Article
Chemistry, Multidisciplinary
Mingqin Zhao, Xinyan Li, Xiaoyu Zhang, Zhihui Shao
Summary: The catalytic dehydrogenation of alcohols is crucial for sustainable production of valuable products, providing a new strategy for green organic synthesis in chemical industries. This study introduces a manganese-based catalytic system that efficiently synthesizes C3-alkylated indoles from benzyl alcohols and indoles via the borrowing hydrogen process. Furthermore, dehydrogenative coupling of 2-arylethanols and indoles yields C3-alkenylated indoles. Additionally, reacting 2-aminophenethanol instead of indoles under the same conditions also yields the corresponding indole products with high selectivity.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Organic
Hao Liu, Wei Chi, Meng-Ling Lin, Lin Dong
Summary: The Ir(iii)-catalyzed C-H alkylation of BINOL units using allyl alcohols as coupling partners has been well explored. With the advantage of the pyridine guiding group, this efficient protocol allows rapid synthesis of diverse BINOL carbonyl compounds while retaining optical purity.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Applied
Yaoguang Sheng, Yi Gao, Bingbing Duan, Mengxia Lv, Yao Chen, Mengjie Yang, Jianmin Zhou, Guang Liang, Zengqiang Song
Summary: A versatile and efficient method for the coupling of maleimides and indoles at the C7-position has been established under Rh(III) catalysis. The protocol is compatible with various functional groups, and yields diverse 3-(indol-7-yl) maleimides and 3-(indol-7-yl)succinimides by switching reaction conditions. Deuteration studies and control experiments have been carried out to explore the mechanism of this transformation.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Organic
Ying-Ying Wang, Man Liu, Lin Dong
Summary: The study successfully synthesized diverse novel compounds through Rh(iii)-catalyzed reactions, demonstrating that achieving selective activation of multiple C-H bonds in complex organic compounds is achievable.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Organic
Fei Zhao, Jin Qiao, Yangbin Lu, Xiaoning Zhang, Long Dai, Xin Gong, Hui Mao, Shiyao Lu, Xiaowei Wu, Siyu Liu
Summary: In this study, alkynylated imidazo[1,5-a]indoles and alpha,alpha-difluoromethylene tetrasubstituted alkenes were successfully synthesized via Rh(III)-catalyzed [4 + 1] annulation/alkyne moiety migration and C-H alkenylation/DG migration, showing excellent product selectivity, high yields, and good tolerance of functional groups.
Article
Chemistry, Organic
Ke-Wei Chen, Dan-Dan Wang, Si-Jia Liu, Xue Wang, Yu-Chen Zhang, Yi-Ming Tian, Qiong Wu, Feng Shi
Summary: The study focuses on the catalytic asymmetric dearomative cycloaddition of 3-alkyl-2-vinylindoles using chiral phosphoric acid, resulting in the synthesis of chiral pyrroloindolines with two tetrasubstituted stereogenic centers in good yields and excellent stereoselectivities. This reaction introduces new reactivity to 3-alkyl-2-vinylindoles and presents a potential strategy for discovering anti-cancer drug candidates.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Subhendu Pramanik, Sarat Chatterjee, Rumjhum Banerjee, Chinmay Chowdhury
Summary: This study presents a direct synthesis method for carbazoles containing aryl and aryl ketone groups. The reaction involves Pd(II)-catalyzed cascade reactions, which enables the fast assembly of carbazoles through four carbon-carbon bond formations. The absence of aldehyde substrates leads to the formation of C4-aryl-substituted carbazoles. The method is versatile for the synthesis of biscarbazole derivatives.
