Journal
GROWTH FACTORS
Volume 31, Issue 3, Pages 90-97Publisher
INFORMA HEALTHCARE
DOI: 10.3109/08977194.2013.795958
Keywords
Differentiation; ERK1/2; MMPs; neuroblastoma; SK-N-BE cell line
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Epidermal growth factor (EGF) and other EGF-related growth factors, such as transforming growth factor-alpha, are able to stimulate neuroblastoma (NB) cell proliferation. Epiregulin (Epi) is a growth factor belonging to the EGF family known to be more potent than EGF in mediating mitogenic signals. In this study, we tested the ability of Epi to stimulate a human NB cell line (SK-N-BE) proliferation. Surprisingly, Epi (50-1000 ng/ml) induced a reduction in SK-N-BE proliferation along with a morphological differentiation, associated with an increase in MMP-9 expression. Moreover, Epi-induced differentiation was inhibited by ERK1/2 phosphorilation inhibition. In conclusion, Epi could represent a novel and useful tool to oppose NB cell proliferation.
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