Article
Environmental Sciences
Yanfeng Sun, Yanjian Wan, Ying Jiang, Huaiji Wang
Summary: The study found that exposure to Acetaminophen (AAP) was common in young children in central and south China, with AAP concentrations positively correlated with oxidative stress biomarkers 8-hydroxy-guanosine (8-OHG) and 8-hydroxy-2'-deoxyguanosine (8-OHdG). This suggests a potential association between AAP exposure and DNA and RNA damage.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Analytical
Raluca-Ioana Stefan-van Staden, Oana-Raluca Musat
Summary: This article proposes two stochastic microsensors based on single-walled and multi-walled carbon nanotubes modified with alpha-cyclodextrin for the assay of 8-hydroxy-2'-deoxyguanosine in whole blood. The microsensor based on single-walled carbon nanotubes showed a wider linear concentration range, while the microsensor based on multi-walled carbon nanotubes showed the highest sensitivity.
MICROCHEMICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Francisco Javier Martinez-Noguera, Cristian Marin-Pagan, Jorge Carlos-Vivas, Pedro E. Alcaraz
Summary: The study showed that chronic ingestion of 2S-hesperidin can increase endogenous antioxidant capacity, decrease oxidative stress, and reduce inflammation in amateur cyclists, providing positive effects on their internal status.
Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Jianhui Xu, Jiaxin Zhang, Ruijin Zeng, Ling Li, Meijin Li, Dianping Tang
Summary: This work presents an ultrasensitive photoelectrochemical aptasensor for the detection of 8-hydroxy-2'-deoxyguanosine (8-OHdG). The sensor utilizes target-triggered hemin/G-quadruplex photocurrent polarity switching on ultrathin ZnIn2S4 nanosheets, and demonstrates a broad detection range, low detection limit, and good sensitivity, stability, and selectivity in complex biological matrices.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biochemistry & Molecular Biology
Hyehun Choi, Michael R. Miller, Hong-Ngan Nguyen, Victoria E. Surratt, Stephen R. Koch, Ryan J. Stark, Fred S. Lamb
Summary: TNF alpha activates NADPH oxidase 1, which produces extracellular superoxide anion. The secreted protein ecSOD converts superoxide anion to hydrogen peroxide, playing a role in TNF alpha signaling in vascular smooth muscle cells. Knockdown of ecSOD suppresses downstream TNF alpha signals and reduces expression of TNF alpha receptors.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jelena Mirnic, Milanko Djuric, Ivana Gusic, Tanja Veljovic, Sasa Cakic, Jasmina Katanic, Karolina Vukoje, Bojana Ramic, Snezana Brkic
Summary: This study aimed to evaluate the influence of nonsurgical periodontal treatment on salivary 8-hydroxy-deoxyguanosine (8-OHdG) levels and glycemic control in patients suffering from both type 2 diabetes mellitus (DM2) and periodontitis. The results showed that nonsurgical periodontal treatment significantly reduced salivary 8-OHdG levels and resulted in modest improvement in glycemic control for DM2 patients.
Article
Electrochemistry
Maria G. Trachioti, Jan Hrbac, Mamas Prodromidis
Summary: The development of an advanced sensor for the biomarker 8-OHdG on a low-cost graphite screen-printed electrode was reported in this study, which showed resistance to interference by dopamine, ascorbic acid, and uric acid. A simple treatment method based on uricase was optimized to eliminate interference caused by uric acid, and the sensor was successfully applied to the determination of 8-OHdG in synthetic urine samples with a recovery rate of 95%.
ELECTROCHIMICA ACTA
(2021)
Article
Cardiac & Cardiovascular Systems
Jin Li, Deli Zhang, Kennedy S. Ramos, Lucienne Baks, Marit Wiersma, Eva A. H. Lanters, Ad J. J. C. Bogers, Natasja M. S. de Groot, Bianca J. J. M. Brundel
Summary: The study revealed a gradual increase in 8-OHdG levels during the progression of arrhythmia in patients with AF. Patients with AF recurrence after PVI treatment showed significantly elevated 8-OHdG levels. Furthermore, patients with POAF after cardiac surgery had significantly higher 8-OHdG levels compared to those without POAF.