Article
Chemistry, Organic
Pei-Pei Xu, Jun-Yi Liao, Jia-Jie Zhang, Wei-Min Shi, Cui Liang, Gui-Fa Su, Dong-Liang Mo
Summary: Various N-vinylindoles and N-vinylpyrroles were synthesized in moderate to good yields through nickel(II)-catalyzed [3 + 2] cycloaddition. A rational mechanism for the formation of N-vinylindoles was proposed based on labeled experiments and key intermediates detected by mass spectrometry. The method highlights nickel(II)-controlled cyclization, atom-economical reaction, broad substrate scope, good functional group tolerance, and high Z-stereoselectivity.
Article
Chemistry, Organic
Rui-Han Niu, Jing Zhang, Ru-Yuan Zhao, Quan-Jian Luo, Jin-Heng Li, Bo Sun
Summary: A cobalt(III)-catalyzed directed C-7 alkynylation of indolines with easily accessible bromoalkynes has been developed, which provides a powerful route for the synthesis of 7-alkynyl-substituted indolines with broad substrate scope and excellent yields. Furthermore, the reaction can also be applied to the coupling of N-aryl 7-azaindoles, demonstrating the synthetic practicability of this strategy.
Article
Chemistry, Physical
Ge Yin, Yue Li, Rong-Hua Wang, Jiang-Fei Li, Xue-Tao Xu, Yu-Xin Luan, Mengchun Ye
Summary: Conventional C-H alkenylation of 2-pyridone with electron-deficient C-H bonds typically occurs at the C6 or C4 position using low-valent transition-metal catalysis. However, a Ni-Al bimetallic catalyst with a bifunctional ligand resulted in a reversed selectivity, providing high yields of C3-alkenylated 2-pyridones.
Article
Chemistry, Organic
Pragati Biswal, Tanmayee Nanda, Namrata Prusty, Smruti Ranjan Mohanty, Ponneri C. Ravikumar
Summary: A rhodium-catalyzed oxidative C-H/N-H dehydrogenative[3 + 2] annulation strategy has been developed for the synthesis of 2-methylindole scaffolds by reacting anilines and N-allylbenzimidazole. This transformation involves the cleavage of the thermodynamically stable C-N bond of allylamine and proceeds through a cascade of C(sp(2))-H alkylation followed by intramolecular cyclization. Detailed mechanistic studies have been performed to identify a key intermediate.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Smruti Ranjan Mohanty, Namrata Prusty, Tanmayee Nanda, Shyam Kumar Banjare, Ponneri C. Ravikumar
Summary: In this study, the ruthenium-catalyzed regioselective sp2(C-H) monoalkenylation of N-arylpyridones was demonstrated, where the pyridone served as a weakly coordinating directing group. Importantly, this methodology was effectively applied to the synthesis of various drug analogues, with high yields up to 93%. HRMS analysis also revealed the presence of a six-membered ruthenium complex.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Chi-Fan Zhu, Cong-Hui Gao, Wen-Juan Hao, Yi-Long Zhu, Shu-Jiang Tu, De-Cai Wang, Bo Jiang
Summary: A novel chelation-controlled hydrofuranization of unactivated olefins using a-alkynyl arylols has been reported, leading to the production of a variety of C-3-alkylated benzofurans with good yields under mild conditions. The use of a bidentate directing group helps to suppress competing reactions and no additional ligands, additives, or bases/acids are required, making the transformation simple and efficient. This catalysis opens up new possibilities for catalytic difunctionalization of alkynes and olefins with 100% atom utilization.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Bo Zhou, Xiaotian Qi, Peng Liu, Guangbin Dong
Summary: The intermolecular C-H alkenylation of enamides with vinyl acetate is a versatile method to access functionalized ketones efficiently. The reaction involves selective cross-coupling of structurally similar alkenes without the need for large excess of reactants, producing only one stoichiometric by-product. This transformation offers a new pathway for the synthesis of structurally modified ketones.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Yunlong Zhao, Rou Xiao, Weibin Fang, Junling Zhao
Summary: This study presents a protocol for the highly selective addition reaction of isatin-derived beta,gamma-unsaturated alpha-ketoesters with 4-aminoindoles at the C7 position. The reaction, catalyzed by a SPINOL-derived chiral phosphoric acid, yields bisindole derivatives with up to 97% enantiomeric excess. Further biological testing revealed that the products have high cytotoxicity against various cancer cell lines.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Multidisciplinary
