Review
Immunology
Tewodros Shibabaw, Banchamlak Teferi, Birhanu Ayelign
Summary: Metastatic breast cancer is a common cause of death for women worldwide. Th-17, a pro-inflammatory infiltrative cell, plays a significant role in the proliferation, invasiveness, and metastasis of breast cancer. IL-17, a cytokine generated by Th-17, is upregulated in metastatic breast cancer. IL-17 and its downstream signaling molecules are potential targets for the prevention and treatment of breast cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Chenyi Shao, Yi Liu, Jiaci Li, Ziyun Liu, Yuxia Zhao, Yaqing Jing, Zhe Lv, Ting Fu, Zihan Wang, Guang Li
Summary: Osteogenesis imperfecta (OI), a congenital bone dysplasia, is mainly caused by defective production or assembly of type I collagen. Studies have found that increased osteoclasts and excessive bone resorption exist in collagen-related OI, which is associated with inflammation. Transcriptomic analysis of bone marrow cells from OI mouse models revealed dysregulated genes and pathways related to interferon response, IL17 signaling, tumor necrosis factor signaling, and osteoclast differentiation. These findings contribute to understanding the mechanism of enhanced bone absorption in OI and provide evidence for potential anti-inflammatory therapies.
Article
Dentistry, Oral Surgery & Medicine
J. Zhang, L. Sun, M. H. H. Withanage, S. M. Ganesan, M. A. Williamson, J. T. Marchesan, Y. Jiao, F. R. Teles, N. Yu, Y. Liu, D. Wu, K. L. Moss, A. K. Mangalam, E. Zeng, Y. L. Lei, S. Zhang
Summary: This study identified a risk locus TRAF3IP2 associated with periodontitis and investigated its underlying mechanism in the development of periodontitis. The results showed that TRAF3IP2 plays a significant role in the production of chemokines mediated by IL-17 and in host defense against periodontal pathogens.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Immunology
Xiaoting Liao, Weikang Zhang, Huijun Dai, Ren Jing, Mengling Ye, Wanyun Ge, Shenglin Pei, Linghui Pan
Summary: The study found that IL-17 plays a pro-inflammatory role in ventilator-induced lung injury (VILI) and could serve as a new target for treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Kingston H. G. Mills
Summary: IL-17 cytokines have both protective and pathological functions in the context of infection and autoimmunity. They promote protective immunity against pathogens but can also drive inflammatory pathology. Dysregulated IL-17 responses can contribute to immunopathology, and IL-17 is implicated in various inflammatory diseases.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Krishna Bhan Singh, Reena Rai, Sonu Khanka, Divya Singh
Summary: This study investigated the potential of sequential treatment with NIL17 after PTH withdrawal as a promising therapeutic approach for osteoporosis. The results showed that SHIFT therapy could preserve bone density and microarchitectural parameters while suppressing osteoclast numbers, indicating its potential as a replacement therapeutic option post PTH discontinuation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Arnaud Goepfert, Carmen Barske, Sylvie Lehmann, Emmanuelle Wirth, Joschka Willemsen, Johann E. Gudjonsson, Nicole L. Ward, Mrinal K. Sarkar, Rene Hemmig, Frank Kolbinger, Jean-Michel Rondeau
Summary: Through crystallography, biophysics, and mutational studies, this research demonstrates that IL-17A, IL-17F, and IL-17A/F induce IL-17RA dimerization, leading to the formation of a 2:2:2 hexameric signaling assembly. The formation of the IL-17 signalosome potentiates IL-17-induced IL-36 gamma and CXCL1 mRNA expression in human keratinocytes compared to a dimerization-defective IL-17RA variant.
Article
Microbiology
Xinyi He, Xin Song, Hui Cao, Qun Zhou, Jiaqi Zhang, Hua Yue, Bin Zhang
Summary: This study found that infection with Glaesserella parasuis induces the production of IL-17A in host cells, which is correlated with the degree of pathological injury and bacterial content. The activation of PKC-ERK/MAPK and I kappa B/NF-kappa B signaling pathways is essential for the induction of IL-17 by G. parasuis infection.
