells.