Yibo Zhou, Zhengxuan Gu, Changhui Liu, Sheng Yang, Xiaofei Ma, Qiaoshu Chen, Yanli Lei, Ke Quan, Juewen Liu, Zhihe Qing, Ronghua Yang
Summary: This study used a polymeric nanobeacon to investigate the fluctuation of H2Sn during early embryonic development. The results showed that the level of H2Sn significantly increased after fertilization, then was partially suppressed during embryonic development, and finally remained stable.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemical Research Methods
Chuangpeng Shen, Zhisen Pan, Xiaojie Wu, Chong Zhong, Qiao Li, Yuqi Si, Changhui Liu, Haitao Tu, Zhijun Deng, Zhangzhi Zhu, Jiewen Guo, Xiaoyi Xin, Min Liu
Summary: A simple, rapid, and sensitive LC-MS/MS method was developed for the determination of toosendanin in rat plasma. The method showed good linearity, low variability, and stability, and was successfully applied to a pharmacokinetic study of toosendanin in rats.
JOURNAL OF CHROMATOGRAPHIC SCIENCE
(2022)
Article
Thermodynamics
Qingyi Liu, Jiahao Zhang, Jian Liu, Wenjie Sun, Huan Xu, Changhui Liu
Summary: Inorganic phase change materials, especially salt hydrate, have superior energy storage density and thermal conductivity compared to organic phase change materials. They are also safer in terms of flammability and toxicity. However, supercooling and poor shape flexibility have hindered their practical application. By utilizing flexible starch and self-healing capabilities, as well as adding graphite, these issues can be overcome, allowing for the wide application of inorganic phase change materials in low-grade thermal energy harvesting and management.
APPLIED THERMAL ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Mengke Tang, Keke Xu, Han Shang, Xinyu Li, Xinjian He, Lv Ke, Minghui Xie, Zheng Zhou, Changhui Liu, Shengyang Du, Yanqing Wang, Jiefeng Gao, Huan Xu
Summary: Biomimetic mineralization was used to synthesize graphene-hydroxyapatite nanohybrids, which exhibited similar composition, diameter, crystallinity, and rodlike geometry to bone apatite. These nanohybrids were incorporated into poly(lactic acid) (PLA) microfibers, resulting in composite membranes with improved mechanical properties. The PLA/Gr-HA scaffolds also showed excellent cytocompatibility and bioactivity, making them promising for tissue/bone regeneration therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Wenjie Sun, Qingyi Liu, Jiateng Zhao, Hafiz Muhammad Ali, Zafar Said, Changhui Liu
Summary: With the development of electronic machinery, the traditional heat exchange working fluid is inadequate in extreme working environments. Deep eutectic solvent, as a new type of fluid, demonstrates promising thermal stability, low cost, and non-toxicity through hydrogen bond association, making it an efficient heat transfer working fluid. This study utilized glycerol/sodium acetate trihydrate deep eutectic solvent as a base solution, prepared nanofluids filled with TiO2, Al2O3, and Fe2O3 nanoparticles, and discussed the mechanism of thermal conductivity change at the atomic and microscopic levels. Experimental results showed that the prepared deep eutectic solvent system reduced viscosity by 58.03% and increased thermal conductivity by 17.2% compared to glycerol at 25 degrees Celsius. Furthermore, the impact of nanoparticles on thermal conductivity and specific heat capacity was investigated, with thermal conductivity being improved by the addition of Fe2O3 nanoparticles and the specific heat capacity of nanofluids more than doubling after nanoparticle incorporation.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Qingyi Liu, Tong Xiao, Jiateng Zhao, Wenjie Sun, Changhui Liu
Summary: Uneven and insufficient encapsulation between supporting and phase change materials can be avoided by simultaneously forming supporting materials in the same solvent as the melted phase change materials. A one-pot one-step (OPOS) protocol is developed for synthesizing TiO2-supported PCM composite, resulting in a high encapsulation ratio, thermal conductivity enhancement, light-to-thermal conversion efficiency, and bacterial inhibition activity without any leakage. The preparation process is environmentally friendly and easily scalable.