VETERINARY MICROBIOLOGY
(2022)
Article
Immunology
Dominika Borowska, Samantha Sives, Lonneke Vervelde, Kate M. Sutton
Summary: This study analyzes chicken macrophages and dendritic cells, revealing differences in phenotype, function, and transcription. The BM cultures with CSF2 and IL-4 tend to represent cells of the macrophage lineage rather than conventional dendritic cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Tomoko Ikeuchi, Niki M. Moutsopoulos
Summary: This review focuses on the mechanisms of induction, amplification, and pathogenicity of Th17 cells in periodontitis.
Article
Plant Sciences
Ya-Jun Yang, Lu-Jiao Lu, Jia-Jia Wang, Shao-Yong Ma, Bi-Lian Xu, Rui Lin, Qiu-Sheng Chen, Zhi-Guo Ma, Yu-Lin Mo, Dong-Tao Wang
Summary: This study demonstrates that TBD has intervening effects on RA-induced osteoporosis, possibly through the downregulation of the IL-17/MAPK signaling pathway by ICA. The findings of this study provide valuable insights for further research in this area.
Article
Medicine, Research & Experimental
Mohammad Reza Aslani, Afshan Sharghi, Mohammad Hossein Boskabady, Hassan Ghobadi, Rana Keyhanmanesh, Mohammad Reza Alipour, Mahdi Ahmadi, Saeideh Saadat, Parya Naghizadeh
Summary: This study investigates the gene expression levels and pro-inflammatory cytokine levels in the lung tissue of obese Ovalbumin (OVA)-sensitized rats, and suggests that the IL-17 axis may play a role in the pathogenesis of obesity-related asthma.
Review
Medicine, General & Internal
Kamran Ghoreschi, Anna Balato, Charlotta Enerback, Robert Sabat
Summary: Psoriasis is a chronic inflammatory disease affecting 2-3% of the global population, characterized by sharply demarcated erythematous and scaly skin lesions. The disease results from hyperproliferation and disturbed differentiation of epidermal keratinocytes provoked by immune mediators of the IL-23 and IL-17 pathway. Therapeutics targeting IL-23, IL-17, and IL-17RA have shown excellent efficacy in treating psoriasis.
Review
Endocrinology & Metabolism
Erica L. Scheller, Meghan E. McGee-Lawrence, Beata Lecka-Czernik
Summary: The BMA2020 meeting aimed to facilitate communication and collaboration among scientists worldwide interested in bone marrow adiposity research, attracting experts from various fields including bone biology, endocrinology, and stem cell biology.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Rheumatology
Anella Saviano, Adel Abo Manosour, Federica Raucci, Francesco Merlino, Noemi Marigliano, Anna Schettino, Mussarat Wahid, Jenefa Begum, Andrew Filer, Julia E. Manning, Gian Marco Casillo, Marialuisa Piccolo, Maria Grazia Ferraro, Simona Marzano, Pasquale Russomanno, Rosa Bellavita, Carlo Irace, Jussara Amato, Mohammed Alfaifi, Peter Rimmer, Tariq Iqbal, Stefano Pieretti, Valentina Vellecco, Francesco Caso, Luisa Costa, Roberto Giacomelli, Raffaele Scarpa, Giuseppe Cirino, Mariarosaria Bucci, Helen M. McGettrick, Paolo Grieco, Asif Jilani Iqbal, Francesco Maione
Summary: This study identified a novel IL-17A/F-derived peptide and generated a new anti-IL-17 antibody that can effectively reverse the pro-inflammatory actions of IL-17A/F. The antibody showed less off-target effects compared to the current gold-standard biologic. Preclinical and clinical evidence demonstrated the high efficacy and therapeutic potency of the antibody in patients with IMIDs.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Anatomy & Morphology
Slavko Mojsilovic, Sonja S. Mojsilovic, Suncica Bjelica, Juan F. Santibanez
Summary: TGF-beta 1 and MDSCs play crucial roles in tumor progression, with simultaneous inhibition potentially improving the efficacy of cancer immunotherapy.
