Biology and significance of signalling pathways activated by IGF-II

IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development

(2011) P. Li et al.   DEVELOPMENT

Plasma Distribution and Signaling Activities of IGF-II Precursors

(2011) Alicia G. Marks et al.   ENDOCRINOLOGY

Placental-SpecificIgf2Deficiency Alters Developmental Adaptations to Undernutrition in Mice

(2011) A. N. Sferruzzi-Perri et al.   ENDOCRINOLOGY

Loss of heterozygosity proximal to the M6P/IGF2R locus is predictive for the presence of disseminated tumor cells in the bone marrow of ovarian cancer patients before and after chemotherapy

(2011) Jan Dominik Kuhlmann et al.   GENES CHROMOSOMES & CANCER

Insulin-like growth factor-2 (IGF-2) activates estrogen receptor-α and -β via the IGF-1 and the insulin receptors in breast cancer cells

(2011) A. E. Richardson et al.   GROWTH FACTORS

IGF-I, IGF-II, free IGF-I and IGFBP-1, -2 and -3 levels in venous cord blood: relationship to birthweight, length and gestational age in healthy newborns

(2010) D Klauwer et al.   ACTA PAEDIATRICA

IGF2 Actions on Trophoblast in Human Placenta Are Regulated by the Insulin-Like Growth Factor 2 Receptor, Which Can Function as Both a Signaling and Clearance Receptor1

(2010) Lynda K. Harris et al.   BIOLOGY OF REPRODUCTION

Serum IGF-I, IGF-II, IGFBP-3, and IGF-I/IGFBP-3 Molar Ratio and Risk of Pancreatic Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

(2010) J. B. Douglas et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Silencing of the Insulin Receptor Isoform A Favors Formation of Type 1 Insulin-Like Growth Factor Receptor (IGF-IR) Homodimers and Enhances Ligand-Induced IGF-IR Activation and Viability of Human Colon Carcinoma Cells

(2010) G. V. Brierley et al.   ENDOCRINOLOGY

Impairment of insulin receptor signal transduction in placentas of intra-uterine growth-restricted newborns and its relationship with fetal growth

(2010) M E Street et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

A novel two-chain IGF-II-derived peptide from purified β-cell granules

(2010) Christina M. Buchanan et al.   GROWTH HORMONE & IGF RESEARCH

Maternal growth factor regulation of human placental development and fetal growth

(2010) Karen Forbes et al.   JOURNAL OF ENDOCRINOLOGY

Mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) in carcinogenesis

(2009) Irena Martin-Kleiner et al.   CANCER LETTERS

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Hypermethylation of the IGF2 differentially methylated region 2 is a specific event in insulinomas leading to loss-of-imprinting and overexpression

(2009) Emelyne Dejeux et al.   ENDOCRINE-RELATED CANCER

The Protein-Tyrosine Phosphatase, Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2, Is a Crucial Mediator of Exogenous Insulin-Like Growth Factor Signaling to Human Trophoblast

(2009) Karen Forbes et al.   ENDOCRINOLOGY

MEK5 and ERK5 are mediators of the pro-myogenic actions of IGF-2

(2009) E. J. Carter et al.   JOURNAL OF CELL SCIENCE

Leu27IGF2 plays an opposite role to IGF1 to induce H9c2 cardiomyoblast cell apoptosis via Gαq signaling

(2009) Ray-Jade Chen et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Insulin-like growth factor I and II regulate the life cycle of trophoblast in the developing human placenta

(2008) Karen Forbes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLC 2 axis

(2008) Y.-S. Maeng et al.   BLOOD

Activation of Insulin-Like Growth Factor II Receptor Induces Mitochondrial-Dependent Apoptosis through Gαq and Downstream Calcineurin Signaling in Myocardial Cells

(2008) Chun-Hsien Chu et al.   ENDOCRINOLOGY

Precursor Igf-ii (Proigf-ii) And Mature Igf-ii (Migf-ii) Induce Bcl-2 And Bcl-xlExpression Through Different Signaling Pathways In Breast Cancer Cells

(2008) S. Kalla Singh et al.   GROWTH FACTORS

The IGF Axis and Placental Function

(2008) Karen Forbes et al.   Hormone Research in Paediatrics

IGF-II/mannose-6-phosphate receptor signaling induced cell hypertrophy and atrial natriuretic peptide/BNP expression via Gαq interaction and protein kinase C-α/CaMKII activation in H9c2 cardiomyoblast cells

(2008) Chun-Hsien Chu et al.   JOURNAL OF ENDOCRINOLOGY

IGF-II/mannose 6-phosphate receptor activation induces metalloproteinase-9 matrix activity and increases plasminogen activator expression in H9c2 cardiomyoblast cells

(2008) Mu-Hsin Chang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Maternal Insulin-like Growth Factor-II Promotes Placental Functional Development Via the Type 2 IGF Receptor in the Guinea Pig

(2008) A.N. Sferruzzi-Perri et al.   PLACENTA