Article
Nanoscience & Nanotechnology
Mengke Tang, Liang Jiang, Cunmin Wang, Xinyu Li, Xinjian He, Yichen Li, Changhui Liu, Yanqing Wang, Jiefeng Gao, Huan Xu
Summary: By using the parallel spinning approach, a micro/nanoscale architecture was created in electrospun PLA membranes, resulting in bimodal fibers that reduce air resistance. The addition of bone-like nanocrystalline hydroxyapatite bioelectret (HABE) enhanced the dielectric and polarization properties of the membranes, leading to improved filtration efficiency. The combination of the nanostructured electret and multistructuring strategy allows for efficient filtration and low resistance, making them highly useful for fully biodegradable filters.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Thermodynamics
Wenjie Sun, Tong Xiao, Qingyi Liu, Jiateng Zhao, Changhui Liu
Summary: This study prepares low viscosity and high thermal conductivity glycerol nanofluids by adding nanoparticles, which enhance the thermal conductivity and specific heat capacity of nanofluids and reduce the viscosity. The addition of 15% acetylacetone and 2% TiO2 nanoparticles increases the thermal conductivity by 8.12% and reduces the viscosity by 47%.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2023)
Review
Energy & Fuels
Tong Xiao, Long Geng, Yucheng Dai, Jiateng Zhao, Changhui Liu
Summary: UV-cured polymerization systems are widely used in coatings, adhesives, and electronic packaging due to their fast curing speed and mild conditions. The cured polymers can encapsulate solid-liquid phase change materials, solving the leakage problem and providing heat storage and thermal management functions. UV-cured polymer-based 3D printing technology offers flexible solutions for complex thermal management and multifunctional phase change material integration. This review summarizes the strategies for UV-cured polymers in phase change energy storage and discusses their classification, curing mechanism, preparation strategies, research progress, and future directions in 3D printing phase change materials.
JOURNAL OF ENERGY STORAGE
(2023)
Article
Chemistry, Analytical
Zhiya Wang, Rong Liu, Zhifang Fu, Xin Yi, Yongjun Hu, Changhui Liu, Dong Pan, Zhaoyang Wu
Summary: In this study, tungsten disulfide quantum dots and gold silver nanoclusters were used as fluorescent probes to construct a nano-sensor for detecting the concentration of copper ions, and successfully eliminated the interference of lead and cadmium ions.
ANALYTICAL METHODS
(2023)
Review
Chemistry, Multidisciplinary
Guoqiang Tang, Wenyuan Qiao, Zheng Wang, Fang Liu, Liang He, Minghao Liu, Wenbo Huang, Hongqu Wu, Changhui Liu
Summary: Efficient and clean recycling of plastic waste is crucial in reducing environmental pollution and carbon emissions. Current disposal methods, such as landfill and incineration, not only cause pollution but also waste natural resources. Recent studies have focused on the high-value conversion of waste plastics into flame retardants, catalysts, adsorption materials, and energy storage. This study reviews the progress in converting waste plastics into electricity storage materials, heat storage materials, hydrogen energy, and other small molecule fuels, providing valuable insights for further research in comprehensive utilization of waste plastics and carbon emissions reduction.
Article
Green & Sustainable Science & Technology
Tong Xiao, Qingyi Liu, Yixuan Lin, Tingyu Lin, Jiateng Zhao, Wenjie Sun, Xiao Chen, Changhui Liu
Summary: Enhancement of shape stability of phase-change materials is achieved through an organic-inorganic composite, solving the leakage problem during the phase-change process and promoting their development and application in practice.