Article
Chemistry, Analytical
Raluca-Ioana Stefan-van Staden, Liliana-Roxana Balahura, Hassan Y. Aboul-Enein
Summary: Three stochastic sensors based on different modifications of reduced graphene oxide were reported for detecting two biomarkers in whole blood and urine samples. Among them, the sensor based on reduced graphene oxide decorated with TiO(2)and gold nanoparticles showed the highest sensitivity for the electroanalysis of 8-nitroguanine and 8-hydroxy-2`-deoxyguanosine.
ANALYTICAL LETTERS
(2021)
Article
Cell Biology
Ali Sani, Ibrahim Lawal Abdullahi, Muhammad Idrees Khan, ChengXi Cao
Summary: This study investigated the oxidative stress levels and DNA damage in coal vendors in Nigeria. The results showed that prolonged exposure to coal dusts could lead to higher levels of oxidative stress and DNA damage in coal vendors.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Viktoria Premusz, Dominika Lendvai-Emmert, Alexandra Makai, Krisztina Amrein, Shalini Chauhan, Jozsef Bodis, Kalman Andras Kovacs, Akos Varnagy
Summary: This study aimed to investigate the impact of oxidative stress induced by habitual physical activity on outcome measures in IVF patients. The results showed that physical activity was positively related to the number of matured oocytes, embryo quality, and ss-hCG levels. Additionally, a positive correlation was found between 8-OHdG and ss-hCG levels, and there were significant differences in 8-OHdG levels in biochemical pregnancies.
Article
Genetics & Heredity
Monika Oldakowska, Milena Sciskalska, Marta Kepinska, Grzegorz Marek, Halina Milnerowicz
Summary: Interleukin-6 plays a key role in acute pancreatitis, while superoxide dismutase isoenzyme SOD1 may protect against oxidative damage.
Article
Biochemistry & Molecular Biology
Yongzheng Ma, Xinyue Meng, Alphonse Sowanou, Jian Wang, Hanying Li, Ailin Li, Nan Zhong, Yingjie Yao, Junrui Pei
Summary: Excessive exposure to fluoride can cause damage to both bones and soft tissues, and is believed to induce oxidative DNA damage. This study investigated the effects of fluoride on 8-hydroxy-2'-deoxyguanosine (8-OHdG) expression in various tissues of rats exposed to different concentrations of fluoride for different time periods. The results showed that fluoride accumulation in soft tissues varied significantly. The expression patterns of 8-OHdG in response to fluoride were tissue-specific and non-monotonic, with differences observed between the first and third months of fluoride exposure. Correlation analysis revealed inverse correlations between blood 8-OHdG and blood fluoride levels, as well as dental fluorosis grade. These findings suggest that the effects of fluoride on 8-OHdG are dependent on concentration and time of exposure, and vary by tissue.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Peripheral Vascular Disease
Fumihiro Tomoda, Tsutomu Koike, Atsumi Nitta, Hiroko Kurosaki, Hiroko Sugimori, Maiko Oh-hara, Koichiro Kinugawa
Summary: This study investigated the relationship between stress hormones and oxidative DNA damage in human hypertension. The results showed that urinary cortisol levels were significantly positively correlated with 8-hydroxy-2'-deoxyguanosine, a marker of oxidative DNA damage. However, urinary adrenaline or noradrenaline did not show a significant correlation with 8-hydroxy-2'-deoxyguanosine. These findings suggest that the overactivation of the hypothalamic-pituitary-adrenal axis may contribute to oxidative stress and DNA oxidation in primary hypertension.
JOURNAL OF HYPERTENSION
(2023)