DEVELOPMENTAL DYNAMICS
(2022)
Article
Cell Biology
Aleksandra Jaukovic, Tamara Kukolj, Drenka Trivanovic, Ivana Okic-Dordevic, Hristina Obradovic, Maja Miletic, Vanja Petrovic, Slavko Mojsilovic, Diana Bugarski
Summary: The study found that IL-17 and bFGF have different effects on the proliferation and clonogenicity of dental pulp stem cells from primary and permanent teeth, as well as on the expression of pluripotency markers, while showing similar effects on differentiation capacity.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Engineering, Chemical
Ana Z. Stancic, Ivana T. Drvenica, Vesna L. J. Ilic, Branko M. Bugarski, Diana S. Bugarski
Summary: This study investigated the effects of porcine hemoglobin on different cell types and found its potential role as a supplement in cell culture, particularly in multilineage differentiation capacity. Through a model of porcine hemoglobin, the findings contribute to improving the understanding of extracellular hemoglobin's influence on MSCs in vivo.
Article
Biochemistry & Molecular Biology
Ana Borojevic, Aleksandra Jaukovic, Tamara Kukolj, Slavko Mojsilovic, Hristina Obradovic, Drenka Trivanovic, Milena Zivanovic, Zeljko Zecevic, Marija Simic, Borko Gobeljic, Dragana Vujic, Diana Bugarski
Summary: The precursor of vitamin D3, VD3, can stimulate proliferation and osteogenic differentiation potential of bone marrow stem cells (BM-MSCs), while reducing their senescence. These effects are partially mediated by the SIRT1 signaling pathway.
Article
Immunology
Sanja Knezevic, Dejana Kosanovic, Luka Dragacevic, Irena Zivkovic, Vesna Ilic, Ljiljana Hajdukovic, Olivera Savic, Rajna Minic
Summary: This study aimed to explore the differences in levels of S. pneumoniae specific antibodies among different age and gender groups. The results showed that older individuals had lower titres of specific antibodies, especially in men. Men over 50 years of age also had lower antibody levels compared to women under 50 years of age. The study highlights the deficiency in immune response in older individuals, especially males, and suggests immunization with pneumococcal vaccines for this population.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Tamara Kukolj, Jasmina Lazarevic, Ana Borojevic, Uros Ralevic, Dragana Vujic, Aleksandra Jaukovic, Nenad Lazarevic, Diana Bugarski
Summary: This study used Raman spectroscopy to investigate inter-individual differences between bone marrow mesenchymal stem cells (BM-MSCs). The results showed that despite similar biological characteristics, slight differences in the Raman spectra of BM-MSCs from each donor could be detected. Raman spectroscopy, as a label-free assay, has the potential to understand stem cell heterogeneity and sort cell populations with a similar biochemical background.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Physiology
Sanja Vignjevic Petrinovic, Aleksandra Jaukovic, Maja Milosevic, Diana Bugarski, Mirela Budec
Summary: Cancer-related anemia (CRA) is a common disorder that negatively affects the quality of life and prognosis in cancer patients. Stress erythropoiesis (SE) plays a pivotal role in CRA, but chronic SE may lead to ineffective erythropoiesis, worsening the condition. Therefore, there is an urgent need to control ineffective erythropoiesis in cancer patients and develop personalized treatment strategies for CRA management.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Immunology
Slavomir Nikodijevic, Veljko Blagojevic, Ivana Curuvija, Dejana Kosanovic, Tamara Djukic, Brizita Djordjevic, Vesna Ilic, Rajna Minic
Summary: Increased interest in microbiota has led to the need for thorough analysis of antibody reactivity to different microorganisms. This study investigated the binding and specificity of salivary IgA, a key component of the immune defense against microorganisms, to various microorganisms. The results showed that this analysis method can differentiate species/strains with high IgA binding capacity and should be further confirmed on a larger sample size. Additionally, comparisons were made between the binding of salivary IgA and serum IgA in response to whole microbial cells and purified microbial components, revealing higher specificity in the serum IgA repertoire. The study concludes that the composition of the steady state salivary IgA repertoire raises questions about its ability to select resident microbiota.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2022)
Review
Cell Biology
S. Haeusner, A. Jaukovic, E. Kupczyk, M. Herrmann
Summary: The use of autografts is the current gold standard approach for treating critical size bone defects and nonunion defects. Bone marrow mononuclear cells (BM-MNCs) from autografts provide an abundant and readily available cell source for bone healing, without the need for time-consuming and regulatory challenging cell expansion. However, the exact anatomy and cellularity of BM-MNCs in humans, as well as their limitations in isolation and characterization procedures, still require further research.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ivana T. Drvenica, Ana Z. Stancic, Irina S. Maslovaric, Drenka I. Trivanovic, Vesna Lj. Ilic
Summary: Hemoglobin is not only crucial in maintaining cellular bioenergetic homeostasis by binding and transporting oxygen, but also plays significant roles in cellular signaling and modulation of the inflammatory response. The latest research reveals the impact of extracellular hemoglobin on various cellular functions such as redox status, inflammatory state, proliferation and chemotaxis, mitochondrial dynamics, chemoresistance, and differentiation.