ADVANCED ENERGY AND SUSTAINABILITY RESEARCH
(2023)
Article
Chemistry, Organic
Wenbo Huang, Xiaofeng Rao, Liqiao Shi, Bing Yang, Buxiao Kuang, Hongqu Wu, Shaoyong Ke, Changhui Liu
Summary: This study presents a novel method for the N-arylation of amino acid esters using alpha-bromoacetaldehyde acetal and acetoacetate via an I2-mediated metal-free benzannulation strategy. The synthesized N-arylated amino acid derivatives exhibited promising selective inhibition against cancer cells, suggesting their potential for drug development.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Engineering, Environmental
Tong Xiao, Jiateng Zhao, Long Geng, Zheng Wang, Wenyuan Qiao, Changhui Liu
Summary: In light of the growing recognition of low-carbon initiatives, this study proposes a simplified encapsulation and molding strategy for phase change materials, which can enhance the efficiency of renewable energy utilization. The method involves grafting the phase change materials onto polymer backbones to construct self-supported materials with complex geometry. The process is environmentally friendly and does not require curing agents or organic solvents.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Zafar Said, Maham Aslam Sohail, Rashmi Walvekar, Changhui Liu
Summary: This study investigates the effect of functionalized-multi walled carbon nanotubes (f-MWCNTs/water) nanofluid on stability and thermophysical properties. The results show that the optimum volume concentration of 0.10 vol.% exhibits the best stability and enhanced thermal conductivity. The research provides insights for incorporating the optimum sonication duration in nanofluid studies.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Multidisciplinary
Xuemei Liu, Chaonan Cui, Shuoshuo Wei, Jinyu Han, Xinli Zhu, Qingfeng Ge, Hua Wang
Summary: This study presents a new strategy for designing efficient photocatalysts that can convert CO2 into hydrocarbons by utilizing synergistic catalytic sites. The findings provide a solution for the selective photocatalytic reduction of CO2 to CH4.
Article
Chemistry, Multidisciplinary
Chengxian Hu, Dan Wang, Lu Wang, Ying Fu, Zhengyin Du
Summary: A novel one-pot, three-component reaction conducted under electrochemical conditions was studied. The reaction involved 2-aminothiophenols, aldehydes, and malononitrile, using TBABF4 as an electrolyte and CuI as a catalyst. The proposed reaction mechanism suggested that CuI served as an electron relay. This method offers simplified operation, high atom economy, and mild reaction conditions.
Article
Chemistry, Multidisciplinary
Zhi Yang, Yu Chen, Linxi Wan, Yuxiao Li, Dan Chen, Jianlin Tao, Pei Tang, Fen-Er Chen
Summary: A highly enantioselective method for the complete hydrogenation of pyrimidinium salts using Ir/(S,S)-f-Binaphane complex as the catalyst was developed. This method provides easy access to fully saturated chiral hexahydropyrimidines, which are prevalent in many bioactive molecules. The reactions exhibit high yields and enantioselectivities under mild reaction conditions without additives. Successful application of this methodology in a continuous flow fashion further extends its practical utility.
Article
Chemistry, Multidisciplinary
Tina Jeoh, Jennifer Danger Nill, Wujun Zhao, Sankar Raju Narayanasamy, Liang Chen, Hoi-Ying N. Holman
Summary: In this study, the enzymatic hydrolysis of cellulose was investigated using real-time infrared spectromicroscopy. The spatial heterogeneity of cellulose was found to impact the hydrolysis kinetics. Hydration affected cellulose ordering, and Cel7A preferentially removed less extensively hydrogen bonded cellulose.
Article
Chemistry, Multidisciplinary
Tiphaine Richard, Walid Abdallah, Xavier Trivelli, Mathieu Sauthier, Clement Dumont
Summary: An effective method of grafting functionalities onto lignin based on glycerol carbonate has been developed using an efficient nickel-catalysed telomerisation reaction. This method allows lignin to have new reactive functions and reduces the glass transition temperatures of modified lignins, thereby expanding the application range of lignin-based resins.
Article
Chemistry, Multidisciplinary
Jing Qi, Xiyan Wang, Gan Wang, Srinivas Reddy Dubbaka, Patrick ONeill, Hwee Ting Ang, Jie Wu
Summary: This study presents a green and environmentally friendly approach for the synthesis of imides using electrocatalytic oxidation with H2O as the oxygen source. The method eliminates the need for toxic or expensive oxidants and achieves high yields under mild reaction conditions. It shows broad substrate compatibility and potential for industrial applications.
Article
Chemistry, Multidisciplinary
Babasaheb Sopan Gore, Lin-Wei Pan, Jun-Hao Lin, Yi-Chi Luo, Jeh-Jeng Wang
Summary: Here, we report a visible light-promoted intramolecular radical cascade reaction for the construction of fluorenol and naphthalene-fused cyclopropyl carbaldehyde derivatives. This method offers mild reaction conditions, a broad substrate scope, excellent step efficiency, and scalability, without the need for external chemical oxidants. The novelty of this protocol was demonstrated by synthesizing chrysene analogs and performing late-stage functionalizations.
Article
Chemistry, Multidisciplinary
Juho Antti Sirvio, Idamaria Romakkaniemi, Juha Ahola, Svitlana Filonenko, Juha P. Heiskanen, Ari Ammala
Summary: This article discusses the method of using supramolecular interaction between an aromatic hydrogen bond donor and lignin to achieve rapid delignification of softwood at low temperatures.
Article
Chemistry, Multidisciplinary
Yunyan Meng, Chunxiang Pan, Na Liu, Hongjiang Li, Zixiu Liu, Yao Deng, Zixiang Wei, Jianbin Xu, Baomin Fan
Summary: A novel visible light-driven synthesis method for 2,3-diamines has been developed, which has mild conditions, avoids the use of metal reagents, and can synthesize diamines and diols in one pot.
Article
Chemistry, Multidisciplinary
Mingqing Huang, Haiyang Huang, Mengyao You, Xinxin Zhang, Longgen Sun, Chao Chen, Zhichao Mei, Ruchun Yang, Qiang Xiao
Summary: A direct air-oxidized strategy for the synthesis of benzo[b]phosphole oxides was developed in this study. Arylphosphine oxides were transformed into phosphinoyl radicals, which were further combined with various alkynes to achieve the desired products. DFT calculations revealed the mechanism of phosphinoyl radical formation.
Article
Chemistry, Multidisciplinary
Anwei Wang, Jiayin Huang, Chunsheng Zhao, Yu Fan, Junfeng Qian, Qun Chen, Mingyang He, Weiyou Zhou
Summary: This study demonstrates an innovative strategy for the aerobic oxidation of C(sp(3))-H bonds using gamma-valerolactone. By optimizing the reaction conditions and utilizing specific catalysts, efficient oxidation of C(sp(3))-H bonds is achieved with good chemoselectivity in certain cases.
Article
Chemistry, Multidisciplinary
Shun Li, Likai Tong, Zhijian Peng, Bo Zhang, Xiuli Fu
Summary: Sulfide compounds show promise as electrocatalysts for water splitting, but their performance is limited by factors such as limited active sites and hindered substance transport. This study successfully prepared a high-entropy sulfide (ZnCoMnFeAlMg)(9)S-8, which reduced grain size and increased specific surface area, enabling the realization of a dual-functional catalyst with multiple catalytic sites. High entropy also modulated the electronic properties of sulfides, reducing the potential energy barrier for hydrolysis. This research introduces a new approach for functionalizing high entropy nanomaterials and improves the performance of water splitting catalysts.