Article
Biochemical Research Methods
Tamara Djukic, Ivana Drvenica, Marijana Kovacic, Rajna Minic, Dusan Vucetie, Dragana Majeric, Mirjana Sefik-Bukilica, Olivera Savic, Branko Bugarski, Vesna Ilic
Summary: This study analyzed the size and electrokinetic potential of circulating immune complexes (CICs) in rheumatoid arthritis (RA) patients, healthy young adults, and age-matched controls. The results showed that RA patients and their age-matched controls had narrower size distributions compared to young adults, and RA patients had larger particles compared to controls. The study suggests that CIC size analysis could be a potential method for diagnosing IC-mediated diseases.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Mihajlo D. Radmilovic, Ivana T. Drvenica, Mihailo D. Rabasovic, Vesna Lj. Ilic, Danica Pavlovic, Sho Oasa, Vladana Vukojevic, Mina Peric, Stanko N. Nikolic, Aleksandar J. Krmpot
Summary: This study characterized the fluorescent behavior of hemoglobin upon interaction with ultrashort laser pulses. The fluorescence intensity gradually increased and reached saturation after prolonged exposure. The formed fluorescent photoproduct exhibited high stability and showed potential applications in biolmaging and blood tracking.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Dragana C. Markovic, Irina S. Maslovaric, Marijana Kovacic, Sanja Vignjevic Petrinovic, Vesna Lj. Ilic
Summary: Myeloproliferative neoplasms (MPNs) are hematologic malignancies characterized by gene mutations and abnormal signaling pathways. Chronic inflammation is believed to play a key role in the progression of MPNs. Neutrophils in MPNs show abnormal activation and apoptotic machinery, leading to inflammation and the formation of neutrophil extracellular traps (NETs). NETs induce hematopoietic precursor proliferation in the bone marrow microenvironment, affecting hematopoietic disorders. This review discusses the potential pathophysiological significance of NET formation in MPNs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Ivana Okic-Djordjevic, Tamara Kukolj, Hristina Obradovic, Drenka Trivanovic, Andjelija Petrovic, Slavko Mojsilovic, Maja Miletic, Diana Bugarski, Aleksandra Jaukovic
Summary: Periodontal disease is a chronic infection that causes degradation of the periodontal tissue. Interleukin-17 (IL-17) plays a crucial role in this process by activating the ERK1/2 MAPK signaling pathway, which promotes the expression and activity of urokinase-type plasminogen activator (uPA) and matrix metalloproteinase-2 (MMP2) in periodontal ligament mesenchymal stem cells (PDLMSCs), leading to extracellular matrix degradation.
ARCHIVES OF BIOLOGICAL SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Ivana Drvenica, Milica Stojic, Natalija Fratric, Marijana Kovacic, Jelica Grujic-Milanovic, Branislav Vejnovic, Dragana Markovic, Dragan Gvozdic, Vesna Ilic
Summary: Redox imbalance in the peripartum period can affect the health of dairy cows and their foetus. Supplementation with organically modified clinoptilolite can improve redox status and enhance antioxidant capacity in cows, contributing to their adaptation to redox imbalance.
ITALIAN JOURNAL OF ANIMAL SCIENCE
(2022)
